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Shigeyuki Nakamura

Ministry of Agriculture, Forestry and Fisheries

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Yoshihiro Sakoda

Hokkaido University

Shōko Suzuki

Mitsubishi Tanabe Pharma Corporation

Akio Fukusho

Nippon Veterinary and Life Science University

Makiko Harada

OncoTherapy Science (Japan)

Hiroshi Aoki

Teikoku Seiyaku (Japan)

Yoshimitsu INOUE

Ministry of Agriculture, Forestry and Fisheries

Tomoaki Shimazaki

Ministry of Agriculture, Forestry and Fisheries

Yohko SHIMAZAKI

Ministry of Agriculture, Forestry and Fisheries

Chieko Tanimura

Ministry of Agriculture, Forestry and Fisheries

Hideharu Sasaki

Ministry of Agriculture, Forestry and Fisheries

Cooperative Institutions

Hokkaido University

Ministry of Agriculture, Forestry and Fisheries

Nippon Veterinary and Life Science University

Tokyo University of Agriculture and Technology

Suzuki (Japan)

Ministry of Agriculture Forestry and Fisheries

The University of Tokyo

National Institute of Animal Health

Kagoshima University

Osaka University

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Molecular, biological, and antigenic characterization of a Border disease virus isolated from a pig during classical swine fever surveillance in Japan

Journal of Veterinary Diagnostic Investigation (2014)

Makoto Nagai Hiroshi Aoki Yoshihiro Sakoda Takashi Kozasa Kaho Tominaga-Teshima

In the current study, molecular, biological, and antigenic analyses were performed to characterize Border disease virus (BDV) strain FNK2012-1 isolated from a pig in 2012 in Japan. The complete genome comprises 12,327 nucleotides (nt), including a large open reading frame of 11,685 nt. Phylogenetic analysis revealed that FNK2012-1 was clustered into BDV genotype 1 with ovine strains. FNK2012-1 grew in porcine, bovine, and ovine primary cells and cell lines, but grew better in bovine and ovine cells than in porcine cells. Specific pathogen-free pigs inoculated with FNK2012-1 did not show any clinical signs. Noninoculated contact control pigs also did not show clinical signs and did not seroconvert. The results suggest that FNK2012-1 may be of ruminant origin and is poorly adapted to pigs. Such observations can provide important insights into evidence for infection and transmission of BDV, which may be of ruminant origin, among pigs.

Domestic pig

Classical swine fever

10.1177/1040638714541837

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Citations (17)

Inhibitory effect of heparin on Rhabdovirus and Bunyavirus isolated from cattle

Australian Veterinary Journal (1993)

Shigeyuki Nakamura Yoshihito Ishihara K. Ishikawa Tomoaki Shimazaki Y. Inoue

Epizootiology

National laboratory

10.1111/j.1751-0813.1993.tb08046.x

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Citations (5)

High-performance liquid chromatographic determination of pamaquine, primaquine and carboxy primaquine in calf plasma using electrochemical detection

Journal of Chromatography B Biomedical Sciences and Applications (1992)

Y. S. Endoh H. Yoshimura Nobuo Sasaki Yoshihito Ishihara Hideharu Sasaki

Primaquine

10.1016/0378-4347(92)80370-6

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Citations (16)

Genipin, a New Type of Protein Crosslinking Reagent from Gardenia Fruits

Agricultural and Biological Chemistry (1988)

Shigeaki Fujikawa Shigeyuki Nakamura Kunimasa Kooa

Journal Article Genipin, a New Type of Protein Crosslinking Reagent from Gardenia Fruits Get access Shigeaki Fujikawa, Shigeaki Fujikawa Institute for Fundamental Research, Sun tory Ltd., Shimamoto-cho, Mishima-gun, Osaka 618, Japan Search for other works by this author on: Oxford Academic Google Scholar Shigeyuki Nakamura, Shigeyuki Nakamura Institute for Fundamental Research, Sun tory Ltd., Shimamoto-cho, Mishima-gun, Osaka 618, Japan Search for other works by this author on: Oxford Academic Google Scholar Kunimasa Kooa Kunimasa Kooa Institute for Fundamental Research, Sun tory Ltd., Shimamoto-cho, Mishima-gun, Osaka 618, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 52, Issue 3, 1 March 1988, Pages 869–870, https://doi.org/10.1080/00021369.1988.10868755 Published: 01 March 1988 Article history Received: 27 October 1987 Published: 01 March 1988

Genipin

Gardenia

10.1080/00021369.1988.10868755

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Citations (43)

Cleavage of the NS2‐3 protein in the cells of cattle persistently infected with non‐cytopathogenic bovine viral diarrhea virus

Microbiology and Immunology (2008)

