Alfonso Barbarisi

Research Field

Carnitine, gamma-trimethyl-beta-hydroxybutyrobetaine, is a small molecule widely present in all cells from prokaryotic to eukaryotic ones. It is the sole source of carbon and nitrogen in some bacteria; it serves as osmoprotectant in others. It is a carrier of acyl moieties, and exclusively of long-chain fatty acids for mitochondrial beta-oxidation in mammals. The conspicuously similar composition of the intracellular milieu among widely different species in relation to organic osmolyte systems involves the methylamine family to which carnitine belongs. This prompted us to examine the osmolytic properties of carnitine in an attempt to clarify the metabolic functions carnitine has acquired during evolution. An understanding of the metabolic functions of this organic compatible solute impinge on research involving this compound.

Osmolyte

10.1002/1097-4644(20010101)80:1<1::aid-jcb10>3.0.co;2-w

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Citations (80)

Phase I Dose Escalation Study of Gemcitabine and Paclitaxel Plus Colony-Stimulating Factors in Previously Treated Patients with Advanced Breast and Ovarian Cancer

Clinical Oncology (2000)

R.V. Iaffaioli A. Tortoriello Michele Santangelo Giacinto Turitto M Libutti

10.1053/clon.2000.9167

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Citations (13)

New chitosan-coated liposomes for controlled release of active substances in HepG2 cells: Synthesis, biological characterization, cell viability and anti-inflammatory studies

Digestive and Liver Disease (2016)

Vincenzo Quagliariello Mario Masarone Emilia Armenia Alfonso Barbarisi Marcello Persico

Viability assay

Biodistribution

Anti-inflammatory

10.1016/j.dld.2016.07.030

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Citations (0)

Cross-linked hyaluronic acid sub-micron particles: in vitro and in vivo biodistribution study in cancer xenograft model

Journal of Materials Science Materials in Medicine (2013)

Francesco Rosso Vincenzo Quagliariello Chiara Tortora A. Lazzaro Alfonso Barbarisi

Biodistribution

10.1007/s10856-013-4895-4

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Citations (34)

Modulation of in vitro myogenesis induced by different polymer substrates.

Journal of Materials Science Materials in Medicine (1999)

Orsolina Petillo Sabrina Margarucci Gianfranco Peluso Alfonso Barbarisi Mariarosa Anna Beatrice Melone

C2C12

Creatine kinase

10.1023/a:1008998604276

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Citations (6)

Genetics and Clinicopathological Findings in Thyroid Carcinomas Associated with Familial Adenomatous Polyposis

American Journal Of Pathology (1999)

Francesco Cetta Mariarosa Pelizzo Maria Cristina Curia Alfonso Barbarisi

Adenomatous polyposis coli

10.1016/s0002-9440(10)65091-2

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Citations (61)

β-Tricalcium phosphate 3D scaffold promote alone osteogenic differentiation of human adipose stem cells: in vitro study

Journal of Materials Science Materials in Medicine (2009)

G. Marino Francesco Rosso Gennaro Cafiero Carla Tortora Marco Moraci

10.1007/s10856-009-3840-z

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Citations (81)

Preventing seroma formation after axillary dissection for breast cancer: a randomized clinical trial

The American Journal of Surgery (2011)

Francesco Iovino Pasquale Pio Auriemma Francesca Ferraraccio G. Antoniol Alfonso Barbarisi

Seroma

Axilla

Harmonic scalpel

Axillary Dissection

10.1016/j.amjsurg.2011.06.051

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Citations (51)

Nonsurgical management of multiple splenic abscesses in an obese patient that underwent laparoscopic sleeve gastrectomy: case report and review of literature

Clinical Case Reports (2015)

Luigi Schiavo Giuseppe Scalera Gabriele De Sena Francesca Romana Ciorra Pasquale Pagliano

Sleeve gastrectomy (SG) is a surgical weight-loss procedure. Splenic abscess is a rare complication of SG. Four cases of splenic abscess after SG have been reported, all managed by surgical intervention. We report the first documented case of multiple splenic abscesses following SG managed conservatively by an integrated medical treatment.

Sleeve gastrectomy

Splenic disease

10.1002/ccr3.368

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Citations (15)

Galectin‐3 expression in thyroid fine needle cytology (t‐FNAC) uncertain cases: Validation of molecular markers and technology innovation

Journal of Cellular Physiology (2012)

Ferdinando Papale Gioacchino Cafiero Anna Grimaldi G. Marino Francesco Rosso

Abstract Thyroid cancer is not very common, accounting for 1–2% of all cancers, with a population incidence of about 0.004%. Currently, the ability to discriminate between follicular adenoma and carcinoma represents the major challenge in preclinical diagnosis of thyroid proliferative lesions. Better discrimination between the two would help avoid unnecessary thyroidectomy and save valuable resources. Over the years, galectin‐3 (Gal‐3) has been proposed as a diagnostic marker with varied success. In this paper, we used Environmental Scanning Electron Microscopy Immunogold Labelling (ESEM‐IGL) to investigate the expression of Gal‐3 on Thin‐Prep fine needle aspiration cytology (FNAC). We optimized the ESEM‐IGL method on thyroid cell lines (RO‐82 and FTC‐133) comparing our membrane Gal‐3 labeling data with Western blot. We evaluated 183 thyroid FNAC from Italian patients with a uncertain pre‐surgical diagnosis. ESEM‐IGL method marker sensitivity is 71.2%, while specificity is 53.3% and diagnostic efficacy is 61.2%. Our results confirmed that Gal‐3 expression is associated with situations of hypertrophy and/or cellular hyperproliferation, pathophysiological situations common both to adenomas and to thyroid carcinomas. The innovation of thyroid FNAC Thin‐Prep ESEM‐IGL shows the levels of Gal‐3 immunolabeling clearly, even through the individual cells of a thyroid nodule. However, Gal‐3 alone, as a molecular marker of thyroid cancer, can still have a limited application in pre‐surgery diagnosis. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.

Thyroid Nodules

Proliferation Marker

Immunolabeling

10.1002/jcp.24242

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Citations (34)

Alfonso Barbarisi

Papers

Citation

H-Index

i-10 index

Papers

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H-Index

i-10 index