Huaizhong Hu

Xi'an Jiaotong University

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Stuart J. Knechtle

Duke Medical Center

John H. Fechner

University of Wisconsin–Madison

Majed M. Hamawy

University of Wisconsin–Madison

Yanyun Wang

Sichuan University

Soh Ha Chan

National University of Singapore

Yinchen Dong

University of California, Davis

Yuanli Cai

Naval University of Engineering

José Torrealba

The University of Texas Southwestern Medical Center

Changping Song

Beihua University

Turan Kanmaz

Koç University

Cooperative Institutions

Microsoft (Brazil)

126

New Valve Technology (Germany)

123

University of New Orleans

122

Sichuan University

University of Wisconsin–Madison

Xi'an Jiaotong University

West China Second University Hospital of Sichuan University

Harvard University

Massachusetts General Hospital

UW Health University Hospital

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In vivo administration of plasmid DNA encoding recombinant immunotoxin DT390-IP-10 attenuates experimental autoimmune encephalomyelitis

Journal of Autoimmunity (2007)

Wenjie Chen Hong Li Jia Yi Meili Lv Mingyuan Li

CXCR3

Encephalomyelitis

10.1016/j.jaut.2006.11.001

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Citations (22)

Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-β1+ CD4+ T regulatory cell infiltrates

THE journal (2004)

Huaizhong Hu

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Citations (0)

Combined moving horizon estimation and model predictive control for main steam temperature system

Huaizhong Hu Yu Li Qingyu Yang Yuanli Cai

This paper considers a robust control strategy for main steam temperature system of thermal power plant that is affected by immeasurable bounded disturbances. An output-feedback min-max optimization approach is proposed to obtain a controller which could effectively reject disturbances and stabilize the system. This approach combines moving horizon estimation with model predictive control and is formulated into a min-max optimization. At each sampling time, the optimization criterion is maximized over worst-case estimate of disturbance sequence and minimized over optimal control sequence via a primal-dual interior-point method. In this way, the controller can improve robustness under constrained disturbances. Simulation results verify that the presented approach could provide significant anti-disturbance capability compared with a conventional DMC-PID strategy.

Robustness

Model Predictive Control

Sequence (biology)

Time horizon

10.23919/chicc.2017.8027840

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Citations (1)

Cytokine kinetics profiling in pediatric renal transplant recipients

Pediatric Transplantation (2010)

Silke V. Niederhaus Debra D. Bloom Zhen Chang Huaizhong Hu Sharon M. Bartosh

Pediatric renal transplant recipients experience side effects of immunosuppression. Few immunoassays exist which can assess the adequacy of immunosuppression. We developed a CKT, whereby cytokine levels are measured in a five-day mixed lymphocyte reaction. We describe the in vitro cytokine responses to donor and third-party antigen in a pilot study of nine children after living-donor renal transplantation. The CKT identified five patterns of IFN-gamma secretion relative to donor and third-party alloantigen: no response to alloantigen (n = 2), hypo-response to donor (n = 3), equal response (n = 1), hyper-response to donor (n = 1), and intermediate response (n = 2). IL-2 and IL-13 patterning correlated with IFN-gamma expression. Two of nine subjects had acute rejection, which correlated with intermediate and hyper-responsive profiles. No rejection occurred during immunosuppression or donor-specific hypo-responsiveness. Significant immunosuppression was universal early after transplantation. Two of four children showed strong pretransplant responses to donor, which were regained three months post-transplant, and associated with rejection in one subject. The CKT reflects the level of immunosuppression and may offer a method to assess the adequacy of immunosuppression. A pattern of complete non-responsiveness or hypo-responsiveness correlated with lack of acute rejection. The CKT may prove useful in titrating immunosuppression and in improving live donor selection.

Immunosuppression

Mixed lymphocyte reaction

10.1111/j.1399-3046.2010.01309.x

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The fast Local Compression Rule In Distributed Signal Detection System

Microelectronics & Computer (2003)

Huaizhong Hu

After analyzing the result of optimal central fusion under given fusion rule, A novel optimal local compression rule is presented. The optimal local sensors' data compression is also studied. With a given optimal search path, the question of search the optimal result in two dimension is transform into finding the maximize result with one variable. This algorithm makes the things simple, improves the search efficiency and optimizes the result. The simulated result shows that this algorithm have better accuracy, fewer CPU time.

