V. Marinello

University of Glasgow

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Christine A. Edwards

London Borough of Tower Hamlets

Emilie Combet

University of Glasgow

Ricardo Rueda

Abbott (Spain)

ÁG

Ángel Gil

Universidad de Granada

Douglas J. Morrison

Scottish Universities Environmental Research Centre

Catherine Stanton

Teagasc - The Irish Agriculture and Food Development Authority

William Mullen

University of Glasgow

Susan E. Ozanne

University of Cambridge

Tom Preston

Scottish Universities Environmental Research Centre

Marieke H. Schoemaker

FrieslandCampina (Netherlands)

Cooperative Institutions

University of Glasgow

Scottish Universities Environmental Research Centre

Wageningen University & Research

Radboud University Nijmegen

Glasgow Royal Infirmary

University Medical Center Groningen

University of Groningen

Reckitt Benckiser (Netherlands)

Radboud University Medical Center

Mead Johnson (United States)

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Changes in human colonic bacteria production of phenolic acids from rutin in the presence of different dietary fibres

Proceedings of The Nutrition Society (2018)

Jaroslav Havlík Min Hou V. Marinello Andrew Gardyne William Mullen

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the ‘Save PDF’ action button.

10.1017/s0029665118000265

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Citations (2)

Harmless? Mixed perception and awareness of vitamin and mineral supplements

Proceedings of The Nutrition Society (2016)

V. Marinello Christina Buckton Emilie Combet

Content (measure theory)

10.1017/s0029665116000562

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Citations (4)

A systematic review of breast milk microbiota composition and the evidence for transfer to and colonisation of the infant gut

Beneficial Microbes (2022)

Christine A. Edwards C.A. Bouwman Janna A. van Diepen Marieke H. Schoemaker Susan E. Ozanne

The intestinal microbiota plays a major role in infant health and development. However, the role of the breastmilk microbiota in infant gut colonisation remains unclear. A systematic review was performed to evaluate the composition of the breastmilk microbiota and evidence for transfer to/colonisation of the infant gut. Searches were performed using PUBMED, OVID, LILACS and PROQUEST from inception until 18th March 2020 with a PUBMED update to December 2021. 88 full texts were evaluated before final critique based on study power, sample contamination avoidance, storage, purification process, DNA extraction/analysis, and consideration of maternal health and other potential confounders. Risk of skin contamination was reduced mainly by breast cleaning and rejecting the first milk drops. Sample storage, DNA extraction and bioinformatics varied. Several studies stored samples under conditions that may selectively impact bacterial DNA preservation, others used preculture reducing reliability. Only 15 studies, with acceptable sample size, handling, extraction, and bacterial analysis, considered transfer of bacteria to the infant. Three reported bacterial transfer from infant to breastmilk. Despite consistent evidence for the breastmilk microbiota, and recent studies using improved methods to investigate factors affecting its composition, few studies adequately considered transfer to the infant gut providing very little evidence for effective impact on gut colonisation.

Colonisation

Dysbiosis

Infant feeding

10.3920/bm2021.0098

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Citations (13)

Impact of inulin on phenolic acid bioavailability of tomato onion and lovage soup in healthy individuals: a randomized cross-over trial

Proceedings of The Nutrition Society (2019)

Wenjuan Cong V. Marinello Mircea Martiniuc B. Nemeckova W. S. Chung

An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the 'Save PDF' action button.

10.1017/s0029665119000818

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Citations (2)

Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut? – a systematic review

Critical Reviews in Microbiology (2020)

Ángel Gil Ricardo Rueda Susan E. Ozanne Eline M. van der Beek C.A. Bouwman

With the important role of the gut microbiome in health and disease, it is crucial to understand key factors that establish the microbial community, including gut colonization during infancy. It has been suggested that the first bacterial exposure is via a placental microbiome. However, despite many publications, the robustness of the evidence for the placental microbiome and transfer of bacteria from the placenta to the infant gut is unclear and hence the concept disputed. Therefore, we conducted a systematic review of the evidence for the role of the placental, amniotic fluid and cord blood microbiome in healthy mothers in the colonization of the infant gut. Most of the papers which were fully assessed considered placental tissue, but some studied amniotic fluid or cord blood. Great variability in methodology was observed especially regarding sample storage conditions, DNA/RNA extraction, and microbiome characterization. No study clearly considered transfer of the normal placental microbiome to the infant gut. Moreover, some studies in the review and others published subsequently reported little evidence for a placental microbiome in comparison to negative controls. In conclusion, current data are limited and provide no conclusive evidence that there is a normal placental microbiome which has any role in colonization of infant gut.

Cord blood

Gut microbiome

10.1080/1040841x.2020.1800587

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Citations (27)

Dietary Fibres Differentially Impact on the Production of Phenolic Acids from Rutin in an In Vitro Fermentation Model of the Human Gut Microbiota

Nutrients (2020)

Jaroslav Havlík V. Marinello Andrew Gardyne Min Hou William Mullen

Polyphenols are often ingested alongside dietary fibres. They are both catabolised by, and may influence, the intestinal microbiota; yet, interactions between them and the impact on their resultant microbial products are poorly understood. Dietary fibres (inulin, pectin, psyllium, pyrodextrin, wheat bran, cellulose—three doses) were fermented in vitro with human faeces (n = 10) with and without rutin (20 µg/mL), a common dietary flavonol glycoside. Twenty-eight phenolic metabolites and short chain fatty acids (SCFA) were measured over 24 h. Several phenolic metabolites were produced during fibre fermentation, without rutin. With rutin, 3,4-dihydroxyphenylacetic acid (3,4diOHPAA), 3-hydroxyphenylacetic acid (3OHPAA), 3-(3 hydroxyphenyl)propionic acid (3OHPPA) and 3-(3,4-dihydroxyphenyl)propionic acid (3,4diOHPPA; DOPAC) were produced, with 3,4diOHPAA the most abundant, confirmed by fermentation of 13C labelled quercetin. The addition of inulin, wheat bran or pyrodextrin increased 3,4diOHPAA 2 2.5-fold over 24 h (p < 0.05). Rutin affected SCFA production, but this depended on fibre, fibre concentration and timepoint. With inulin, rutin increased pH at 6 h from 4.9 to 5.6 (p = 0.01) but increased propionic, butyric and isovaleric acid (1.9, 1.6 and 5-fold, p < 0.05 at 24 h). Interactions between fibre and phenolics modify production of phenolic acids and SCFA and may be key in enhancing health benefits.

Prebiotic

Short-chain fatty acid

Phenolic acid

10.3390/nu12061577

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Citations (38)

ROLE OF THE BREASTMILK MICROBIOME IN COLONISATION OF THE INFANT GUT: A SYSTEMATIC REVIEW

Christine A. Edwards Ángel Gil Eline van der Beek Marieke H. Schoemaker Susan E. Ozanne

Colonisation

Gut microbiome

10.17863/cam.26507

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Citations (0)