Ziang Huang

First Affiliated Hospital of Anhui Medical University

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Ziwen Gao

First Affiliated Hospital of Anhui Medical University

Xiaoshu Li

Anhui Medical University

Wanqiu Zhu

First Affiliated Hospital of Anhui Medical University

Hui Li

First Affiliated Hospital of Anhui Medical University

Xiaohu Li

First Affiliated Hospital of Anhui Medical University

Yuqing Li

Huazhong Agricultural University

Yongqiang Yu

First Affiliated Hospital of Anhui Medical University

Shanshan Zhou

First Affiliated Hospital of Anhui Medical University

Shanshan Zhou

State Key Laboratory of Food Science and Technology

Yongqiang Yu

First Affiliated Hospital of Anhui Medical University

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Anhui Medical University

First Affiliated Hospital of Anhui Medical University

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Guangxi Medical University

Research Center for Eco-Environmental Sciences

Sichuan University

Chinese PLA General Hospital

Anhui Mental Health Center

Air Force Medical University

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Author response for "Sex differences in functional connectivity and the predictive role of the connectome‐based predictive model in Alzheimer's disease"

Yuqing Li Wanqiu Zhu Shanshan Zhou Hui Li Ziwen Gao

10.1002/jnr.25307/v2/response1

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Sex difference in general cognition associated with coupling of whole-brain functional connectivity strength to cerebral blood flow changes during Alzheimer’s disease progression

Research Square (Research Square) (2022)

Hui Li Ziang Huang Ziwen Gao Wanqiu Zhu Yuqing Li

Abstract Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disorder that results in irreversible cognitive impairments. Nonetheless, there are numerous sex-dependent differences in clinical course that may provide clues to disease pathogenesis and more effective individualized treatments. We examined potential contributions of neurovascular coupling deficits to sex differences in AD progression. Resting-state functional magnetic resonance imaging were acquired from 50 AD patients (28 females), 52 amnesic mild cognitive impairment patients (31 females), and 59 healthy controls (36 females). Short- and long-range functional connectivity strength (FCS) and cerebral blood flow (CBF) were calculated for all participants. Then, the CBF/FCS coupling ratio was calculated for each voxel. Two-way ANOVA was performed to identify group × sex interactions and main effects of group. Correlation analysis was used to assess associations between CBF/FCS ratios and general cognitive status as measured by the Mini-Mental State Examination (MMSE).There were significant group × sex interaction effects on short-range coupling ratios of right middle temporal gyrus, left angular gyrus, left infraorbital frontal gyrus, and left superior frontal gyrus as well as on the long-range coupling ratios of right middle temporal gyrus, left precuneus, left posterior cingulate, and left angular gyrus. There were significant negative correlations between MMSE scores and CBF/FCS ratios for all regions with significant interactions among all female patients, while positive correlations were found between MMSE and CBF/FCS ratios for some regions among all male patients. Our results demonstrate significant sex differences in neurovascular coupling mechanisms associated with cognitive function during the course of AD.

Middle frontal gyrus

Superior frontal gyrus

Posterior cingulate

Angular gyrus

Gyrus

Middle temporal gyrus

Medial frontal gyrus

10.21203/rs.3.rs-1694584/v1

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Correlation study of periodontitis with cognitive impairment.

PubMed (2022)

Yufei Tao Mengna He HU Hong-yan Ziwen Gao Ziang Huang

This study aimed to determine the association of periodontitis with cognitive impairment by evaluating periodontal conditions in middle-aged and elderly people of normal cognition and cognitive impairment.

Clinical attachment loss

10.7518/hxkq.2022.05.007

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Periodontitis is associated with altered brain structure and function in normal cognition middle‐aged and elderly individuals

Journal of Periodontal Research (2023)

Xiaoshu Li Yufei Tao Hui Li Ziang Huang Yuqing Li

Abstract Background Numerous studies have proposed that periodontitis is a potential risk factor for Alzheimer's disease. However, the association between periodontitis and brain normal cognition in aged and elderly individuals (NCs) is unclear. Such a link could provide clues to Alzheimer's disease development and strategies for early prevention. Objective To explore the associations between periodontal condition and metrics of both brain structure and function among NCs with the help of multimodal magnetic resonance imaging (MRI). Methods High‐resolution T1‐weighted structural data, resting‐state functional‐MRI data, and measures of periodontal condition were collected from 40 NCs. Cortical volume, thickness, and area as well as regional homogeneity were calculated with the aid of DPABISurf software. Correlation analyses were then conducted between each imaging metric and periodontal index. Results Consistent negative correlations were observed between severity of periodontitis (mild, moderate, severe) and cortical volume, area, and thickness, not only in brain regions that took charge of primary function but also in brain regions associated with advanced cognition behavior. Among participants with mild attachment loss (AL) and a shallow periodontal pocket depth (PPD), periodontal index was positively correlated with most measures of brain structure and function, while among participants with severe AL and deep PPD, periodontal index was negatively correlated with measures of brain structure and function (all p < .005 for each hemisphere). Conclusions Our results demonstrate that periodontitis is associated with widespread changes in brain structure and function among middle‐aged and elderly adults without signs of cognitive decline, which might be a potential risk factor for brain damage.