Linear search

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Abstract A25: Variations of human papillomavirus type 16 in cervical, lung, and skin cancers in Sichuan, China

Clinical Cancer Research (2010)

Jian Zhang Tao Wang Min Han Zhihui Yang Min Zhang

Abstract Human papillomavirus (HPV) is closely related with many kinds of cancers such as cervical, lung, and skin cancers, etc. HPV 16 showed intratypic variations that were known to differ in oncogenic potential and geographic distribution. This study was designed to analyze sequence variants in oncogenes E6, E7 and L1 of HPV 16 in cervical, lung, and skin cancers in Sichuan, China. Materials from 138 non-malignant controls, 122 cervical cancer patients, 104 lung cancer patients and 104 skin cancer patients were analyzed by PCR and direct sequencing. The infection rates of HPV 16 in cervical, lung, skin cancers were respectively 68.9%, 17.3%, 5.8%. The Asian prototype was the most prevalent variant in cervical cancer in Sichuan (40%). Compared with that detected in cervical cancer, lung and skin cancers showed more monotonous variations, but several mutations on L1 genes existed only in lung or skin cancers such as G6818C, C7011A, and C7017A. Citation Information: Clin Cancer Res 2010;16(14 Suppl):A25.

10.1158/1078-0432.tcmusa10-a25

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Robust Non-rigid Registration Based on Affine ICP Algorithm and Part-Based Method

Neural Processing Letters (2017)

Lei Xiong Liyang Wu Wenting Cui Sirui Zhang Guanglin Xu

Image registration

10.1007/s11063-017-9760-x

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Citations (2)

T-lymphocyte Alloresponses of Campath-1H-Treated Kidney Transplant Patients

Transplantation (2006)

Debra D. Bloom Huaizhong Hu John H. Fechner Stuart J. Knechtle

Background. Kidney transplant patients given Campath-1H (Alemtuzumab) immunodepletion therapy and long-term rapamycin monotherapy have excellent graft survival and function at three years. As an initial step in understanding the characteristics of repopulated T lymphocytes in these patients, we performed several assays to assess alloreactivity. Methods. We measured T-cell responses using CFSE-labeled recipient lymphocytes in a direct one-way MLR, and also analyzed the kinetics of expression of IFN-γ. We examined the T-cell responses of Campath-treated transplant patients on monotherapy versus those treated with anti-CD25 (Basiliximab) induction therapy and maintenance immunosuppression consisting of cyclosporine A, mycophenolate mofetil, and steroids. Results. On average, proliferative responses to donor antigen were equal between Campath and control groups. However, the Campath group displayed a greater response to third party compared to donor antigen (CD3+P=0.04, CD4+P=0.07, CD8+P<0.01), whereas the control group did not display a greater response to third party (CD3+P=0.69, CD4+P=0.72, CD8+P=0.60). Interestingly, more Campath patients (4 of 15) than control patients (0 of 8) displayed donor specific unresponsiveness as gauged by IFN-γ expression and T-cell proliferation (P=0.15). Conclusions. These studies suggest that Campath-1H in conjunction with rapamycin monotherapy retains intact immune responses to third party alloantigen, yet may promote hyporesponsiveness to donor antigen.

Basiliximab

Immunosuppression

Mixed lymphocyte reaction

10.1097/01.tp.0000191940.13473.59

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Citations (85)

Campath-1H Induction Plus Rapamycin Monotherapy for Renal Transplantation: Results of a Pilot Study

American Journal of Transplantation (2003)

