Luis García‐Marcos

Universidad de Murcia

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Manuel Sánchez‐Solís

Hospital Universitario Virgen de la Arrixaca

Virginia Pérez‐Fernández

Universidad de Murcia

Eva Morales

Universidad de Murcia

Philippa Ellwood

University of Auckland

Javier Mallol

Universidad de Santiago de Chile

Neil Pearce

London School of Hygiene & Tropical Medicine

David P. Strachan

St George's, University of London

José A. Castro‐Rodríguez

Pontificia Universidad Católica de Chile

Chen‐Yuan Chiang

National Yang Ming Chiao Tung University

María Morales‐Suárez‐Varela

Universitat de València

Cooperative Institutions

Universidad de Murcia

158

Instituto Murciano de Investigación Biosanitaria

115

Hospital Universitario Virgen de la Arrixaca

Charité - Universitätsmedizin Berlin

London School of Hygiene & Tropical Medicine

Boston Children's Hospital

Instituto de Salud Carlos III

National and Kapodistrian University of Athens

ENT and Allergy

Karolinska Institutet

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Are environmental risk factors for current wheeze in the International Study of Asthma and Allergies in Childhood (ISAAC) phase three due to reverse causation?

Clinical & Experimental Allergy (2018)

Richard J. Silverwood Charlotte E Rutter Edwin A. Mitchell M. Innes Asher Luis García‐Marcos

Abstract Background Phase Three of the International Study of Asthma and Allergies in Childhood ( ISAAC ) measured the global prevalence of symptoms of asthma in children. We undertook comprehensive analyses addressing risk factors for asthma symptoms in combination, at both the individual and the school level, to explore the potential role of reverse causation due to selective avoidance or confounding by indication. Objective To explore the role of reverse causation in risk factors of asthma symptoms. Methods We compared two sets of multilevel logistic regression analyses, using (a) individual level exposure data and (b) school level average exposure (ie prevalence), in two different age groups. In individual level analyses, reverse causation is a possible concern if individual level exposure statuses were changed as a result of asthma symptoms or diagnosis. School level analyses may suffer from ecologic confounding, but reverse causation is less of a concern because individual changes in exposure status as a result of asthma symptoms would only have a small effect on overall school exposure levels. Results There were 131 924 children aged 6‐7 years (2428 schools, 25 countries) with complete exposure, outcome and confounder data. The strongest associations in individual level analyses (fully adjusted) were for current paracetamol use (odds ratio = 2.06; 95% confidence interval 1.97‐2.16), early life antibiotic use (1.65; 1.58‐1.73) and open fire cooking (1.44; 1.26‐1.65). In school level analyses, these risk factors again showed increased risks. There were 238 586 adolescents aged 13‐14 years (2072 schools, 42 countries) with complete exposure, outcome and confounder data. The strongest associations in individual level analyses (fully adjusted) were for current paracetamol use (1.80; 1.75‐1.86), cooking on an open fire (1.32; 1.22‐1.43) and maternal tobacco use (1.23; 1.18‐1.27). In school level analyses, these risk factors again showed increased risks. Conclusions & clinical relevance These analyses strengthen the potentially causal interpretation of previously reported individual level findings, by providing evidence against reverse causation.

Wheeze

Causation

10.1111/cea.13325

Cite

Citations (26)

Estudio de la presencia de animales domésticos: gatos y perros, y su papel en el asma, la rinitis alérgica y la dermatitis atópica en niños

Atención Primaria (2005)

María Manuela Morales Suárez-Varela Marco-Antonio Jiménez-López Agustín Llopis González Luis García‐Marcos

10.1016/s0212-6567(05)70557-6

Cite

Citations (2)

International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life

Pediatric Allergy and Immunology (2010)

Luis García‐Marcos Javier Mallol Dirceu Solé Paul L.P. Brand

Garcia-Marcos L, Mallol J, Solé D, Brand PLP and EISL group. International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life.Pediatr Allergy Immunol 2010: 21: 878–888.© 2010 John Wiley & Sons A/S Risk factors for wheezing during the first year of life (a major cause of respiratory morbidity worldwide) are poorly known in non-affluent countries. We studied and compared risk factors in infants living in affluent and non-affluent areas of the world. A population-based study was carried out in random samples of infants from centres in Latin America (LA) and Europe (EU). Parents answered validated questionnaires referring to the first year of their infant’s life during routine health visits. Wheezing was stratified into occasional (1–2 episodes, OW) and recurrent (3 + episodes, RW). Among the 28687 infants included, the most important independent risk factors for OW and RW (both in LA and in EU) were having a cold during the first 3 months of life [OR for RW 3.12 (2.60–3.78) and 3.15 (2.51–3.97); population attributable fraction (PAF) 25.0% and 23.7%]; and attending nursery school [OR for RW 2.50 (2.04–3.08) and 3.09 (2.04–4.67); PAF 7.4% and 20.3%]. Other risk factors were as follows: male gender, smoking during pregnancy, family history of asthma/rhinitis, and infant eczema. Breast feeding for >3 months protected from RW [OR 0.8 (0.71–0.89) in LA and 0.77 (0.63–0.93) in EU]. University studies of mother protected only in LA [OR for OW 0.85 (0.76–0.95) and for RW 0.80 (0.70–0.90)]. Although most risk factors for wheezing are common in LA and EU; their public health impact may be quite different. Avoiding nursery schools and smoking in pregnancy, breastfeeding babies >3 months, and improving mother’s education would have a substantial impact in lowering its prevalence worldwide.

