Ingmar Janse

National Institute for Public Health and the Environment

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Bart J. van Rotterdam

National Institute for Public Health and the Environment

Gabriël Zwart

Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic

W.E.A. Kardinaal

Bureau Waardenburg (Netherlands)

Arno Swart

Eindhoven Cancer Registry

P. Visser

University of Amsterdam

Raditijo A. Hamidjaja

University of Applied Sciences Utrecht

Leo M. Schouls

National Institute for Public Health and the Environment

Engeline van Duijkeren

National Institute for Public Health and the Environment

Michael Visser

Netherlands Food and Consumer Product Safety Authority

Mark van Passel

National Institute for Public Health and the Environment

Cooperative Institutions

National Institute for Public Health and the Environment

Utrecht University

Wageningen University & Research

University of Amsterdam

University of Groningen

University Medical Center Utrecht

Erasmus MC

Erasmus University Rotterdam

European Centre for Disease Prevention and Control

Swedish Defence Research Agency

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succession of toxic and non-toxic microcystis genotypes in Dutch lakes revealed by molecular techniques

W.E.A. Kardinaal P. Visser Ingmar Janse Gabriël Zwart

Microcystis

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THE STORAGE GLUCAN OF PHAEOCYSTIS GLOBOSA (PRYMNESIOPHYCEAE) CELLS¹

Journal of Phycology (1996)

Ingmar Janse Marion van Rijssel Pieter‐Jan van Hall Gerrit J. Gerwig Jan C. Gottschal

ABSTRACT A non‐colony‐forming axenic strain of Phaeocystis globosa (Harlot) Lagerheim was shown to produce a water‐soluble β‐ d ‐glucan. This glucan consisted of about 20 glucose units, mainly (l→3)‐linked, with branching at position 6. Therefore, it can be classified as a chrysolaminaran. Glucan production occurred mainly during the stationary growth phase and resulted in concentrations as high as 76 pg glucose per cell. When cultures were deprived of light the glucans were consumed, which supports their possible role as compounds used for temporary storage of energy.

Axenic

Strain (injury)

10.1111/j.0022-3646.1996.00382.x

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Citations (46)

A predictive risk map for human leptospirosis guiding further investigations in brown rats and surface water

Infection Ecology & Epidemiology (2023)

Miriam Maas Ankje de Vries Tryntsje Cuperus Joke van der Giessen Matthijs Kruisheer

Leptospirosis is a zoonosis caused by the spirochete Leptospira spp. It is often not clear why certain areas appear to be hotspots for human leptospirosis. Therefore, a predictive risk map for the Netherlands was developed and assessed, based on a random forest model for human leptospirosis incidence levels with various environmental factors and rat density as variables. Next, it was tested whether misclassifications of the risk map could be explained by the prevalence of Leptospira spp. in brown rats. Three recreational areas were chosen, and rats (≥25/location) were tested for Leptospira spp. Concurrently, it was investigated whether Leptospira spp. prevalence in brown rats was associated with Leptospira DNA concentration in surface water, to explore the usability of this parameter in future studies. Approximately 1 L of surface water sample was collected from 10 sites and was tested for Leptospira spp. Although the model predicted the locations of patients relatively well, this study showed that the prevalence of Leptospira spp. infection in rats may be an explaining variable that could improve the predictive model performance. Surface water samples were all negative, even if they had been taken at sites with a high Leptospira spp. prevalence in rats.

Zoonosis

10.1080/20008686.2023.2229583

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Rodents as Potential Couriers for Bioterrorism Agents

Biosecurity and Bioterrorism Biodefense Strategy Practice and Science (2013)

Mare Lõhmus Ingmar Janse Frank van de Goot Bart J. van Rotterdam

Many pathogens that can cause major public health, economic, and social damage are relatively easily accessible and could be used as biological weapons. Wildlife is a natural reservoir for many potential bioterrorism agents, and, as history has shown, eliminating a pathogen that has dispersed among wild fauna can be extremely challenging. Since a number of wild rodent species live close to humans, rodents constitute a vector for pathogens to circulate among wildlife, domestic animals, and humans. This article reviews the possible consequences of a deliberate spread of rodentborne pathogens. It is relatively easy to infect wild rodents with certain pathogens or to release infected rodents, and the action would be difficult to trace. Rodents can also function as reservoirs for diseases that have been spread during a bioterrorism attack and cause recurring disease outbreaks. As rats and mice are common in both urban and rural settlements, deliberately released rodentborne infections have the capacity to spread very rapidly. The majority of pathogens that are listed as potential agents of bioterrorism by the Centers for Disease Control and Prevention and the National Institute of Allergy and Infectious Diseases exploit rodents as vectors or reservoirs. In addition to zoonotic diseases, deliberately released rodentborne epizootics can have serious economic consequences for society, for example, in the area of international trade restrictions. The ability to rapidly detect introduced diseases and effectively communicate with the public in crisis situations enables a quick response and is essential for successful and cost-effective disease control.

