Mohamed A. Idris

Universiti Teknologi MARA

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Gabriel Mouahid

Université de Perpignan

Hélène Moné

Université de Perpignan

Mahmoud A. Shaban

Ministry of Health

Ali A. Al‐Jabri

Sultan Qaboos University

A. Ruppel

Heidelberg University

Elias A. Said

Sultan Qaboos University

Mohammed S. Al‐Balushi

Sultan Qaboos University

Salem Al Yafae

Directorate General of Health Services

Joanne P. Webster

London Centre for Neglected Tropical Disease Research

Crystal Y. Koh

Sultan Qaboos University

Cooperative Institutions

Wake Forest University

915

Rush University Medical Center

291

Curtin University

201

Monash University

University of Tasmania

University of Pittsburgh

Sultan Qaboos University

University College London

Hennepin Healthcare Research Institute

Berman Center for Outcomes and Clinical Research

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The seroprevalence of cystic hydatidosis in Oman

Annals of Tropical Medicine and Parasitology (1999)

Mohamed A. Idris A. Ruppel H. Gehrig-Feistel Aliya Al-Ansari A. K. Al-Rejaibi

AbstractThe presence of antibodies against Echinococcus granulosus in sera from 306 humans and 390 camels in Oman was investigated by indirect haemagglutination assays. Only one of the human and five of the camel sera gave positive reactions. The reactivities of the human sera were confirmed by ELISA. These results, together with isolated reports of hydatid cysts, indicate that E. granulosus is endemic in Oman, although with a low prevalence.

Seroprevalence

Cystic echinococcosis

Hydatid cyst

Parasitology

Tropical Medicine

10.1080/00034983.1999.11813421

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Citations (7)

Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen

Malaria Journal (2013)

Salama Al-Hamidhi Mohammed A. K. Mahdy Zainab Al-Hashami Hissa M. Al-Farsi Abdulsalam M. Al-Mekhlafi

Abstract Background Despite evident success of malaria control in many sites in the Arabian Peninsula, malaria remains endemic in a few spots, in Yemen and south-west of Saudi Arabia. In addition to local transmission, imported malaria sustains an extra source of parasites that can challenge the strengths of local control strategies. This study examined the genetic diversity of Plasmodium falciparum in Yemen and mutations of drug resistant genes, to elucidate parasite structure and distribution of drug resistance genotypes in the region. Methods Five polymorphic loci ( MSP-2 , Pfg377 and three microsatellites on chromosome 8) not involved in anti-malarial drug resistance, and four drug resistant genes ( pfcrt , pfmdr1 , dhfr and dhps ) were genotyped in 108 P . falciparum isolates collected in three sites in Yemen: Dhamar, Hodeidah and Taiz. Results High diversity was seen in non-drug genes, pfg377 ( He = 0.66), msp - 2 ( He = 0.80) and three microsatellites on chr 8, 7.7 kb ( He = 0.88), 4.3 kb ( He = 0.77) and 0.8 kb ( He = 0.71). There was a high level of mixed-genotype infections (57%), with an average 1.8 genotypes per patient. No linkage disequilibrium was seen between drug resistant genes and the non-drug markers (p < 0.05). Genetic differentiation between populations was low (most pair-wise F ST values <0.03), indicating extensive gene flow between the parasites in the three sites. There was a high prevalence of mutations in pfmdr1 , pfcrt and dhfr ; with four mutant pfmdr1 genotypes (NFCDD[57%], NFSND[21%], YFCDD[13%] and YFSND[8% ]), two mutant pfcrt genotypes (CVIET[89%] and SVMNT[4%]) and one mutant dhfr genotype (ICNI[53.7%]). However, no dhps mutations were detected. Conclusion The high diversity of P . falciparum in Yemen is indicative of a large parasite reservoir, which represents a challenge to control efforts. The presence of two distinct pfcrt genotype, CVIET and SVMNT, suggests that chloroquine resistance can possibly be related to a migratory path from Africa and Asia. The absence of the triple mutant dhfr genotype (IRN) and dhps mutations supports the use of artesunate + sulphadoxine-pyrimethamine as first-line therapy. However, the prevalent pfmdr1 genotype NFSND [21%] has previously been associated with tolerance/resistance response to artemisinin combination therapy (ACT). Regular surveys are, therefore, important to monitor spread of pfmdr1 and dhfr mutations and response to ACT.

DHPS

Linkage Disequilibrium

Parasitology

10.1186/1475-2875-12-244

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Citations (30)

Schistosomiasis in the southern region of Oman: vector snails and serological identification of patients in several locations.

PubMed (1994)

Mohamed A. Idris A. Ruppel P Numrich A. Eschlbeck Mahmoud A. Shaban

The snail Biomphalaria arabica is apparently ubiquitous in the south of Oman (Dhofar province). Snails bred in the laboratory were susceptible to infection with miracidia of Schistosoma mansoni (Puerto Rican strain). The snail Bulinus wrighti, a potential intermediate host of S. haematobium, was found for the first time in Dhofar. Human sera from five localities had antibodies against adult worm antigens and in particular against Sm31/32. The prevalence of seropositive patients was 28% of 47 farm workers, 12% of 99 out-patients from a clinic and 1% of 389 children from four localities. Autochthonous transmission of schistosomiasis in Dhofar is discussed.

