Christopher S. P. McErlean

University of Sydney

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Ionic liquids are compatible with on-water catalysis

Chemical Communications (2013)

Kaitlin D. Beare Alexander K. L. Yuen Anthony F. Masters Thomas Maschmeyer Christopher S. P. McErlean

A major limitation of on-water catalysis has been the need for liquid reactants to enable emulsification. We demonstrate that ionic liquids are compatible with on-water catalysis, enabling on-water catalysed reactions for otherwise unreactive solid-solid systems. The unique solvation properties of ionic liquids dramatically expands the scope of on-water catalysis.

Scope (computer science)

10.1039/c3cc44150d

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Citations (15)

Generation and reaction of alkyl radicals in open reaction vessels

Organic & Biomolecular Chemistry (2020)

Elene Tatunashvili Christopher S. P. McErlean

An operationally simple process to transform alkyl iodides into reactive alkyl radicals is described. Aryl diazonium salts react with Hantzsch esters and molecular oxygen to give aryl radicals, which participate in halogen atom transfers to give alkyl radicals. These intermediates react with a variety of acceptors. The reaction cascade occurs at room temperature, in open reaction vessels, with short reaction times.

Radical disproportionation

Reactive intermediate

10.1039/d0ob01892a

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Citations (17)

The potential of foxtail millet as a trap crop for sunflower broomrape

Acta Physiologiae Plantarum (2016)

Xiaoxin Ye Jie Chen Christopher S. P. McErlean Meng Zhang Rui Yu

Foxtail

Trap crop

10.1007/s11738-016-2300-x

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Citations (38)

Synthesis of modified binol-phosphoramidites

Tetrahedron (2011)

Carl Recsei Christopher S. P. McErlean

Phosphoramidite

Stereocenter

10.1016/j.tet.2011.11.020

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Citations (20)

Dynamic Imaging of the Hepatitis C Virus NS5A Protein during a Productive Infection

Journal of Virology (2014)

Nicholas S. Eyre Guillaume Fiches Amanda L. Aloia Karla J. Helbig Erin M. McCartney

Hepatitis C virus (HCV) NS5A is essential for viral genome replication within cytoplasmic replication complexes and virus assembly at the lipid droplet (LD) surface, although its definitive functions are poorly understood. We developed approaches to investigate NS5A dynamics during a productive infection. We report here that NS5A motility and efficient HCV RNA replication require the microtubule network and the cytoplasmic motor dynein and demonstrate that both motile and relatively static NS5A-positive foci are enriched with host factors VAP-A and Rab5A. Pulse-chase imaging revealed that newly synthesized NS5A foci are small and distinct from aged foci, while further studies using a unique dual fluorescently tagged infectious HCV chimera showed a relatively stable association of NS5A foci with core-capped LDs. These results reveal new details about the dynamics and maturation of NS5A and the nature of potential sites of convergence of HCV replication and assembly pathways.Hepatitis C virus (HCV) is a major cause of serious liver disease worldwide. An improved understanding of the HCV replication cycle will enable development of novel and improved antiviral strategies. Here we have developed complementary fluorescent labeling and imaging approaches to investigate the localization, traffic and interactions of the HCV NS5A protein in living, virus-producing cells. These studies reveal new details as to the traffic, composition and biogenesis of NS5A foci and the nature of their association with putative sites of virus assembly.

NS5A

NS2-3 protease

10.1128/jvi.02490-13

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Citations (54)

Avenaol, a germination stimulant for root parasitic plants from Avena strigosa

Phytochemistry (2014)

Hyun Il Kim Takaya Kisugi Pichit Khetkam Xiaonan Xie Kaori Yoneyama

Striga hermonthica

Avena

Orobanche

Orobanchaceae

10.1016/j.phytochem.2014.03.030

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Citations (98)

Stetter Reactions of Unsaturated 1‐Acyl‐1H‐pyrroles

European Journal of Organic Chemistry (2011)

Christopher B. W. Phippen Anna M. Goldys Christopher S. P. McErlean

Abstract α,β‐Unsaturated 1‐acyl‐1 H ‐pyrroles are employed as enabling units for the construction of 1,4‐dicarbonyl systems using the organocatalytic Stetter reaction. The enhanced electrophilicity of the 1‐acyl‐1 H ‐pyrrole unit allows for the catalytic construction of fused and non‐fused pyranones from aliphatic aldehydes, is compatible with aromatic aldehydes, and also facilitates an intermolecular variant of the reaction involving both aromatic and aliphatic aldehydes.

Pyrrole

10.1002/ejoc.201101151

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Citations (9)

Sub-structure syntheses and relative stereochemistry in the bistramide (bistratene) series of marine metabolites

Tetrahedron Letters (2002)

Paul O Gallagher Christopher S. P. McErlean Mark F. Jacobs Dianne Watters William Kitching

Moiety

10.1016/s0040-4039(01)02219-5

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Citations (27)

Enantioselective Synthesis of the Strigolactone Mimic (+)-GR24

The Journal of Organic Chemistry (2014)

Liam J. Bromhead Johan Visser Christopher S. P. McErlean

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTEnantioselective Synthesis of the Strigolactone Mimic (+)-GR24Liam J. Bromhead, Johan Visser, and Christopher S. P. McErlean*View Author Information School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia*Fax: +61 2 9351 3329. Tel: +61 2 9351 3970. E-mail: [email protected]Cite this: J. Org. Chem. 2014, 79, 3, 1516–1520Publication Date (Web):January 14, 2014Publication History Received8 December 2013Published online17 January 2014Published inissue 7 February 2014https://pubs.acs.org/doi/10.1021/jo402722phttps://doi.org/10.1021/jo402722pbrief-reportACS PublicationsCopyright © 2014 American Chemical SocietyRequest reuse permissionsArticle Views3171Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Ethyl groups,Ligands,Mixtures,Organic compounds,Solvents Get e-Alerts

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10.1021/jo402722p

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Citations (35)

Revitalizing the aromatic aza-Claisen rearrangement: implications for the mechanism of ‘on-water’ catalysis

Organic & Biomolecular Chemistry (2013)

Kaitlin D. Beare Christopher S. P. McErlean

For too long the aromatic aza-Claisen rearrangement has been the poor relation of its oxygen counterpart. We demonstrate that on-water catalysis facilitates the rearrangement of reverse N-prenylated naphthylamines and anilines, and transforms the aromatic aza-Claisen rearrangement into a synthetically viable reaction. We use this reaction to probe the mechanism of on-water catalysis, and provide compelling support for the acid-catalysis hypothesis.

Carroll rearrangement

Cope rearrangement

Rearrangement reaction

10.1039/c3ob40118a

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Citations (35)