Sijie Lin

Xiamen University of Technology

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Pu Chun Ke

National Engineering Research Center for Nanotechnology

André E. Nel

University of California, Los Angeles

Tian Xia

Chinese Academy of Sciences

Zhaoxia Ji

California NanoSystems Institute

Haiyuan Zhang

Tianneng Power (China)

Huan Meng

National Center for Nanoscience and Technology

Guotao Peng

Karolinska Institutet

Chong Hyun Chang

Hainan University

Tianyu Yu

Shanghai Pudong New Area Gongli Hospital

Xiang Wang

City University of Hong Kong

Cooperative Institutions

University of California, Los Angeles

Tongji University

Columbia University

Columbia University Irving Medical Center

California NanoSystems Institute

Chinese Academy of Sciences

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State Key Laboratory of Pollution Control and Resource Reuse

Shanghai Institute of Pollution Control and Ecological Security

Shanghai East Hospital

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Research on improving the quality of groundwater self-monitoring via Blockchain technology

Environmental Impact Assessment Review (2025)

Haixiang Li Dongxue Fu Mo Yang Sijie Lin Song Zongzhong

10.1016/j.eiar.2025.107811

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Citations (0)

Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade

Nano Today (2021)

Olesja Bondarenko Monika Mortimer Anne Kahru Neus Feliu Ibrahim Javed

Nanotoxicology

10.1016/j.nantod.2021.101184

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Citations (88)

Differential Uptake of Carbon Nanoparticles by Plant and Mammalian Cells

Small (2010)

Ran Chen Tatsiana A. Ratnikova Matthew B. Stone Sijie Lin Mercy Lard

Differential uptake of carbon nanoparticles by plant cells is illustrated. Specifically, the left panel shows accumulation of hydrophilic C60(OH)20 between a plant cell wall and a plasma membrane, while the right panel displays aggregation and retention of C70–NOM assembly in a plant cell wall.

Plant cell

Carbon fibers

Carbon Nanoparticles

10.1002/smll.200901911

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Citations (218)

Uptake, Translocation, and Transmission of Carbon Nanomaterials in Rice Plants

Small (2009)

Sijie Lin Jason Reppert Qian Hu JoAn S. Hudson Michelle L. Reid

A transmission electron microscopy (TEM) image shows the significant uptake of C70 particles by a plant leaf cell. The C70 particles appear as numerous small aggregates in the vacuole and the cell walls of the leaf cell are shown as dark layered structures in the image. Scale of image: 5 × 6 µm. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Nanomaterials

Carbon fibers

10.1002/smll.200801556

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Citations (644)

Graphene quantum dots against human IAPP aggregation and toxicity in vivo

Nanoscale (2018)

Miaoyi Wang Yunxiang Sun Xueying Cao Guotao Peng Ibrahim Javed

Graphene quantum dots are biocompatible zero-dimensional nanostructures, which displayed a potency in rescuing zebrafish embryos from the toxicity of human islet amyloid polypeptide.

Amyloid (mycology)

Biocompatible material

10.1039/c8nr07180b

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Citations (118)

Understanding the Transformation, Speciation, and Hazard Potential of Copper Particles in a Model Septic Tank System Using Zebrafish to Monitor the Effluent

ACS Nano (2015)

Sijie Lin Alicia A. Taylor Zhaoxia Ji Chong Hyun Chang Nichola M. Kinsinger

Although copper-containing nanoparticles are used in commercial products such as fungicides and bactericides, we presently do not understand the environmental impact on other organisms that may be inadvertently exposed. In this study, we used the zebrafish embryo as a screening tool to study the potential impact of two nano Cu-based materials, CuPRO and Kocide, in comparison to nanosized and micron-sized Cu and CuO particles in their pristine form (0-10 ppm) as well as following their transformation in an experimental wastewater treatment system. This was accomplished by construction of a modeled domestic septic tank system from which effluents could be retrieved at different stages following particle introduction (10 ppm). The Cu speciation in the effluent was identified as nondissolvable inorganic Cu(H2PO2)2 and nondiffusible organic Cu by X-ray diffraction, inductively coupled plasma mass spectrometry (ICP-MS), diffusive gradients in thin-films (DGT), and Visual MINTEQ software. While the nanoscale materials, including the commercial particles, were clearly more potent (showing 50% hatching interference above 0.5 ppm) than the micron-scale particulates with no effect on hatching up to 10 ppm, the Cu released from the particles in the septic tank underwent transformation into nonbioavailable species that failed to interfere with the function of the zebrafish embryo hatching enzyme. Moreover, we demonstrate that the addition of humic acid, as an organic carbon component, could lead to a dose-dependent decrease in Cu toxicity in our high content zebrafish embryo screening assay. Thus, the use of zebrafish embryo screening, in combination with the effluents obtained from a modeled exposure environment, enables a bioassay approach to follow the change in the speciation and hazard potential of Cu particles instead of difficult-to-perform direct particle tracking.

