Hyung Wook Kwon

Incheon National University

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Rustem Ilyasov

Vavilov Institute of General Genetics

Yang‐Seop Bae

Incheon National University

Ulziijargal Bayarsaikhan

Incheon National University

Je Won Jung

Kongju National University

Myeong Uk Kuk

Incheon National University

Yun Haeng Lee

Incheon National University

Zakir Ullah

Institut de Ciència de Materials de Barcelona

Joon Tae Park

Incheon National University

Soon Il Kim

Seoul National University

Ural Yunusbaev

Kansas State University

Cooperative Institutions

Incheon National University

100

Seoul National University

Yonsei University

Korea University

Sungkyunkwan University

Kyung Hee University

Kangwon National University

Hallym University

National Institute of Agricultural Science and Technology

Korea Advanced Institute of Science and Technology

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Formation of Value-Added Cyclic Carbonates by Coupling of Epoxides and CO₂by Ruthenium Pincer Hydrazone Complexes under Atmospheric Pressure

Energy & Fuels (2023)

Habib Ullah Zakir Ullah Zafar A. K. Khattak Mohsin Ali Marwat Baoyi Yu

Transforming atmospheric CO2 into industrially valuable cyclic carbonates is of great importance and one of the attractive approaches for reducing CO2 concentration in the biosphere. However, the selectivity and conversion of ruthenium catalysts for cyclic carbonate formation via CO2 insertion to epoxides are low at high pressure. Here, a series of novel ruthenium complexes supported by ONN pincer-type hydrazone ligands were successfully generated, and their potential for CO2 valorization to cyclic carbonates was investigated. NMR, Fourier transform infrared (FT-IR), mass spectrometry, elemental analysis, and single-crystal diffraction analysis further confirmed the structures of these ruthenium compounds. These compounds were utilized for the CO2/coupling reaction after thorough characterization. Fortunately, these complexes outperform the reported ruthenium catalysts with a turn-over frequency of 833 h–1 and >99% selectivity at atmospheric pressure without any assisted cocatalyst. The designed catalyst showed consistent catalytic performance over five repeating cycles.

Hydrazone

Coupling reaction

10.1021/acs.energyfuels.2c03611

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Citations (8)

The cadastral survey of honey plant resources in the Altyn Solok Nature Reserve in the Urals, Russia

Journal of Apicultural Research (2025)

Rustem Ilyasov Rail R. Khisamov Р.Г. Фархутдинов Alla Yuryevna Ilyasova R.R. Khisamova

The cadastral survey of honey plant resources entails a thorough assessment of nectar plant flora, covering quantitative, qualitative, and territorial aspects, alongside economic evaluation. Our research aimed to conduct such a survey within the Altyn Solok Nature Reserve. Modern beekeeping prioritizes exploring nectar-bearing potential and species diversity among wild-growing woody, shrubby, and herbaceous nectar-bearing plants in protected conservation areas with minimal human intervention. These natural biocenoses contrast sharply with modern agrocenoses, optimized for crop productivity but often lacking the diversity of nectar-bearing plants crucial for sustainable bee colony development and survival. Investigating nectar-bearing flora in stable feral biocenoses can guide the creation of an agricultural environment tailored for optimized honey bee breeding. In the Altyn Solok Nature Reserve, the linden tree (Tilia cordata) stands out as the dominant nectar plant, contributing to 91% of all nectar production. The Nature Reserve hosts a diverse array of nectar plants, including 18 tree species, 23 bush species, and 210 herb species. Determining the optimal number of honey bee (A. m. mellifera) colonies in the region revealed that managing approximately 8,109 colonies (increasing tenfold from the current 800 colonies) would maximize beekeeping efficiency while preserving the reserve's ecological integrity. This calculation considers available nectar plant resources and aims to ensure sustainable beekeeping practices. Only 30% of the maximum possible nectar-producing potential of honey plants is used to calculate the number of bee colonies. The remaining 70% of the nectar is inaccessible to bees since it is consumed by insects of other species living in parts of the reserve inaccessible to bees.

