A series of 270 patients with Hodgkin's disease, diagnosed between July 1953 and July 1968, and classified according to the Lukes-Butler histologic classification scheme, is used to illustrate two statistical procedures for evaluating the simultaneous effect of various prognostic factors. The results are presented as equations in which median years of survival depend jointly on histologic type, sex, stage of disease, and symptoms at diagnosis. The data included in this report are sufficient for illustrating the statistical methods, although a much larger series of Hodgkin's disease patients would be required for carrying out an analysis of this type that would provide valid results for survival prediction.