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Łukasz Kroc

Medical University of Lodz

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i-10 index

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Tomasz Kostka

Medical University of Lodz

Bartłomiej K. Sołtysik

Houston Advanced Research Center

Agnieszka Guligowska

Medical University of Lodz

Elizaveta Fife

Istituto Nazionale di Riposo e Cura per Anziani

Małgorzata Pigłowska

Medical University of Lodz

Joanna Kostka

Medical University of Lodz

Fabrizia Lattanzio

Istituto Nazionale di Riposo e Cura per Anziani

Romano Firmani

Maccabi Health Care Services

Mónica González Alonso

Istituto Nazionale di Riposo e Cura per Anziani

Giuliano Enzi

Istituto Nazionale di Riposo e Cura per Anziani

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

Istituto Nazionale di Riposo e Cura per Anziani

Medical University of Lodz

I.R.C.C.S. Oasi Maria SS

Bellvitge University Hospital

Institut d'Investigació Biomédica de Bellvitge

Ben-Gurion University of the Negev

Institute on Aging

Houston Advanced Research Center

Hospital Clínico San Carlos

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Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men

BMC Geriatrics (2018)

Elizaveta Fife Joanna Kostka Łukasz Kroc Agnieszka Guligowska Małgorzata Pigłowska

Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological aging. The study aimed to test whether there is a relationship between these plasma circulating proteins and muscle strength, power and optimal shortening velocity (υopt) of older adults. The cross-sectional study included 56 women and 45 men aged 60 years and older. Every participant underwent examination which included anthropometric and bioimpedance analysis measurements, functional and cognitive performance tests, muscle strength of upper and lower extremities, muscle power testing with two different methods and blood analyses. Women had higher plasma levels of myostatin and GDF11 than men. Men had higher plasma level of follistatin than women. In women, plasma level of myostatin was negatively correlated with left handgrip strength and υopt. Follistatin was negatively correlated with maximum power output (Pmax), power relative to kg of body mass (Pmax∙kg− 1) (friction-loaded cycle ergometer) and power at 70% of the 1-repetition maximum (1RM) strength value (P70%) of leg press (Keiser pneumatic resistance training equipment), and positively correlated with the Timed Up & Go (TUG) test. GDF11 was negatively correlated with body mass, body mass index, waist circumference, fat mass and the percentage of body fat. In men, there were no significant correlations observed between circulating plasma proteins and muscle function measures. The circulating plasma myostatin and follistatin are negatively associated with muscle function in older women. There is stronger relationship between these proteins and muscle power than muscle strength. GDF11 has a higher association with the body mass and composition than muscle function in older women.

Follistatin

Myostatin

10.1186/s12877-018-0888-y

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Citations (53)

Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study

Aging Clinical and Experimental Research (2023)

Francesç Formiga Ana Tejero Andrea Corsonello Johan Ärnlöv Axel C. Carlsson

Cognitive Decline

Stroke

10.1007/s40520-023-02536-2

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Citations (1)

Validation of the Vulnerable Elders Survey-13 (VES-13) in hospitalized older patients

European Geriatric Medicine (2016)

Łukasz Kroc Konrad Socha Bartłomiej K. Sołtysik A. Cieślak-Skubel Edyta Piechocka-Wochniak

Geriatric Depression Scale

Depression

Mini–Mental State Examination

Elderly people

10.1016/j.eurger.2016.03.008

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Citations (13)

Comparison of Nutrition Risk Screening 2002 and Subjective Global Assessment Form as Short Nutrition Assessment Tools in Older Hospitalized Adults

Nutrients (2021)

Łukasz Kroc Elizaveta Fife Edyta Piechocka-Wochniak Bartłomiej K. Sołtysik Tomasz Kostka

The aim of the present study was to compare two widely recommended short nutrition assessment tools-Nutrition Risk Screening 2002 (NRS-2002) and Subjective Global Assessment Form (SGA)-with other Comprehensive Geriatric Assessment (CGA) measurements. The study included 622 consecutively hospitalized older subjects, aged 81.7 ± 7.8 years. The criteria to participate were the ability to communicate and given consent. Both NRS-2002 and SGA were inversely related to anthropometric measurements, functional assessment tests, Mini-Mental State Examination (MMSE) and positively associated with the Vulnerable Elders Survey-13 (VES-13) score. Results of SGA and NRS-2002 were not related to sex and 15-item Geriatric Depression Scale (GDS) score. Comparison of well-nourished subjects and patients with suggested problems with nutrition according to NRS-2002 (0-2 vs. 3-7) and SGA (A vs. B + C) gave comparable results. Both nutritional scales at given cut-off points similarly discriminated anthropometric data and other CGA tools in the populations of well-nourished vs. malnourished hospitalized older subjects. In conclusion, we can recommend using both NRS-2002 and SGA to detect malnutrition or risk of malnutrition in a routine clinical practice of the geriatric department ward.