Biological Warfare

10.1089/bsp.2012.0085

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Citations (14)

Hoge resolutie typering van Coxiella burnetii : Definitieve versie

Ingmar Janse Alex Bossers Roest Hj van Rotterdam B

Coxiella burnetii is een intracellulaire bacterie die Q-koorts veroorzaakt. De genoomsequenties van een aantal isolaten die verkregen werden tijdens de Nederlandse Q-koorts uitbraak werden opgehelderd. Deze genoomsequenties dienen als basis voor verbeterde typeringsmethodes die nauwkeurigere bronopsporing en epidemiologische studies mogelijk maken. Daarnaast zijn de sequenties uiterst waardevol voor allerhande overig onderzoek, zoals naar de samenhang tussen de Nederlandse uitbraken en veranderde virulentiekenmerken. Als resultaat van dit project zijn er nu 19 C. burnetii isolaten van de Nederlandse uitbraak in kweek. Deze isolaten zijn voornamelijk afkomstig van veterinaire bronnen, maar er zijn ook enkele stammen van humane en omgevingsbronnen verkregen. De genomen van 3 isolaten zijn grotendeels opgehelderd en enkele voorlopige analyses zijn erop uitgevoerd. De ruwe sequentiedata van nog 4 isolaten komen binnenkort beschikbaar. De isolaten en genoomsequenties spelen een essentiele rol spelen in meerdere vervolgprojecten van de deelnemende onderzoeksgroepen. De ervaring die opgedaan is met het opwerken en sequencen van de C. burnetii genomen is van grote waarde voor lopend en toekomstig onderzoek naar C. burnetii en andere intracellulaire micro-organismen.

Coxiella burnetii

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Airborne Emissions from Livestock Farms and Exposure of Nearby Residents using an Atmospheric Dispersion Model

Springer proceedings in complexity (2017)

H.A.M. Sterk A. N. Swart Jeroen P. G. van Leuken Jack Schijven A.J.A. Aarnink

Proxy (statistics)

10.1007/978-3-319-57645-9_77

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DYNATOX: dynamics, toxin induction and early detection of toxic cyanobacteria in Dutch lakes

Nederlands tijdschrift voor medische microbiologie (2001)

W.E.A. Kardinaal Ingmar Janse Manoela Franke J. Snoek P. Visser

Dynamics

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Environmental surveillance during an outbreak of tularaemia in hares, the Netherlands, 2015

Eurosurveillance (2017)

Ingmar Janse Miriam Maas Jolianne M. Rijks Miriam Koene Rozemarijn QJ van der Plaats

Tularaemia, a disease caused by the bacterium Francisella tularensis , is a re-emerging zoonosis in the Netherlands. After sporadic human and hare cases occurred in the period 2011 to 2014, a cluster of F. tularensis -infected hares was recognised in a region in the north of the Netherlands from February to May 2015. No human cases were identified, including after active case finding. Presence of F. tularensis was investigated in potential reservoirs and transmission routes, including common voles, arthropod vectors and surface waters. F. tularensis was not detected in common voles, mosquito larvae or adults, tabanids or ticks. However, the bacterium was detected in water and sediment samples collected in a limited geographical area where infected hares had also been found. These results demonstrate that water monitoring could provide valuable information regarding F. tularensis spread and persistence, and should be used in addition to disease surveillance in wildlife.

Zoonosis

Zoonotic disease

Tularemia

Francisella

Animal ecology

Trichinella

One Health

10.2807/1560-7917.es.2017.22.35.30607

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Citations (20)

High-Resolution Differentiation of Cyanobacteria by Using rRNA-Internal Transcribed Spacer Denaturing Gradient Gel Electrophoresis

Applied and Environmental Microbiology (2003)

Ingmar Janse Marion Meima W.E.A. Kardinaal Gabriël Zwart

ABSTRACT For many ecological studies of cyanobacteria, it is essential that closely related species or strains can be discriminated. Since this is often not possible by using morphological features, cyanobacteria are frequently studied by using DNA-based methods. A powerful method for analysis of the diversity and dynamics of microbial populations and for checking the purity and affiliation of cultivated strains is denaturing gradient gel electrophoresis (DGGE). We realized high-resolution discrimination of a variety of cyanobacteria by means of DGGE analysis of sections of the internal transcribed spacer between the 16S and 23S rRNA genes (rRNA-ITS). A forward primer specific for cyanobacteria, targeted at the 3′ end of the 16S rRNA gene, was designed. The combination of this primer and three different reverse primers targeted to the rRNA-ITS or to the 23S rRNA gene yielded PCR products of different sizes from cultures of all 16 cyanobacterial genera that were tested but not from other bacteria. DGGE profiles produced from the shortest section of rRNA-ITS consisted of one band for all but one cyanobacterial genera, and those generated from longer stretches of rRNA-ITS yielded DGGE profiles containing one to four bands. The suitability of DGGE for detecting intrageneric and intraspecific variation was tested by using strains of the genus Microcystis . Many strains could be discriminated by means of rRNA-ITS DGGE, and the resolution of this method was strikingly higher than that obtained with previously described methods. The applicability of the developed DGGE assays for analysis of cyanobacteria in field samples was demonstrated by using samples from freshwater lakes. The advantages and disadvantages associated with the use of each developed primer set are discussed.

23S ribosomal RNA

Spacer DNA

Primer (cosmetics)

10.1128/aem.69.11.6634-6643.2003

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Citations (145)

Succession of Microcystis genotypes in Dutch lakes revealed by molecular techniques

W.E.A. Kardinaal Ingmar Janse P. Visser Gabriël Zwart

Microcystis

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