Mohamed Ichou

Mohammed V University

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Hassan Errihani

Mohammed V University

Rachid Tanz

Mohammed V University

Tarik Mahfoud

Mohammed V University

Aziz Bazine

Sidi Mohamed Ben Abdellah University

Yassir Sbitti

Mohammed V University

Mohamed Réda Khmamouche

Mohammed V University

Mohamed Fetohi

Hôpital Militaire Moulay Ismail

Khaoula Alaoui Slimani

Institut National d'Oncologie

A. Debbagh

Centre Hospitalier Universitaire Ibn Rochd

M. Khmamouche

Mohammed V University

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Mohammed V University

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Hôpital Militaire Moulay Ismail

Institut National d'Oncologie

Military Hospital

Centre Hospitalier Ibn Sina

University of Hassan II Casablanca

U.S. Army Combat Capabilities Development Command Chemical Biological Center

Sidi Mohamed Ben Abdellah University

United States Army

Mohamed I University

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Occult Breast Carcinoma Presenting With Anti-Ri-Associated Paraneoplastic Cerebellar Degeneration Revealed With FDG-PET

Cancer and Clinical Oncology (2014)

Aziz Bazine Mohamed Fetohi Maha Aït Berri Y. Oufroukhi Mohamed Ichou

Paraneoplastic neurological syndromes are rare diseases affecting less than 0,01 % of the cancerous patients. Here, we present a rare case of paraneoplastic cerebellar degeneration with anti-Ri antibodies as the presenting manifestation of an occult breast cancer. Our observation emphasizes the importance of the nature of the anti-neuronal antibody and the fluorodeoxyglucose-positron emission tomography to make a definitive diagnosis in patients with subactue onset of neurological deficit suggesting paraneoplastic cerebellar degeneration.

Paraneoplastic cerebellar degeneration

Occult

Cerebellar Degeneration

Degeneration (medical)

Fluorodeoxyglucose

Neurological deficit

10.5539/cco.v4n1p9

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Citations (1)

Inhabituel Toxicity of Sorafenib: Eryhema Multiform: A New Case Report and Review

Scholars Journal of Medical Case Reports (2022)

Lamia Aalaoui Anouar Mokhlis Mohamed Réda Khmamouche Rachid Tanz Hassan Errihani

Sorafenib, an oral small molecule multikinase inhibitor indicated for the treatment of some solid tumors, has been associated with a variety of cutaneous adverse events. Erythema multiforme is one of the extremely rare skin toxicities reported. We present this interesting case to show and discuss the cutaneous side effects of sorafenib, in particular the erythema multiforme that occurred in a woman treated for metastatic hepatocellular cancer after only five days of treatment.

Erythema multiforme

Erythema

10.36347/sjmcr.2022.v10i02.010

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Citations (1)

À propos de 13 cas de compression médullaire métastatique du cancer du sein

Cancer/Radiothérapie (2010)

Tarik Mahfoud M. Khmamouche A. Debbagh R. Aassab Aziz Bazine

Regimen

10.1016/j.canrad.2010.07.462

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Citations (1)

Triple malignancy in a single patient including a squamous cell carcinoma of the cervix, a colloid adenocarcinoma of the colon and a lung adenocarcinoma: A case report and literature review

International Journal of Surgery Case Reports (2017)