Genetic algorithm

Septic tank

Model system

10.1021/nn507216f

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Citations (57)

Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation

ACS Nano (2012)

Haiyuan Zhang Zhaoxia Ji Tian Xia Huan Meng Cécile Low‐Kam

We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction band energy levels to delineate their toxicological potential at cellular and whole animal levels. Among the materials, the overlap of conduction band energy (Ec) levels with the cellular redox potential (−4.12 to −4.84 eV) was strongly correlated to the ability of Co3O4, Cr2O3, Ni2O3, Mn2O3, and CoO nanoparticles to induce oxygen radicals, oxidative stress, and inflammation. This outcome is premised on permissible electron transfers from the biological redox couples that maintain the cellular redox equilibrium to the conduction band of the semiconductor particles. Both single-parameter cytotoxic as well as multi-parameter oxidative stress assays in cells showed excellent correlation to the generation of acute neutrophilic inflammation and cytokine responses in the lungs of C57 BL/6 mice. Co3O4, Ni2O3, Mn2O3, and CoO nanoparticles could also oxidize cytochrome c as a representative redox couple involved in redox homeostasis. While CuO and ZnO generated oxidative stress and acute pulmonary inflammation that is not predicted by Ec levels, the adverse biological effects of these materials could be explained by their solubility, as demonstrated by ICP-MS analysis. These results demonstrate that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premised on oxidative stress. This establishes a robust platform for modeling of MOx structure–activity relationships based on band gap energy levels and particle dissolution. This predictive toxicological paradigm is also of considerable importance for regulatory decision-making about this important class of engineered nanomaterials.

10.1021/nn3010087

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Citations (774)

Transcriptional and Physiological Responses to Nutrient Loading on Toxin Formation and Photosynthesis in Microcystis Aeruginosa FACHB-905

Toxins (2017)

Guotao Peng Sijie Lin Zhengqiu Fan Xiangrong Wang

An important goal of understanding harmful algae blooms is to determine how environmental factors affect the growth and toxin formation of toxin-producing species. In this study, we investigated the transcriptional responses of toxin formation gene (mcyB) and key photosynthesis genes (psaB, psbD and rbcL) of Microcystis aeruginosa FACHB-905 in different nutrient loading conditions using real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR). Three physio-biochemical parameters (malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH)) were also evaluated to provide insight into the physiological responses of Microcystis cells. We observed an upregulation of mcyB gene in nutrient-deficient conditions, especially in nitrogen (N) limitation condition, and the transcript abundance declined after the nutrient were resupplied. Differently, high transcription levels were seen in phosphorus (P) deficient treatments for key photosynthesis genes throughout the culture period, while those in N-deficient cells varied with time, suggesting an adaptive regulation of Microsystis cells to nutrient stress. Increased contents of antioxidant enzymes (SOD and GSH) were seen in both N and P-deficient conditions, suggesting the presence of excess amount of free radical generation caused by nutrient stress. The amount of SOD and GSH continued to increase even after the nutrient was reintroduced and a strong correlation was seen between the MDA and enzyme activities, indicating the robust effort of rebalancing the redox system in Microcystis cells. Based on these transcriptional and physiological responses of M. aeruginosa to nutrient loading, these results could provide more insight into Microcystis blooms management and toxin formation regulation.

Microcystis aeruginosa

Microcystis

10.3390/toxins9050168

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Citations (21)

Anionic nanoplastic exposure induces endothelial leakiness

Nature Communications (2022)

Wei Wei Yuhuan Li Myeongsang Lee Nikolaos K. Andrikopoulos Sijie Lin

The global-scale production of plastics has been instrumental in advancing modern society, while the rising accumulation of plastics in landfills, oceans, and anything in between has become a major stressor on environmental sustainability, climate, and, potentially, human health. While mechanical and chemical forces of man and nature can eventually break down or recycle plastics, our understanding of the biological fingerprints of plastics, especially of nanoplastics, remains poor. Here we report on a phenomenon associated with the nanoplastic forms of anionic polystyrene and poly(methyl methacrylate), where their introduction disrupted the vascular endothelial cadherin junctions in a dose-dependent manner, as revealed by confocal fluorescence microscopy, signaling pathways, molecular dynamics simulations, as well as ex vivo and in vivo assays with animal model systems. Collectively, our results implicated nanoplastics-induced vasculature permeability as primarily biophysical-biochemical in nature, uncorrelated with cytotoxic events such as reactive oxygen species production, autophagy, and apoptosis. This uncovered route of paracellular transport has opened up vast avenues for investigating the behaviour and biological effects of nanoplastics, which may offer crucial insights for guiding innovations towards a sustainable plastics industry and environmental remediation.

10.1038/s41467-022-32532-5

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Citations (60)

Assessing major factors impacts on the hydrogeochemistry in a riverside alluvial aquifer, northeast China

Arabian Journal of Geosciences (2020)

Li Wang Tao Du Qing Hu Sijie Lin Mingzhu Liu

10.1007/s12517-020-06058-3

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Citations (3)