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Ümit Aydoğan

Gülhane Askerî Tıp Akademisi

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Yusuf Çetin Doğaner

Sağlık Bilimleri Üniversitesi

Oktay Sarı

University of Health Sciences Antigua

Kenan Sağlam

Gülhane Askerî Tıp Akademisi

Halil Akbulut

Turkish Armed Forces

Aydoğan Aydoğdu

Sağlık Bilimleri Üniversitesi

Alper Sönmez

Güven Hospital

James E. Rohrer

Walden University

Adem Parlak

Gazi Hastanesi

Oktay Sarı

Sağlık Bilimleri Üniversitesi

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Tuncer Çaycı

Turkish Armed Forces

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Turkish Armed Forces

127

Gülhane Askerî Tıp Akademisi

122

Military Medical Academy

Sağlık Bilimleri Üniversitesi

Ministry of Health

University of Health Sciences

University of Health Sciences Antigua

Hacettepe University

University of Health Science

Gazi University

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Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease

The Anatolian Journal of Cardiology (2014)

Yusuf Çetin Doğaner Ümit Aydoğan James E. Rohrer Aydoğan Aydoğdu Tuncer Çaycı

Several new equations (GFRCKD-EPI-cr, GFRCKD-EPI-CysC, GFRCKD-EPI Cr+CysC) are used for the calculation of estimated GFR (eGFR) to evaluate renal function. These equations explicitly demonstrate the association of coronary artery disease (CAD) and severe renal impairment cases. However, these equations are considered insufficient to explain the relation with normal or mildly impaired eGFR and CAD. Our hypothesis was to indicate the inversely proportional relationship of eGFR values, calculated by the different equations, with the presence of CAD in patients with normal or mildly impaired renal function.Eighty-eight patients who underwent elective coronary angiographic intervention were enrolled into the study. The study population was divided into two groups based on angiographic documents: patients with normal coronary arteries (CAD-) and patients with CAD (CAD +). These patients were stable and decided to implement angiography for the purpose of suspicion about CAD and control. Since it is thought that eGFR equations based on creatinine are inadequate to determine chronic kidney disease (CKD) and overestimate CKD diagnosis, cystatin C-based equations are considered an alternative. Due to the potential effects of inflammatory events of the markers used in equations, patients with diabetes mellitus, severe CKD, and inflammatory bowel disease were excluded from the study.The average age of all participants was 51.93±9.31 (32-65 years); 80.7% (n=71) was male. A statistical difference was found between the CAD (-) group and the CAD (+) group in terms of the variables of age (45.46±8.48 vs. 54.95±8.11, p<0.001), gender (67.9% vs. 86.7%, male, p=0.037), cystatin C values (1.37±0.34 vs. 0.85±0.39, p<0.001), and GFR equations defined by the Chronic Kidney Disease Epidemiology: GFRCKD-EPI-cr (85.86±14.20 vs. 79.45±10.25, p=0.018), GFRCKD-EPI-CysC (58.61±21.87 vs. 100.82±32.00, p<0.001), and GFRCKD-EPI Cr+CysC (68.29±13.49 vs. 90.75±18.34, p<0.001). After adjustment of the variables in multiple regression analyses, only age (OR, 1.199; 95% CI, 1.077 to 1.335, p=0.001), gender (OR, 8.252; 95% CI, 0.223 to 55.659, p=0.030), and the GFRCKD-EPI-CysC equation (OR, 1.059; 95% CI, 1.028 to 1.090, p<0.001) were detected as predictors for presence of CAD.GFR equations based on cystatin C or combined with creatinine may have superiority to GFR equations based on creatinine alone in CAD patients. However, the impact of different variables on the GFRCKD-EPI-CysC equation should not be ignored in specific groups, such as CAD.

10.5152/akd.2014.5535

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Women with Polycystic Ovary Syndrome Have Increased Plasma Chitotriosidase Activity: A Pathophysiological Link Between Inflammation and Impaired Insulin Sensitivity?

Experimental and Clinical Endocrinology & Diabetes (2012)

Aydoğan Aydoğdu İlker Taşçı Serkan Tapan Alper Sönmez Ümit Aydoğan

Polycystic ovary syndrome (PCOS) is characterized by insulin resistance. Chronic low grade inflammation has been reported to participate in the pathogenesis of insulin resistance. Chitotriosidase (ChT), a protein secreted by activated macrophages, has been shown to be involved in chronic inflammatory responses. In the present study, serum chitotriosidase activity and its relationship with insulin resistance were determined in patients with PCOS.34 patients with PCOS and 44 age and body mass index (BMI) matched healthy controls were enrolled in the study. ChT activity was measured by the fluorescence method. High sensitivity C reactive protein (hs-CRP) and adiponectin levels were determined by enzyme immunoassay (EIA). Insulin resistance was calculated by the homeostasis model assessment of insulin resistance (HOMA-IR) formula.Plasma ChT activity, hs-CRP level and HOMA-IR score were significantly higher (p=0.024, p=0.002, p=0.001, respectively) while plasma adiponectin concentration was significantly lower (p=0.018) in women with PCOS compared to healthy controls. Blood ChT activity correlated positively with age, waist-to-hip ratio (WHR), BMI, hs-CRP, HOMA-IR and negatively with blood adiponectin level. After adjustment for age and BMI, ChT activity, total testosterone level and WHR remained as the independent predictors of HOMA-IR score in logistic regression analysis.ChT activity is increased in patients with PCOS in concordance with insulin resistance. These findings may reflect the pronounced risk for metabolic syndrome and atherosclerotic diseases in this particular patient group.