Ken‐ichiro Kameyama Yoshihiro Sakoda Keita Matsuno Asako Ito Motoshi Tajima

ABSTRACT The NS2‐3 of BVDV is cleaved in cultured cells infected with cp BVDV but not in those infected with ncp BVDV when tested more than 10 hours post infection. However, it is not known whether cleavage of NS2‐3 occurs in vivo . In the present study, cleavage of NS2‐3 in cattle persistently infected with BVDV was investigated. All BVDV isolated from PI animals were of the ncp biotype, and NS2‐3 proteins were detected in bovine fetal muscular cells infected with these viruses. On the other hand, in the leukocytes of those PI animals, NS3 proteins, products of the cleavage of NS2‐3 proteins, were detected. In addition, the NS3 proteins were also detected in leukocytes artificially infected with ncp BVDV. These results reveal that the NS2‐3 protein of BVDV is cleaved in leukocytes. Furthermore, NS3 proteins were detected in many tissues of PI cattle, such as lymphoid tissue, brain, thyroid, lung, and kidney. These results suggest that the NS2‐3 protein of ncp BVDV cleaves in vivo .

Cleavage (geology)

Cattle Diseases

10.1111/j.1348-0421.2008.00013.x

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Citations (9)

Variation from Cytopathogenic Biotype to Non-Cytopathogenic Biotype is Correlated with the Deletion of Cellular Sequence from Bovine Viral Diarrhea Viruses.

Journal of Veterinary Medical Science (1997)

Shigeyuki Nakamura Kenichi Sakamoto Yoshihiro Sakoda Tomoaki Shimazaki Yoshimitsu INOUE

Non-cytopathogenic (NCP) viruses of bovine viral diarrhea (BVD) virus were detected at a low ratio by the reverse plaque formation method from virus samples after several plaque clonings of cytopathogenic (CP) BVD viruses; NADL and Osloss strains. This phenomenon suggests that the NCP BVD viruses are produced at a low ratio during the propagation of CP BVD viruses in vitro. To investigate the differences between the parent CP BVD virus and the NCP BVD virus as a real progeny, the regions flanking the insertion of cellular mRNA in the p125 domain of NADL and Osloss strains were amplified by RT-PCR and cloned into pGEM 3Z plasmid vector, and then sequenced. Consequently, it was confirmed that sequences of cellular mRNA insertion of CP BVD viruses, NADL and Osloss strains, were completely and exactly deleted from the NCP BVD viruses which were real progeny of CP BVD viruses, NADL and Osloss strains. These results suggest that NCP BVD viruses may revert from CP biotype to NCP biotype by the deletion of cellular mRNA insertion in the viral genome of CP BVD viruses (NADL and Osloss strains).

Pestivirus

10.1292/jvms.59.361

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Citations (8)

The pharmacokinetics of primaquine in calves after subcutaneous and intravenous administration

Veterinary Research Communications (1993)

H. Yoshimura Y. S. Endoh Yoshihito Ishihara Shigeyuki Nakamura Y. Inoue

Primaquine

Half-life

Drug Administration

10.1007/bf01839241

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Citations (2)

Methods to select suitable fetal bovine serum for use in quality control assays for the detection of adventitious viruses from biological products

Biologicals (2011)

Takashi Kozasa Hiroshi Aoki Nao Nakajima Akio Fukusho Masatoshi Ishimaru

Pestivirus

Fetal bovine serum

10.1016/j.biologicals.2011.06.001

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Citations (33)

Introduction of an update system for vaccine strains of veterinary influenza vaccines in Japan

Biologicals (2015)

Koichiro GAMOH Shigeyuki Nakamura

Equine influenza

Culling

Christian ministry

Inactivated vaccine

Vaccine efficacy

10.1016/j.biologicals.2014.12.003

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Citations (7)

Effects of Enalapril in children with IgA Nephropathy.

Japanese journal of pediatric nephrology (1995)

Makoto Ninomiya T Ohkawa Yasuhiro Kiyoshi Ryuji Nakashima Shigeyuki Nakamura

小児IgA腎症18例に対してAngiotensin変換酵素阻害剤であるEnalaprilまたは抗血小板剤であるDipyridamoleを2年間投与し，尿所見および組織所見を比較検討した。Enalapril投与群 (E群)，Dipyridamole投与群 (D群) 共に，軽症例は単独投与とし，中等症例にはPrednisolone，Azathioprine，Heparin，Warfarinをそれぞれ併用した。 E群では尿所見の有意な改善を認め，組織所見で増悪の所見は認めず，急性病変の一部に有意な改善を認めた。D群では尿所見で改善は認めず，組織所見で細胞増殖スコアの有意な減少を認めたが，慢性病変とChronicity Indexの有意な増悪を認めた。2年の治療後，E群はD群に比し尿所見は改善し，組織障害も軽度であった。以上より小児IgA腎症に対してEnalaprilは，Dipyridamoleに比し有効である可能性が示唆された。

Dipyridamole

Prednisolone

10.3165/jjpn.8.137

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