Bulinus

Biomphalaria

Freshwater mollusc

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Assessment of Possible Biological Risk of the Share and Non- Share Locations at the Base Transceiver Station (BTS) for Companies Operation in Khartoum State, Sudan

Abdelmoneim Sulieman Amr A. Abd-Elghany Mubarak Dirar Mohamed Waseem Osman Mohamed A. Idris

Telecommunication technology has become a very crucial method of communication nowadays in all countries. However, there many concerns regarding the safety and biological risk from telecommunications towers. This study aims to analyze the number and distribution of the base transceiver station (BTS) in Khartoum state and assess the possible biological risk. Khartoum State was divided into seven districts are calculated and compared with the Ministry of Communications. This study's results were obtained from the Telecommunication companies (A, B, and C) operating in the Khartoum State (. Khartoum state has 2214 BTs distributed in its seven districts (area =22,142 km2). The largest number of antennas was found in Khartoum, with 515 antennas, at 23 %, and the lowest in the district is Karari districts, with only 206(9%). The number of BTS in company A has 10 locations, 0.1% and None share 817 , 99% ,In Company B =492 location ,share lactation 233,47.35% ,Non Share 259(52.6%) and the Company C has 791 Locations, Share location= 695 (87.8%) , Non share has 200 ( 25.28%). According to the companies operation, the mean share locations in Khartoum state 45.3%, and Non-share locations are 59%. The study revealed that the number of non-shared antennas in the state of Khartoum is greater than the common antennas, and therefore, the resulting emitted power is less than the Share antennas. The current number of BTs comply with international guidelines. Based on the distribution of BTs, the risk is minimal to the general population.

Christian ministry

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Influence of pattern of exposure, parasite genetic diversity and sex on the degree of protection against reinfection with Schistosoma mansoni

Parasitology Research (2007)

Marc G. Dumont Hélène Moné Gabriel Mouahid Mohamed A. Idris Mahmoud A. Shaban

Infectivity

Medical microbiology

10.1007/s00436-007-0476-0

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Citations (29)

Leishmania tropica is a probable cause of cutaneous leishmaniasis in the Sultanate of Oman: case report in a Pakistani resident

Transactions of the Royal Society of Tropical Medicine and Hygiene (1999)

Euan M. Scrimgeour J.J. Windsor Maithili Shetty D.D. Banodkar Bronwen E. Lambson

Journal Article Leishmania tropica is a probable cause of cutaneous leishmaniasis in the Sultanate of Oman: Case report in a Pakistani resident Get access E.M. Scrimgeour, E.M. Scrimgeour ⋆ 1Department of Medicine Sultan Qaboos University, P.O. Box 35, Al-Khod (Muscat, Sultanate of Oman ⋆Author for correspondence; fax +968 513 419. serim@gto.net.om Search for other works by this author on: Oxford Academic PubMed Google Scholar J.J. Windsor, J.J. Windsor 2Department of Microbiology and Immunology, Sultan Qaboos University, P.O. Box 35, Al-Khod (Muscat, Sultanate of Oman Search for other works by this author on: Oxford Academic PubMed Google Scholar M.K. Shetty, M.K. Shetty 3Department of Dermatology, Al-Nahda Hospital, Muscat, Sultanate of Oman Search for other works by this author on: Oxford Academic PubMed Google Scholar D.D. Banodkar, D.D. Banodkar 1Department of Medicine Sultan Qaboos University, P.O. Box 35, Al-Khod (Muscat, Sultanate of Oman Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Lambson, B. Lambson 4Division of Microbiology and Parasitology, Cambridge University Department of Pathology, Tennis Court Rd, Cambridge CB2 1QP, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar D.C. Barker, D.C. Barker 4Division of Microbiology and Parasitology, Cambridge University Department of Pathology, Tennis Court Rd, Cambridge CB2 1QP, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar M.A. Idris, M.A. Idris 2Department of Microbiology and Immunology, Sultan Qaboos University, P.O. Box 35, Al-Khod (Muscat, Sultanate of Oman Search for other works by this author on: Oxford Academic PubMed Google Scholar S.H.E. McCann, S.H.E. McCann 4Division of Microbiology and Parasitology, Cambridge University Department of Pathology, Tennis Court Rd, Cambridge CB2 1QP, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar A.R. Al-Suwaid A.R. Al-Suwaid 3Department of Dermatology, Al-Nahda Hospital, Muscat, Sultanate of Oman Search for other works by this author on: Oxford Academic PubMed Google Scholar Transactions of The Royal Society of Tropical Medicine and Hygiene, Volume 93, Issue 3, May-June 1999, Pages 233–234, https://doi.org/10.1016/S0035-9203(99)90003-2 Published: 01 June 1999 Article history Received: 27 October 1998 Revision received: 27 January 1999 Accepted: 18 March 1999 Published: 01 June 1999