Respiratory sounds

10.1111/j.1399-3038.2010.01035.x

Cite

Citations (149)

Electroanalytical Determination of Cadmium and Lead in Deciduous Teeth after Microwave Oven Digestion

Journal of AOAC International (2001)

Javier Bayo Stella Moreno‐Grau M José Martínez J. Moreno José M. Angosto

A method using differential pulse anodic stripping voltammetry after microwave oven digestion was developed for the simultaneous determination of Cd(II) and Pb(II) in the deciduous teeth of children. Each tooth was weighed; deposited in a 120 mL capped Teflon vessel with 5 mL 65% nitric acid, Suprapur analytical grade; and digested in a 2-step microwave oven for 15 min. The detection limits for Cd(II) and Pb(II) in the final solution were 0.078 and 0.323 microg/L, and the quantitation limits 0.394 and 1.613 microg/L, respectively, with a linearity range of 2 microg/L for Cd(II) and 23.3 microg/L for Pb(II). The sensitivity was 2.51 nA/microg-L and 1.37 nA/microg-L, for Cd(II) and Pb(II). The main advantages of this technique are a complete and satisfactory dissolution of the tooth material with the proposed microwave oven digestion procedure, without sample pretreatments, such as drying, ashing, or powdering. The voltammetric procedure proved to be well designed because of significant goodness of fit to a linear model, and the accuracy of the method was established as compared with standard reference material. The methodology has enabled us to study Cd(II) and Pb(II) in 371 deciduous teeth from school children in Cartagena, Spain.

Microwave oven

Ashing

Nitric acid

Microwave digestion

Standard addition

Digestion

Anodic Stripping Voltammetry

10.1093/jaoac/84.1.111

Cite

Citations (4)

Lesiones morfologicas producidas en ratas lactantes por la aspiracion de diversos tipos de leche, aceites y sus componentes

Luis García‐Marcos

LA ASPIRACION EXPERIMENTAL EN RATAS LACTANTES DE DIFERENTES SUSTANCIAS QUE ENTRAN A FORMAR PARTE DE LA ALIMENTACION DEL NINO LACTANTE DEMUESTRA QUE EXISTEN VARIAS REACCIONES TISULARES ANTE LA AGRESION A LO LARGO DE 45 DIAS. LOS ACEITES Y ACIDOS GRASOS PRODUCEN UNA NEUMONIA INTERSTICIAL CON GRAN COMPONENTE GRANULOMATOSO QUE SE RESUELVE A LO LARGO DE ESTE TIEMPO. LOS GRANULOMAS APARECENMAS TARDIAMENTE Y EN MENOR CANTIDAD EN LAS ASPIRACIONES DE LOS DISTINTOS TIPOS DE LECHE SIENDO ESTA NEUMONIA INTERSTICIAL MAS INTENSA QUE LA ANTERIOR. EN LA ASPIRACION DE PROTEINAS NO EXISTE COMPONENTE GRANULOMATOSO Y LA NEUMONIA INTERSTICIAL ES MUY INTENSA NO RESOLVIENDOSE EN LOS 45 DIAS DEL ESTUDIO.

Source

Cite

Citations (0)

The International Study of Wheezing in Infants: Questionnaire Validation

International Archives of Allergy and Immunology (2007)

Javier Mallol Luis García‐Marcos Viviana Aguirre Antonela Martínez-Torres Virginia Pérez‐Fernández

Background: There are no internationally validated questionnaires to investigate the prevalence of infant wheezing. This study was undertaken to validate a questionnaire for the International Study on the Prevalence of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). Material and Methods: Construct and criterion validity were tested for the question ‘Has your baby had wheezing or whistling in the chest during his/her first 12 months of life?’. Construct validity (i.e. the ability of parents and doctors to refer to the same symptoms with the same words) was tested in a sample of 50 wheezing and 50 non-wheezy infants 12–15 months of age in each of 10 centres from 6 different Spanish- or Portuguese-speaking countries. Criterion validity (i.e. the ability of parents to correctly detect the symptom in the general population) was evaluated in 2 samples (Santiago, Chile and Cartagena, Spain) of 50 wheezing and 50 non-wheezing infants (according to parents) of the same age, randomly selected from the general population, who were later blindly diagnosed by a paediatric pulmonologist. Results: Construct validity was very high (ĸ test: 0.98–1) in all centres. According to Youden’s index, criterion validity was good both in Cartagena (75.5%) and in Santiago (67.0%). Adding questions about asthma medication did not improve diagnosis accuracy. Conclusions: The EISL questionnaire significantly distinguished wheezy infants from healthy ones. This questionnaire has a strong validity and can be employed in large international multicentre studies on wheezing during infancy.

