L. Job

Hôpital Maison Blanche

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Suresh K. Arya

Mahatma Gandhi Central University

Carter Wa

Roswell Park Comprehensive Cancer Center

Julius S. Horoszewicz

Roswell Park Comprehensive Cancer Center

Horoszewicz Js

W.A. Carter

University at Buffalo, State University of New York

Sydney E. Salmon

Firouzé Bani‐Sadr

Inserm

W.A. Carter

University at Buffalo, State University of New York

Julian Melamed

Laurent Andréoletti

Université de Reims Champagne-Ardenne

Cooperative Institutions

Université de Reims Champagne-Ardenne

Centre Hospitalier Universitaire de Reims

Hôpital Robert-Debré

University at Buffalo, State University of New York

Istituto Zooprofilattico Sperimentale delle Venezie

Inserm

Roswell Park Comprehensive Cancer Center

National Institutes of Health

Générale de Santé

Université Paris Cité

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Book Review

Oncology (1979)

C. Barone N Gentiloni Carlo Bartoloni G Gambassi T. Terranova

10.1159/000225317

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Citations (0)

The polymerase chain reaction for the identification of different species of Mycobacterium

Comparative Immunology Microbiology and Infectious Diseases (1997)

Cristina Valente Suzanne Demas Salvatore Scarso Vincenzo Cuteri L. Job

Mycobacterium tuberculosis complex

10.1016/s0147-9571(96)00046-x

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Citations (4)

Retrovirus-Like Particles Released by Human Prostatic Cells

Oncology (1980)

Suresh K. Arya L. Job Ram Chawda

A cell strain has been obtained from an explant culture of a human prostatic tissue. The tissue was diagnosed as benign prostatic hyperplasia. Cultured cells displayed human male karyotype and chromosome modal number of 43–46. Cultures of these cells appear to release retrovirus-like entities. The extracellular particulate material obtained from the culture medium showed the following characteristics: (1) it banded at a density of 1.12–1.18 g/ml in a sucrose density gradient; (2) it contained particles with a sedimentation rate approximating that of the known retroviruses; (3) these particles contained RNA and RNA-directed DNA polymerase; (4) the RNA-directed DNA polymerase utilized poly (Cm) as a template, and (5) the particles synthesized DNA in an endogenous DNA polymerase reaction. The DNA thus synthesized was associated with RNA, some of it with high molecular weight RNA. These observations can be interpreted to suggest that human prostatic cells produce retrovirus(es). However, we were not able to detect a 60–70S RNA species in the labeled RNA of the released particles. The isolated RNA, however, displayed a 30–35S component.

Density gradient

10.1159/000225421

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Citations (4)

P-19 Kystes arachnoïdiens intra-diploïques : à propos de deux cas

Journal of Neuroradiology (2005)

L. Job S. Kremer Candice Delcourt S. Gallas Serge Bracard

10.1016/s0150-9861(05)83099-8

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Human fibroblast interferon in human neoplasia: clinical and laboratory study.

PubMed (1978)

Horoszewicz Js Leong Ss Ito M Buffett Rf Constantine P. Karakousis

Human fibroblast interferon (HFIF) produced on a large scale from normal diploid cell strains was highly purified and then evaluated as to its safety clinical investigation. The selective antiproliferative activity of HFIF was observed in vitro against certain human malignant cell lines and in vivo against human bladder tumors grown in nude mice. Direct injections of HFIF into metastatic melanoma lesions of two patients resulted in either the disappearance of malignant cells or the significant reduction in tumor volume.

Human bladder

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Citations (48)

Reverse Transcriptase Activity in Extracts of Human Prostatic Tissues

Oncology (1978)

L. Job W.A. Carter Suresh K. Arya

The extracts of human prostatic tissue specimens contain oncornavirus-like reverse transcriptase activity. This activity was isolated by banding the tissue extract in an equilibrium sucrose density gradient followed by phosphocellulose chromatography of the lysate of the material banding at a density of 1.14--1.20 g/cc. It was characterised by its utilisation of poly (Cm) as a template and its inhibition by selective inhibitors of viral reverse transcriptase. Human prostatic tissues of three histo-pathologic types--normal, hyperplastic and adenocarcinoma--were examined. One out of four normal, five out of six hyperplastic, and two out of two adenocarcinoma specimens displayed virus-like reverse transcriptase activity.

10.1159/000225285

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Citations (3)

Une lésion kystique atypique du crochet du pancréas

Journal de Chirurgie Viscérale (2017)

Abdul Rahman Al Sadairi G. Ledoux L. Job Camille Boulagnon‐Rombi Tullio Piardi

10.1016/j.jchirv.2017.08.009

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RNA tumor virus-like activities in human prostate: possible novel pharmacologic approaches.

PubMed (1977)

Arya Sk L. Job Horoszewicz Js Zeigel Rf Carter Wa

The cytoplasmic extracts of human prostatic tissues yield two classes of "particles" when centrifuged to equilibrium in a sucrose density gradient, one class banding at a density of 1.15-1.18 g/cm3 ("high density particles") and another at a density of 1.07-1.14 g/cm3 ("low density particles"). Both bands display endogenous DNA polymerase activity which is largely resistant to actinomycin D inhibition. The endogenous DNA products synthesized by high density particles give some indication of high molecular weight RNA:DNA complexes. The tissue extracts from normal, hyperplastic, and neoplastic prostate behave similarly in these assays. In addition, explant cultures of hyperplastic and neoplastic prostate either release, or can be induced to release, particles by treatment with bromodeoxyuridine. These particles band at a density of 1.15-1.18 g/cm3 in a sucrose density gradient and possess RNA and associated DNA polymerase activity which utilizes poly(A):oligo(dT). Our results suggest that human prostatic tissues may contain functions analogous in some ways to those of known RNA tumor viruses of other species.

Density gradient

Bromodeoxyuridine

Tumor Virus

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Citations (2)

Oncornavirus-Like Particles Released by Human Prostatic Explant Cultures

Oncology (1979)

L. Job Suresh K. Arya W.A. Carter Julius S. Horoszewicz

Explant cultures from several human prostatic tissues have been examined for oncornavirus production. Some of these explants, epithelial in morphology, appear to release oncornavirus-like particles. The extracellular particulate material, obtained from the culture medium of these explants display the following characteristics: (1) It contains particles that band at a density of 1.1–1.2 g/cm3 in a sucrose density gradient. (2) The particles contain RNA-directed DNA polymerase. This polymerase utilizes poly(Cm) as a template and shows preference for poly(A) over poly(dA) and manganese over magnesium. (3) Apparently, the particles also contain RNA that directs the synthesis of DNA in vitro. The DNA thus synthesized is associated with RNA, some of it with high molecular weight RNA. Such particles are not observed in the culture medium from monolayers of monkey kidney CV-1 cells. We have found that explant cultures from 5 out of 15 tissue specimens with prostatic hyperplasia and 3 out of 4 with prostatic adenocarcinoma release particles that band at a density of 1.1–1.2 g/cm3 and contain RNA-directed DNA polymerase. Explant cultures of two normal prostates examined did not release such particles.

10.1159/000225353

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Citations (1)

Concomitant Pasteurella multocida aortic endograft infection and Bartonella henselae endocarditis

Médecine et Maladies Infectieuses (2015)

A. Robbins L. Fouilhé L. Job Laurent Andréoletti Firouzé Bani‐Sadr

Bartonella

Concomitant

10.1016/j.medmal.2015.09.004

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Citations (3)