Clinical attachment loss

10.1111/jre.13214

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Citations (2)

Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels

Environment International (2024)

Qiuju Liang Jiajun Jing Huiming He Xiaofeng Huang Jia‐Ning Liu

Manganese (Mn) is an essential micronutrient required for various biological processes but excess exposure to Mn can cause neurotoxicity. However, there are few reports regarding the toxicity effect of Mn on the kidney as well as the underlying molecule mechanism. Herein, in vivo experiments were adopted to assess the toxicity effects associated with Mn, and found that chronic Mn treatment induced the injury of glomerular podocytes but not renal tubule in rats. Genome-wide CRISPR/Cas9 knockout screen was then employed to explore the biotargets of the toxic effect of Mn on podocytes. Through functional analyses of the enriched candidate genes, NLRP10 was found to be significantly up-regulated and mediated Mn-induced podocyte apoptosis. Further mechanism investigation revealed that NLRP10 expression was regulated by demethylase AlkB homolog 5 (ALKBH5) in an m6A-dependent fashion upon Mn treatment. Moreover, Mn could directly bind to Metadherin (MTDH) and promoted its combination with ALKBH5 to promote NLRP10 expression and cell apoptosis. Finally, logistic regressions, restricted cubic spline regressions and uniform cubic B-spline were used to investigate the association between Mn exposure and the risk of chronic kidney disease (CKD). A U-shaped nonlinear relationship between CKD risk and plasma Mn level, and a positive linear relationship between CKD risk and urinary Mn levels was found in our case-control study. To sum up, our findings illustrated that m6A-dependent NLRP10 regulation is indispensable for podocyte apoptosis and nephrotoxicity induced by Mn, providing fresh insight into understanding the health risk of Mn and a novel target for preventing renal injury in Mn-intoxicated patients.

10.1016/j.envint.2024.108672

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Citations (1)

Author response for "Sex differences in functional connectivity and the predictive role of the connectome‐based predictive model in Alzheimer's disease"

Yuqing Li Wanqiu Zhu Shanshan Zhou Hui Li Ziwen Gao

10.1002/jnr.25307/v3/response1

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Research and design of a self-sensing processing device for the installation environment of high-voltage cross-linked cable accessories

Zhidong Zhao Rong Xia Jianjun Yuan Lei Zhang Ziang Huang

High Voltage

10.1117/12.3049382

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Sex-dependent changes in emotional memory associated with cerebral blood flow alterations during Alzheimer’s disease progression

Neuroradiology (2022)

Ziwen Gao Shanshan Zhou Wanqiu Zhu Hui Li Ziang Huang

10.1007/s00234-022-03099-1

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Citations (2)

Education reduces cognitive dysfunction in Alzheimer’s disease by changing regional cerebral perfusion: An in-vivo arterial spin labeling study

Neurological Sciences (2023)

Wanqiu Zhu Ziwen Gao Hui Li Ziang Huang Xiaohu Li

Cognitive reserve

Posterior cingulate

Cognitive Decline

Neurocognitive

10.1007/s10072-023-06696-x

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Citations (3)

Sex Difference in General Cognition Associated with Coupling of Whole-brain Functional Connectivity Strength to Cerebral Blood Flow Changes During Alzheimer’s Disease Progression

Neuroscience (2022)

Hui Li Ziang Huang Ziwen Gao Wanqiu Zhu Yuqing Li

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder that results in irreversible cognitive impairments. Nonetheless, there are numerous sex-dependent differences in clinical course. We examined potential contributions of neurovascular coupling deficits to sex differences in AD progression. T1-weighted three-dimensional structural magnetic resonance images, functional blood oxygen level dependent and arterial spin labeling images were acquired from 50 AD patients (28 females), 52 amnesic mild cognitive impairment patients (31 females), and 59 healthy controls (36 females). Short- and long-range functional connectivity strength (FCS) and cerebral blood flow (CBF) values were calculated for all participants. Then, the CBF/FCS coupling ratio, which represented the amount of blood supply per unit of connectivity strength, was calculated for each voxel. Two-way ANOVA was performed to identify group × sex interactions and main effects of group. Correlation analysis was used to assess associations between CBF/FCS ratios and Mini-Mental State Examination (MMSE). There were significant group × sex interaction effects on short-range coupling ratios of right middle temporal gyrus, left angular gyrus, left inferior orbital frontal gyrus, and left superior frontal gyrus as well as on the long-range coupling ratios of right middle temporal gyrus, left precuneus, left posterior cingulate cortex, and left angular gyrus. There were significant negative correlations between MMSE scores and CBF/FCS ratios for all regions with significant group × sex interactions among female patients, while positive correlations were found among male patients. Our results demonstrate significant sex differences in neurovascular coupling mechanisms associated with cognitive function during the course of AD.

Middle frontal gyrus

Superior frontal gyrus

Posterior cingulate

Angular gyrus

Middle temporal gyrus

Gyrus

Inferior frontal gyrus

10.1016/j.neuroscience.2022.12.001

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Citations (10)