Lei Shan-chuan

Chongqing Medical University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Xichuan Yang

Army Medical University

Li Song

Binzhou University

Junling Zhang

Tianjin University of Traditional Chinese Medicine

Zhifang Zhai

Southwest Hospital

Yongqiang Yuan

Chongqing Medical University

Xing Zeng

Northeast Agricultural University

Ding’an Zhou

Affiliated Hospital of Guizhou Medical University

Yong He

Daping Hospital

Dong‐Lai Ma

Chinese Academy of Medical Sciences & Peking Union Medical College

Shan Geng

Chongqing Medical University

Cooperative Institutions

Chongqing Medical University

Army Medical University

First People's Hospital of Chongqing

Fudan University

Southwest Hospital

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Chongqing Public Health Medical Center

Shanghai Jiao Tong University

Sichuan University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Effects of Paevnia lactiflora Total Glucosides Capsules on T Cell Immune Balance of Chronic Urticaria

Zhongguo yaofang (2012)

Wu Yin Lei Shan-chuan Yuan Chen

OBJECTIVE:To investigate the effects of Paevnia lactiflora total glucosides capsule combined with levocetrizine on T cell immune balance and its curative effect.METHODS:102 patients with chronic urticaria were randomized into therapy groups and control groups,and all patients taken treatment with ananaphylaxis.Therapy group was additionally given 0.6 g,tid,P.lactiflora total glucosides capsules.After 8 weeks of treatment,clinical curative effect and T cell subpopulation were compared be-tween 2 groups.RESULTS:After 8 weeks of treatment,clinical effective rate was 96.1%in therapy groups and was 86.3%in con-trol groups,clinical effective rate was significantly higher in therapy group than in control groups(P0.05);symptom score was(0.31±0.19)in therapy group and(1.02±0.20)in control groups,symptom score was significantly lower in therapy group than in control group(P0.05).The levels of Th1,Th2 and Th1/Th2 were 15.14±2.17,20.06±3.74 and 0.71±0.20 in control group and 16.52±3.04,17.29±3.29 and 0.84±0.23 in therapy group,and the level of Th1 and Th1/Th2 was higher and level of Th2 was low-er in therapy group than control group,there was statistical significance(P0.05).CONCLUSION:P.lactiflora total glucosides capsules could be as adjustive therapy for chronic urticaria and adjust T cell immune balance in patients with chronic urticaria.

Clinical efficacy

Source

Cite

Citations (0)

Merkel cell carcinoma overlapping Bowen’s disease: two cases report and literature review

Journal of Cancer Research and Clinical Oncology (2024)

Xueqin Chen Xiao Song Hui Huang Lian Zhang Zhiqiang Song

Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin, which mainly occurs in the sun exposed sites of white patients over 65 years, with a higher recurrence and metastasis rate. Clinically, MCC overlapping Bowen's disease (BD) is a very rare subtype of MCC. Few cases in the literature have been described and the management is not well defined. We summarize and update the epidemiology, clinical and histopathological features, metastasis characteristics, local recurrence rate and management of it by presenting two cases of MCC overlapping BD and reviewing the literature over the last 11 years.

Histopathology

Merkel cell polyomavirus

Bowen's disease

Wide local excision

Hematology

10.1007/s00432-024-05743-0

Cite

Citations (1)

A novel P53/POMC/Gαs/SASH1 autoregulatory feedback loop activates mutated SASH1 to cause pathologic hyperpigmentation

Journal of Cellular and Molecular Medicine (2016)

Ding’an Zhou Zhiyun Wei Zhongshu Kuang Huangchao Luo Jiangshu Ma

Abstract p53‐Transcriptional‐regulated proteins interact with a large number of other signal transduction pathways in the cell, and a number of positive and negative autoregulatory feedback loops act upon the p53 response. P53 directly controls the POMC /α‐ MSH productions induced by ultraviolet ( UV ) and is associated with UV ‐independent pathological pigmentation. When identifying the causative gene of dyschromatosis universalis hereditaria ( DUH ), we found three mutations encoding amino acid substitutions in the gene SAM and SH 3 domain containing 1 ( SASH 1), and SASH 1 was associated with guanine nucleotide‐binding protein subunit‐alpha isoforms short (Gαs). However, the pathological gene and pathological mechanism of DUH remain unknown for about 90 years. We demonstrate that SASH 1 is physiologically induced by p53 upon UV stimulation and SASH and p53 is reciprocally induced at physiological and pathophysiological conditions. SASH 1 is regulated by a novel p53/ POMC /α‐ MSH /Gαs/ SASH 1 cascade to mediate melanogenesis. A novel p53/ POMC /Gαs/ SASH 1 autoregulatory positive feedback loop is regulated by SASH 1 mutations to induce pathological hyperpigmentation phenotype. Our study demonstrates that a novel p53/ POMC /Gαs/ SASH 1 autoregulatory positive feedback loop is regulated by SASH 1 mutations to induce pathological hyperpigmentation phenotype.

