Qiaolin Liu

National Center for Nanoscience and Technology

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Tiaoyi Xiao

Hunan Agricultural University

Baohong Xu

Hunan Agricultural University

Huige Zhou

National Center for Nanoscience and Technology

Jianming Su

Hunan Agricultural University

Xiao Tiao-yi

Changsha University

Ru Bai

National Center for Nanoscience and Technology

Ronghua Wang

University of Pittsburgh

Chunying Chen

National Center for Nanoscience and Technology

Guixiang Yuan

Hunan Agricultural University

Hui Fu

China Institute of Water Resources and Hydropower Research

Cooperative Institutions

Hunan Agricultural University

Chinese Academy of Sciences

National Center for Nanoscience and Technology

University of Chinese Academy of Sciences

Huazhong University of Science and Technology

Sun Yat-sen University

Capital Medical University

Sichuan University

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Agriculture and Rural Affairs

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Structural comparison and expression function analysis of BF/C2 in Ctenopharyngodon idella and Squaliobarbus curriculus

Fish & Shellfish Immunology (2023)

Yuling Wei Zhao Lv Qiaolin Liu Jianbo Yu Yu Xiao

Expression (computer science)

10.1016/j.fsi.2023.109154

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Gonadal Development and Differentiation of Hybrid F1 Line of Ctenopharyngodon idella (♀) × Squaliobarbus curriculus (♂)

International Journal of Molecular Sciences (2024)

Qiaolin Liu Shitao Hu Xiangbei Tang Chong Wang Le Yang

The hybrid F1 offspring of Ctenopharyngodon idella (♂) and Squaliobarbus curriculus (♀) exhibit heterosis in disease resistance and also show abnormal sex differentiation. To understand the mechanism behind gonadal differentiation in the hybrid F1, we analyzed the transcriptomes of C. idella, S. curriculus, and the hybrid F1; screened for genes related to gonad development in these samples; and measured their expression levels. Our results revealed that compared to either C. idella or S. curriculus, the gene expressions in most sub-pathways of the SNARE interactions in the vesicular transport pathway in the hypothalamus, pituitary, and gonadal tissues of their hybrid F1 offspring were significantly up-regulated. Furthermore, insufficient transcription of genes involved in oocyte meiosis may be the main reason for the insufficient reproductive ability of the hybrid F1 offspring. Through transcriptome screening, we identified key molecules involved in gonad development, including HSD3B7, HSD17B1, HSD17B3, HSD20B2, CYP17A2, CYP1B1, CYP2AA12, UGT2A1, UGT1A1, and FSHR, which showed significant differences in expression levels in the hypothalamus, pituitary, and gonads of these fish. Notably, the expression levels of UGT1A1 in the gonads of the hybrid F1 were significantly higher than those in C. idella and S. curriculus. These results provide a scientific basis for further research on the gonadal differentiation mechanism of hybrid F1 offspring.

10.3390/ijms251910566

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CLONING AND EXPRESSION ANALYSIS OF CYTOCHROME P450 HOMOLOG FROM HYRIOPSIS CUMINGII

Acta Hydrobiologica Sinica (2012)

Tiaoyi Xiao Qiaolin Liu Xiaoze Guo Zhang Huai-yun Shuliang Cui

Cloning (programming)

Expression (computer science)

10.3724/sp.j.1035.2012.00987

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An Oxidative Stress Nanoamplifier to Enhance the Efficacy of Cisplatin in Head and Neck Cancer

Angewandte Chemie (2025)

Zhenzhen Li Qiaolin Liu Guorong Wang Ru Bai Shengmin Li

Cisplatin (CP) is a first‐line platinum‐based drug used for the treatment of head and neck cancer. However, tumor cells can diminish the therapeutic effects of CP through the detoxification system mediated by glutathione (GSH) and the nucleotide excision repair (NER) pathway. Herein, we present a light‐activable and pH‐responsive oxidative stress nanoamplifier (FPLC@IR OSNA), comprising an amphiphilic compound (FPLC) with Fmoc‐lysine acting as a connector between a nitroimidazole derivative and a pH‐responsive cinnamaldehyde (CA) derivative, loaded with photosensitizer IR780. The acidic microenvironment of lysosome can trigger the release of CA to produce H2O2, which breaks down into oxygen, further improving the phototherapy efficacy mediated by IR780 irradiation. The consumption of oxygen during the phototherapy process induces hypoxia, prompting the reduction of nitroimidazole to aminoimidazole and leading to reduced GSH synthesis, enhancing tumor cell death induced by CP. Meanwhile, the accumulation of intracellular reactive oxygen species (ROS) during phototherapy attenuates the nuclear NER pathway, further augmenting the therapy effect of CP. This strategy, by combining FPLC@IR OSNA with laser and CP, significantly promotes the therapeutic effect in vitro, and notably inhibits tumor growth in both Cal27 cell line‐derived xenograft models and patient‐derived xenograft models.

