André Sanches de Ávila

Universidade Estadual do Oeste do Paraná

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Andressa Faccenda

Universidade Estadual de Maringá

Ricardo Vianna Nunes

Universidade Estadual do Oeste do Paraná

Maximiliane Alavarse Zambom

Universidade Estadual do Oeste do Paraná

Jomara Broch

Universidade Estadual do Oeste do Paraná

Cínthia Eyng

Universidade Estadual do Oeste do Paraná

Cibele Regina Schneider

Universidade Estadual de Maringá

Cleison de Souza

Universidade Estadual do Oeste do Paraná

Fernando André Anschau

Universidade Estadual do Oeste do Paraná

E.H. Cirilo

Universidade Estadual do Oeste do Paraná

Nilton Rohloff

Universidade Estadual do Oeste do Paraná

Cooperative Institutions

Universidade Estadual do Oeste do Paraná

University of Florida

Universidade Estadual de Maringá

Ministerio de Salud

Universidade Estadual do Paraná

National University of Río Negro

Universidade Tecnológica Federal do Paraná

Universidade Estadual Paulista (Unesp)

Universidade do Estado de Santa Catarina

Weatherford College

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Effect of feeding dried distillers' grains with solubles to broiler chickens from day 0 to 21

Livestock Science (2020)

J.L. Damasceno Carina Scherer Rocha Cínthia Eyng Jomara Broch Cléverson de Souza

Completely randomized design

Distillers grains

10.1016/j.livsci.2020.104232

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Citations (9)

Effect of dietary guanidinoacetic acid or nucleotides supplementation on growth performances, carcass traits, meat quality and occurrence of myopathies in broilers

Livestock Science (2021)

Cleison de Souza Cínthia Eyng Aline de Marco Viott André Sanches de Ávila W.J. Pacheco

Creatine kinase

10.1016/j.livsci.2021.104659

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Citations (15)

Sodium propionate and sodium butyrate effects on histone deacetylase (HDAC) activity, histone acetylation, and inflammatory gene expression in bovine mammary epithelial cells1

Journal of Animal Science (2018)

Lorrayny Galoro da Silva Bradley S. Ferguson André Sanches de Ávila A.P. Faciola

Histone deacetylase (HDAC) inhibition attenuates inflammation in rodents and short-chain fatty acids (SCFAs) are effective HDAC inhibitors. Therefore, the objective of this study was to evaluate the role of the SCFAs sodium propionate (SP) and sodium butyrate (SB) as HDAC-dependent regulators of inflammatory gene expression in bovine mammary epithelial cells (MAC-Ts). We postulated that SP and SB would decrease inflammation in MAC-Ts by inhibiting HDAC activity and increasing histone H3 acetylation and consequently decreasing inflammatory gene expression. For this study, MAC-Ts stimulated with lipopolysaccharide (LPS) were used as a model for bovine mammary epithelial cell inflammation. MAC-Ts were cultured in a basal medium. Cell lysates were incubated with SP or SB (0 to 5 mM) for 2 h prior to HDAC substrates incubation for an additional 2 h and HDACs activity was determined. Next, cells were pretreated with SP or SB (0 to 3.0 mM) for 2 h prior to LPS (1 µg/mL) stimulation for an additional 2 h and assessed for histone H3 acetylation. Then, cells were pretreated with SP or SB (1 mM) for 24 h prior to LPS (1 µg/mL) stimulation for an additional 2 h and RNA was isolated for inflammatory gene expression evaluation by PCR array and gene validation was performed using quantitative real-time PCR. One-way ANOVA followed by Tukey post hoc analysis was conducted and statistical significance set at P < 0.05. SP and SB concentration-dependently and selectively inhibited class I HDAC activity, which differed between SCFAs, where SB inhibited (P < 0.05) HDACs 2, 3, and 8, while SP inhibited (P < 0.05) HDACs 2 and 8. Histone H3 acetylation was concentration-dependently increased by SCFAs and likewise the differential regulation of HDAC activity, SCFAs effected differently histone H3 acetylation, where SB increased (P < 0.05) H3K9/14, H3K18 and H3K27 acetylation, while SP increased (P < 0.05) H3K9/14 and H3K18 acetylation. However, SCFAs did not decrease (P > 0.05) overall inflammatory gene expression. Under our experimental conditions, findings suggest that in MAC-Ts, SCFAs regulate epigenetic markers on nucleosomal DNA in addition to regulation of inflammatory gene events independent of HDAC activity. Nevertheless, examination of SCFAs and/or HDACs inhibitors in bovine mammary gland is worth being further investigated to delineate the potential impact of HDAC inhibition and histones hyperacetylation on mammary gland tissue inflammation.