10.1080/00218839.2024.2402611

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Olfactory modulation by neuropeptides in cockroaches

한국응용곤충학회 심포지엄 (2009)

Hyung Wook Kwon June-Sun Yoon Soon Il Kim Terry L. Page

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A New Anatomical Classification for Tibialis Posterior Tendon Insertion and Its Clinical Implications: A Cadaveric Study

Diagnostics (2021)

Jeong-Hyun Park Digud Kim Hyung Wook Kwon Mijeong Lee Yujin Choi

The variations in the tibialis posterior tendon (TPT) could not be defined by previous classification; thus, this study used a larger-scale cadaver with the aim to classify the types of TPT insertion based on the combination of the number and location of TPT insertions. A total of 118 feet from adult formalin-fixed cadavers were dissected (68 males, 50 females). The morphological characteristics and measurements of TPT insertion were evaluated. Four types of TPT insertions were classified, wherein the most common type was type 4 (quadruple insertions, 78 feet, 66.1%), which was divided into four new subtypes that were not defined in the previous classification. The second most common type was type 3 (triple insertions, 25 feet, 21.2%) with three subtypes, including the new subtype. Type 2 was found in 13 feet (11%), and the rarest type was type 1 (2 feet, 1.7%), wherein the main tendon was only attached to the navicular bone and the medial cuneiform bone. We suggest high morphological variability of the TPT in relation to the insertion location, along with the possibility of significant differences according to race and gender. Moreover, this classification will help clinicians understand adult flatfoot deformity-related posterior tibial tendon dysfunction (PTTD).

Cadaveric spasm

Navicular bone

10.3390/diagnostics11091619

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Citations (6)

Genetic Properties and Evolution of Asian Honey Bee Apis cerana ussuriensis from Primorsky Krai, Russia

Russian Journal of Genetics (2021)

Rustem Ilyasov Guangjie Han M. L. Lee Kyungmin Kim Mаxim Yu. Proshchаlykin

Subspecies

Apis cerana

Genetic divergence

10.1134/s1022795421050033

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Citations (4)

Functional restoration of lysosomes and mitochondria through modulation of AKT activity ameliorates senescence

Experimental Gerontology (2023)

Myeong Uk Kuk Haneur Lee Eun Seon Song Yun Haeng Lee Ji Yun Park

Senescence is a phenomenon defined by alterations in cellular organelles and is the primary cause of aging and aging-related diseases. Recent studies have shown that oncogene-induced senescence is driven by activation of serine/threonine protein kinases (AKT1, AKT2 and AKT3). In this study, we evaluated twelve AKT inhibitors and revealed GDC0068 as a potential agent to ameliorate senescence. Senescence-ameliorating effect was evident from the finding that GDC0068 yielded lysosomal functional recovery as observed by reduction in lysosomal mass and induction in autophagic flux. Furthermore, GDC0068-mediated restoration of lysosomal function activated the removal of dysfunctional mitochondria, resulting in restoration of mitochondrial function. Together, our findings revealed a unique mechanism by which senescence is recovered by functional restoration of lysosomes and mitochondria through modulation of AKT activity.

Senescence

10.1016/j.exger.2023.112091

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Citations (7)

Classification and Morphological Analysis of Vector Mosquitoes using Deep Convolutional Neural Networks

Scientific Reports (2020)