Respiratory sounds

Pulmonologists

Content Validity

10.1159/000102613

Cite

Citations (80)

Changes in the prevalence and severity of recurrent wheezing in infants: The results of two surveys administered 7 years apart

Journal of Asthma (2017)

Javier Mallol Dirceu Solé Viviana Aguirre Herberto José Chong‐Neto Nelson Augusto Rosário Filho

To identify changes in the prevalence and severity of recurrent wheezing (RW) in infants using data obtained from two surveys administered seven years apart.A cross-sectional, international, population-based study in infants aged 12-15 months was conducted. Data were obtained from two surveys (S1 and S2, in 2005 and 2012, respectively) using the same methodology in three large Latin American cities: Curitiba (Brazil), São Paulo (Brazil), and Santiago (Chile).A decrease in the overall prevalence of RW was identified between S1 (23.3%) and S2 (20.4%), p = 0.004, but it was mainly driven by the reduction observed in São Paulo; in Curitiba and Santiago, this change was not significant. The mean prevalence of the following RW severity indicators remained high and stable: severe wheezing episodes (56.9% in S1 and 54.2% in S2, p = 0.32) and emergency department (ED) visits for wheezing (S1 = 68.1%, S2 70.9%, p = 0.21). A significant increase in admissions for wheezing (21.1% to 26.7%, p = 0.004) was observed. In Curitiba and São Paulo, there were significant increases in the prevalence of physician-diagnosed asthma and in the use of inhaled corticosteroids and oral antileukotrienes.The prevalence and severity of RW during the first year of life remained high over time, with remarkably high rates of ED visits, admissions for wheezing and use of asthma medications. This study suggests the need for considering early asthma diagnosis and to establish an appropriate treatment in infants with recurrent and severe asthma-like symptoms.

10.1080/02770903.2017.1403625

Cite

Citations (14)

Prevalencia de síntomas de rinitis alérgica en preescolares de 3 a 5 años de Cartagena, Lorca y Murcia, España.

Curare (2016)

Sandra Úsuga-Perilla Luis García‐Marcos

Introduccion: La rinitis atopica es una patologia frecuente, poco estudiada en ninos preescolares. Objetivos: Describir la prevalencia y gravedad de la rinitis alergica en los ninos de 3 a 5 anos que viven en las ciudades de Lorca, Cartagena y Murcia (ciudades de la provincia de Murcia, Espana) y establecer correlaciones entre sintomas sugestivos de rinitis atopica y diferentes factores descritos en la literatura medica como agravantes, precipitantes o relacionados. Metodos: Estudio transversal en 1.694 ninos de 3 a 5 anos realizado en tres diferentes ciudades de Murcia, sus padres rellenaron un cuestionario, validado por el International Study on Ashtma and Allergies in Childhood. Resultados: La prevalencia global de sintomas de rinoconjuntivitis en los ultimos 12 meses fue 8,6%. La prevalencia en cada ciudad fue: Cartagena 8,4%, Lorca 10,2% y Murcia 7,5%. La regresion logistica mostro que la rinoconjuntivitis se asocio a pruebas de alergia realizada al nino (resultado positivo: OR:14,7, IC95%:4,96-43 80; resultado negativo: OR:5,23, IC95%:1,93-14,14), pruebas de alergia a la madre (resultado positivo: OR:2,4, IC95%: 1,30-4,48; resultado negativo: OR 0,2, IC95%:0,05-0,82), uso de paracetamol hasta los 12 meses de edad (OR:2,6, IC95%:1,62-4,31), frecuente exposicion durante el embarazo a animales de granja (OR:2,1, IC95%:1,00-4,45), no tener gato por si causaba alergia (OR:8,1, IC95%:2,81-23,20) y consumo frecuente de verduras cocinadas (OR:2,5, IC95%:1,22-5,00). Conclusion: Se necesita mas exploracion de los factores asociados con sintomas de rinitis alergica.

10.16925/cu.v3i1.1605

Cite

Citations (0)

The unpredictable levels of vitamin D and their effects on asthma

Allergologia et Immunopathologia (2019)

Luis García‐Marcos

10.1016/j.aller.2019.07.001

Cite

Citations (0)

Author response

Annals of Allergy Asthma & Immunology (2020)

Désirée Larenas‐Linnemann Sergio de Jesús Romero Tapia César A. Virgen Javier Mallol Manuel Antonio Baeza Bacab

Wheeze

10.1016/j.anai.2020.05.010

Cite

Citations (0)