Gleidice Eunice Lavalle

University of Turin

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Geovanni Dantas Cassali

Universidade Federal de Minas Gerais

Rodrigo dos Santos Horta

Universidade Federal de Minas Gerais

Cecília Bonolo de Campos

Mayo Clinic in Florida

R.B. Araújo

Universidade Federal de Minas Gerais

Fernanda Camargo Nunes

Universidade de Caxias do Sul

Rubens Antônio Carneiro

Universidade Federal de Minas Gerais

Angélica Cavalheiro Bertagnolli

Secretaria de Agricultura e Abastecimento

Karine Araújo Damasceno

Fundação Oswaldo Cruz

Conrado de Oliveira Gamba

Universidade do Oeste de Santa Catarina

S.V. Teixeira

Universidade Federal de Minas Gerais

Cooperative Institutions

Universidade Federal de Minas Gerais

125

Universidade Estadual Paulista (Unesp)

118

Universidade Federal de Santa Maria

Universidade Federal do Rio Grande do Sul

Universidade de Franca

Núcleo de Pesquisas Aplicadas (Brazil)

Universidade de São Paulo

Fundação de Estudo e Pesquisa em Medicina Veterinária e Zootecnia

Associação Brasileira de Oncologia Veterinária

Universidade Federal de Goiás

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Consensus for the diagnosis, prognosis and treatment of canine mammary tumors

Brazilian Journal of Veterinary Pathology (2011)

Geovanni Dantas Cassali Gleidice Eunice Lavalle Ênio Ferreira Alessandra Estrela‐Lima Andrígo Barboza De Nardi

Mammary neoplasms are described as the third most common type of feline tumor, after haematopoietic and skin tumors, and present a challenge for clinicians because the prognosis for feline mammary tumors ranges from guarded to poor. Thus, it is necessary to define new therapeutic approaches and establish more in-depth knowledge about this disease in felines. The main aspects of the diagnosis, prognosis and treatment of feline mammary neoplasia were discussed, aiming to standardize the criteria and to serve as a guide for pathologists and veterinary clinicians.

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Metastatic well differentiated squamous cell carcinoma in the prepuce of a dog: a report of clinicopathological, immunophenotypic and therapeutic approach

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2014)

P.A. Auler Conrado de Oliveira Gamba Rodrigo dos Santos Horta Gleidice Eunice Lavalle Geovanni Dantas Cassali

This report describes a case of a well differentiated squamous cell carcinoma (SCC) of the foreskin of a dog, with metastasis in the regional lymph node. A six-year-old male intact Pit Bull dog presented a preputial ulcerated lesion with an evolution time of one year and enlarged left inguinal lymph node. Surgical resection of the preputial lesion and inguinal lymph nodes was made. The diagnosis of a well differentiated SCC was made following histopathological analysis and immunohistochemistry technique was used to confirm lymph node metastasis and to determine the histological features of the tumor. Here we demonstrated that immunohistochemistry can be an important complementary diagnostic tool to assess the prognostic features of SCC and to determine the treatment of choice. Also, the combination of COX-2 selective inhibitors in adjuvant therapy is presented as an effective alternative treatment for metastatic SCC in dogs.

Preputial gland

10.1590/1678-6741

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Surgical technique´s influence on overall survival, disease free interval and new lesion development interval in dogs with mammary tumors

Rodrigo dos Santos Horta Gleidice Eunice Lavalle Rúbia Monteiro de Castro Cunha Larissa Layara de Moura R.B. Araújo

Mammary gland tumors represent 42% of all tumors in the bitch. Although there are numerous studies about disease development and progression, some questions remain concerning the surgical treatment. Many surgical techniques may be used for the treatment of canine mammary tumors similar to Medicine, the advantages and disadvantages of each procedure have been extensively discussed. The purpose of this study is to evaluate the influence of surgical procedure on survival, disease free interval and new lesion development interval in dogs with mammary tumors treated according to the biological behavior of these lesions. For this, 143 intact bitches were submitted to surgery for the treatment of mammary tumors between 2007 and 2011. Removal of mammary tumors was performed through the simplest and less invasive surgical procedure necessary for the complete removal of all tumors and main known lymphatic connections between affected glands: lumpectomy, mammectomy, regional mastectomy (including abdominal cranial mammary gland or not) or radical mastectomy. Mean clinical follow-up was 738.5 days. Considering only the first surgical event, 84.6% of animals had more than one mammary tumor, and 52.5% had tumors in both mammary chains. Comparing surgical techniques, there was no difference in ipsilateral and contralateral tumor development. Only 33 dogs developed new lesions in remaining mammary tissue, without correlation with primary lesion. Surgical technique had no effect on overall survival, disease-free interval and new lesion development interval in patients on this study, treated according to oncological surgery principles and established prognostic factors for mammary gland tumors in dogs. It is important to consider these results when deciding on the surgical management of dogs with mammary tumors, to avoid aggressive surgical procedures that will not translate into clinical advantages to the patient.

