Yosh Maruyama

University of Tsukuba

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John R. van Nagell

University of Kentucky

J.M. Feola

Battelle

J.L. Beach

Electric Power Research Institute

J. Yoneda

University of Kentucky

José M. Feola

University of Kentucky

J. Wierzbicki

Wayne State University

Elvis S. Donaldson

Charing Cross Hospital

Richard J. Kryscio

University of Kentucky

Holly H. Gallion

Markey Cancer Center

Phillip A. Tibbs

University of Kentucky

Cooperative Institutions

University of Kentucky

124

Albert B. Chandler Hospital

University of Minnesota

University of Tsukuba Hospital

United States Department of Veterans Affairs

Lexington VA Health Care System

University of Minnesota Medical Center

Harvard University

University of Tsukuba

Massachusetts General Hospital

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Biological Effects of Cf-252 Neutrons at Low Dose Rates

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine (1982)

José M. Feola Chester A. Nava Yosh Maruyama

SummaryThe EMT6 tumour of the Balb/c mouse and the LSA ascites lymphoma of the C57BL/YM mouse have been used to study the effects of Cf-252 neutrons at low dose rates. EMT6 and LSA cells were irradiated in vitro in a hypoxic state; EMT6/KY cells were plated after exposure for colony-forming ability assays, while TD50 assays were used to test the tumour-forming ability of LSA cells.EMT6 cells showed r.b.e.n values of 5·3, 4·7, and 3·0 for Cf-252 dose rates of 26·8, 10·2, and 5·2 cGy/hour (≡ rad/hour), respectively, when compared to Cs-137 irradiations at dose rates of 79·7, 25·7 and 12·1 cGy/hour, respectively. The LSA ascites gave r.b.e.n values of 5·6 and 5·2 at dose rates of 27·0 and 6·94 cGy/hour of Cf-252, when compared to Cs-137 irradiations at 79·6 and 24·9 cGy/hour, respectively. However, changes in r.b.e. values for both systems were entirely dependent on comparison with Cs-137 survival curves.

Dose rate

10.1080/09553008214550031

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Citations (38)

Treatment of Liver Metastases with a Combination of Chemotherapy and Hyperfractionated External Radiation Therapy

American Journal of Clinical Oncology (1987)

P.I. Raju Yosh Maruyama Paolo De Simone J. S. Macdonald

Twelve patients with liver metastases from colorectal cancer were treated with 5-FUdR hepatic artery, or 5-FU i.v. infusion therapy and hyperfractionated whole liver irradiation (2,100 rad in 14 fractions, two fractions/day over a period of 9 days). All 12 patients tolerated treatments well and no unusual toxicity was noted from this therapy. Response was assessed on completion of treatment and on follow-up examinations by physical examination, repeat liver function tests (LFTS), and CT scans. Symptomatic relief was achieved in all patients. Decreased liver size and improved LFTS were noted in 10/12 (83%) of patients. CT scans showed decrease in size of metastases. Survivals ranged from 16 to 120 weeks. Infusion therapy was given either by implanted infusion pump or continuous i.v. infusion therapy, 5-FUdR 0.3 mg/kg of body weight/day or 5-FU 1,000 mg/m2/day. Hyperfractionated external radiotherapy with concomitant 5-FUdR hepatic artery of 5-FU i.v. infusion therapy for liver metastases was well-tolerated, and both subjective and objective response and quality of survival were noted. Hyperfractionated external beam irradiation with concurrent chemotherapy can be effective in palliating patients with liver metastases.

Concomitant

Liver function

10.1097/00000421-198702000-00009

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Citations (16)

Human cervical cancer clearance after 252Cf neutron brachy therapy versus conventional photon brachytherapy

American Journal of Clinical Oncology (1984)

Yosh Maruyama William M. Muir

TUMOR CLEARANCE PATTERN WAS STUDIED FOR Stage IB carcinoma of the cervix using 252CA neutron brachytherapy followed by fractionated radiotherapy as compared to conventional therapy using fractionated radiotherapy followed by 137Cs photon low-dose rate (LDR) implant therapy. Reduction in bulk of tumor was assessed by regular and frequent serial clinical observations. The tumor clearance pattern of the neutron-treated patients was greatly accelerated and radically different from those treated using conventional radiation.

10.1097/00000421-198408000-00010

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Citations (18)

Thoracic vertebral photopenia may predict fatty changes of the corresponding bone marrow following irradiation.

PubMed (1989)

Shih Wj Li Cy Coffey Cw Yosh Maruyama

Blood supply

Thoracic vertebrae

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Significance of specimen histology in preoperative 252Cf vs. 137Cs brachytherapy of stage IB bulky/barrel cervical cancer

International Journal of Radiation Oncology*Biology*Physics (1990)

Yosh Maruyama John R. van Nagell Deborah E. Powell J. Yoneda Elvis S. Donaldson

Histology

10.1016/0360-3016(90)90661-3

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Citations (2)

A clinical study with brain brachytherapy for malignant gliomas.

PubMed (1986)

Chin Hw Yosh Maruyama B Young William R. Markesbery Phillip A. Tibbs

Single Center

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Citations (3)

1,3-bis(2-chloroethyl)-1-nitrosourea treatment of spontaneous radiogenic C57BL mouse leukemia/lymphoma.

PubMed (1983)

Yosh Maruyama José M. Feola William M. Muir

Spontaneous radiation-induced or radiation leukemia virus (RadLV)-induced leukemias were treated in vivo in an early-to-advanced lymphomatous state by using 1,3-bis(2-chloroethyl)-1-nitrosouea (BCNU). BCNU was given at various times after the tumor induction procedure. Treatment was based upon the findings that the RadLV-derived transplant lymphosarcoma (LSA) tumor was cured with a frequency of greater than 90% and a tumor-resistant state was produced by tumor cure. Death from RadLV lymphomas which had been initiated in newborn C57BL mice by ip injection of RadLV was scored in untreated or BCNU-treated mice. At 150 days after initiation, control mice had developed extensive thymic lymphomas, whereas BCNU-treated mice had developed less extensive tumors, had a reduced incidence by approximately 50% and had an increased survival time. Similar findings were noted for the radiation (190 rad of cobalt-60 gamma rays weekly X 4)-induced thymic lymphoma-bearing C57BL mice. Injection of 10(6) living LSA cells before BCNU treatment greatly decreased the tumor load for all groups treated but also shortened the mean survival time. Challenge of long-term survivors with small numbers of viable LSA tumor cells did not identify any host resistance of the survivors to the transplant LSA tumor and indicated that the induction procedure, whether RadLV or radiation, was strongly immunosuppressive.

Nitrosourea

Neoplasm

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Correlation between retinal and pelvic vascular status: A determinant factor in patients undergoing pelvic irradiation for gynecologic malignancy

American Journal of Obstetrics and Gynecology (1979)

John R. van Nagell Richard A. Kielar Elvis S. Donaldson E. C. Gay D.F. Powell

10.1016/0002-9378(79)90840-8

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Citations (4)

Tumors of the Nervous System H. G. Seydel, editor, John Wiley & Sons, New York, 1975, 193 pp., $18.50