10.1002/ange.202421481

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Hydrological gradients and functional diversity of plants drive ecosystem processes inPoyang Lakewetland

Ecohydrology (2018)

Hui Fu Qian Lou Taotao Dai Guixiang Yuan Zhenrong Huang

Abstract Functional trait approaches have greatly improved the mechanistic understanding of the impacts of biodiversity in ecosystem. We evaluated how hydrological gradients (i.e., soil water content and elevation) affected the taxonomic diversity, functional identity, and functional diversity and assessed how changes in these measures of diversity ultimately drove variations in above‐ground biomass (AGB). Results showed that a combination of hydrological gradients and functional trait composition (i.e., the community weighted means, the single‐trait functional diversity and the multiple‐trait functional diversity) better explained variations (40.8%) of AGB. No significant relationships between taxonomic diversity and AGB were observed. The dominant species became taller with thicker stem, and co‐occurring species showed greater divergent distribution of stem diameter towards higher soil water content. As elevation increased, the dominant plant had thinner leaves with later onset of flowering and longer flowering duration, and co‐occurring species showed less divergent distribution of lamina thickness and leaf dry‐mass content. Our results highlighted that the positive biodiversity–ecosystem functioning relations were largely attributed to the co‐operations of selection and complementary effects, as evidences showed that the dominant trait values (i.e., community weighted mean of shoot height) and trait diversity (i.e., functional evenness) improved biomass production of wetland plants.

Trait

Specific leaf area

10.1002/eco.1950

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Complete mitochondrial genome of Brochis multiradiatus

Mitochondrial DNA Part B (2020)

Baohong Xu Hang Su Qiaolin Liu Ligang Lv Kaijian Chen

We reported the complete mitochondrial genome yielded by next-generation sequencing of Brochis multiradiatus in this study. The total length of the mitochondrial genome is 16,916 bp, with the base composition of 32.49% A, 25.47% T, 27.12% C, and 14.91% G. It contains 2 ribosomal RNA genes, 13 protein-coding genes, 22 transfer RNA genes, and a major non-coding control region (D-loop region). The arrangement of these genes is the same as that found in the Corydoras. The complete mitochondrial genomes of B. multiradiatus and other 12 species from Siluriformes were used for phylogenetic analysis using neighbor-joining method. The topology demonstrated that all species belong to four genera and are divided into two groups (Siluridae and Callichthyidae), the B. multiradiatus was clustered with genus Corydoras. Brochis multiradiatus' molecular classification is consistent with the external morphological feature results, so the information of the mitogenome could be used for future identification of Brochis.

10.1080/23802359.2019.1711227

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Identification of the C1qDC gene family in grass carp (Ctenopharyngodon idellus) and the response of C1qA, C1qB, and C1qC to GCRV infection in vivo and in vitro

Fish & Shellfish Immunology (2024)

Le Yang Chong Wang Yühong Huang Baohong Xu Yi Liu

Grass carp

Subfamily

10.1016/j.fsi.2024.109477

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Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Regenerative Biomaterials (2023)

Qiaolin Liu Yuliang Zhao Huige Zhou Chunying Chen

Abstract Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection and has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance and low targeting ability, hindering their clinical applications. Nanotechnology provides new opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others and have been widely researched because of their unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application of those stimuli-responsive nanomaterials in ferroptosis. Here, we describe the physiological feature of ferroptosis and illustrate the current challenges to induce ferroptosis for cancer therapy. Then, nanomaterials that induce ferroptosis are classified and elaborated according to the external and internal stimuli. Finally, the future perspectives in the field are proposed. We hope this review facilitates paving the way for the design of intelligent nano-ferroptosis inducers.

Cancer Therapy

Nanomaterials

Cancer Treatment

10.1093/rb/rbad004

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Citations (33)

Complete mitochondrail genome of Corydoras panda (Teleostei, Siluriformes, Callichthyidae, Corydoradinae)

Mitochondrial DNA Part B (2019)

Qiaolin Liu Yi Liu Tiaoyi Xiao Baohong Xu

We reported the complete mitochondrial genome yielded by next-generation sequencing of Corydoras panda in this study. The total length of the mitochondrial genome is 16,611 bp, with the base composition of 32.50% A, 26.30% T, 26.10% C, and 15.10% G, respectively. It contains two ribosomal RNA genes, 13 protein-coding genes, 22 transfer RNA genes, and a major non-coding control region (D-loop region). The arrangement of these genes is the same as that found in the Siluriformes. The complete mitogenomes of C. panda and other 18 species from Siluriformes were used for phylogenetic analysis using Neighbor-Joining method. The topology demonstrated that all species belong to nine genera are divided into three groups (Siluridae, Loricariidae, and Callichthyidae), and the C. panda was clustered with other species from genus Corydoras. Corydoras panda external morphological feature classification is consistent with the molecular classification results, so the information of the mitogenome could be used for future identification of Corydoras species.

Loricariidae

Teleostei

10.1080/23802359.2019.1660253

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Citations (4)

Automatic Dehazing Algorithm of Single Image

Journal of Chengdu University (2013)

Qiaolin Liu

In order to improve the visual quality of fog-degraded images,this paper proposes a fast image dehazing algorithm based on physical model. The algorithm starts from the atmospheric scattering model,and uses erosion and dilation to infer the atmospheric veil from the fog-degraded image. Then,the rough estimate of the atmospheric veil is refined by guided-image filtering. Finally,the scene albedo is recovered by inverting this simplified model. The experimental results show that the proposed algorithm can achieve more accurate atmospheric veil,and the edge outline and scenery features of the recovered image are clear,and the halo effect is also inhibited,and the speed of the algorithm is significantly improved,which can be used in real-time fog image processing.

Dilation (metric space)

Albedo (alchemy)

Diffuse sky radiation

Atmospheric models

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