Lumpectomy

Mammary tumor

10.7287/peerj.preprints.143v1

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Glycogen-rich clear cell carcinoma of the feline mammary gland: case report

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2016)

Cecília Bonolo de Campos Conrado de Oliveira Gamba Karine Araújo Damasceno Gleidice Eunice Lavalle Geovanni Dantas Cassali

ABSTRACT The aim of this report is to describe the first histopathological, immunohistochemical, and clinical characteristics of a feline glycogen-rich clear cell carcinoma (GRCCC). A Persian queen was admitted with mammary gland tumors and underwent radical unilateral mastectomy. Overall survival was considered 33 days and death was due to clinical evolution of the disease. Microscopic evaluation demonstrated epithelial cells arranged in a predominantly solid pattern, tumor cells presented an ample, granular, and foamy clear cytoplasm, and moderate cellular pleomorfism. The presence of cytoplasmatic glycogen was confirmed through diastase digestion followed by PAS staining. Histopathological and histochemical findings lead to the diagnosis of GRCCC with regional metastases.

Periodic acid–Schiff stain

10.1590/1678-4162-8797

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Serum evaluation of leptin, IL-6, IGF-1 and estrogen in obese bitches with early stages of mammary carcinoma

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2019)

S.V. Teixeira I.L.D. Silva Fernanda Camargo Nunes Cecília Bonolo de Campos Márcia Rosa de Oliveira

ABSTRACT The aim of this study was to relate the serum concentration IL-6, IGF-1, leptin and estrogen in non-castrated bitches with or without overweight and early stage mammary carcinomas. Forty-three bitches were divided into four groups, two groups without mammary carcinomas with and without overweight, and two groups with mammary carcinomas with and without overweight. Overweight bitches, with or without mammary carcinomas, were statistically different from bitches by ideal weight, in relation to ECC, IMCC and body fat percentages (P< 0.0001). There was a positive correlation between ECC and IMCC (P< 0.0001), ECC and % GC (P< 0.0001), and IMCC and % GC (P< 0.0001). A positive correlation was found between serum leptin and IL-6 (P= 0.0451) and leptin and IGF-1 (P= 0.05). A positive correlation (P= 0.0053) between ECC and leptin was found in the analysis of body evaluation methods and serum concentrations, and a negative correlation between ECC and IL-6 (P= 0.0435). Among the fat percentage and the leptin concentration, there was a positive correlation (P= 0.0016), as found between the IMCC and leptin (P= 0, 0209). In this study, no association was observed between excessive weight and the presence of early stage mammary carcinomas.

Mammary carcinoma

Mammary tumor

Positive correlation

10.1590/1678-4162-10259

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Citations (2)

Consensus for the diagnosis, prognosis and treatment of feline mammary tumors

Brazilian Journal of Veterinary Research and Animal Science (2018)

Geovanni Dantas Cassali Cecília Bonolo de Campos Angélica Cavalheiro Bertagnolli Alessandra Estrela‐Lima Gleidice Eunice Lavalle

10.11606/issn.1678-4456.bjvras.2018.135084

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Citations (22)

CA15.3, CEA and LDH in Dogs with Malignant Mammary Tumors

Journal of Veterinary Internal Medicine (2012)

Liliane Cunha Campos Gleidice Eunice Lavalle Alessandra Estrela‐Lima Joyce Costa Melgaço de Faria J.E. Guimarães

Background Presence of tumor markers in serum might be connected to the number of secreting cells and with the stage of the neoplasm. However, there are few studies regarding these markers in veterinary clinical oncology. Objectives To determine the serum concentrations of cancer antigen 15.3 ( CA 15.3), carcinoembryonic antigen ( CEA ), and lactate dehydrogenase ( LDH ) in female dogs with different stages of mammary cancer. Animals Ninety female dogs, including 30 that were healthy, 40 that had nonmetastatic cancer, 12 with regional metastasis, and 8 with distant lymph node metastasis. Methods Prospective case‐controlled observational study. Serum samples were collected to measure CA 15.3, CEA , and LDH from 60 female dogs with mammary cancer during mastectomy and 30 healthy female dogs during routine check‐up. CA 15.3 and CEA were determined by chemiluminescent immunoassay and LDH by ultraviolet kinetic method. Western blotting analysis was performed to confirm the specificity and possible cross‐reactivity of human CA 15.3 and CEA antibodies with canine serum. Group data were compared by ANOVA followed by Student‐Newman‐Keuls and Tukey's tests. Correlations were investigated by Pearson and Spearman tests. Results CEA , CA 15.3, and LDH were measurable in all groups. Higher serum concentration of CA 15.3 and LDH was associated with regional and distant metastases. There was a significantly higher serum CA 15.3 concentration in animals with lymph node metastasis when compared with animals without metastasis. There were no significant differences in CEA among groups. Expression of CA 15.3 and CEA in canine serum was confirmed by Western blotting. Conclusions and Clinical Importance Serum CA 15.3 can be used to distinguish nonmetastatic from metastatic carcinomas.

