Weibin Ma

Henan University of Technology

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Yanli Xie

Central South University

Yuhui Yang

Hainan University

Qian Li

Ningxia Medical University

Hang Jia

Henan University of Technology

Fred Mwabulili

Henan University of Technology

Shumin Sun

Henan University of Technology

Renyong Zhao

Henan University of Technology

Xiao Li

Henan University of Technology

Zhili Jiang

Zhejiang University

Eric T. Johnson

National Center for Agricultural Utilization Research

Cooperative Institutions

Henan University of Technology

Northwest A&F University

Central South University

Chinese Academy of Sciences

Zhengzhou University

Shanghai Jiao Tong University

Shandong First Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Shanghai Pesticide Research Institute

Wuhan University

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Research progress on the protection and detoxification of phytochemicals against aflatoxin B1-Induced liver toxicity

Toxicon (2021)

Tingting Fan Yanli Xie Weibin Ma

Detoxification

Toxic hepatitis

Liver toxicity

Biotransformation

10.1016/j.toxicon.2021.03.007

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Citations (38)

Natural flavour (E,E)-2,4-heptadienal as a potential fumigant for control of Aspergillus flavus in stored peanut seeds: Finding new antifungal agents based on preservative sorbic acid

Food Control (2021)

Weibin Ma Eric T. Johnson

Sorbic acid

10.1016/j.foodcont.2021.107938

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Citations (23)

Characterization, Structural Analysis, and Thermal Stability Mutation of a New Zearalenone-Degrading Enzyme Mined from Bacillus subtilis

Journal of Agricultural and Food Chemistry (2024)

Jinghao Shi Fred Mwabulili Yanli Xie Yuhui Yang Shumin Sun

Zearalenone (ZEN) is a widespread mycotoxin that causes serious damage to animal husbandry and poses a threat to human health. A screen of ZEN-degrading soil bacteria yielded Bacillus subtilis YT-4, which yielded 80% ZEN degradation after 6 h and 95% after 36 h. The gene sequence encoding the degradative enzyme ZENY was mined from the genome of YT-4 and expressed in yeast. ZENY is an α/β-hydrolase with an optimal enzyme activity at 37 °C and pH 8. By breaking the lactone ring of ZEN, it produces ZENY-C18H24O5 with a molecular weight of 320.16 g/mol. Sequence comparison and molecular docking analyses identified the catalytic ZENY triad 99S-245H-123E and the primary ZEN-binding mode within the hydrophobic pocket of the enzyme. To improve the thermal stability of the enzyme for industrial applications, we introduced a mutation at the N-terminus, specifically replacing the fifth residue N with V, and achieved a 25% improvement in stability at 45 °C. These findings aim to achieve ZEN biodegradation and provide insight into the structure and function of ZEN hydrolases.

Hydrolase

Catalytic triad

Bacillus licheniformis

10.1021/acs.jafc.3c06767

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Citations (10)

(E)-2-Hexenal, as a Potential Natural Antifungal Compound, Inhibits Aspergillus flavus Spore Germination by Disrupting Mitochondrial Energy Metabolism

Journal of Agricultural and Food Chemistry (2019)

Weibin Ma Luling Zhao Wenhong Zhao Yanli Xie

Fungal contamination imposes threats to agriculture and food production and human health. A method to safely and effectively restrict fungal contamination is still needed. Here, we report the effect and mode of action of ( E)-2-hexenal, one of the green leaf volatiles (GLVs), on the spore germination of Aspergillus flavus, which can contaminate a variety of crops. The EC50 value, minimum inhibitory concentration (MIC), and minimum fungicidal concentration (MFC) of ( E)-2-hexenal were 0.26, 1.0, and 4.0 μL/mL, respectively. As observed by scanning electron microscopy (SEM), the surface morphology of A. flavus spores did not change after treatment with the MIC of ( E)-2-hexenal, but the spores were shrunken and depressed upon treatment with the MFC of ( E)-2-hexenal. The MIC and MFC of ( E)-2-hexenal induced evident phosphatidylserine (PS) externalization of A. flavus spores as detected by double staining with Annexin V-FITC and propidium iodide, indicating that early apoptosis was potentially induced. Furthermore, sublethal doses of ( E)-2-hexenal disturbed pyruvate metabolism and reduced the intracellular soluble protein content of A. flavus spores during the early stage of germination, and MIC treatment decreased acetyl-CoA and ATP contents by 65.7 ± 3.7% and 53.9 ± 4.0% ( P < 0.05), respectively. Additionally, the activity of mitochondrial dehydrogenases was dramatically inhibited by 23.8 ± 2.2% ( P < 0.05) at the MIC of ( E)-2-hexenal. Therefore, the disruption of mitochondrial energy metabolism and the induction of early apoptosis are involved in the mechanism of action of ( E)-2-hexenal against A. flavus spore germination.

