Mengxia Yan

Dezhou University

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Xiurong Yang

Changchun Institute of Applied Chemistry

Jianshe Huang

Changchun Institute of Applied Chemistry

Jing Ye

Nanjing University

Liping Zhu

Sichuan Normal University

Qiuju Zhu

Xuzhou Medical College

Dan Xu

Jilin University

Sinuo Feng

Chinese Academy of Sciences

Yongwang Li

Tianjin University

Yu Xue

Changchun Institute of Applied Chemistry

Libing Fan

Northwest Research Institute of Chemical Industry

Cooperative Institutions

Chinese Academy of Sciences

Changchun Institute of Applied Chemistry

University of Science and Technology of China

Shandong Academy of Sciences

Qilu University of Technology

University of Chinese Academy of Sciences

Energy Research Institute

Jilin University

Institute of Coal Chemistry

Dezhou University

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Sensitive and Programmable “Signal-Off” Electrochemiluminescence Sensing Platform Based on Cascade Amplification and Multiple Quenching Mechanisms

Analytical Chemistry (2021)

Liping Zhu Jing Ye Mengxia Yan Linying Yu Yao Peng

A versatile and sensitive quantum dot (QD)-based "signal-off" electrochemiluminescence (ECL) sensing system was constructed using target-initiated dual Mg2+-dependent DNAzyme (MNAzyme) recycling and catalytic hairpin assembly (CHA) amplification strategies. After the cascade amplification, numerous ferrocene-labeled Y-shaped DNA complexes generated on the QD-modified electrode surface. In the presence of hemin, moreover, the terminal sequence of the formed complex could assemble into hemin/G-quadruplex. Therefore, the highly efficient ECL quenching was achieved due to the multiple quenching mechanisms, including electron/energy transfer between ferrocene and QDs, the steric hindrance effects, and the horseradish peroxidase-mimicking activity of hemin/G-quadruplex. Furthermore, owing to the flexibility in regulating the recognition sequences of MNAzyme, the assaying targets can be programmed. Based on the cascade amplification and multiple ECL quenching mechanisms, the developed programmable "signal-off" ECL sensing platform demonstrates excellent sensitivity and the detection limits of 35.00 aM, 3.71 fM, and 0.28 pM (S/N = 3) for target DNA, aptamer substrate (ATP as a model), and ion (Ag+ as a model), respectively.

Electrochemiluminescence

Deoxyribozyme

Hemin

Aptamer

G-quadruplex

10.1021/acs.analchem.0c04839

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Citations (36)

Dual-Wavelength Ratiometric Electrochemiluminescence Immunosensor for Cardiac Troponin I Detection

Analytical Chemistry (2018)

Jing Ye Liping Zhu Mengxia Yan Qiuju Zhu Qingqing Lu

Ratiometric electrochemiluminescence (ECL) has attracted special focus in the biological analysis field, because it could eliminate the environmental interference and allow for precise measurement. Herein, a dual-wavelength ratiometric ECL biosensor was designed for the detection of cardiac troponin I (cTnI), where (4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) (Ru(dcbpy)32+) and Au nanoparticle-loaded graphene oxide/polyethylenimine (GPRu–Au) nanomaterial acts as an acceptor, and Au nanoparticle-modified graphitic phase carbon nitride nanosheet composite (Au–CNN) acts as donor. Au–CNN shows a high and steady ECL signal centered at 455 nm, which is well-matched with the adsorption of GPRu–Au; thereby, a highly efficient electrochemiluminescent resonance energy transfer (ECL-RET) sensing platform is designed. AuNPs facilitate the immobilization of antibody on the nanomaterials through a Au–N bond. The high surface area of graphene oxide/polyethylenimine allows a large number of Ru(dcbpy)32+ to be loaded, immensely amplifying the ECL signal. This sensing platform exhibits outstanding analytical performance toward cTnI with a detection limit of 3.94 fg/mL (S/N = 3). The high reliability, selectivity, and sensitivity of this ratiometric ECL biosensor provides a versatile sensing platform for the bioanalysis.

Electrochemiluminescence

Luminescent Measurements

10.1021/acs.analchem.8b04640

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Citations (118)

N-(Aminobutyl)-N-(ethylisoluminol)-functionalized gold nanoparticles on cobalt disulfide nanowire hybrids for the non-enzymatic chemiluminescence detection of H₂O₂

Nanoscale (2018)

Qiuju Zhu Jianshe Huang Mengxia Yan Jing Ye Dewen Wang

Efficient chemiluminescence nanomaterials are rapidly synthesized through a microwave-assisted method to reduce HAuCl₄ on CoS₂ NWs with ABEI.

10.1039/c8nr03990a

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Citations (29)

Cu2+ enhanced chemiluminescence of carbon dots-H2O2 system in alkaline solution

Talanta (2019)

Qiuju Zhu Guoyong Liu Mengxia Yan Jing Ye Liping Zhu

Alkaline earth metal

Carbon fibers

10.1016/j.talanta.2019.120380

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Citations (18)

Holey nitrogen-doped graphene aerogel for simultaneously electrochemical determination of ascorbic acid, dopamine and uric acid

Talanta (2020)

Sinuo Feng Linying Yu Mengxia Yan Jing Ye Jianshe Huang

Electrochemical gas sensor

10.1016/j.talanta.2020.121851

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Citations (86)

An electrochemical sensor for sensitive detection of dopamine based on a COF/Pt/MWCNT–COOH nanocomposite

Chemical Communications (2022)

Sinuo Feng Mengxia Yan Yu Xue Jianshe Huang Xiurong Yang

Herein, an electrochemical sensor was developed for sensitive detection of dopamine (DA) based on a novel COF-based nanocomposite named COF/Pt/MWCNT-COOH, which possesses large specific surface area, excellent electrical conductivity, and high catalytic activity, thus broadening the application of COFs in the electrochemical sensing area.

Electrochemical gas sensor

Specific surface area

10.1039/d2cc01376b

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Citations (59)

Zinc-assisted nanometric Pt cluster stabilized on KL zeolite via atomic layer deposition for the n-heptane aromatization

Applied Catalysis A General (2023)

Dan Xu Li Wei Mengxia Yan Fengjiao Yi Guoyan Zhao

Heptane

Aromatization

Deposition

10.1016/j.apcata.2023.119308