COVID-19 has spread and continues to spread rapidly across the world. There is still no approved and effective treatment for the disease. Several drugs are being administered empirically to patients, based on results from studies with limited methodologies. There is an urgent need for systematic reviews to support decision makers and the development of guidelines. The purpose of this paper was to conduct a systematic review of drug studies carried out worldwide for COVID-19, verifying the effectiveness and methodological quality. The search for relevant articles was performed in the Cochrane Central, MEDLINE, and Embase databases. The terms and combinations used for the search were ((coronavirus OR "2019-nCoV" OR 2019nCoV OR nCoV2019 OR "nCoV-2019" OR "COVID-19" OR COVID19 OR "HCoV-19" OR HCoV19 OR CoV OR "2019 novel*" OR Ncov OR "n-cov" OR "SARS-CoV-2" OR "SARSCoV-2" OR "SARSCoV2" OR "SARSCoV2" OR SARSCov19 OR "SARS-Cov19" OR "SARS-Cov-19") OR "severe acute respiratory syndrome*" OR ((corona* OR corono*) AND (virus* OR viral* OR virinae*)) AND ((treatment) OR (medication) OR (symptoms)) AND (drugs)). The review process of the articles was carried out independently by four reviewers using the PRISMA-P method. As a result, a total of 30 articles were selected, which addressed the study of one or more medications for severe cases of COVID-19, which were hydroxychloroquine (or chloroquine) and azithromycin, lopinavir/ritonavir, lopinavir/ritonavir, arbidol, and Shufeng Jiedu Capsule, Combinations: remdesivir/lopinavir/homoharringtonine/emetine, remdesivir, interferon, lopinavir and ritonavir, thalidomide/methylprednisolone, tocilizumab, antimicrobial therapy. Despite efforts and studies, research does not provide evidence for the use of any drug to treat COVID-19, as the effects, safety, and efficacy are still uncertain. Thus, there is a need for systematic reviews to monitor, synthesize, and update the literature data on the subject, generating reliable evidence for decision makers. COVID-19 should be monitored and the need to develop effective drugs and vaccines to prevent disease progression must be reinforced.
A construcao civil agrega importante desenvolvimento economico e social, visto que alem de gerar renda, tambem gera empregos e infraestrutura a populacao. No mesmo sentido, a construcao civil influencia em milhares de empregos indiretos nas industrias, empreiteiras, fornecedoras e transportadoras de materiais. Ressaltamos que o trabalho e uma atividade significativa na vida dos individuos. Contudo, por vezes, pode provocar riscos e acidentes. Nesse sentido, tais situacoes fazem surgir na seguranca e saude ocupacionais a adocao de medidas de prevencao a exposicao de trabalhadores aos riscos existentes. A seguranca do trabalho busca a prevencao desses acidentes laborais, a partir de um conjunto de atividades de antecipacao, reconhecimento, avaliacao e controle dos riscos ocupacionais. Com o objetivo de discorrer acerca do assunto e apresentar possiveis solucoes, o foco deste trabalho e apurar de forma qualitativa e comparativa, os principais riscos e causas de acidentes nas obras de engenharia, especificamente abordando um estudo de caso ocorrido na cidade de Goiânia, Goias.
COVID-19 is a disease caused by SARS-CoV-2 (coronavirus type 2 of the severe acute respiratory syndrome), isolated in China, in December 2019. The strategy currently used by physicians is to control disease and to treat symptoms, including non-pharmacological treatments, as there is still no specific treatment for COVID-19. Thus, the aim of this article is to carry out a systematic review about non-pharmacological treatments used for COVID-19, addressing current status and consensus found in the literature. Three databases were consulted for evidence referring to the drugs indicated for COVID-19 (Cochrane Central, MEDLINE and Embase). The following terms and combinations were used: (("2019-nCoV" OR 2019nCoV OR nCoV2019 OR "nCoV-2019" OR "COVID-19" OR COVID19 OR "HCoV-19" OR HCoV19 OR CoV OR "2019 novel*" OR Ncov OR "n-cov" OR "SARS-CoV-2" OR "SARSCoV-2" OR "SARSCoV2" OR "SARSCoV2" OR SARSCov19 OR "SARS-Cov19" OR "SARS-Cov-19") OR "severe acute respiratory syndrome*" OR ((corona* OR corono*) AND (virus* OR viral* OR virinae*)) AND (("lung injury") OR ("ventilation use") OR ("respiratory injuries" OR prone)) AND (treatment)) NOT Drugs NOT medicines NOT antivirals. A total of 28 articles were selected. These articles adopted one or more treatment methods for patients with severe cases of COVID-19, i.e., oxygen therapy, prone position, inhaled nitric oxide, intravenous infusion, passive immunotherapy, mesenchymal stem cells (MSC). There is still no specific treatment approved for patients with COVID-19. The available evidence is not able yet to indicate the benefits or harms of non-pharmacological treatments, but some studies show that some treatments can play an important role in relation to COVID-19. The current consensus among researchers is that several studies using a randomized clinical trial should be carried out to provide evidence of safety and efficacy of the proposed treatments.