Ajay Khanna

Banaras Hindu University

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Satyendra K. Tiwary

Banaras Hindu University

Christopher A. Miller

Washington University in St. Louis

Sridhar Nonavinkere Srivatsan

Washington University in St. Louis

Robert S. Fulton

Washington University in St. Louis

Catrina C. Fronick

James S. McDonnell Foundation

Timothy J. Ley

Washington University in St. Louis

Matthew J. Walter

Washington University in St. Louis

Daniel C. Link

Washington University in St. Louis

Puneet Kumar

King George's Medical University

Michele O’Laughlin

Washington University in St. Louis

Cooperative Institutions

Institute of Medical Sciences

138

Banaras Hindu University

125

All India Institute of Medical Sciences

Washington University in St. Louis

All India Institute of Medical Sciences Bhopal

Indian Institute of Technology BHU

All India Institute of Medical Sciences Raipur

King George's Medical University

Creative Commons

Post Graduate Institute of Medical Education and Research

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Necrotizing Soft Tissue Infection

Springer eBooks (2016)

Ajay Khanna Parameswaran Sundaran Soumya Khanna

10.1007/978-81-322-2635-2_17

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Citations (1)

Evidence-Based Clinical Practice Points for the Management of Venous Ulcers

Indian Journal of Surgery (2018)

Ravul Jindal Devendra Dekiwadia Pinjala Rama Krishna Ajay Khanna Malay Patel

Varicose Ulcer

10.1007/s12262-018-1726-3

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Citations (30)

Implementation of Early Detection Services for Cancer in India During COVID-19 Pandemic

Cancer Control (2020)

Divya Khanna Naveen Khargekar Ajay Khanna

Early detection of cancer greatly increases the chances of better survival. The emergence of COVID-19 pandemic has disrupted several essential health services globally and early detection of cancer services is one of them. The routine cancer screenings have plummeted in many developed countries since the crisis. India has highest estimated lip and oral cavity cancer cases worldwide (119,992, 33.8%) and the secondhighest number of breast (162,468, 17.8%) and cervix uteri (96,922,30.7%) cancers in Asian sub-continent. Not only India has high burden of cancer, but the majority (75-80%) of patients have advanced disease at the time of diagnosis. Hence is it imperative that early detection services should be kept functional at out-patient settings so that at least the patients coming to hospitals with early signs and symptoms can be diagnosed as early as possible. Strategies need to be adopted to continue early detection services and ensure safety of patients and health care workers from COVID-19 transmission.

Pandemic

10.1177/1073274820960471

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Citations (13)

Study of association of varicose veins and inflammation by inflammatory markers

Phlebology The Journal of Venous Disease (2020)

Satyendra K. Tiwary Anoop Kumar Shiv Prakash Mishra Puneet Kumar Ajay Khanna

Objective In varicose veins, increased levels of inflammatory markers are indicators of endothelial damage and increased procoagulant activity. These findings support the assumption that the constitution of blood in varicose veins differs from that of systemic blood. The purpose of the study was a correlative study of blood constituents in varicose veins and peripheral veins (normal vein) in same individual with varicose vein which was done by comparing the level of concentration of interleukin-6, fibrinogen, haemoglobin from blood of varicose veins and normal peripheral vein (antecubital vein). Method Using citrated plasma samples withdrawn from arms and legs of same patient and plasma obtained by centrifugation of citrated venous blood at 5000 r/min for 10 min was used for correlation. Serum concentration of interleukin-6 and fibrinogen were determined by human enzyme-linked immunosorbent assay Kit for both interleukin-6 and fibrinogen, which is based on the standard sandwich enzyme-linked immunosorbent assay technology. This assay employs a monoclonal antibody specific for human interleukin-6 coated on a 96-well plate. Result Expressed as median (interquartile range) in pg/mL, leg samples from patient having varicose vein has significantly increased interleukin-6 in cases as compared to controls ( p value of <0.001). Leg samples from patient having varicose vein has significantly increased fibrinogen concentration than their arm samples ( p value of <0.001). Concentration of haemoglobin significantly increased in leg samples as compared to blood withdrawn from arms ( p value of 0.012). Conclusion Blood withdrawn from the site of varicose vein appears to have significantly increased concentration of interleukin-6, fibrinogen and haemoglobin when compared to same patient’s antecubital blood sample supporting the hypothesis that inflammation is increased in tissues drained by varicose vein.