10.1111/jcmm.13022

Cite

Citations (19)

The analysis of immunohistopathology in properative resection range evaluation by skin malignant tumors

Jiguang zazhi (2013)

Lei Shan-chuan

Objective:To investigate the significance of them ethods about properative resection range evaluation of immunohistopathology examinations for three common skin malignant tumors.Methods Multipoint tissues were selected with skin surgeons diagnosis and therapeutic purpose are used for directing to evaluate survey cut-limits,which were observed by microscope observation and measured the distance and depth.Furthermore,pathology examinations for tumor tissues after operation.Result immunohistopathology examinations in thirty-one skin malignant tumors'survey borders evaluations,ex-brest paget is the most significant,besids,basal cell carcinoma and squamous-celled carcinoma.Conclusion while HEstaining can be used for evaluating,it's better accurate combinated with immunohistochemical evaluation of tumors infiltrating borders.

Source

Cite

Citations (0)

Characteristics influencing high-risk sexual behaviours in elderly men

International Journal of STD & AIDS (2018)

Guiyuan Xiao Bin Peng Ying Hu Dou Qu Min-Qing Lai

With the objective of investigating the characteristics influencing high-risk sexual behaviours in elderly men (60-74 years of age) in Chongqing, China, a total of 1433 healthy elderly men with sexual intercourse frequencies of one to six times/month who were willing to participate in the questionnaires were studied at four hospitals. We measured serum testosterone levels and performed follow-ups every six months, with a total of 1128 elderly men followed up after two years. We also investigated socio-economic and demographic characteristics (age, education, income, location, marital status and number of marriages), types of sexual partners, age differences with fixed sexual partners, frequency of sexual intercourse, combined basic age-related diseases, sexually transmitted infections (STIs) education, elderly self-care ability and high-risk sexual behaviours (frequency of sexual intercourse and number of sexual partners) using questionnaires. We analysed the influencing factors of high-risk sexual behaviours in elderly men using a univariate analysis, multivariate logistic regression analysis, BP neural network prediction and cluster analysis. Finally, we found that serum total testosterone, age, types of sexual partners, age differences with fixed partners and frequency of sexual intercourse are five factors that influence high-risk sexual behaviours in elderly men.

Sexual intercourse

Marital status

Univariate analysis

10.1177/0956462418804652

Cite

Citations (1)

Vesiculobullous Diseases

Springer eBooks (2018)

Lei Shan-chuan Xichuan Yang Xuejun Zhu Li Song Zuo-Gang Xie

Dermatitis herpetiformis

Pemphigus foliaceus

Pemphigus vulgaris

Paraneoplastic pemphigus

10.1007/978-981-10-8037-1_11

Cite

Citations (1)

Evaluation of Case-based Method in Dermatological Skill Operation of Clinical Practice Teaching

Jiguang zazhi (2013)

Lei Shan-chuan

Objective:To investigate the application value of clinical case-based teaching method on dermatological skill operation.Methods: 57 medical interns were randomly divided into experimental group(n=30) and control group(n=27).Traditional teaching mehod was used in the Control group,which is,the teacherfirst teach and explain then the students operate.While in the experimental group,typical case and questions were first given and discussed,then the students operate in the teacher's guidance.Summary of discussion was carried out after students' actual clinical operation.Finally,statistical analysis of test scores and teaching satisfaction and patient satisfaction questionnaire were analyzed.Results: the result of experimental group was better than that of control group(P0.05);evaluation of teaching satisfaction rate(86.7%) was significantly higher than that of the control group(63%);patient satisfaction survey were significantly higher than those in control group.Conclusion: case-based teaching mehod helps to mobilize students' learning enthusiasm,improve students' ability of comprehensive analysis,practical skills,innovative ability and communication skills,which are generally recognized by students and teachers and can be promoted.

Clinical Practice

Source

Cite

Citations (0)

One Case of Child Hemorrhagic Varicella treated by Combine High-dose Immunoglobulin with Glucocorticoids

The Chinese Journal of Dermatovenereology (2011)

Lei Shan-chuan

Objective To investigate the method of the treatment to hemorrhagic varicella.Method A 6-year-old boy with hemorrhagic varicella was treated by glucocorticoids combined with high-dose immunoglobulin (7.5g once a day for 4 days).Results The organs′bleeding was controlled in short order by this therapeutic schedule.The counts of platelet recovered to normal and skin rashes almost subsided after 1 week.Conclusion High-doses immunoglobulin combined with glucocorticoids could be used to treat the hemorrhagic varicella in a short time,besides the symptomatic treatment such as antiviral and hemostasis.

Source

Cite

Citations (0)