Insulin resistance (IR) evolved from excessive energy intake and poor energy expenditure, affecting the patient's quality of life. Amino acid and acylcarnitine metabolomic profiles have identified consistent patterns associated with metabolic disease and insulin sensitivity. Here, we have measured a wide array of metabolites (30 acylcarnitines and 20 amino acids) with the MS/MS and investigated the association of metabolic profile with insulin resistance.The study population (n = 403) was randomly chosen from non-diabetic participants of the Surveillance of Risk Factors of NCDs in Iran Study (STEPS 2016). STEPS 2016 is a population-based cross-sectional study conducted periodically on adults aged 18-75 years in 30 provinces of Iran. Participants were divided into two groups according to the optimal cut-off point determined by the Youden index of HOMA-IR for the diagnosis of metabolic syndrome. Associations were investigated using regression models adjusted for age, sex, and body mass index (BMI).People with high IR were significantly younger, and had higher education level, BMI, waist circumference, FPG, HbA1c, ALT, triglyceride, cholesterol, non-HDL cholesterol, uric acid, and a lower HDL-C level. We observed a strong positive association of serum BCAA (valine and leucine), AAA (tyrosine, tryptophan, and phenylalanine), alanine, and C0 (free carnitine) with IR (HOMA-IR); while C18:1 (oleoyl L-carnitine) was inversely correlated with IR.In the present study, we identified specific metabolites linked to HOMA-IR that improved IR prediction. In summary, our study adds more evidence that a particular metabolomic profile perturbation is associated with metabolic disease and reemphasizes the significance of understanding the biochemistry and physiology which lead to these associations.
Изучено в длительном полевом опыте на дерново-подзолистой рыхлопесчаной, радиоактивно загрязненной почве действие органических, органоминеральных и минеральных удобрений, как при отдельном применении, так и в сочетании с пестицидами и биопрепаратом Гумистим, на урожайность и качество клубней картофеля сорта Кураж, возделываемого в плодосменном севообороте. Показано, что в среднем за годы исследований наиболее высокая урожайность (35,1 т/га) картофеля получена по органоминеральной системе удобрения (навоз 40 т/га + N75P30K90) в комплексе с пестицидами и биопрепаратом Гумистим. Величина прибавки урожая клубней картофеля от применения пестицидов составляла 4,8 т/га, а от биопрепарата Гумистим - 4,4 т/га. Данные средства химизации повышали товарность клубней картофеля. Наиболее высокая концентрация остаточных нитратов в клубнях картофеля отмечалась при внесении полного минерального удобрения в дозах N150P60K180 и N225P90K270, как при отдельном применении, так и в комплексе со средствами защиты растений и биопрепаратом Гумистим, но она не превышала ПДК. Удельная активность 137Сs в урожае клубней картофеля под влиянием изучаемых средств химизации по сравнению с абсолютным контролем снижалась от 2,67 до 8,0 раз. The effect of organic, organic-mineral and mineral fertilizers both in separate application and in combination with pesticides and the biopreparation Gumistim on the yields and quality of potato variety Kurazh cultivated in crop rotation has been studied in the long field experiment on sod-podzolic loose sandy, radioactively contaminated soil. It has been shown that, on average, over the years of researches, the highest yields of 35.1 t/ha of potatoes was obtained using an organomineral fertilizer system (manure 40 t/ha + N75P30K90) in combination with pesticides and the biopreparation Gumstim. The additional yields of potato tubers from the use of pesticides was 4.8 t/ha, and from biopreparation Gumistim – 4.4 t/ha. The applied chemicals increased the marketability of potato tubers. The highest concentration of residual nitrates in potato tubers was observed with the introduction of full mineral fertilizer in a dose of N150P60K180 and N225P90K270, both when used separately and in combination with plant protection products and the biopreparation Gumistim, but it did not exceed the LOC. The specific activity of 137Cs in the crop of potato tubers under the influence of the studied agrochemicals, compared with the absolute control, decreased from 2.67 to 8.0 times.
Many Earthworm (EW) related effects have been introduced so far including, wound healing effects as well as anti-microbial, anti-inflammatory and anti-thrombosis effects. EW biomaterials could also be a therapeutic agent for various neuroinflammatory conditions. Besides, indigenous people traditionally have practiced the extraction of medicinal compounds from EW. Therefore, the present study aimed to investigate the EW capacities in nerve regeneration. An exhaustive literature search was performed using databases including PubMed, Scopus, Web of Science and Google. A total of 13 studies were included. All of them included an animal model or were cell culture studies between 2009 and 2018. The description of these findings is given in table 1. Despite the limited number of publications and their controversial results, EW can be regarded as a new promising option for nerve repair, given the several pieces of evidence confirming the effects of EW biomaterials on nerve injury and regeneration.
Virus-related cancer is cancer where viral infection leads to the malignant transformation of the host's infected cells. Seven viruses (e.g., human papillomavirus (HPV), Epstein-Barr virus (EBV), Kaposi's sarcoma herpesvirus (KSHV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human T-lymphotropic virus (HTLV), and Merkel cell polyomavirus (MCV)) that infect humans have been identified as an oncogene and have been associated with several human malignancies. Recently, growing attention has been attracted to exploring the pathogenesis of virus-related cancers. One of the most mysterious molecules involved in carcinogenesis and progression of virus-related cancers is circular RNAs (circRNA). These emerging non-coding RNAs (ncRNAs), due to the absence of 5' and 3' ends, have high stability than linear RNAs and are found in some species across the eukaryotic organisms. Compelling evidence has revealed that viruses also encode a repertoire of circRNAs, as well as dysregulation of these viral circRNAs play a critical role in the pathogenesis and progression of different types of virus-related cancers. Therefore, understanding the exact role and function of the virally encoded circRNAs with virus-associated cancers will open a new road for increasing our knowledge about the RNA world. Hence, in this review, we will focus on emerging roles of virus-encoded circRNAs in multiple cancers, including cervical cancer, gastric cancer, Merkel cell carcinoma, nasopharyngeal carcinoma, Kaposi cancer, and liver cancer.
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