Daniel C. Glade

The University of Texas Health Science Center at San Antonio

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Huiyun Liang

The University of Texas Health Science Center at San Antonio

Joshua L. Owen

Audie L. Murphy Memorial VA Hospital

Andrew Slaga

The University of Texas Health Science Center at San Antonio

Anna Mancha-Ramirez

The University of Texas Health Science Center at San Antonio

Julia Wool

Johns Hopkins Medicine

Aleksandar L. Krunic

Northwestern University

Maricruz Espinoza

The University of Texas Health Science Center at San Antonio

Sarah F. Bovio

The University of Texas Health Science Center at San Antonio

Jacob J. Junco

Children's Cancer Center

Jianxiong Zeng

Sun Yat-sen University

Cooperative Institutions

The University of Texas Health Science Center at San Antonio

The University of Texas at San Antonio

Hudson Institute

The University of Texas Health Science Center at Houston

John Wiley & Sons (United States)

Sun Yat-sen University

National Cancer Institute

University of Chinese Academy of Sciences

Sun Yat-sen University Cancer Center

Chinese Academy of Sciences

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Response to Letter to the Editor for “‘stacked stitch’ for efficient closure of deep cutaneous defects”

JAAD International (2024)

Daniel C. Glade Aleksandar L. Krunic Joshua L. Owen

Closure (psychology)

10.1016/j.jdin.2023.12.007

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Spreading Vesicles in a Neonate

The Journal of Pediatrics (2020)

Daniel C. Glade Amreen Z. Sitabkhan Sandra Osswald

Incontinentia Pigmenti

Genodermatosis

Erythema

Girl

10.1016/j.jpeds.2019.12.020

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Enlarging lesion on the back of a 17‐year‐old boy

Pediatric Dermatology (2019)

Daniel C. Glade Zachary D. Gillooly John Browning

Miami

10.1111/pde.13696

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Issue Information ‐ Ed Board

Molecular Carcinogenesis (2018)

Ziqi Zhou Jingjing Zhao Changlong Chen Yuan Liu Jianxiong Zeng

10.1002/mc.22854

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Harnessing the gatekeepers of glucocorticoids for chemoprevention of non‐melanoma skin cancer

Molecular Carcinogenesis (2018)

Anna Mancha-Ramirez Xiaoyu Yang Huiyun Liang Jacob J. Junco Kevin P. Lee

Despite effective surgical methods for non‐melanoma skin cancer (NMSC), patients suffer from tissue damage, scarring, or even disfigurement; thus, there is a need for chemopreventive approaches. Because of the complex interplay between glucocorticoids (GCs), inflammation, and cancer, we sought to determine the role of 11β‐hydroxysteroid dehydrogenase 1 and 2 (11βHSD1 and 2) in regulating GCs during skin cancer development and progression. 11βHSDs modulate the activation of GCs in a tissue‐specific manner and have been reported to play a role in development and progression of other types of cancer, but their role has not yet been reported in NMSC. Here, we found a significant upregulation of 11βHSD2 protein in skin cancer cells when compared to normal skin cells, suggesting a role for this enzyme in the multifactorial process of skin cancer development. In addition, inhibition of 11βHSD2 with siRNA resulted in significant reduction in colony formation in vitro. Finally, our in vivo study elucidated that inhibition of 11βHSD2 with pharmacological inhibitor, Glycyrrhetinic acid (GA) could significantly diminish tumorigenesis in a well‐studied in vivo mouse model of NMSC. Overall, these studies highlight for the first time a potential novel role for 11βHSD2 in NMSC development and may allow for new GC treatment approaches capable of avoiding deactivation by the enzyme. If 11βHSD2 can be inhibited as we have done here, or circumvented using modified GCs, this may lead to more efficacious outcomes for NMSC patients by preventing deactivation of the GC and minimizing resistance.

10.1002/mc.22912

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Citations (5)

“Stacked Stitch” for efficient closure of deep cutaneous defects

JAAD International (2023)

Daniel C. Glade Aleksandar L. Krunic Joshua L. Owen

Closure (psychology)

10.1016/j.jdin.2023.01.008

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Citations (2)