Homeostatic model assessment

Waist–hip ratio

10.1055/s-0032-1309010

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Complaint and diagnostic profiles of breast disease patients

Meme sağlığı dergisi/Meme sağlığı dergisi (2009)

Ümit Aydoğan Halil Akbulut Oktay Sarı Murat Bilgin Salih Müjdat Balkan

Complaint

Breast disease

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Bir Eğitim Hastanesine Başvuranlarda Horlama, Habitüel Horlama, Tanıklı Apne ve İlişkili Faktörlerin Değerlendirilmesi

Tamer Onar Ümit Aydoğan Yusuf Çetin Doğaner Timur Akçam Kenan Sağlam

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A Rare Condition Causing Dysphagia: Aberrant Right Subclavian Artery

DergiPark (Istanbul University) (2016)

Adem Parlak Aykut Aytekin Sedat Develı Ümit Aydoğan Yusuf Emrah Eyı

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General approach to red eye in primary care

Turkish Journal of Family Practice (2010)

Ümit Aydoğan

Red eye

Primary (astronomy)

10.2399/tahd.10.077

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Investigation of Delay in The Diagnosis of Ankylosing Spondylitis and Associated Factors on The Diagnosis Process

Turkish Journal of Family Medicine & Primary Care (2019)

Erkan BERKE Ümit Aydoğan Yusuf Çetin Doğaner Sedat Yılmaz

Aim: Since Ankylosing Spondylitis (AS) is an insidious disease, delays may occur in the diagnosis and treatment. This study aims to reveal the initial symptoms, determine the duration between initial symptoms and the time of diagnosis and associated socio-demographic factors. Methods: This cross-sectional study was conducted in the Department of Rheumatology, University of Health Sciences Gulhane Medical Faculty in April 2015 – June 2016. A survey with 25 questions prepared by the researchers was applied to 269 participants by face-to-face interview method. Results: The median duration of the delay time in diagnosis was 2 (0.08-16) years (mean; 3.28 ± 3.32) years. The current median age was 27 (19-70) years, the median age at onset of symptoms was 21 (4-64) years, and the median age at diagnosis was 24 (11-66) years. Statistically significant positive correlations were found between the delay time in diagnosis and the current age (r=0.195, p=0.001) and the age at diagnosis (r=0.247, p

Cross-sectional study

Spondylitis

10.21763/tjfmpc.651510

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The Relationship Between Coronary Artery Disease and Undiagnosed Glucose Metabolism Disorders in Patients who Have Undergone Angiography

Turkish Journal of Endocrinology and Metabolism (2013)

Halil Akbulut Aydoğan Aydoğdu Ümit Aydoğan Cem Barçın Serkan Tapan

Address for Correspondence/Yazisma Adresi: Halil Akbulut MD, Gulhane Military Medical Academy, Department of Family Medicine, Ankara, Turkey Phone: +90 312 304 31 43 E-posta: halilakbulut@live.com Received/Gelis Tarihi: 15/05/2013 Accepted/Kabul Tarihi: 19/10/2013 Halil Akbulut, Aydogan Aydogdu*, Umit Aydogan, Cem Barcin**, Serkan Tapan***, Yusuf Cetin Doganer, Turker Turker****, Tuncer Cayci***, Ersoy Isik**, Hurkan Kursatlioglu**, Kenan Saglam

Carbohydrate Metabolism

10.4274/tjem.2366

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Prolonged usage of intravaginal clindamycin cream combined with ampicillin for the management of PPROM - a case report

Journal of the Turkish-German Gynecological Association (2011)

Cihangir Mutlu Ercan Ümit Aydoğan Kazım Emre Karaşahin İbrahim Alanbay İskender Başer

