Haibo Jia

Huazhong University of Science and Technology

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Co-Authors

Bo Yu

Icahn School of Medicine at Mount Sinai

117

Sining Hu

Harbin Medical University

Rocco Vergallo

Agostino Gemelli University Polyclinic

Jinwei Tian

Second Affiliated Hospital of Harbin Medical University

Ik‐Kyung Jang

Massachusetts General Hospital

Hang Lee

Massachusetts General Hospital

Shaosong Zhang

Yunnan Academy of Agricultural Sciences

Jingbo Hou

Harbin Medical University

Tsunenari Soeda

Nara Medical University

Ik‐Kyung Jang

Massachusetts General Hospital

Cooperative Institutions

Harbin Medical University

259

Huazhong University of Science and Technology

241

Second Affiliated Hospital of Harbin Medical University

164

Ministry of Education of the People's Republic of China

123

Harvard University

116

Massachusetts General Hospital

Providence College

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Nanjing Medical University

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Pancoronary plaque vulnerability in patients with acute coronary syndrome and ruptured culprit plaque: A 3-vessel optical coherence tomography study

American Heart Journal (2013)

Rocco Vergallo Xuefeng Ren Taishi Yonetsu Koji Kato Shiro Uemura

Culprit

Fibrous cap

Vulnerable plaque

10.1016/j.ahj.2013.10.011

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Citations (97)

Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy

Coronary Artery Disease (2016)

Zhao Wang Young‐Seok Cho Tsunenari Soeda Yoshiyasu Minami Lei Xing

Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy.We applied a novel computer algorithm to investigate the fibrous cap 3D morphological change over time in patients with coronary artery disease. Patients were treated with either atorvastatin 20 mg/day (moderate intensity) or atorvastatin 60 mg/day (high intensity). Optical coherence tomography was performed at baseline, 6, and 12 months. A total of 31 lipid plaques from 21 patients were analyzed.Conventional metrics such as the minimum fibrous cap thickness change between the two treatment groups were not significantly different between the baseline and the 12-month follow-up. In contrast, the 3D metric thin cap (<80 μm) surface area change between the baseline and the 12-month follow-up showed dose-dependent, significant differences between the statin treatment groups (P<0.001). 3D reconstructions of fibrous caps further indicated that fibrous caps showed diverse (scattered vs. confluent) patterns and could evolve in a complex manner.High-intensity statin therapy more effectively stabilized fibrous caps at follow-up. The new 3D algorithm provided more comprehensive and detailed information on the changes in plaque phenotype in response to statin therapy.

Fibrous cap

Intensity

Combination therapy

10.1097/mca.0000000000000370

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Citations (10)

ACUTE CORONARY SYNDROME CAUSED BY NON-CRITICAL CORONARY STENOSIS: INSIGHT FROM AN IN VIVO OPTICAL COHERENCE TOMOGRAPHY STUDY

Journal of the American College of Cardiology (2015)

Haibo Jia Sining Hu Amir Lerman Catalin Toma Harold L. Dauerman

10.1016/s0735-1097(15)60237-6

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Citations (0)

EFFECTS OF STATIN THERAPY ON CORONARY PLAQUE MORPHOLOGY IN PATIENTS WITH ACUTE CORONARY SYNDROME VERSUS STABLE ANGINA PECTORIS

Journal of the American College of Cardiology (2015)

Rocco Vergallo Jingbo Hou Haibo Jia Yoshiyasu Minami Tsunenari Soeda

Stable angina

10.1016/s0735-1097(15)60208-x

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Citations (0)

AnimalTFDB 2.0: a resource for expression, prediction and functional study of animal transcription factors

Nucleic Acids Research (2014)

Hongmei Zhang Teng Liu Chunjie Liu Shuangyang Song Xiantong Zhang

Transcription factors (TFs) are key regulators for gene expression. Here we updated the animal TF database AnimalTFDB to version 2.0 (http://bioinfo.life.hust.edu.cn/AnimalTFDB/). Using the improved prediction pipeline, we identified 72 336 TF genes, 21 053 transcription co-factor genes and 6502 chromatin remodeling factor genes from 65 species covering main animal lineages. Besides the abundant annotations (basic information, gene model, protein functional domain, gene ontology, pathway, protein interaction, ortholog and paralog, etc.) in the previous version, we made several new features and functions in the updated version. These new features are: (i) gene expression from RNA-Seq for nine model species, (ii) gene phenotype information, (iii) multiple sequence alignment of TF DNA-binding domains, and the weblogo and phylogenetic tree based on the alignment, (iv) a TF prediction server to identify new TFs from input sequences and (v) a BLAST server to search against TFs in AnimalTFDB. A new nice web interface was designed for AnimalTFDB 2.0 allowing users to browse and search all data in the database. We aim to maintain the AnimalTFDB as a solid resource for TF identification and studies of transcription regulation and comparative genomics.

Functional Genomics

Genome browser

10.1093/nar/gku887

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Citations (300)

[The polymorphism distribution of angiotensin converting enzyme gene in Northern Han and Dahur].