Sodium butyrate

Sodium propionate

HDAC11

HDAC4

10.1093/jas/sky373

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Citations (73)

Effect of prepartum source and amount of vitamin D supplementation on lactation performance of dairy cows

Journal of Dairy Science (2022)

M.B. Poindexter R. Zimpel A. Vieira-Neto A. Husnain A.C.M. Silva

The objectives of this experiment were to determine the effects of supplementing 25-hydroxyvitamin D3 (calcidiol, CAL) compared with vitamin D3 (cholecalciferol, CHOL) at 1 or 3 mg/d in late gestation on production outcomes of dairy cows. One hundred thirty-three parous and 44 nulliparous pregnant Holstein cows were enrolled in the experiment. Cows were blocked by parity and previous lactation milk yield (parous) or genetic merit (nulliparous) and assigned randomly to receive 1 or 3 mg/d of CAL or CHOL in a 2 × 2 factorial arrangement of treatments (CAL1, CAL3, CHOL1, and CHOL3). Treatments were provided to individual cows as a top-dress to the prepartum diet from 250 d in gestation until parturition. The prepartum diet had a dietary cation-anion difference of −128 mEq/kg of dry matter. Production and disease were evaluated for the first 42 d in milk, and reproduction was evaluated to 300 d in milk. Incidence of postpartum diseases did not differ among treatments. Feeding CAL compared with CHOL increased yields of colostrum and colostrum fat, protein, and total solids, resulting in an increased amount of net energy for lactation secreted as colostrum (CHOL = 7.0 vs. CAL = 9.0 ± 0.7 Mcal). An interaction between source and amount was observed for milk yield: CAL3 increased milk yield compared with CHOL3 (CHOL3 = 34.1 vs. CAL3 = 38.7 ± 1.4 kg/d) but milk yield did not differ between CAL1 and CHOL1 (CHOL1 = 36.9 vs. CAL1 = 36.4 ± 1.4 kg/d). Concentrations of serum calcidiol on day of calving and average serum Ca from d 2 to 11 postpartum were positively associated with milk yield in the first 42 d in milk. Interactions between source and amount of vitamin D were also observed for pregnancy after first AI: the percentage of cows receiving CHOL1 and CAL3 that became pregnant was smaller than that of cows receiving CHOL3 and CAL1. However, pregnancy per AI and pregnancy by 300 d in milk did not differ among treatments. Overall, CAL3 increased milk yield compared with CHOL3, whereas in cows fed 1 mg/d (CAL1 and CHOL1), the source of vitamin D generally had no effect. The effect of CAL3 may be explained in part by serum CAL concentrations and postpartum serum Ca, which were associated with milk yield.