Geriatric Depression Scale

Depression

10.3390/nu13010225

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Citations (30)

Associations between plasma osteopontin, sex, and 2-year global and cardiorenal outcomes in older outpatients screened for CKD: a secondary analysis of the SCOPE study

Clinical Kidney Journal (2024)

Luca Soraci Johan Ärnlöv Axel C. Carlsson Tobias Feldreich Anders Larsson

Plasma osteopontin (pOPN) is a promising aging-related biomarker among individuals with and without kidney disease. The interaction between sex, pOPN levels, and global and cardiorenal outcomes among older individuals was not previously evaluated.

Osteopontin

Cardiorenal syndrome

Scope (computer science)

10.1093/ckj/sfae336

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Citations (0)

Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance

BMC Geriatrics (2020)

Andrea Corsonello Paolo Fabbietti Francesç Formiga Rafael Moreno‐González Lisanne Tap

Abstract Background Chronic kidney disease (CKD) is known to be associated with several co-occurring conditions. We aimed at exploring multimorbidity patterns associated with CKD, as well as the impact of physical performance and CKD severity on them in a population of older outpatients. Methods Our series consisted of 2252 patients enrolled in the Screening of CKD among Older People across Europe multicenter observational study. Hypertension, stroke, transient ischemic attack, cancer, hip fracture, osteoporosis, Parkinson’s disease, asthma, chronic obstructive pulmonary disease, congestive heart failure, angina, myocardial infarction, atrial fibrillation, anemia, CKD (defined as GFR < 60, < 45 or < 30 ml/min/1.73 m 2 ), cognitive impairment, depression, hearing impairment and vision impairment were included in the analyses. Physical performance was assessed by the Short Physical Performance Battery (SPPB) and used as stratification variable. Pairs of co-occurring diseases were analyzed by logistic regression. Patterns of multimorbidity were investigated by hierarchical cluster analysis. Results CKD was among the most frequently observed conditions and it was rarely observed without any other co-occurring disease. CKD was significantly associated with hypertension, anemia, heart failure, atrial fibrillation, myocardial infarction and hip fracture. When stratifying by SPPB, CKD was also significantly associated with vision impairment in SPPB = 5–8 group, and hearing impairment in SPPB = 0–4 group. Cluster analysis individuated two main clusters, one including CKD, hypertension and sensory impairments, and the second including all other conditions. Stratifying by SPPB, CKD contribute to a cluster including diabetes, anemia, osteoporosis, hypertension and sensory impairments in the SPPB = 0–4 group. When defining CKD as eGFR< 45 or 30 ml/min/1.73 m 2 , the strength of the association of CKD with hypertension, sensory impairments, osteoporosis, anemia and CHF increased together with CKD severity in pairs analysis. Severe CKD (eGFR< 30 ml/min/1.73 m 2 ) contributed to a wide cluster including cardiovascular, respiratory and neurologic diseases, as well as osteoporosis, hip fracture and cancer. Conclusions CKD and its severity may contribute significantly to specific multimorbidity patterns, at least based on the cluster analysis. Physical performance as assessed by SPPB may be associated with not negligible changes in both co-occurring pairs and multimorbidity clusters. Trial registration The SCOPE study is registered at clinicaltrials.gov ( NCT02691546 ).

Hip Fracture

Stroke

10.1186/s12877-020-01696-4

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Citations (27)

Gonadotropins and steroid hormones in older people: their mutual connections and relations to body mass indices

Endokrynologia Polska (2019)

Marek Pawlikowski Tomasz Kostka Hanna Pisarek Agnieszka Guligowska Jacek Świętosławski