Stuart J. Knechtle John D. Pirsch John H. Fechner Bryan N. Becker Andreas Friedl

Campath‐1H, an anti‐CD52 monoclonal antibody, was used as induction therapy (40 mg i.v. total dose) in 29 primary human renal transplants, and the patients were maintained on rapamycin monotherapy (levels 8–15 ng/mL) post‐transplant. Campath‐1H profoundly depletes lymphocytes long‐term and more transiently depletes B cells and monocytes. All patients are alive and well at 3–29 months of follow up. One graft was lost because of rejection. There have been no systemic infections and no malignancies. Eight of 29 patients have experienced rejection, which was successfully treated in seven of eight patients. Five of these patients had pathological evidence of a humoral component of their rejection. Seven of the 29 patients were converted to standard triple therapy on account of rejection. Rapamycin was generally well tolerated in that there were no significant wound‐healing problems; two lymphoceles required surgical drainage; and most patients were treated with a lipid‐lowering agent. Flow crossmatch testing post‐transplant revealed evidence of alloantibody in two patients tested with previous combined cellular and humoral rejection. Biopsies have shown no chronic allograft nephropathy to date. In view of the relatively high incidence of early humoral rejection, we plan to modify the immunosuppressive regimen in subsequent pilot studies. This clinical trial provides insight into the use of Campath‐1H induction in combination with rapamycin maintenance monotherapy. Campath‐1H, an anti‐CD52 monoclonal antibody, was used as induction therapy (40 mg i.v. total dose) in 29 primary human renal transplants, and the patients were maintained on rapamycin monotherapy (levels 8–15 ng/mL) post‐transplant. Campath‐1H profoundly depletes lymphocytes long‐term and more transiently depletes B cells and monocytes. All patients are alive and well at 3–29 months of follow up. One graft was lost because of rejection. There have been no systemic infections and no malignancies. Eight of 29 patients have experienced rejection, which was successfully treated in seven of eight patients. Five of these patients had pathological evidence of a humoral component of their rejection. Seven of the 29 patients were converted to standard triple therapy on account of rejection. Rapamycin was generally well tolerated in that there were no significant wound‐healing problems; two lymphoceles required surgical drainage; and most patients were treated with a lipid‐lowering agent. Flow crossmatch testing post‐transplant revealed evidence of alloantibody in two patients tested with previous combined cellular and humoral rejection. Biopsies have shown no chronic allograft nephropathy to date. In view of the relatively high incidence of early humoral rejection, we plan to modify the immunosuppressive regimen in subsequent pilot studies. This clinical trial provides insight into the use of Campath‐1H induction in combination with rapamycin maintenance monotherapy.

10.1034/j.1600-6143.2003.00120.x

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Citations (381)

Increased Risk of Neonatal Pneumonia in Pregnant Women with Atypical Pre-Labor Rupture of Membrane Assessed at Pregnancy Week 39

Open Journal of Obstetrics and Gynecology (2024)

Fu Li Haiyan Pei Yuefeng Wang Dan Zhang Xiaodan Liu

Purpose: Neonatal pneumonia is a major newborn disease with a high morbidity rate. We aimed to evaluate whether atypical prelabor rupture of membranes (PROM) is a high-risk factor for causing neonatal pneumonia in a prospective real-world study. Patients and Methods: A total of 250 pregnant women at pregnancy week 39 were non-selectively recruited. All were examined by PROM and neonatal pneumonia related clinical, bedside and lab tests, including body temperature, blood pressure, increased vagina discharge, posterior vault pooling, abdominal tenderness, WBC count, nitrazine test, amniotic fluid index, Leakection (a sICAM-1 based lateral flow immunoassay) and vagina streptococcus examinations. Increased vagina discharge with a Leakection positivity was adopted as a working criterium for identifying atypical PROM. Neonatal pneumonia was diagnosed based on the clinical presentation and lab tests. Results: Twenty cases of neonatal pneumonia (8.0%) were diagnosed after the deliveries of the 250 pregnant women. In these neonatal pneumonia cases, 12 (16.7%) occurred in 72 deliveries with atypical PROM, 2 (16.7%) in 12 deliveries with typical PROM, and 6 (3.6%) in 166 deliveries with non-PROM. Conclusion: In this real-world study, we find that a systematic screening at pregnancy week 39 was very meaningful in revealing atypical PROM. Moreover, atypical PROM is a major risk factor for neonatal pneumonia. Therefore, an early diagnosis and intervention on atypical PROM could potentially reduce the occurrence of neonatal pneumonia.

10.4236/ojog.2024.144046

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