Dina S. El‐Agamy

Mansoura University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Gamal A. Mohamed

King Faisal Specialist Hospital & Research Centre

Sabrin R. M. Ibrahim

Batterjee Medical College

Mohamed A. Elkablawy

Menoufia University

Hany M. Abo‐Haded

Children's Hospital Mansoura University

Nishat Ahmed

Taibah University

Wael M. Elsaed

Mansoura University

Hossam M. Abdallah

King Abdulaziz University

Hani Z. Asfour

King Abdulaziz University

Ahmed A. Shaaban

Mansoura University

Dalia H. El‐Kashef

Mansoura University

Cooperative Institutions

Taibah University

King Abdulaziz University

Mansoura University

Jeddah University

Al-Azhar University

Maternity and Children's Hospital

Sohag University

King Abdul Aziz University Hospital

Menoufia University

Ain Shams University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis through enhancing SIRT1/Nrf2/HO-1 and inhibiting NF-ĸB/NLRP3 signaling pathways

Journal of Ethnopharmacology (2022)

Gamal A. Mohamed Sabrin R. M. Ibrahim Dina S. El‐Agamy Wael M. Elsaed Alaa Sirwi

Malondialdehyde

10.1016/j.jep.2022.115223

Cite

Citations (33)

Nilotinib ameliorates lipopolysaccharide-induced acute lung injury in rats

Toxicology and Applied Pharmacology (2011)

Dina S. El‐Agamy

Malondialdehyde

10.1016/j.taap.2011.03.023

Cite

Citations (49)

HEPATOPROTECTIVE ACTIVITY OF COSTUS SPECIOSUS (KOEN. EX. RETZ.) AGAINST PARACETAMOL-INDUCED LIVER INJURY IN MICE

African Journal of Traditional Complementary and Alternative Medicines (2018)

Baiaan H. AlSaadi Shoaa H. AlHarbi Sabrin R. M. Ibrahim Amal A. El-Kholy Dina S. El‐Agamy

Background: Liver diseases are a common cause of mortality and morbidity over the world. It is caused mainly by toxic chemicals and chemotherapeutic agents. Costus speciosus (Koen ex. Retz.) (Zingiberaceae) is widely employed in various traditional medicines for the prevention and treatment of different aliments. The purpose of this study is to assess the protective effect of C. speciosus rhizomes MeOH extract against the injury of the liver induced by paracetamol (PA) in mice. Material and Methods: The mice were pretreated for seven days with distilled H2O, silymarin 12 mg/kg or 100 and 200 mg/kg MeOH extract. Then, PA (750 mg/kg) was also intra-peritoneal administrated once a day. Animals were euthanatized 24 h after the damage inducement. The levels of the serum enzymes aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase, in addition to the tumor necrosis factor-alpha (TNF-α), were determined. Moreover, the histopathological examination was carried out. Results: Administration of the MeOH extract (200 mg/kg) showed improvement in the toxic effects of PA through significant fall on the serum markers enzymes of liver damage: AST, ALT, and ALP, as well as TNF-α, compared to silymarin. In parallel, the histopathological profile in the mice` liver also proved that extract markedly minimized the PA toxicity and maintained the liver tissues` histoarchitecture to near the normal ones more than that achieved by silymarin. Conclusion: The findings suggested that C. speciosus extract acts as a potential hepatoprotective agent against PA-induced liver toxicity. This hepato-protection effect may be due to the existence of steroids, saponins, different glycosides, and phenolic compounds in C. speciosus.

Zingiberaceae

Alanine aminotransferase

Liver toxicity

10.21010/ajtcamv15i2.5

Cite

Citations (9)

Protective effects of hydrogen sulfide against high glucose induced-endothelial dysfunction: An in vitro study

Journal of Taibah University for Science (2013)

Dalia H. El‐Kashef Dina S. El‐Agamy Nareman M. Gamil

This study was undertaken to investigate the effect of hydrogen sulfide against endothelial dysfunction induced by high glucose in isolated rabbit aorta. Isolated aortic rings of adult male New-Zealand white rabbits were used for the study. The endothelial dysfunction was induced by incubation with high glucose (44 mM) for 4 h. The effect of co-incubation of NaHS with high glucose was investigated using aortic reactivity measurement and estimation of oxidative stress and nitric oxide release. Incubation of aortic rings with high glucose (44 mM) for 4 h resulted in significant decrease in phenylephrine (PE)-induced contraction and a significant inhibition of acetylcholine-induced endothelium dependent relaxation (EDR); however it had no effects on sodium nitroprusside endothelium independent relaxation (EIR). High glucose produced a significant increase in lipid peroxidation and reduction in the level of superoxide dismutase (SOD) and reduced glutathione (GSH) in the aortic homogenates. In addition, high glucose produced a significant decrease in nitrite/nitrate concentrations (NOx) in the aortic homogenates. These changes were counteracted by hydrogen sulfide co-incubation as it significantly attenuated impairment in vascular reactivity. Furthermore, hydrogen sulfide showed potent antioxidant activity as well as causing a significant increase in NOx. These results suggest that hydrogen sulfide can restore impaired endothelial dysfunction induced by high glucose in isolated rabbit aorta, which may be related to scavenging oxygen free radicals and enhancing NO production.