Carcinoembryonic antigen

Chemiluminescent immunoassay

10.1111/j.1939-1676.2012.01014.x

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Citations (35)

Leiomiossarcoma pulmonar e renal em cão: relato de caso

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2000)

Rogéria Serákides Fabiano José Ferreira de Sant’Ana Rubens Antônio Carneiro Gleidice Eunice Lavalle

Este relato descreve um caso de leiomiossarcoma pulmonar e renal em cão da raça Husky Siberiano, macho, de nove anos de idade e com histórico de emagrecimento progressivo há mais de três meses. Ao exame clínico, o animal apresentava palidez discreta das mucosas e dor intensa à palpação abdominal, além de aumento de volume acentuado dos rins. No hemograma, foi evidenciada anemia discreta e na urinálise foram observados isostenúria e grumos de células do epitélio renal. Os níveis plasmáticos de uréia e creatinina estavam dentro dos limites considerados normais. O animal foi sacrificado após a confirmação de neoplasia renal bilateral por laparotomia exploratória. À necropsia, os rins apresentavam vários nódulos de 0,5 a 4cm de diâmetro, esbranquiçados e firmes. Na região do hilo e no lobo apical esquerdo dos pulmões havia aumento de volume, com 11 × 7cm de extensão, de superfície irregular e bem vascularizada, esbranquiçada e com áreas de consistência ora firmes, ora friáveis. No lobo apical direito também havia um nódulo com 1cm de diâmetro, firme e esbranquiçado. Secções histológicas dos pulmões e dos rins foram coradas pela hematoxilina-eosina, Masson e Van Gieson. Foi detectada positividade, pela imuno-histoquímica, para a vimentina e actina alfa de músculo liso. Não houve imunomarcação para citoqueratinas 1, 5, 10, 14, 8 e 7, proteína S100 e para CD68. Com base nos achados anatomopatológicos e imuno-histoquímicos foi firmado o diagnóstico de leiomiossarcoma pulmonar e renal, sem, no entanto, definir o sítio primário da neoplasia.

10.1590/s0102-09352000000600008

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Citations (3)

Adjuvant Thalidomide and Metronomic Chemotherapy for the Treatment of Canine Malignant Mammary Gland Neoplasms

In Vivo (2018)

Cecília Bonolo de Campos Gleidice Eunice Lavalle Lidianne N. Monteiro G.R.A. Pêgas Sílvia Ligório Fialho

The aim of the present study was to evaluate a multimodal approach for the treatment of canine malignant mammary gland neoplasms, including surgery, chemotherapy, thalidomide, and metronomic chemotherapy (MC).Fifty-eight female dogs were submitted to four different treatments: surgery; surgery with chemotherapy; surgery with chemotherapy and thalidomide; and surgery with chemotherapy and metronomic chemotherapy and overall survival was evaluated.No statistical difference was found in the proliferative index and microvessel density of primary neoplasms and distant metastases following thalidomide treatment. Diffuse intense inflammatory infiltrate was predominant in primary tumors and diffuse moderate inflammatory infiltrate in metastatic lesions. No statistically significant difference was observed in median survival time (MST) between treatment groups when including all clinical stages (p=0.3177). However, animals diagnosed with distant metastasis treated with surgery and chemotherapy associated with thalidomide or MC presented longer MST when compared to animals treated only with surgery or surgery and chemotherapy (p<0.0001).The proposed multimodal therapy protocols including antiangiogenic and immunomodulatory therapies demonstrated a clinical benefit for patients in advanced clinical stages.

10.21873/invivo.11429

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Citations (20)

Lipossarcoma em cão: relato de dois casos

Arquivo Brasileiro de Medicina Veterinária e Zootecnia (2003)

Fabiano José Ferreira de Sant’Ana Rogéria Serákides Gleidice Eunice Lavalle

This work aims to describe the clinical and anatomopathological findings of two cases of liposarcoma diagnosed in the subcutaneous and abdominal cavity of dogs. In both cases, the tumoral masses were surgically removed and samples were submitted for histopathological analyses. Microscopic examination of each case revealed a highly cellular, pleomorphic neoplasm with round or polygonal fat cells. The nuclei was elongate or splindle-shape (subcutaneous liposarcoma) and round or ovoid (abdominal liposarcoma), contained margined chromatin, and prominent nucleolus. Cytoplasmic vacuoles that stained positively with Sudan IV varied highly in size.

10.1590/s0102-09352003000100020

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