Isao Tabei

Jikei University School of Medicine

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Hiroshi Takeyama

Jikei University School of Medicine

Ken Uchida

Meiji Yasuda Life Foundation of Health and Welfare

Hiroko Nogi

Japan Surgical Society

Toshiaki Tachibana

Jikei University School of Medicine

Katsuhiko Yanaga

Sanno Medical Center

Toshiaki Morikawa

JR Tokyo General Hospital

Yasuo Toriumi

Jikei University School of Medicine

Hisashi Hashimoto

Yokohama City University

H. Kubo

Chiba University of Commerce

Hiroshi Ishikawa

Shizuoka Cancer Center

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Jikei University School of Medicine

113

The University of Tokyo

Keio University

Osaka University

University of Tsukuba

Nihon University

Jikei University Kashiwa hospital

Tohoku University

Showa University

Kyoto University

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99mTc-MIBI SPECT compared with201TI SPECT for the detection of breast cancer and lymph node metastasis

Breast Cancer (1997)

H. Kubo Nobuyoshi Fukumitsu Toru Nagata Haruro Tomita Isao Tabei

Surgical oncology

10.1007/bf02966525

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Determination of the Optimum Excitation Wavelength for the Parathyroid Gland Using a Near-Infrared Camera

Frontiers in Surgery (2021)

Isao Tabei Azusa Fuke Astushi Fushimi Hiroshi Takeyama

When performing thyroid/parathyroid surgery, difficulty detecting the parathyroid gland is a common experience because it is frequently mistaken with surrounding structures, including the thyroid gland, lymph nodes, and fat. To obtain successful surgical results, the auto fluorescent property of the parathyroid gland occurring at 820–830 nm has been used. Intraoperative visualization and detection by fluorescence enable protection of the gland from damage and unintended removal. Use of a near-infrared (NIR) camera has been proposed to indicate the parathyroid gland, but the devices and success rates have varied. This study aimed to define optimum excitation wavelength (EWL) by measuring the EWL of the parathyroid gland for its autofluorescence. Glands were exposed to EWL at 10-nm intervals from 670–790 nm with a light-emitting diode monochromator; autofluorescence intensity was recorded with a conventional NIR video camera. Autofluorescence intensity curves of three normal parathyroid glands were depicted; the optimum EWL was measured as 760–770 nm. Also, the illumination of the surrounding structures were compared at the optimum EWL. The auto fluorescent intensity of the parathyroid gland was 2-fold greater than for surrounding structures. This difference in fluorescence intensity should enable distinction of the parathyroid gland from surrounding structures. The clarification of the optimum EWL can guide refinements of the NIR camera for better surgical outcomes by improving detection of the parathyroid glands. Also, an understanding of optimum EWL should lead to developments for microscopic devices to unravel the still unknown mechanisms of the intrinsic autofluorescence of the parathyroid gland.

Parathyroid gland

Autofluorescence

10.3389/fsurg.2020.619859

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The Effect of Viscosity Regulating Solution for Enteral Nutrition Against Gastro Esophageal Reflux.

The Japanese Journal of Gastroenterological Surgery (2003)

Isao Tabei H. Kubo Fumiaki Yano H Inada

経腸栄養管理中における胃食道逆流による誤嚥性肺炎予防のために栄養剤の粘度に着目した. 経腸栄養剤に含まれる遊離Ca2+とペクチンが結合し粘調度が高まる性質を利用, 胃食道逆流障害に起因する誤嚥性肺炎の予防に寄与できると考えた. 対象と方法: 1) LMペクチンを主成分とするREF-P1 (90g) と遊離型カルシウムを60mg/ml含有する市販経腸栄養剤K-3S (400ml) を混合したときの粘度の変化を調べた. 2) 4人の健常人ボランテアーに対し急速に経腸栄養剤を投与し, REF-P1投与の有無で胃食道pH モニタリングを行い, 胃食道逆流障害を観察した. 3) 全国9施設における16例の嚥下障害患者における使用アンケート調査を紹介する. 結果: 1) 経管栄養剤K-3Sの粘度は8cpであり, REF-P1を加えたとき粘度は900cpまで上昇し安定した. 2) K-3Sのみの胃食道逆流率が3 時間の検査中2.1%だったのに対し, REF-P1を使用した場合はわずか0.3%だった. 3) 毎食逆流の見られた患者はいなくなり, 嘔吐, 下痢, 熱発などの副作用を訴える患者数も減少した. まとめ: 胃食道逆流による誤飲性肺炎の予防のためペクチン液を開発, 投与することにより胃内で経腸栄養剤をゲル化し, 粘度を調整, 逆流を防止することができた. さらに投与時間の短縮が計れ治療計画上, 有用な経腸栄養剤投与法と思われる.

Gastro-

Enteral administration

10.5833/jjgs.36.71

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Assessment of NST management under JSPEN guidline for enteral nutrition with gastro-itesitinal surgical patients

静脈経腸栄養 (2002)

Hiromi Shiraishi H. Kubo Makoto Nakamura Isao Tabei Youko Nakamura

Gastro-

Enteral administration

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[Parenteral and enteral nutritional management for hemorrhagic gastric and duodenal ulcer patients].

