Tahereh Farkhondeh

Birjand University of Medical Sciences

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Saeed Samarghandian

University of Neyshabur

230

Milad Ashrafizadeh

Shandong First Medical University

Ali Mohammad Pourbagher‐Shahri

Mashhad University of Medical Sciences

Mohsen Azimi‐Nezhad

University of Neyshabur

Babak Roshanravan

Birjand University of Medical Sciences

Michael Aschner

Albert Einstein College of Medicine

Marjan Talebi

Shahid Beheshti University of Medical Sciences

Fariborz Samini

Mashhad University of Medical Sciences

Hamed Aramjoo

Birjand University of Medical Sciences

Mohsen Talebi

The University of Texas at Arlington

Cooperative Institutions

Birjand University of Medical Sciences

119

Mashhad University of Medical Sciences

Tehran University of Medical Sciences

University of Tehran

Shiraz University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Ferdowsi University of Mashhad

Ahvaz Jundishapur University of Medical Sciences

Shiraz University

Instituto de Salud Carlos III

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Modulatory effect of opioid administration on the activity of cholinesterase enzyme: a systematic review of mice/rat models

Environmental Science and Pollution Research (2021)

Hamed Aramjoo Bamdad Riahi‐Zanjani Tahereh Farkhondeh Fatemeh Forouzanfar Mahmood Sadeghi

Cholinesterase

10.1007/s11356-021-16044-1

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Citations (8)

Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review

Environmental Science and Pollution Research (2020)

Tahereh Farkhondeh Omid Mehrpour Fatemeh Forouzanfar Babak Roshanravan Saeed Samarghandian

Neurotoxicity

10.1007/s11356-020-09045-z

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Citations (118)

Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases

Biomedicine & Pharmacotherapy (2021)

Zeynab Kohandel Tahereh Farkhondeh Michael Aschner Ali Mohammad Pourbagher‐Shahri Saeed Samarghandian

Astaxanthin (AST) is a red pigmented carotenoid with significant antioxidant, anti-inflammatory, anti-proliferative, and anti-apoptotic properties. In this study, we summarize the available literature on the anti-inflammatory efficacy of AST in various chronic and acute disorders, such as neurodegenerative, renal-, hepato-, skin- and eye-related diseases, as well as gastrointestinal disorders. In addition, we elaborated on therapeutic efficacy of AST and the role of several pathways, including PI3K/AKT, Nrf2, NF-κB, ERK1/2, JNK, p38 MAPK, and JAK-2/STAT-3 in mediating its effects. However, additional experimental and clinical studies should be performed to corroborate the anti-inflammatory effects and protective effects of AST against inflammatory diseases in humans. Nevertheless, this review suggests that AST with its demonstrated anti-inflammatory property may be a suitable candidate for drug design with novel technology.

Anti-inflammatory

10.1016/j.biopha.2021.112179

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Citations (129)

Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat

CNS & Neurological Disorders - Drug Targets (2018)

Tahereh Farkhondeh Saeed Samarghandian Fariborz Samini Ali Rajabpour Sanati

Background & Objective: Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study investigated the effects of crocetin on oxidative damage induced by chronic restraint stress in the rat brain. For this reason, rats were kept in the restrainers for 1 hour every day, for 21 consecutive days. The animals were injected crocetin (20, 40, 60 mg/kg) or vehicle daily for 21 days. Findings showed that the immobility time significantly increased in the rodents subjected to the chronic stress compared with the normal group. However, the number of crossing beams in the rats submitted to the chronic stress significantly decreased versus the non-stress rats. Treatment with crocetin ameliorated the immobility time and the number of crossing in the chronic restraint stress rats versus the non-treated stress group. Crocetin also reverted the levels of MDA and GSH and also the activities of antioxidant enzymes to the normal levels in the stress groups. Conclusion: The present study suggests that crocetin may be useful for the management of depressantlike effects induced by chronic stress through decreasing oxidative damage in the brain.