Junyoung Park Dong In Kim B.J. Choi Woochul Kang Hyung Wook Kwon

Abstract Image-based automatic classification of vector mosquitoes has been investigated for decades for its practical applications such as early detection of potential mosquitoes-borne diseases. However, the classification accuracy of previous approaches has never been close to human experts’ and often images of mosquitoes with certain postures and body parts, such as flatbed wings, are required to achieve good classification performance. Deep convolutional neural networks (DCNNs) are state-of-the-art approach to extracting visual features and classifying objects, and, hence, there exists great interest in applying DCNNs for the classification of vector mosquitoes from easy-to-acquire images. In this study, we investigated the capability of state-of-the-art deep learning models in classifying mosquito species having high inter-species similarity and intra-species variations. Since no off-the-shelf dataset was available capturing the variability of typical field-captured mosquitoes, we constructed a dataset with about 3,600 images of 8 mosquito species with various postures and deformation conditions. To further address data scarcity problems, we investigated the feasibility of transferring general features learned from generic dataset to the mosquito classification. Our result demonstrated that more than 97% classification accuracy can be achieved by fine-tuning general features if proper data augmentation techniques are applied together. Further, we analyzed how this high classification accuracy can be achieved by visualizing discriminative regions used by deep learning models. Our results showed that deep learning models exploit morphological features similar to those used by human experts.

Discriminative model

Contextual image classification

Similarity (geometry)

10.1038/s41598-020-57875-1

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Citations (92)

Anatomical Characteristics of Extensor Hallucis Longus Tendon Variations and Its Clinical Implications: A Korean Cadaveric Study

International Journal of Environmental Research and Public Health (2022)

Jeong-Hyun Park Yu-Jin Choi Mijeong Lee Digud Kim Hyung Wook Kwon

The purpose of this study is to ascertain the morphological characteristics of the extensor hallucis longus (EHL) tendon variation using larger-scale dissection of Korean cadavers and to classify the types of variation along with incidence. A total of 158 feet from adult formalin-fixed cadavers (50 males, 29 females) were dissected. The morphological characteristics and measurements of the EHL tendon variants were evaluated. Three types of the EHL tendon variation were classified, wherein the most common type was Type 2 (106 feet, 67.1%), Type 3 (3 feet, 1.9%) was the rarest type, and Type 1 without accessory tendon was found in 49 feet (31.0%). Type 2K (11 feet, 7%) and Type 3K (1 foot, 0.6%) were described as new subtypes. The present study suggests morphological characteristics of the EHL tendon variation in Korean populations and high morphological variability of the EHL tendon along with the possibility of differences according to race or ethnicity and gender. Furthermore, a newly updated classification complemented by new subtypes of variation will help foot and ankle surgeons in diagnosis and surgical planning with hallux problems.

Cadaveric spasm

Foot (prosody)

10.3390/ijerph19169833

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Citations (6)

Optimization of the effect of physical treatment on soybean trypsin inhibitor activity by response surface methodology

Research on Crops (2013)

Yao Qin Hyung Wook Kwon Seon Wook Kim

Trypsin inhibitor

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Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence

Antioxidants (2024)

Myeong Uk Kuk D. Kim Yun Haeng Lee Jee Hee Yoon Ji Ho Park

Reactive oxygen species (ROS)-mediated damage to macromolecules and cellular organelles is one of the major causes of senescence. Therapeutic strategies that lower ROS levels have been proposed as important treatments for senescence, but effective mechanisms for reducing ROS levels have not been discovered. Here, we aimed to find a combination that has a synergistic effect on ROS reduction using senomorphics known to reduce ROS. Combination treatment with BRAF inhibitor SB590885 and p38 MAPK inhibitor SB203580 showed a synergistic effect on ROS reduction compared to treatment with either drug alone. The synergistic effect of ROS reduction through this combination led to a synergistic effect that restored mitochondrial function and ameliorated senescence-associated phenotypes. To elucidate the underlying mechanism by which the synergistic effect of the two drugs reverses senescence, we performed RNA sequencing and identified metallothionein 2A (MT2A) as a key gene. MT2A was upregulated in response to combination therapy, and overexpression of MT2A led to a decrease in ROS and subsequent recovery of senescence-associated phenotypes, similar to the effects of combination therapy. Taken together, we found a drug combination that showed synergistic effects on ROS reduction, which contributed to the recovery of senescence-associated phenotypes through MT2A gene regulation. This study opens up a new avenue in aging research by demonstrating that combination therapy with existing senomorphics can enhance the ability to reverse senescence and that similar reversal effects can be achieved through gene regulation regulated by combination therapy.

Senescence

Mitochondrial ROS

10.3390/antiox13121465

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