Venous blood

10.1177/0268355520932410

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Citations (16)

Varicose Vein

Jaypee Brothers Medical Publishers (P) Ltd. eBooks (2016)

Ajay Khanna Shashi P Mishra

10.5005/jp/books/12806_11

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Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

Andrew J. Menssen Ajay Khanna Christopher A. Miller Sridhar Nonavinkere Srivatsan Gue Su Chang

Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

10.1158/2643-3230.22544969.v1

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Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

Andrew J. Menssen Ajay Khanna Christopher A. Miller Sridhar Nonavinkere Srivatsan Gue Su Chang

Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

10.1158/2643-3230.22544960.v1

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Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

Andrew J. Menssen Ajay Khanna Christopher A. Miller Sridhar Nonavinkere Srivatsan Gue Su Chang

Supplementary Table from Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression

Convergent evolution

10.1158/2643-3230.22544957.v1

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Clinico-histopathological study of varicose vein and role of matrix metalloproteinases-1, matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinase-1 in varicose vein formation.

DOAJ (DOAJ: Directory of Open Access Journals) (2016)

Bitan Naik Mohan Kumar Ajay Khanna Pradeep Kumar Suman

Varicose vein (VV) is an important cause of morbidity in the young and elderly population. Many studies of the Western country suggest that matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs have a crucial role in the pathogenesis of VV, but limited work has been done in Indian population. The aim of this study is to study detailed histology of VV and to see the expression of MMP-1, MMP-9 and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1).A total of 63 cases of VV and 10 control leg veins were included in this prospective study. Paraffin sections of VV were prepared. Hematoxylin and eosin (H and E), Masson trichrome and Verhoeff's staining were performed. Immunohistochemistry of VV was done with MMP-1, MMP-9, and TIMP-1 antibodies. Cytoplasmic expression of MMP-1, MMP-9 and TIMP-1 were graded as intense positive (++), weak/slight positive (+), and absent (-).Focal intimal thickening (47.6%), increased medial thickening (73%) and fragmentation of elastin fibers (84.1%) were the major histological changes noted in H and E and special stained sections. MMP-1 expression increased in all layers of VV in 58 cases (92.1%) as compared to control veins. As compared to the control veins, intimal and adventitial expression of MMP-9 were increased in 31 (49.2%) and 40 (63.5%) cases, respectively. Expression of TIMP-1 was absent in both the varicose and the control veins.Increased expression of MMP-1 and MMP-9 suggests they have an important role in the pathogenesis of VV.

Masson's trichrome stain

Trichrome

Pathogenesis

Histology

10.4103/0377-4929.178217

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Citations (14)

Determinants of Uptake of Cervical Cancer Screening in Northern India

Indian Journal of Public Health Research & Development (2019)

Divya Khanna Sunita Vashist Anuradha Khanna Ajay Khanna

Background: The launch of operational framework for India’s first national cancer screening programme in 2016 was a landmark event in the background of poor screening coverage status. Our study aims to determine the factors deciding the uptake of cervical screening amongst women in rural India. Method: A cross-sectional, observational study was carried out amongst the women attending a secondary health centre of a district from Northern India. A total of 1250 women aged above 30 years who were never diagnosed or treated for cervical cancer were enrolled. After taking informed consent all women were interviewed about their bio-social profile and if they ever underwent screening of cervical cancer. Chi-square or Fisher’s exact test was applied to find out significant difference in distribution of bio-social variables (predictors) amongst the study population. The significant predictor variables were subjected to Binary and Multiple Logistic Regression. Unadjusted and Adjusted Prevalence Odds Ratio with 95% Confidence Interval were generated. Results: Religion, working status of the women, history of multiple sexual contacts were important factors influencing the utilization of screening. Conclusion: We conclude that cervical cancer screening is a cost-effective strategy in saving lives. We can tap its benefits only when we identify and remove the hurdles in the utilization of cervical cancer screening.

10.5958/0976-5506.2019.01946.6

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