Crocetin

Chronic Stress

10.2174/1871527317666180515120212

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Citations (16)

A Review of the Dual Role of MicroRNA-21 in Cardiovascular Diseases: Risk Factor or a Potential Therapeutic Target

Current Molecular Pharmacology (2024)

Amir Masoud Jafari‐Nozad Negin Rostami Melika Esmaeili Haniye Vahdati Serajoddin Hosseini

Cardiovascular diseases [CVD] are the number one reason for morbidity and mortality in the modern world, and their incidence is increasing at an incredible pace. Increasing evidence has shown the significant functions of microRNAs in the cardiovascular system and has highlighted their potential application as a new era of diagnostic and therapeutic targets for CVD that can improve the prognosis and life expectancy of patients. Among more than 2,000 microRNAs, microRNA-21 [miR-21] is highly expressed in human hearts and has earned the interest of researchers as a potential biomarker in a wide range of common heart conditions. Here, we summarized recent research progress regarding the significant role of miR-21 in CVD, focusing on cardiotoxicity, heart arrhythmias, cardiomyopathies, and hypertension. Several signaling pathways [TGF-β1/Smad2 signaling, FGFR1/FGF21/PPARγ, NF-κB/miR-21/SMAD7, miR-21/SPRY1/ERK/mTOR …] and molecular targets [BTG2, PDCD4, PTEN, STAT3…] were reported to be controlled, at least partially, by miR-21 and are linked to CVD pathogenesis. Most investigations highlighted miR-21 cardioprotective functions in heart injury, while some other studies showed that this miR is elevated in the serum/tissue of patients, promoting fibrosis and cardiac dysfunction. This dual role can be explained by the fact that miR-21 has multiple regulatory functions depending on the microenvironment, downstream signaling, and target genes, which indicates that cell-type-specific investigations should receive more attention. With further investigations, miR-21 can be considered a novel tailored therapy with favorable outcomes.

Cardiotoxicity

Pathogenesis

10.2174/0118761429287057240116040703

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A Systematic and Meta-Analysis Study on the Prevalence of Tuberculosis and Relative Risk Factors for Prisoners in Iran

Infectious Disorders - Drug Targets (2021)

Sedigheh Taherpour Mojtaba Mousavi Bazaz HamidReza Naderi Saeed Samarghandian Alireza Amirabadizadeh

Introduction: Tuberculosis (TB) is a serious infectious disease that affects human health globally. The incidence of TB in prisons is usually much higher than the general population in different countries. The aim of this study was to evaluate the incidence of TB among prisoners in Iran, estimating the relative risk factors by performing a systematic and meta-analysis study on the related articles. Methodology: Our systematic and meta-analysis study was performed according to the PRISMA guidelines. Two authors systematically searched Scopus, Iran doc, Cochrane, Pubmed, Medline, Embase, Iran medex, Magiran, SID, Google Scholar, and EBSCO. The quality assessment of articles was performed by using the Newcastle-Ottawa Scale. After article quality assessment, a fixed or random model, as appropriate, was used to pool the results in a meta-analysis. Heterogeneity between the studies was assessed using I-square and Q-test. Forest plots demonstrating the point and pooled estimates were drawn. Results: Overall, data from 19562 prisoners indicated 63 cases of TB. The prevalence of TB in prisoners was reported to range from 0.025% to 52% in eight studies. The highest prevalence of tuberculosis was related to the study of Rasht, 517 in 100,000, and the lowest rate was related to the study of Sought Khorasan, 25 in 100,000. The ES of the random effect model is 0.003 (95% CI, 0.001-0.005) and p-value <0.0001. The Higgins’ I2 of all studies is 86.55%, and the p-value of the Cochrane Q statistics is <0.001, indicating that there is heterogeneity. Based on the Egger regression plot (t=2.18, p = 0.08, CI 95%: -0.001, 0.005), no publication bias existed. Conclusion: According to the analysis findings, the frequency of tuberculosis among the prison in Iran was low. The highest prevalence obtained in our systematic study was 517 in 100,000 in Rasht, which was near the world statistics in the systematic review of world studies. Due to significant limitations in this study, it is not possible to indicate the exact prevalence of TB in prisons in Iran and compare this with the general population. However, more studies are needed to assess the related risk factors for designing health intervention plans to decrease the incidence rate of TB among prisoners.

Forest plot

10.2174/1871526521666210913111612

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The Hepato-protective Effects of Portulaca oleracea L. extract: Review

Current Drug Discovery Technologies (2018)

Tahereh Farkhondeh Saeed Samarghandian Mohsen Azimi‐Nezhad Soroush Hozeifi

Portulaca oleracea L. (Purslane) has been used in traditional medicine against hepatic injury, although its actual efficacy has not been fully understood. The present study aimed to critically review the recent literature data from 1990 to 2017 regarding the hepato-protective effects of Portulaca oleracea L. and its underlying mechanisms.Online literature resources were checked using different search engines such as Medline, PubMed, Iran Medex, Scopus, and Google Scholar to identify articles, editorials, and reviews about antidotal effects of Portulaca oleracea L. against hepatotoxic agents.Few studies have indicated that Portulaca oleracea L. shows protective effects against hepatotoxic agents. However, due to lack of information in humans, more studies are needed to confirm the efficacy of Portulaca oleracea L. as a hepato-protective agent.The study found that Portulaca oleracea L. may be effective on hepatotoxicity by modulating oxidative stress and inflammation.

