The theoretical background for the diagnosis and treatment of upper digestive ulcer, gastritis and stomach carcinema was challenged by H. pylori, a microbe seems only under the microscope. This paper makes a brief review on the brief history of discovery and recent conclusion on the microbe, and explores its challenge to the traditional conception.
Background: Data on prognostic value of long non-coding RNAs (lncRNAs) to sporadic gastric cancer have been published at a growing pace. However, there has been no comprehensive quantitative overview has been available. We aim to investigate the association between the expression of long non-coding RNAs (lncRNAs), clinicopathological factors and prognosis of gastric cancer.
// Fujiao Duan 1, 2, 6 , Weigang Liu 3 , Xiaoli Fu 2 , Yajing Feng 2, 4 , Liping Dai 2, 6 , Shuli Cui 5 and Zhenxing Yang 1 1 Medical Research Office, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China 2 College of Public Health, Zhengzhou University, Zhengzhou, Henan, China 3 Medical Record Statistics Office, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei, China 4 Department of Nosocomial Infection Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China 5 College of Professional Study, Northeastern University, Boston, Massachusetts, USA 6 Henan Key Laboratory of Tumor Epidemiology, Zhengzhou, Henan, China Correspondence to: Fujiao Duan, email: fjduan@yeah.net Zhenxing Yang, email: yangzhenxing59@126.com Keywords: miR-148/152 family, prognosis, cancer, systems assessment Received: July 14, 2017 Accepted: August 27, 2017 Published: September 11, 2017 ABSTRACT Background: The prognostic significance of MicroRNA-148/152 (miR-148/152) family expression in various cancers has been investigated by many studies with inconsistent results. To address this issue, we performed a meta-analysis to clarify this relationship. Materials and Methods: Eligible studies were recruited by a systematic literature search and assessed the quality of included studies based on Quality In Prognosis Studies (QUIPS) and Newcastle-Ottawa Scale (NOS). Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and disease free survival/progressive free survival/recurrence free survival (DFS/PFS/RFS) were calculated to estimate the effects of miR-148/152 family expression on prognosis. Results: A final total of 23 articles (26 studies) were considered in evidence synthesis. A significant association was observed between low miR-148a level and poor OS in patients (HR = 1.59, 95% CI: 1.14 – 2.20, P = 0.00), especially with digestive tract cancer (DTC) (HR = 1.29, 95% CI: 1.03–1.63, P = 0.03), and another significant association was observed between low miR-148b level and poor OS in patients (HR=2.09, 95% CI: 1.70–2.56, P = 0.00), especially with (hepatocellular carcinoma) HCC (HR = 1.97, 95% Cl: 1.52–2.56, P = 0.00) and non-small cell lung cancer (NSCLC) (HR = 2.29, 95% Cl: 1.64–3.18, P = 0.00). The significant correlation between miR-152 and DFS/RFS was found in our research (HR = 3.49, 95% Cl: 1.13–10.08, P = 0.03). Conclusions: Our findings suggest that low miR-148/152 family expression is significantly associated with poor prognosis and may be a feasible prognostic biomarker in some cancers, especially in HCC and NSCLC.
The purpose of this study is to clarify and quantify the potential dose-response association between the intake of total red and total processed meat and risk of nasopharyngeal carcinoma (NPC). Relevant studies were identified by searching PubMed, EMBASE, and Chinese databases (CNKI and Wanfang). The summary relative risk (RR) with 95% confidence interval (95%CI) was calculated. A total of 15 independent studies with 12,735 subjects were identified. Compared with the low-rank intake, the summary RR of NPC was 1.35 (95%CI, 1.21–1.51) for total red meat and 1.46 (95%CI, 1.34–1.64) for total processed meat. For the moderate-rank intake, the summary RR of NPC was 1.54 (95%CI, 1.36–1.79) for total red meat and 1.59 (95%CI, 1.3–1.90) for total processed meat. The summary RR for high-rank intake was 1.71 (95%CI, 1.14–2.55) for total red meat and 2.11 (95%CI, 1.31–3.42) for total processed meat. The combined estimates showed obvious evidence of statistically significant association between total red and total processed meat consumption dose and risk of NPC (Ptrend< 0.01). In conclusion, our data suggest that a high intake of total red or total processed meat is associated with a significantly increased risk of NPC.
Background: Mounting evidence showed that microRNAs may be useful as prognostic biomarkers of cancer. Therefore, we summarize the predictive role of microRNA-218 (miR-218) for survival in patients with various cancers. Methods: We performed a systematic literature review and assessed the quality of included studies based on Meta-analysis of Observational Studies in Epidemiology group (MOOSE). Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to assess the correlation between miR-218 expression and prognosis of different cancers. Results: We identified 10 studies for pooled analyses. For overall survival, a lower expression levels of miR-218 significantly predicted poorer survival, with the pooled HR of 2.61 (95% CI: 2.11–3.22, P < 0.001). For disease-free survival/progressive-free survival/recurrence-free survival (DFS/PFS/RFS), a lower expression level of miR-218 significantly predicted worse DFS/PFS/RFS in various carcinomas, with the pooled HR of 2.73 (95% CI: 2.08–3.58, P < 0.001). Similarly, subgroup analysis by detection method, ethnicity and cancer subtype analysis suggested that lower expression of miR-218 correlated with. Conclusion: Our data demonstrated that lower miR-218 expression is significantly associated with poorer overall survival (OS) and DFS/PFS/RFS and may be a novel prognostic biomarker in some cancer types.
Cervical cancer is the second most common cancer among women worldwide. The potential of microRNAs as novel biomarkers in cervical cancer is growing.In this study, we investigated the functions and targets of miR-466 in cervical cancer tissues.Fresh cervical tissues were obtained from 157 patients with cervical cancer, cervical intraepithelial neoplasia (CIN), and healthy controls, and the tissues were immediately frozen in liquid nitrogen until use. The RNA was extracted and quantitative real-time polymerase chain reaction (PCR) was performed.A total of 157 participants were summarized, including 56 patients with cervical cancer, 60 patients with CIN, and 49 healthy controls. The expression levels of miR-466 in cervical cancers (0.68) were higher than that in healthy controls (0.082) (P < 0.01). The average fold changes of miR-466 in the patients with CIN group and people group were 0.28 and 0.082, respectively (P < 0.01). It was a statistically significant difference in patients with lymph node involvement (P = 0.022). However, the expression of miR-466 was not correlated with International Federation of Gynecology and Obstetrics stages, tumor size, or vascular invasion (P = 0.506, P = 0.667, and P = 0.108, respectively).Our results indicate that the aberrant expression of miR-466 is closely associated with the occurrence and development of cervical cancer.
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