Sodium nitroprusside

Endothelial Dysfunction

Sodium nitrite

10.1016/j.jtusci.2013.05.002

Cite

Citations (1)

Protective effect of pristimerin against LPS-induced acute lung injury in mice

International Immunopharmacology (2018)

Ahmed A. Shaaban Dalia H. El‐Kashef Mohamed F. Hamed Dina S. El‐Agamy

Proinflammatory cytokine

10.1016/j.intimp.2018.03.033

Cite

Citations (41)

Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats

Arzneimittelforschung (2011)

Shehta A. Said Dina S. El‐Agamy

The present study was designed to examine the potential preventive effect of curcumin (CMN; CAS 458-37-7), rosiglitazone (RGN; CAS 155141-29-0), N-acetylcysteine (NAC; CAS 616-91-1), resveratrol (RSV; CAS 501-36-0), and losartan (LOS; CAS 114798-26-4) on sodium valproate-induced hepatotoxicity. Sodium valproate (SVP; CAS 1069-66-5) was given at a dose of 250 mg/kg i. p. 3 times daily for one week. The tested compounds were given simultaneously with SVP for one week. The results demonstrate that CMN, RGN and NAC treatment can confer protection from SVP-induced hepatotoxicity. The second part of the study includes an evaluation of the effect of CMN, RGN and NAC on the anticonvulsant activity of SVP against pentetrazole-induced seizures in mice. The results demonstrate that CMN, RGN and NAC do not affect the anticonvulsant activity of SVP. Combined administration of either of CMN, RGN and NAC with valproate appears to be beneficial in reducing valproate-induced hepatotoxicity.

Rosiglitazone

10.1055/s-0031-1296342

Cite

Citations (12)

Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways

Cancer Management and Research (2018)

Dina S. El‐Agamy Khaled M. El-Harbi Saad Khoshhal Nishat Ahmed Mohamed A. Elkablawy

Pristimerin (Pris) is triterpenoid compound with many biological effects. Until now, nothing is known about its effect on doxorubicin (DOX)-induced cardiotoxicity. Hence, this study investigated the impact of Pris on DOX-induced cardiotoxic effects.Rats were treated with Pris 1 week before and 2 weeks contaminant with repeated DOX injection. Afterwards, electrocardiography (ECG), biochemical, histopathological, PCR, and Western blot assessments were performed.Pris effectively alleviated DOX-induced deleterious cardiac damage. It inhibited DOX-induced ECG abnormities as well as DOX-induced elevation of serum indices of cardiotoxicity. The histopathological cardiac lesions and fibrosis were remarkably improved in Pris-treated animals. Pris reduced hydroxyproline content and attenuated the mRNA and protein expression of the pro-fibrogenic genes. The antioxidant activity of Pris was prominent through the amelioration of oxidative stress parameters and enhancement of antioxidants. Furthermore, Pris enhanced the activation of nuclear factor-erythroid 2 related factor 2 (Nrf2) signaling pathway as it increased the mRNA and protein expression of Nrf2 and Nrf2-dependent antioxidant genes (GCL, NQO1, HO-1). Additionally, the anti-inflammatory effect of Pris was obvious through the inhibition of mitogen activated protein kinase (MAPK)/nuclear factor kappa-B (NF-kB) signaling and subsequent inhibition of inflammatory mediators.This study provides evidence of the cardioprotective activity of Pris which is related to the modulation of Nrf2 and MAPK/NF-kB signaling pathways.

Cardiotoxicity

10.2147/cmar.s186696

Cite

Citations (102)

Modulation of the crosstalk between Keap1/Nrf2/HO-1 and NF-κB signaling pathways by Tomatidine protects against inflammation/oxidative stress-driven fulminant hepatic failure in mice

International Immunopharmacology (2024)

Wesam H. Abdulaal Ulfat M. Omar Mustafa Zeyadi Dina S. El‐Agamy Nabil A. Alhakamy

Fulminant hepatic failure

KEAP1

10.1016/j.intimp.2024.111732

Cite

Citations (7)

Protective role of pirfenidone against experimentally-induced pancreatitis

Pharmacological Reports (2019)

Dalia H. El‐Kashef Ahmed A. Shaaban Dina S. El‐Agamy

Pirfenidone

10.1016/j.pharep.2019.04.005

Cite

Citations (16)

Agmatine protects against sodium valproate–induced hepatic injury in mice via modulation of nuclear factor‐κB/inducible nitric oxide synthetase pathway

Journal of Biochemical and Molecular Toxicology (2018)

Nishat Ahmed Naif Aljuhani Hind S. Al‐Hujaili Manar A. Al‐Hujaili Mohamed A. Elkablawy

Valproate is a widely used drug against epilepsy and several other neurological disorders although it has deleterious hepatotoxic side effects. The current study was designed to test if agmatine as nitric oxide modulator has protective effects against valproate-induced hepatic injury. Male Swiss albino mice were treated with sodium valproate (SVP) with or without agmatine for 7 days. Serum and liver samples were collected for analysis. Results have revealed that agmatine exerted hepatoprotective effects against SVP-associated hepatic injury. Agmatine ameliorated SVP-induced elevated serum biochemical markers of hepatic damage such as serum transaminases, alkaline phosphatase, γ-glutamyl transferase, and lactate dehydrogenase. Histopathological examination of the liver showed improvement of hepatic lesions in case of agmatine treatment. Furthermore, agmatine attenuated oxidative stress and enhanced antioxidants in liver tissue. Agmatine inhibited the activation of nuclear factor-κB and ameliorated the immunoexpression of inducible nitric oxide synthetase. This was accompanied by decrease in the level of inflammatory markers as nitrite/nitrate, tumor necrosis factor-α, and interleukin-6. These data provide new evidence of the hepatoprotective activity of agmatine against SVP-induced hepatotoxic effects.

Agmatine

10.1002/jbt.22227

Cite

Citations (9)