10.3168/jds.2022-22388

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Citations (8)

Use of dried brewers' grains instead of soybean meal to feed lactating cows

Revista Brasileira de Zootecnia (2017)

Andressa Faccenda Maximiliane Alavarse Zambom Deise Dalazen Castagnara André Sanches de Ávila Tatiane Fernandes

The objective of this study was to determine the optimal level of dried brewers' grains (DBG) to replace soybean meal in diets for lactating Holstein cows. Five cows, around 88±28 days in milk, were distributed in a 5 × 5 Latin square design and fed diets containing different levels of DBG (0, 25, 50, 75, and 100%). The forage:concentrate ratio of the diet was 50:50. Feed intake, dry matter, nutrient digestibility, microbial synthesis, milk production and composition, and the economic viability of the diets were evaluated. There was reduction in dry matter intake and, consequently, in crude protein and non-fiber carbohydrates with increased levels of DBG. This occurred due to physical limitation of rumen caused by increased neutral detergent fiber intake. Ether extract intake also increased with levels of DBG due to higher concentrations of this nutrient in the diet. Apparent dry matter, organic matter, ether extract, and neutral detergent fiber digestibility increased with replacement of soybean meal by DBG. Milk production showed a quadratic effect and the levels of fat, protein, and total solids reduced linearly. Each 1% of soybean meal replaced by DBG in concentrate led to a reduction of 0.04, 0.02, and 0.06 g kg-1 of milk fat, protein, and total solids, respectively. The milk production efficiency increased linearly and the microbial synthesis efficiency was not affected. The economic return increased along with the DBG levels. Thus, DBG levels replacing up to 75% of soybean meal can be used to feed lactating cows, since it provides improvements in digestibility, milk production efficiency, and economic return without affecting microbial efficiency.

Neutral Detergent Fiber

Latin square

10.1590/s1806-92902017000100007

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Citations (35)

Impact of dried brewers’ grains supplementation on performance, metabolism and meat quality of broiler chickens

South African Journal of Animal Science (2020)

Wiliam Parpinelli Paulo Segatto Cella Cínthia Eyng Jomara Broch Vaneila Daniele Lenhardt Savaris

The objective was to evaluate increasing levels of dried brewers’ grains (DBG) in feed for broiler chickens from 1 to 21 days old and their effect on performance, blood parameters, intestinal morphometry, carcass characteristics and meat quality. The design was completely randomized with six treatments, which consisted of various levels of DBG inclusion, namely 0 (no inclusion), 20, 40, 60, 80, and 100 g/kg with seven replications and 17 animals per experimental unit, totalling 714 male broilers. Performance parameters, blood biochemical profile, morphology of the intestinal epithelium (duodenum), and carcass yield and composition were evaluated. Feed intake was not changed by DBG inclusion levels. Nor were weight gain and feed conversion ratio. Serum cholesterol levels were not influenced, and there were no effects on triglyceride, uric acid and creatinine levels. Enzyme aspartate aminotransferase showed a quadratic effect, as did alanine aminotransferase, with higher values at 79.5 and 63.9 g/kg DBG inclusion, respectively. No changes in carcass yield and relative organ weight were observed. The composition of the carcass in ether extract showed a quadratic effect, as fat deposition rate, with lowest values at 62.8 and 62.4 g/kg of DBG inclusion levels, respectively. Crude protein levels in carcass reduced linearly, as did fat deposition rate. The parameters of intestinal morphology and meat quality were not changed. Dried brewers’ grains can be included in broiler diet from 1 to 21 days at levels up to 100 g/kg without influencing the metabolic parameters and broiler performance. Keywords: alternative feed, blood, by-product, intestinal villi, performance

Jejunum

10.4314/sajas.v50i2.2

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Citations (7)

Nutrient digestibility and ruminal parameters of cattle fed dried brewers grains and Saccharomyces cerevisiae

Livestock Science (2019)

Andressa Faccenda Maximiliane Alavarse Zambom André Sanches de Ávila Jéssica Garcias Everline Inês Eckstein

