Introduction: With an ever-increasing array of pharmaceutical and biomedical products and literature, health professionals including pharmacists struggle to obtain, evaluate, and apply relevant information. Handheld computers provide pharmacists with mobile access to evidence-informed medical information, decision support tools, and the ability to monitor therapeutic outcomes at the point of care. There is limited literature on the usage of this technology by Canadian pharmacists. The objective of this survey was to determine the scope and nature of handheld computer use by Nova Scotia pharmacists. Method: In 2008, Nova Scotia pharmacists were contacted with a written survey. Descriptive statistics were used to compare users and non-users. Multivariate regression analysis was used to determine demographic and pharmacy practice variables that might be associated with pharmacists’ use of handheld computers. Results: The survey was returned by 296 pharmacists (27.7%). Handheld computers were reported to be used by 51% of respondents. Those respondents who have been in practice longer were less likely to adopt handheld computer use (adjusted OR = 0.97, 95% CI = 0.94–0.99, p = 0.01). Barriers and facilitators to usage were explored. More than two-thirds of pharmacists who had not yet used handheld computers perceived a future value for these devices within their practice. Discussion: Pharmacists are adopting the use of handheld computers. With enhanced clinical practice opportunities for pharmacists including independent prescribing, these tools may offer needed functionality. Further work is required to understand the value of handheld computers as information resources, which may improve the effectiveness and efficiency of patient care.
Abstract Auf dem im Formelschema beschriebenen Weg werden die Carbonsäurehydrazide (IV) dargestellt, die mit 3‐Formyl‐rifamycin SV zu den Verbindungen (V) kondensiert werden.
Abstract Aus den Benzhydrylchloriden (I) werden durch Kondensation mit Piperazin (II), Nitrosierung, Reduktion und Kondensation der gebildeten N‐Aminopiperazine mit Nitrofurfurol (V) die Furfurylidenarninopiperazine (VI) hergestellt.
A series of 14 3-formylrifamycin SV N-(4-substituted phenyl)piperazinoacethydrazones has been synthesized and evaluated for their antimicrobial activity. The compounds were found active against Bacillus subtilis, Staphylococcus aureus, Mycobacterium phlei, and Mycobacterium tuberculosis but not as active as rifampin. The compounds also exhibited significant activity against Clostridium perfringens and in this bacterial system some were more active than rifampin. The QSAR showed that the activity against B. subtilis depended only on lipophilicity, and the regression equation was linear. A parabolic relationship between the antibacterial activity and lipophilicity of the compounds was found in Staph. aureus. Additionally, the activity was dependent upon the electronic and steric effects of the phenyl substituents. The sensitivity of M. phlei to the compounds was found to correlate well with a linear combination of hydrophobic, electronic, and steric parameters. No statistically significant correlation was possible between the physicochemical parameters studied and the activity of the compounds against C. perfringens and M. tuberculosis.
Abstract Die Alkylierung der Hydantoine (I), (IV) und (VI) mit dem Nitrobenzylbromid (II) in wäßrigem Äthanol in Gegenwart von Natriumcarbonat führt zu den Alkylierungsprodukten (III), (V) und (VII).
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