Windsor

10.1016/s0035-9203(99)90003-2

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Citations (10)

A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression

PLoS ONE (2016)

Elias A. Said Iman Al‐Reesi Marwa Al-Riyami Khalid Al‐Naamani Shadia Al-Sinawi

Aim The lack of potent innate immune responses during HCV infection might lead to a delay in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes/macrophages (CD68+ cells) are essential to establish effective anti-HCV responses. They express co-stimulatory molecules, CD80 and CD86. CD86 upregulation induces activator responses that are then potentially regulated by CD80. The relative levels of expression of CD80, CD86 and the inhibitory molecule, PD-L1, on CD68+ cells modulate T cell activation. A few studies have explored CD80 and PD-L1 expression on KCs and infiltrating monocytes/macrophages in HCV-infected livers, and none investigated CD86 expression in these cells. These studies have identified these cells based on morphology only. We investigated the stimulatory/inhibitory profile of CD68+ cells in HCV-infected livers based on the balance of CD80, CD86 and PD-L1 expression. Methods CD80, CD86 and PD-L1 expression by CD68+ cells in the lobular and portal areas of the liver of chronic HCV-infected (n = 16) and control (n = 14) individuals was investigated using double staining immunohistochemistry. Results The count of CD68+ KCs in the lobular areas of the HCV-infected livers was lower than that in the control (p = 0.041). The frequencies of CD68+CD80+ cells and CD68+PD-L1+ cells in both lobular and total areas of the liver were higher in HCV-infected patients compared with those in the control group (p = 0.001, 0.031 and 0.007 respectively). Moreover, in the lobular areas of the HCV-infected livers, the frequency of CD68+CD80+ cells was higher than that of CD68+CD86+ and CD68+PD-L1+ cells. In addition, the frequencies of CD68+CD80+ and CD68+CD86+ cells were higher in the lobular areas than the portal areas. Conclusions Our results show that CD68+ cells have an inhibitory profile in the HCV-infected livers. This might help explain the delayed T cell response and viral persistence during HCV infection.

CD80

CD86

CD68

10.1371/journal.pone.0153191

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Citations (7)

Diagnostic Mr31/32 000 Schistosoma mansoni proteins (Sm31/32): Reaction with sera from Sudanese patients infected with S. mansoni or S. haematobium

Journal of Helminthology (1988)

Mohamed A. Idris Andreas Ruppel

ABSTRACT Sera of Sudanese patients with active infections of Schistosoma mansoni or S. haematobium were tested in immunoblots for their reactivity with Mr31/32 000 proteins of adult S. mansoni (Sm31/32). All sera from patients with intestinal (n=123) and all but one from those with urinary schistosomiasis (n=35) had antibodies against Sm31/32. These and additional data suggest that both specificity and sensitivity of Sm31/32 to detect schistosome infections are close to 100%. Antibodies against these proteins developed also in monkeys after experimental infection with S. haematobium . Sm31/32 antigens reacted in immunoblots as a doublet with most S. haematobium -patient sera and as a broad band with many S. mansoni -sera suggesting that at least two components are present in the molecular weight region of Mr31/32 000. The data demonstrate the potential use of Sm31/32 from adult worms to diagnose patients with intestinal or urinary schistosomiasis in endemic areas.

Schistosoma

10.1017/s0022149x00011305

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Citations (27)

Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea

Immunology Letters (2017)

Elias A. Said Mohammed Al-Abri Iman Al-Saidi Mohammed S. Al‐Balushi Jumaa Z. Al-Busaidi

Respiratory burst

Ex vivo

10.1016/j.imlet.2017.08.009

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Citations (24)

Inflows of Foreign Direct Investment and Its Influence on Primary Sector in India

Research Square (Research Square) (2023)

Mohamed A. Idris

Abstract Till 1990s the paucity of capital is one of the major threats to the developing nations. Since they were not able to mobilize the requisite capital for investment which is very indispensible for economic development. There is always a gap between investment required and availability of investment. When India unwrapped its economy for globalization it gave a new panorama for the FDI in India and acts as a strong viaduct and acted as a bridge between investment required and savings available. The constant support of government of India facilitates in getting more amount of capital from foreign countries. Nevertheless still India is far behind in attracting inflow of FDI when comparing with other developing economies. The foreign direct investment was successful in attracting foreign investment into different sectors such as primary, secondary, tertiary, and quaternary. This paper attempts to ascertain the association between the inflows of FDI and its effect on primary sector in India. For this purpose primary sectors such as Metallurgical industries, Mining, Power, Non-conventional energy, Petroleum and natural gas and cement and gypsum sectors are taken into account for the research.

Investment

Capital (architecture)

10.21203/rs.3.rs-2263348/v1

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