Murali Kannan Maruthamuthu

University of North Carolina at Chapel Hill

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Soon Ho Hong

University of Ulsan

Vidhya Selvamani

University of Ulsan

Mohit S. Verma

Purdue University West Lafayette

Irisappan Ganesh

Vinayaka Missions University

Juliane Nguyen

University of North Carolina at Chapel Hill

Ana Pascual-Garrigos

University of Cambridge

Josiah Levi Davidson

Purdue University West Lafayette

A. Kulandaisamy

Indian Institute of Technology Madras

Timothy A. Johnson

Purdue University West Lafayette

J. P. Schoonmaker

Purdue University West Lafayette

Cooperative Institutions

Purdue University West Lafayette

University of North Carolina at Chapel Hill

University of Ulsan

Thiruvalluvar University

King Saud University

Korea Advanced Institute of Science and Technology

State Street (United States)

North Carolina State University

Korea Institute of Energy Research

University of Illinois Urbana-Champaign

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Characterization of biospheric bacterial community on reduction and removal of chromium from tannery contaminated soil using an integrated approach of bio-enhanced electrokinetic remediation

Journal of environmental chemical engineering (2021)

Adikesavan Selvi Mohamad S. AlSalhi Sandhanasamy Devanesan Murali Kannan Maruthamuthu P. Mani

Electrokinetic Remediation

Human decontamination

10.1016/j.jece.2021.106602

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Citations (15)

Non-destructive processing of silver containing glass ceramic antibacterial coating on polymeric surgical mesh surfaces

Nanoscale (2023)

Amin Zareei Venkat Kasi Allison Thornton Ulisses Heredia Rivera Manoj Sawale

Surgical meshes composed of bioinert polymers such as polypropylene are widely used in millions of hernia repair procedures to prevent the recurrence of organ protrusion from the damaged abdominal wall. However, post-operative mesh infection remains a significant complication, elevating hernia recurrence risks from 3.6% to 10%, depending on the procedure type. While attempts have been made to mitigate these infection-related complications by using antibiotic coatings, the rise in antibiotic-resistant bacterial strains threatens their effectiveness. Bioactive glass-ceramics featuring noble metals, notably silver nanoparticles (AgNPs), have recently gained traction for their wide antibacterial properties and biocompatibility. Yet, conventional methods of synthesizing and coating of such materials often require high temperatures, thus making them impractical to be implemented on temperature-sensitive polymeric substrates. To circumvent this challenge, a unique approach has been explored to deposit these functional compounds onto temperature-sensitive polypropylene mesh (PP-M) surfaces. This approach is based on the recent advancements in cold atmospheric plasma (CAP) assisted deposition of SiO

10.1039/d3nr01317k

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Citations (7)

Engineering Escherichia coli to sense acidic amino acids by introduction of a chimeric two-component system

Korean Journal of Chemical Engineering (2015)

Sambandam Ravikumar Irisappan Ganesh Murali Kannan Maruthamuthu Soon Ho Hong

Pseudomonas putida

Response regulator

Two-component regulatory system

10.1007/s11814-015-0024-z

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Citations (9)

Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair

Nature Communications (2024)

Parth Chansoria Ameya Chaudhari Emma L. Etter Emily E. Bonacquisti Mairead K. Heavey

Abstract Bioadhesive materials and patches are promising alternatives to surgical sutures and staples. However, many existing bioadhesives do not meet the functional requirements of current surgical procedures and interventions. Here, we present a translational patch material that exhibits instant adhesion to tissues (2.5-fold stronger than Tisseel, an FDA-approved fibrin glue), ultra-stretchability (stretching to >300% its original length without losing elasticity), compatibility with rapid photo-projection (<2 min fabrication time/patch), and ability to deliver therapeutics. Using our established procedures for the in silico design and optimization of anisotropic-auxetic patches, we created next-generation patches for instant attachment to tissues while conforming to a broad range of organ mechanics ex vivo and in vivo. Patches coated with extracellular vesicles derived from mesenchymal stem cells demonstrate robust wound healing capability in vivo without inducing a foreign body response and without the need for patch removal that can cause pain and bleeding. We further demonstrate a single material-based, void-filling auxetic patch designed for the treatment of lung puncture wounds.

