ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiresidue Procedures for the Determination of Pesticides in Food Using Capillary Gas Chromatographic, Flame Photometric, and Mass Spectrometric TechniquesMakoto Miyahara, Yutaka Okada, Hisashi Takeda, Gaku Aoki, Akihiko Kobayashi, and Yukio SaitoCite this: J. Agric. Food Chem. 1994, 42, 12, 2795–2802Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jf00048a027https://doi.org/10.1021/jf00048a027research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract Three strains of spirochetes (IKA1 to 3) were isolated from the midgut of Ixodes ovatus collected in the Ikawa region of the northern part of Shizuoka, Japan. These isolates had eight flagella, and their size and other morphological features were similar to Borrelia burgdorferi . They showed similar motility and reacted with monoclonal antibody (MAb) H9724 against borrelial flagella and with MAb H5332 against the outer surface protein A. These strains showed similar SDS‐PAGE profiles to that of B. burgdorferi strain B31 and P/Bi isolated in the U.S.A. and Europe, respectively. Immunoblot with Lyme disease patient serum showed positive reactions with the flagella (41 Kilodalton, kDa), protein C (20 to 22 kDa), and outer surface protein A (29 kDa) of the isolates. Immunological properties, morphological characteristics, and epidemiological features revealed that these isolates were B. burgdorferi .
A 63-year-old woman who underwent aortic and mitral valve replacement developed agranulocytosis just after operation. It was considered that agranulocytosis was caused by bone marrow suppression by antiarrhythmic agent and extracorporeal circulation. Her white blood cell counts decreased to 300/mm3 on the third postoperative day, but increased surprisingly 5 days after administration of G-CSF. Fortunately she did not suffered from severe infection, and thereafter postoperative course was uneventful. Although agranulocytosis just after open heart surgery has not been reported, it appears that G-CSF might be useful.
The multistage extraction of metal ion was studied by a centrifuge extractor, in which oil and water were flown counter-currently through the narrow gap between a rotated inner cylinder and a static outer cylinder. Oil (dodecane) was dispersed finely by increasing the rotating speed of inner cylinder and flown up against the downflow of water. The small drops of dispersed oil were sucked down by Taylor vortices accumulated on the inner-cylinder surface. Stable belt-shaped structures of oil phase were observed at even intervals on the surface of inner cylinder. The extraction of Zn(II) with di-2-ethylhexylphosphoric acid dissolved in dodecane was examined. The extraction of Zn was promoted by the increase of oil hold-up and the improvement of oil dispersion, which were observed by increasing the rotating speed of inner cylinder and the flow rates of oil and water. The number of theoretical stages was evaluated as about 3 stages under the conditions that the rotating speed and the flow rates of oil and water were given as 1200 rpm and 17 ml/min, respectively. The multistage extraction was achievable successfully by the proposed centrifuge extractor with Taylor-Couette flow.
A high-performance bipolar/I 2 L/CMOS on-chip technology has been developed. To combine all devices, three-level epitaxial layers Were used. Both n-p-n and lateral p-n-p bipolar transistors, and p-channel MOSFET's were fabricated on the top level epitaxial layer. I 2 L and n-channel MOSFET's were fabricated on the middle and bottom levels, respectively. Using a thin epitaxial layer and simultaneously reducing the level of regions for n-channel MOSFET's and bi-polar isolation grooves, the process sequence was designed to be as simple as possible. Bipolar n-p-n transistors with a maximum cutoff frequency of 5 GHz, I 2 L circuits having 40-MHz maximum toggle frequency, and CMOS devices operating at a minimum propagation delay time of 300 ps/gate were developed compatibly. This technology has feasibility for application to multifunctional analog/digital VLSI's.
We investigated the in vivo antagonistic activity of ONO-1078 against peptide leukotrienes (LTs) in guinea pigs. ONO-1078, when administered p.o. (0.3-3 mg/kg), caused a dose-dependent reduction of LTC4-, LTD4- and LTE4-induced bronchoconstriction, LTD4-induced airway microvascular leakage and LTD4-induced increase in cutaneous vascular permeability. When administered intravenously, ONO-1078 (3-30 micrograms/kg) inhibited these responses approximately 200-600 fold more potently than FPL55712. When guinea pigs were treated with indomethacin to examine the antagonism of ONO-1078 on the direct action against peptide LTs, intravenous (3-30 micrograms/kg) and oral (0.3-3 mg/kg) administration of ONO-1078 also inhibited LTC4- and LTD4-induced bronchoconstriction, and its activity was approximately 300-500 fold more potent than that of FPL55712. ONO-1078 (10 mg/kg, i.v.) had no inhibitory effect on bronchoconstrictions induced by histamine, acetylcholine, serotonin, arachidonic acid, LTB4, prostaglandin (PG) F2 alpha, PGD2, 9 alpha, 11 beta-PGF2, a stable thromboxane A2 mimetic agent and platelet activating factor. Furthermore, oral administration of ONO-1078 (1-10 mg/kg) inhibited slow-reacting substance of anaphylaxis mediated bronchoconstriction induced by antigen in a dose-dependent manner. These results indicate that ONO-1078 is an extremely potent, selective and orally active peptide LT antagonist and that oral administration of ONO-1078 antagonizes not only exogenously administered peptide LTs but also endogenous peptide LTs.