Portulaca

10.2174/1570163815666180330142724

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Citations (12)

Versatile role of curcumin and its derivatives in lung cancer therapy

Journal of Cellular Physiology (2020)

Milad Ashrafizadeh Masoud Najafi Pooyan Makvandi Ali Zarrabi Tahereh Farkhondeh

Abstract Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such as anti‐inflammatory, neuroprotective, and antidiabetic. The excellent antitumor activity of curcumin has led to its extensive application in the treatment of various cancers. In the present review, we describe the antitumor activity of curcumin against lung cancer. Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer. Curcumin also can induce autophagy, apoptosis, and cell cycle arrest to reduce the viability and proliferation of lung cancer cells. Notably, curcumin supplementation sensitizes cancer cells to chemotherapy and enhances chemotherapy‐mediated apoptosis. Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF‐κB. Curcumin‐loaded nanocarriers enhance the bioavailability, cellular uptake, and antitumor activity of curcumin. The aforementioned effects are comprehensively discussed in the current review to further direct studies for applying curcumin in lung cancer therapy.

Nanocarriers

Targeted Therapy

10.1002/jcp.29819

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Citations (123)

Protective Effect of Curcumin on Metabolic Syndrome Components through the Microbiota

Current Medicinal Chemistry (2025)

Farzane Vafaeie Tahereh Farkhondeh Saeed Samarghandian Ebrahim Miri‐Moghaddam

Abstract: Curcumin, a natural polyphenolic compound found in turmeric, has garnered increasing research interest due to its potential health benefits, particularly in the context of the rising global prevalence of metabolic syndrome (MetS). With MetS affecting a significant portion of the global population and serving as a precursor to chronic diseases, such as type 2 diabetes and cardiovascular diseases, identifying effective, accessible, and safe interventions has become a critical public health priority. This review explores curcumin’s role in regulating gut microbiota composition, enhancing intestinal barrier function, and reducing inflammation, which can collectively improve key components of MetS, such as hyperglycemia, dyslipidemia, obesity, and hypertension. Supplementation with curcumin has shown promising results in improving metabolic health by promoting the production of short-chain fatty acids (SCFAs), such as butyric and propionic acids. These effects may protect against dyslipidemia and reduce the risk of chronic conditions. Furthermore, curcumin has demonstrated potential in reducing hypertension through various mechanisms, including inflammation reduction, modulation of lipopolysaccharide (LPS) production, activation of G-protein-coupled receptor 43 (GPR43), and increased levels of SCFAs. Given the significant public health implications of MetS, understanding curcumin's impact on gut microbiota presents an opportunity for developing novel therapeutic strategies that address this urgent health challenge. Despite its promise, further research is necessary to fully comprehend the underlying mechanisms involved. Additionally, determining the optimal dosage and duration of curcumin supplementation for achieving its effects on metabolic syndrome is crucial for future therapeutic applications. This review highlights curcumin's potential as a natural compound with multifaceted health benefits, particularly in the context of metabolic syndrome and its associated complications, emphasizing the pressing need for clinical studies to validate findings and inform evidence-based therapeutic applications.

Dyslipidemia

10.2174/0109298673371503250210092741

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Citations (0)

Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity

Cardiovascular & Haematological Disorders - Drug Targets (2016)

Tahereh Farkhondeh Saeed Samarghandian

Curcumin, the major phenolic compound in turmeric, shows preventive effects in various diseases. Curcumin is commonly found in rhizome of the Curcuma species and traditionally used in herbal medicine. Numeros studies has indicated that curcumin posses protective effects against toxic agents in various systems including cardiovascular. This study found that curcumin may be effective in cardiovascular diseases induced by toxic agents including Streptozotocin, Doxorubicin, Cyclosporin A, Methotrexate, Isoproterenol, Cadmium, Diesel exhaust particle, Nicotine, Hydrogen peroxide, and tert- Butyl hydroperoxide. However, due to the lake of information on human, further studies are needed to determine the efficacy of curcumin as an antidote agent. The present study aimed to critically review the recent literature data from that regarding the protective effects of curcumin against agents-induced cardiovascular toxicity. Keywords: Antioxidant, cardiovascular, curcumin, toxic agents.

10.2174/1871529x16666160802144510

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Citations (35)