The objective of this study was to evaluate the effect of Saccharomyces cerevisiae on nutrient intake and digestibility, the protozoan population and ruminal fermentation kinetics of cattle fed diets containing brewers grains. Four ruminally cannulated crossbreed steers were distributed in a 4 × 4 Latin square. The treatments were in a 2 × 2 factorial arrangement: with or without the inclusion of brewers grains x with or without the addition of S. cerevisiae. Dried brewers grains were included at 11.7% of the dry matter (DM) of the diet. Yeast (S. cerevisiae CNCM I-1077 containing 1.0 × 109 CFU/g) was supplied at 15 g/day. The use of brewers grains and the addition of yeast did not influence the ingestion of DM, crude protein, neutral detergent fiber or total digestible nutrients. Steers fed with brewers grains ingested lower concentrations of non-fibrous carbohydrates (NFC) (P < 0.01). The addition of yeast did not alter DM or nutrient digestibility, but the inclusion of brewers grains reduced DM (P < 0.05) and NFC digestibility (P < 0.01). The use of brewers grains reduced the protozoa populations of the genera Entodinium (P < 0.05) and Isotricha (P < 0.01). Ruminal pH values were not influenced by brewers grains or yeast. There was an interaction between time and the inclusion of brewers grains (P < 0.05) for ammoniacal nitrogen, wherein two hours after feeding, cattle that consumed this by-product had lower concentrations of ammoniacal nitrogen, compared to those that did not consume brewers grains. The addition of live yeast did not influence the proportion of volatile fatty acids (VFA) or total VFA concentration, but the inclusion of brewers grains reduced the VFA concentration and the percentage of isovalerate (P < 0.05). Thus, the use of S. cerevisiae in the bovine diet did not improve fiber digestibility or ruminal fermentation parameters, and the inclusion of 11.7% dried brewers grains did not compromise the total digestible nutrient intake, ruminal pH or the concentrations of acetate, propionate and butyrate.

Latin square

Neutral Detergent Fiber

10.1016/j.livsci.2019.05.003

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Citations (5)

Performance and milk composition of Holstein cows fed increasing levels of dried distillers’ grains with solubles

Livestock Science (2022)

Caroline Hoscheid Werle Andressa Faccenda André Sanches de Ávila Fernando André Anschau Ana Ruth Estrela Almeida

Distillers grains

Latin square

Neutral Detergent Fiber

Digestion

10.1016/j.livsci.2022.104987

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Citations (0)

Black Wattle (Acacia mearnsii) Condensed Tannins as Feed Additives to Lactating Dairy Cows

Animals (2020)

André Sanches de Ávila Maximiliane Alavarse Zambom Andressa Faccenda Caroline Hoscheid Werle Ana Ruth Estrela Almeida

The objective of this study was to evaluate the effects of five levels of condensed tannins (CT) from black wattle (Acacia mearnsii) in the diets of lactating dairy cows on intake, nutrient digestibility, ruminal microbial protein synthesis, milk production, composition, oxidative profile, and blood metabolites. Five Holstein cows (88 ± 26.8 days in milk) were allocated in a 5 x 5 Latin square design for a period of 20 days (14 days of diet adaptation and six for sampling). Treatments were the inclusion levels of CT at 0, 5, 10, 15 and 20 g/kg of dry matter (DM) in the diet. There was no effect of CT on DM intake. The digestibility of DM and neutral detergent fiber changed quadratically, with the maximum values at 12.2 and 11.4 g/kg of DM, respectively. There was no effect on ruminal microbial protein synthesis and milk production; however, milk casein concentration was reduced linearly. There was no effect on the milk oxidative profile. Inclusion of CT at levels up to 20 g/kg of DM did not affect intake or microbial protein synthesis; however, added CT depressed the production of energy corrected milk and milk casein concentration.

Acacia mearnsii

Latin square

Neutral Detergent Fiber

Wattle (construction)

Tannin

10.3390/ani10040662

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Citations (14)

Performance and milk composition of Holstein cows fed with dried malt bagasse and selenium-enriched Saccharomyces cerevisiae

Livestock Science (2020)

Andressa Faccenda Maximiliane Alavarse Zambom André Sanches de Ávila Cibele Regina Schneider Caroline Hoscheid Werle

Bagasse

Latin square

10.1016/j.livsci.2020.104081

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Citations (13)