Ex vivo

Auxetics

Regenerative Medicine

10.1038/s41467-024-48980-0

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Citations (4)

Enchancement of Gamma-Aminobutyric Acid Production by Co-Localization of Neurospora crassa OR74A Glutamate Decarboxylase with Escherichia coli GABA Transporter Via Synthetic Scaffold Complex

Journal of Microbiology and Biotechnology (2017)

Sivachandiran Somasundaram Murali Kannan Maruthamuthu Irisappan Ganesh Gyeong Tae Eom Soon Ho Hong

Gamma-Aminobutyric Acid

Decarboxylation

10.4014/jmb.1611.11041

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Citations (10)

Novel malate sensing recombinant Escherichia coli by engineering of bacterial two-component system

한국생물공학회 학술대회 (2015)

Irisappan Ganesh Murali Kannan Maruthamuthu Soon Ho Hong

Component (thermodynamics)

Source

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Citations (0)

Instantly adhesive and ultra-elastic patches for dynamic organ and wound repair

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2024)

Parth Chansoria Ameya Chaudhari Emma L. Etter Emily E. Bonacquisti Mairead K. Heavey

10.17615/kznj-xk75

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Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies

Trends in biotechnology (2020)

Murali Kannan Maruthamuthu Scott R. Rudge Arezoo M. Ardekani Michael R. Ladisch Mohit S. Verma

10.1016/j.tibtech.2020.07.004

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Citations (69)

Hierarchical Micro/Mesoporous Copper Structure with Enhanced Antimicrobial Property via Laser Surface Texturing

Advanced Materials Interfaces (2020)

Vidhya Selvamani Amin Zareei Ahmed Elkashif Murali Kannan Maruthamuthu Shirisha Chittiboyina

Abstract Copper (Cu) and its alloys have been shown to eradicate a wide range of multidrug‐resistant microbes upon direct contact. In this study, a facile one‐step laser texturing (LT) process is demonstrated to effectively enhance the bactericidal properties of copper surfaces via concurrent selective modification of surface topography and chemistry of laser textured copper (LT‐Cu). Surface morphology and elemental composition are analyzed via field emission scanning electron microscopy (FE‐SEM), energy‐dispersive X‐ray spectroscopy (EDX), and Raman spectroscopy. Surface area and pore size of LT‐Cu is determined by Barrett–Joyner–Halenda (BJH) and Brunauer–Emmett–Teller (BET) analysis. It reveals direct formation of mesoporous structures with higher surface oxide (Cu 2 O and CuO), which provide a highly stable superhydrophilic property to the LT‐Cu surfaces. The antibacterial properties of LT‐Cu are tested against pathogenic bacterial strains with different concentrations including Pseudomonas aeruginosa , and methicillin‐resistant Staphylococcus aureus (MRSA USA300) at 10 5 CFU mL −1 , and Escherichia coli and Staphylococcus aureus at high bacterial concentrations of 10 8 CFU mL −1 using standard contact killing tests. The analysis shows that LT‐Cu needs 40, 90, 60, and 120 min to completely eradicate the respective bacterial strain. The LT‐Cu causes membrane damage to the bacterial cells immediately after exposure. Furthermore, the biocompatibility of LT‐Cu is investigated by in vitro immune‐staining assays with mammary stromal fibroblasts and T4‐2 cells.

Biocompatibility

Superhydrophilicity

Energy-dispersive X-ray spectroscopy

Specific surface area

10.1002/admi.201901890

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Citations (64)

Additional file 1 of On-farm colorimetric detection of Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni in crude bovine nasal samples

Figshare (2021)

Ana Pascual-Garrigos Murali Kannan Maruthamuthu Aaron Ault Josiah Levi Davidson Grigorii Rudakov

Additional file 1. Screened primer set sequences developed in [16].

Pasteurella

10.6084/m9.figshare.16726925

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Citations (0)