Prolonged PPROM may be catastrophic both for the mother and fetus due to ascending infections. The decision was expectant management in the setting of a spontaneous preterm premature rupture of membranes (PPROM) case and the prevention of chorioamnionitis was essential. We aimed to describe maternal and neonatal outcomes in expectant management of PPROM beginning from the 24(th) gestational week (GW) of pregnancy up to the 34(th) week under treatment with continuous usage of intravaginal clindamycin cream. We concluded that expectant active management of PPROM with antibiotics may be a suitable treatment option in carefully selected patients after receiving the patient's approval. Intravaginal clindamycin cream may be combined with systemic antibiotics (ampicillin and erythromycin) and may be a maintenance single drug for the prophylaxis of ascending vaginal infections. Uzamış PPROM asendan enfeksiyonlara bağlı anne ve bebek için oldukça kötü sonuçlar doğurabilmektedir. Spontan preterm ve prematür membran rüptürü (PPROM) ile müracaat eden olgumuzda, gelişebilecek koryoamnionit riskine karşı korunma zorunlu olup tedavi yaklaşımı ekspektan yönetim olarak belirlenmiştir. Amacımız 24. gebelik haftasında PPROM ile müracaat eden olgunun, 34. gebelik haftasına kadar intravajinal klindamisin kremin sürekli kullanımı ile takibi ve maternal, neonatal sonuçlarını tariflemektir. Sonuç olarak, PPROM olgularında antibiyotikler ile ekspektan aktif yönetim, dikkatli seçilmiş ve onamı alınmış olgularda uygun tedavi yaklaşımı olabilir. Asendan enfeksiyonlardan korunmada vajinal klindamisin sistemik antibiyotiklerle (ampisilin ve eritromisin) kombine tercih edilebileceği gibi idame tedavide tek ajan olarakta kullanılabilir.

10.5152/jtgga.2011.28

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Retrospective Analysis Of End Stage Renal Failure Patients Followed Up In Nephrology Department Between 2005 And 2010

Turkish Nephrology Dialysis Transplantation (2012)

Salim Özenç Mahmut İlker Yılmaz Murat Celiktepe Cengizhan Açıkel Kenan Sağlam

OBJECTIVE: End stage renal failure (ESRF) is irreversible impairment of renal functions that makes surviving impossible without dialysis or renal transplantation. In the present study, we aimed to put forward the characteristics of end stage renal failure (ESRF) patients who were followed up by Nephrology Department between 2005 and 2010. MATERIAL and METHODS: This study was carried out through retrospective analysis of the records of a total of 589 end stage renal failure patients followed up in Department of Nephrology, Gulhane Military Medical Academy and Military Medical School between 2005 and 2010 and received dialysis or underwent transplantation. RESULTS: Of the patients in study group, 71.2% (334 patients) were males and 28.8% (135 patients) were females. The percentage of the patients who had progressed to end stage renal failure was 37.6% in 20-44 age group, and 33% in 65 years and above group. There was a statistically signifi cant difference in terms of distribution of age groups according to gender (p<0.05). Hypertension was the most common disease in both gender among ESRF patients (45%) followed by diabetes mellitus (25.4%). Of renal transplantations, 87 were from live donors and 48 were from cadavers. 48.3% of live donors were composed of mothers. A total of 88 patients underwent biopsy (65 males and 23 females). FSGS was the most common histopathologic diagnosis (29.3%).. doi: 10.5262/tndt.2012.1003.09 Yazisma Adresi: Salim OZENC Gulhane Askeri Tip Akademisi, Aile Hekimligi, Ankara, Turkiye Gsm : 0 538 820 00 64 E-posta : salim.ozenc@yahoo.com Gelis Tarihi : 24.04.2011 Kabul Tarihi : 03.11.2011 Ozenc S ve ark: 2005–2010 Yillari Arasinda Nefroloji Bolumunde Takip Edilen Son Donem Bobrek Yetmezligi Hastalarinin Geriye Donuk Analizi Turk Neph Dial Transpl 2012; 21 (3): 253-257 254 Turk Nefroloji Diyaliz ve Transplantasyon Dergisi Turkish Nephrology, Dialysis and Transplantation Journal Demografi k ozellik olarak;yas yil olarak belirtildi. 0–19, 20– 44, 45–64 ve 65 yas uzeri olarak gruplandirildi. Erkek ve kadin olmak uzere her iki cins calismaya alindi. Son donem bobrek yetmezlikli hastalarin laboratuvar verilerinden serum ure, kreatinin ve albumin degeri mg/dl, 24 saatlik idrarda protein miktari mg/gun olarak diyaliz tedavisi oncesi ve sonrasi seklinde kayit edildi. Bobrek nakli yapilan hastalarin da ayni laboratuvar degerlerine bakildi. Bobrek nakli tedavisi olmadan onceki biyokimyasal degerleri ve nakil olduktan sonraki biyokimyasal degerleri dosyalarindan bulundu ve karsilastirildi. Bobrek nakli yapilan hastalarin, nakillerinin canlidan mi yoksa kadavradan mi olduklari belirtildi. Canlidan nakil olanlar; anne, baba, kardes, akraba ve akraba olmayan olarak diye sinifl andirildi. Son donem bobrek yetmezligi hastalarinin ek hastaliklari olup olmadigi, varsa bunlarin hangi hastaliklar oldugu kaydedildi. Elde edilen veriler SPSS paket istatistik programina aktarilarak bilgisayar ortaminda degerlendirildi. Verilerin istatistiksel analizinde sayisal olmayan verilerde bagimsiz gruplarin karsilastirmasinda ki-kare testi, eslestirilmis gruplarda t testi kullanildi p<0.05 anlamli kabul edildi.

Nephrology

10.5262/tndt.2012.1003.09

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