Introduction: Aging in mammals, including man, is accompanied by deep changes in hormone secretion. In the majority of cases, hormone secretion (mostly of gonadal steroids and adrenocortical hormone dehydroepiandrosterone — DHEA) undergoes pronounced decrease. This decrease is thought to contribute to the progression of aging. In contrast, the secretion of gonadotropins is sharply increased in older adults, as a result of gonadal deficiency. Recent data indicate that gonadotropin excess may also, by itself, influence the aging process. The aim of the present study was to investigate the mutual relation between steroid hormones and gonadotropins and their effect on body mass indices in older people. Material and methods: In a group of 100 patients (61 women and 39 men) aged over 75 years, blood serum concentrations of folliclestimulating hormone (FSH), luteinising hormone (LH), oestradiol (E2), testosterone, dehydroepiandrosterone sulphate (DHEAs), and cortisol were measured. All the patients were measured for the following: body weight (kg), body mass index (BMI) (kg/m 2 ), and waist-to-height ratio (WtHR). The differences of the numerical data were evaluated by Student’s t-test and the correlations between them by means of Pearson’s test. Results and conclusions: The most interesting finding of this study was to show that FSH and LH are negatively correlated with body mass and indices such as BMI and WtHR in older women. Because in older women the mediation of ovary is unlikely, we conclude that gonadotropins may influence the body mass by their direct extra-gonadal action.

Gonadotropin

10.5603/ep.a2019.0037

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Citations (2)

Inappropriate nutrients intake is associated with lower functional status and inferior quality of life in older adults with depression

Clinical Interventions in Aging (2016)

Agnieszka Guligowska Małgorzata Pigłowska Elizaveta Fife Joanna Kostka Bartłomiej K. Sołtysik

Objectives: The study is a case-control analysis of whether depression impairs physical and cognitive functioning and quality of life, and whether there is a relationship between nutrient deficiencies and these adverse changes. Patients and methods: A total of 130 older subjects participated in the study: 65 with diagnosed depression (16 men and 49 women) and 65 age- and sex-matched controls without depression. All patients underwent comprehensive geriatric assessment. Nutritional state was assessed with the Mini Nutritional Assessment, cognitive performance was evaluated by the Mini-Mental State Examination and physical functioning by the Timed "Up & Go" test and handgrip strength. The pattern of consumption of various nutrients was analyzed in detail. Results: The differences in cognitive functioning observed between the groups were related to specific nutrient intake, as was handgrip strength to some extent. The differences in nutritional status, several functional tests and muscle strength were related to both the presence of depression and inappropriate consumption of certain nutrients. Conclusion: The incidence of falls and poor quality of life may be partially associated with the presence of depression. The inappropriate intake of selected nutrients may impair the functioning and quality of life of older adults with depression, such as the excess consumption of sucrose and insufficient consumption of protein, fiber, eicosapentaenoic acid, niacin and vitamin B6. Particular nutrients should be translated into dietary patterns which allow the individual patient to address these nutrient deficiencies. Keywords: aging, cognitive function, depression, nutrition, sucrose, quality of life

Depression

10.2147/cia.s114669

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Citations (31)

Relationship between Prolonged Timed up and Go Test and Worse Cardiometabolic Diseases Risk Factors Profile in a Population Aged 60-65 Years

World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences (2017)

Bartłomiej K. Sołtysik Agnieszka Guligowska Łukasz Kroc Małgorzata Pigłowska Elizavetta Fife

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The association between platelet indices, cognitive screening tests and functional dependence screening questionnaires in hospitalized older people

European Geriatric Medicine (2019)

Krzysztof Socha Elizaveta Fife Łukasz Kroc Tomasz Kostka

Activated platelets have been suggested to play an important role in the pathogenesis of dementia. Recent studies have shown contradictory results concerning the relationship between blood platelet indices and cognitive performance.This cross-sectional study evaluates the relationship between basic platelet indices and cognitive and functional performance of 754 men and women, aged 60-105 years old, admitted to the geriatric hospital unit. Assessment of global cognitive function and functional ability were performed using Mini-Mental State Examination, the seven-point Clock Drawing Test, the Katz Activities of Daily Living, the Lawton Instrumental Activities of Daily Living Scale and the Vulnerable Elders Survey Questionnaire. As platelet indices, platelet count, mean platelet volume, plateletcrit and platelet distribution width were measured.There was no significant correlation between cognitive performance and platelet indices. Out of the functional dependence questionnaires, only the Katz Activities of Daily Living and the Vulnerable Elders Survey Questionnaire were weakly correlated with platelet count (r = - 0.080 and r = 0.096) and plateletcrit (r = - 0.075 and 0.082, respectively), but these associations diminished in sex-specific analyses.Cognitive and functional status are not systematically related to platelet indices in multimorbid hospitalized older adults.

Mean platelet volume

Association (psychology)

Mini–Mental State Examination

10.1007/s41999-019-00214-z

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Citations (2)