PubMed (2001)

Isao Tabei Hiroyuki Kubo T. Aoki

Enteral administration

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Dihydropyridine‐ and voltage‐sensitive Ca²⁺ entry in human parathyroid cells

Experimental Physiology (2009)

Keitaro Yokoyama Douchi Matsuba Satomi Adachi‐Akahane Hiroshi Takeyama Isao Tabei

Patch-clamp and fluorescence measurements of cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) were performed to directly detect extracellular Ca(2+) entry into cultured parathyroid cells from patients with secondary hyperparathyroidism. Cells loaded with fluo-3 AM or fluo-4 AM showed a transient increase in fluorescence (Ca(2+) transient) following 10 s exposure to 150 mm K(+) solution in the presence of millimolar concentrations of external Ca(2+). The Ca(2+) transient was completely inactivated after 30-40 s exposure to the high-K(+) solution, was reduced by dihydropyridine antagonists and was enhanced by FPL-64176, an L-type Ca(2+) channel agonist. The electrophysiological and pharmacological properties of the whole-cell Ca(2+) and Ba(2+) currents were similar to those of L-type Ca(2+) channels. The Ca(2+) transients induced by 10 s exposure to 3.0 mm extracellular Ca(2+) concentration ([Ca(2+)](o)) were inhibited by dihydropyridine antagonists and were partly inactivated following 30-40 s exposure to the high-K(+) solution. These results demonstrate, for the first time, that human parathyroid cells express L-type-like Ca(2+) channels that are possibly involved in the [Ca(2+)](o)-induced change in [Ca(2+)](i). This Ca(2+) entry system might provide a compensatory pathway for the negative feedback regulation of parathyroid hormone secretion, especially in hyperplastic conditions in which the Ca(2+)-sensing receptor is poorly expressed.

Parathyroid chief cell

10.1113/expphysiol.2009.046813

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Citations (8)

[Current micro-element preparations for parenteral nutritional use].

PubMed (2001)

Hitoshi Kubo Isao Tabei Takeyoshi Kaneda

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A Case of Hematogenous Metastasis of Gastric Carcinoma to Appendix and Rectum

Progress of Digestive Endoscopy (2001)

Hidejiro Kawahara Fumiaki Yano Isao Tabei Takemasa Cho Hideyuki Kashiwagi

51 year-old male who had undergone total gastrectomy with splenectomy 4 years ago was admitted to our hospital for examination and treatment for melena. Type 4 tumors were found in the vermiform appendix and the rectum by endoscopic examination. Histopathological fingings showed signet ring cell carcinoma similar to that of the gastric cancer. Therefore it was diagnosed as metastatic diffuse infiltrative type 4 carcinoma of the appendix and rectum. Lymphangio-metastasis and peritoneal dissemination of the gastric cancer was determined negative in relation by pre- and opelative examination. Therefore hematogenous metastasis of the signet ring cell carcinoma from the original gastric cancer through SMA for the appendix and IMA for the rectal lesions were most suspected for the route of metastasis. A rare case of gastric cancer with hematogenous metastasis to the appendix and rectum is reported.

Vermiform

Melena

10.11641/pde.59.2_106

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Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma

Human Cell (2006)

Satoshi OHI Shigeya Kyoda Isao Tabei Kouzou Ninomiya Kayoko Sugiyama

Doubling time

10.1111/j.1749-0774.2006.00020.x

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Citations (3)

Detection of dihydropyridine- and voltage-sensitive intracellular Ca2+ signals in normal human parathyroid cells

The Journal of Physiological Sciences (2013)

Rinako Iida Keitaro Yokoyama Ichiro Ohkido Isao Tabei Hiroshi Takeyama

We recently showed dihydropyridine- and voltage-sensitive Ca(2+) entry in cultured parathyroid cells from patients with secondary hyperparathyroidism. To determine whether normal parathyroid cells have a similar extracellular Ca(2+) entry system, cells were isolated from normal (non-hyperplastic) human parathyroid glands. Fluorescence signals related to the cytoplasmic Ca(2+) concentration ([Ca(2+)]I) were examined in these cells. Cells loaded with fluo-3/AM showed a transient increase in fluorescence (Ca(2+) transient) following a 10-s exposure to a 150 mM K(+) solution in the presence of millimolar concentrations of external Ca(2+). The Ca(2+) transient was reduced by dihydropyridine antagonists or 0.5 mM Cd(2+), but enhanced by FPL-64176, an L-type Ca(2+)-channel agonist. Ca(2+) transients induced by the 10-s exposure to 3.0 mM extracellular Ca(2+) ([Ca(2+)]o) were also inhibited by dihydropyridine antagonists or 0.5 mM Cd(2+). These results provide the first evidence that normal human parathyroid cells express a dihydropyridine-sensitive Ca(2+) entry system that may be involved in the [Ca(2+)]o-induced change in [Ca(2+)]I. This system might provide a compensatory pathway for negative feedback regulation of parathyroid hormone secretion under physiological conditions.

Calcium in biology

10.1007/s12576-013-0255-x

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Citations (2)