Spore germination

10.1021/acs.jafc.8b06367

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Citations (85)

Formation, structure and stability of high internal phase Pickering emulsions stabilized by BSPI-C3G covalent complexes

Food Chemistry X (2022)

Xiaojie Cui Mengyao Ma Yanli Xie Yuhui Yang Qian Li

Food-grade high internal phase Pickering emulsions (HIPPEs) are stabilized by protein-based particles, which have attracted extensive attention due to their good gel-like structure. The black soybean isolate protein/cyanidin-3-O-glucoside (BSPI-C3G) covalent particles were used as a particulate emulsifier to form stable HIPPEs with oil phase fractions (74 % v/v) and low particle concentrations (0.5 %–3 % w/v) The particle size distribution and microstructure demonstrated that the BSPI-C3G covalent particles acted as an interfacial layer and surrounded the oil droplets. As the concentration of BSPI-C3G particles increased from 0.5 % to 3 %, the droplet size, elasticity, antioxidant capacity of the heated or stored HIPPEs more stable. So, the HIPPEs had the best stability with the BSPI-C3G particle at 3 % (w/v) concentration. These findings may extend the application of BSPI and C3G in foods and provide the guidelines for the rational design of food-grade HIPPEs stabilized by protein/anthocyanin complexes.

Pickering emulsion

10.1016/j.fochx.2022.100455

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Citations (7)

Fumigant Activity of 6 Selected Essential Oil Compounds and Combined Effect of Methyl Salicylate AndTrans-Cinnamaldehyde AgainstCulex pipiens pallens

Journal of the American Mosquito Control Association (2014)

Weibin Ma Juntao Feng Zhili Jiang Xing Zhang

We studied the knockdown activity and lethal toxicity of 6 essential oil compounds—methyl salicylate, linalool, 2-phenethyl alcohol, eugenol, β-citronellol, and trans-cinnamaldehyde—as fumigants against adult female Culex pipiens pallens in the laboratory. Of the 6 products tested, trans-cinnamaldehyde was the most toxic (LC50 = 0.26 µl/l air, 24 h) with a slow knockdown time (KT95 = 176.5 min at 0.5 µl/l air). Methyl salicylate displayed a lower toxicity (LC50 = 1.17 µl/l air, 24 h) but the fastest knockdown activity (KT95 = 16.8 min) at the sublethal concentration 0.5 µl/l air. Furthermore, the binary mixture of methyl salicylate and trans-cinnamaldehyde exhibited a combined effect of fast knockdown activity and high toxicity against Cx. p. pallens adults, showing potential for development as natural fumigants for mosquito control.

Methyl salicylate

Methyl eugenol

Culex pipiens

10.2987/14-6412r.1

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Citations (16)

Characteristics of ciliate community in Linxia Section of the Daxiahe River in low water seasons and its relationship with water quality.

Shengtai yu nongcun huanjing xuebao (2010)

Lingyun Chen Rang RuiQin MA Zheng-xue Weibin Ma Chen Delai

Characteristics i.e.species diversity and community structure,of the ciliate community in the Linxia Section of the Daxiahe River in low water seasons were studied by analyzing with microscopy and fixed cell staining method.16 water samples were collected in two times from that section during the period from November 2008 till March 2009.A total of 114 species(including 9 unidentified),belonging to 57 genera of 45 families of 13 orders,were identified.Colpidium colpoda and Tetrahymena pyriformis were dominant species,while Paramecium caudatum,Cyclidium citrullus,Litonotus fasciola,Glaucoma macrostoma,C.campylum,Vorticella microstoma and Cohnilembus fusiformis were sub-dominant ones.They can be cited as indicator species for domestic organic pollution of rivers.Integrated evaluation of the environmental quality of the Daxiahe River was conducted based on the characteristics of ciliate community(number of species,dominant species,biodiversity index,saprobic index,percentage of BS groups,percentage of PA groups,community similarity index) and other biodiversity index,such as fecal coliform bacteria.Results show that the water body is mainly polluted by organic pollutants of domestic sewage.The pollution can be divided into four levels,that is,slightly polluted(Os in Section 1#),moderately polluted(α-ms in Section 4#),moderately polluted(α-ms in Section 2#) and near-heavily polluted(α-ms-Ps in Section 3#).

Diversity index

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Characterization, Mechanism, and Application of Dipeptidyl Peptidase III: An Aflatoxin B₁-Degrading Enzyme from Aspergillus terreus HNGD-TM15

Journal of Agricultural and Food Chemistry (2024)

Hongxin Zhang Lanbin Cui Yanli Xie Xiao Li Renyong Zhao

Aflatoxin B

Aspergillus terreus

Dipeptidyl peptidase

10.1021/acs.jafc.4c03531

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