Tarik Mahfoud Rachid Tanz Réda M. Khmamouche Massine El Hammoumi Mohamed Allaoui

The association of two cancers in the same patient is unusual but has been widely reported in the literature, while triple malignancy in the same patient is exceptional. Indeed, only very rare cases have been described. A 70-year-old woman treated in our institute in 2006 for a tumor of the cervix. She underwent extrafascial hysterectomy. Pathology revealed a well differentiated squamous cell carcinoma of the cervix (pT1N0M0). No external pelvic radiation or brachytherapy were done. The patient remained in good control until 2013 when she presented a tumor of the ascending colon. A right hemicolectomy was made. Pathology confirmed a colloid adenocarcinoma (pT3N0M0). No adjuvant chemotherapy was given. Three years later, a Computed tomography scan of the chest revealed a nodule of the lower lobe of the left lung. Biopsy was made. Histology with immunochemistry revealed the diagnosis of lung adenocarcinoma. Positron emission tomography scan showed abnormal fluorodeoxyglucose uptake in the lung nodule with no anomaly in mediastinal nodes and no metastasis. A left lower lobectomy was performed with lymph node dissection. Pathology confirmed the diagnosis of 2.5 cm lung adenocarcinoma without node invasion (pT1N0M0). No chemotherapy was given. After 14 months, the patient remained in good control. Triple malignancy in a single patient is exceptional. The management depend on stages. Surgery is the standard of care in localized cancers.

10.1016/j.ijscr.2017.11.013

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Citations (2)

Syndrome de Gougerot-Sjögren et carcinome thymique

La Revue de Médecine Interne (2002)

O. Gisserot G. Leyral Mohamed Ichou Ingrid Chabbert Paolo Carli

10.1016/s0248-8663(02)80216-8

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Citations (0)

Bevacizumab 5 or 7.5 mg/kg in Metastatic Colorectal Cancer Can Be Infused Safely Over 10 Minutes

Journal of Gastrointestinal Cancer (2011)

Tarik Mahfoud Rachid Tanz Mohamed Mesmoudi Mohamed Réda Khmamouche Aziz Bazine

Group B

10.1007/s12029-010-9245-x

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Citations (4)

Dynamics of a fractional optimal control HBV infection model with capsids and CTL immune response

Mathematical Modeling and Computing (2023)

Mohamed Ichou Moussa Bachraoui Khalid Hattaf Noura Yousfi

This paper deals with a fractional optimal control problem model that describes the interactions between hepatitis B virus (HBV) with HBV DNA-containing capsids, liver cells (hepatocytes), and the cytotoxic T-cell immune response. Optimal controls represent the effectiveness of drug therapy in inhibiting viral production and preventing new infections. The optimality system is derived and solved numerically. Our results also show that optimal treatment strategies reduce viral load and increase the number of uninfected cells, which improves the patient's quality of life.

CTL*

Dynamics

10.23939/mmc2023.01.239

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Citations (3)

Primary Non-Hodgkin’s Lymphoma of the Colon: A Case Report and Literature Review

Journal of Gastrointestinal Cancer (2012)

Tarik Mahfoud Rachid Tanz Mohamed Réda Khmamouche Asmâa Regragui Mohamed Ichou

10.1007/s12029-012-9406-1

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Citations (2)

A mixed finite element approach for a factional viscoelastic wave propagation in-time-domain

Indian Journal of Pure and Applied Mathematics (2023)

Mohamed Ichou Abdelaâziz Ezziani

10.1007/s13226-023-00461-8

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Spinal Cord Ischemia Secondary to Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma

Case Reports in Gastroenterology (2014)

Aziz Bazine Mohamed Fetohi Maha Aït Berri Ismail Essaadi Kamal Elbakraoui

Transcatheter arterial chemoembolization (TACE) is accepted worldwide as an effective treatment for patients with unresectable hepatocellular carcinoma. Although considered relatively safe, TACE has been associated with several complications. Spinal cord ischemia secondary to TACE is an extremely rare but disastrous complication. We report a very rare case of spinal cord injuries after TACE, together with a literature review. During the procedure, the patient suddenly experienced sensory impairment below the T10 dermatome and bilateral lower extremity motor weakness. She was given high-dose steroids and supportive therapy. The sensory deficits nearly improved completely, but motor strength remained unchanged. Thereafter, a chest computed tomography scan showed tumor metastasis to the lungs. The patient is now receiving sorafenib and follow-up.

Transcatheter arterial chemoembolization

Dermatome

10.1159/000368075

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Citations (10)