PubMed (2012)

Haibo Jia Lin Shi Haiying Jia

Gene polymorphism

Source

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Citations (0)

Artificial Intelligence Driven Plaque Characterization and Functional Assessment from Ccta Using Oct-Based Automation: A Prospective Study

Jincheng Han Zhuozhong Wang Tao Chen Shengliang Liu Jinfeng Tan

Characterization

10.2139/ssrn.5120570

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Comparison of peripheral artery plaque characteristics between ACS patients with plaque rupture and plaque erosion in culprit coronary artery: an OCT and ultrasound study

European Heart Journal (2021)

Ziqian Weng S Hu Chen Zhao Yuhan Qin Xue Feng

Abstract Background Recent research has found that the characteristics of peripheral arterial plaque are related to the increased risk of cardiovascular disease, however, the relationship of plaque characteristics between peripheral artery and coronary is still unknown. Purpose To assess the correlation between coronary plaque characteristics assessed by optical coherence tomography (OCT) and peripheral artery plaque characteristics assessed by ultrasound. Methods 150 patients with acute coronary syndrome (ACS) underwent coronary angiography were prospectively enrolled. OCT imaging of culprit vessel were performed during the procedure and ultrasound examination of bilateral carotid, iliofemoral and popliteal arteries was performed during hospitalization after procedure. Panvascular disease was defined as the presence of observable plaques in two or more vascular beds. Patients were divided into plaque rupture (PR) group and plaque erosion (PE) group according to culprit plaque characteristics on OCT. Results There were 132 (88%) ACS patients had panvascular disease in which 36 (24%) with generalized atherosclerosis (4 sites) and the prevalence of panvascular atherosclerosis in PR group was significantly higher than in PE group especially in carotid arteries and iliofemoral arteries (Figure 1, Figure 2). Compared to PE group, PR group had higher carotid plaque score (p=0.001) which indicates more plaques and severer atherosclerosis. Moreover, there were larger intima-media thickness (IMT) of iliofemoral arteries (6.9±1.4mm vs. 6.5±1.1mm, p=0.036) and more calcified plaques in PR group. Conclusions Panvascular disease is highly prevalent in ACS patients especially in patients with plaque rupture in culprit vessel, in which more than half of the patients had plaques in more than 3 sites of vascular beds. In addition, patients with plaque rupture had thicker iliofemoral IMT and higher panvascular atherosclerosis burden, which indicates that characteristics of coronary plaques are the focal expression of plaques in the whole panvcascular system. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Key R&D Program of China Figure 1. Prevalence of panvascular disease in ACSFigure 2. Comparison of peripheral artery plaques

Culprit

Intravascular Ultrasound

Fibrous cap

Vulnerable plaque

Coronary arteries

10.1093/eurheartj/ehab724.1401

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Citations (0)

Abstract 12399: Differences in Culprit Plaque Morphology in Patients with ST Elevation Myocardial Infarction versus Non ST Elevation Acute Coronary Syndrome: Optical Coherence Tomography Study

Circulation (2011)

Haixia Liu Jingbo Hou Haibo Jia Junying Kong Rong Sun

Objective: To compare the differences in the culprit plaque morphology between patients with ST elevation myocardial infarction (STEMI) and those with non ST elevation acute coronary syndrome (NSTE ACS). Methods: A total of 403 patients were enrolled in this study: 108 with STEMI and 295 with NSTE ACS. All patients underwent OCT during the acute phase. Results: Lipid plaques accounted for 92.6% and 86.1% of the culprit lesion in STEMI and NSTE ACS group, respectively. The STEMI patients had thinner fibrous cap (54.9±22.7 µm versus 75.4±38.7µm, P<0.001), greater lipid core arc (227.3±60.4°vs 213.6±55.6°,P<0.05) and longer lipid core length (15.6±6.8mm vs 13.3±7.4mm,P<0.01). The size of the ruptured cavity were greater in the STEMI than in the NSTE ACS group: depth (0.7±0.4.mm vs 0.6±0.5mm, P<0.05), the length (2.8±1.8mm vs 1.8±1.1mm, P<0.001) and average cross sectional area (0.9±0.7mm2 vs 0.6±0.6mm2,P<0.01). The rupture site was more frequently proximal to the minimal lumen in the STEMI group compared to ...

Culprit

Fibrous cap

ST elevation

Vulnerable plaque

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Citations (0)

CRT-107 Geometrically Accurate Three-Dimensional Coronary Artery Reconstruction Using Frequency-Domain Optical Coherence Tomography and Angiographic Data: New Opportunities for In Vivo Endothelial Shear Stress Assessment

КАРДИОЛОГИЯ УЗБЕКИСТАНА (2013)

Michail I. Papafaklis Christos V. Bourantas Taishi Yonetsu Koji Kato Anna Kotsia

Intravascular Ultrasound

Coronary atherosclerosis

10.1016/j.jcin.2013.01.018

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Citations (3)