Leonor Maria Pacheco Santos

Universidade de Brasília

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Fabrício Vieira Cavalcante

Universidade de Brasília

Mauro Niskier Sanchez

Fundação Oswaldo Cruz

Wallace dos Santos

Universidade de Brasília

Ivana Cristina de Holanda Cunha Barreto

Fundação Oswaldo Cruz

Helena Eri Shimizu

Universidade de Brasília

Erly Catarina de Moura

Universidade de Brasília

Muriel Bauermann Gubert

Universidade de Brasília

Maurício L. Barreto

Universidade Federal da Bahia

Everton Nunes da Silva

Universidade de Brasília

Gustavo Saraiva Frio

Pontifícia Universidade Católica do Rio Grande do Sul

Cooperative Institutions

Universidade de Brasília

124

Fundação Oswaldo Cruz

Universidade Federal da Bahia

Ministério da Saúde

Instituto de Saúde

Ministério da Saúde

Universidade de São Paulo

Universidade Federal da Paraíba

Universidade Federal do Rio de Janeiro

Hospital Ana Nery

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Health collapse in Manaus: the burden of not adhering to non-pharmacological measures to reduce the transmission of Covid-19

Saúde em Debate (2021)

Ivana Cristina de Holanda Cunha Barreto Raimundo Valter Costa Filho Ronaldo Ramos Luciana Gonzaga de Oliveira Natália Regina Alves Vaz Martins

ABSTRACT This article aims to compare the evolution of Covid-19 in Manaus and Fortaleza, two epicenters of the pandemic in 2020, analyzing legal measures by local governments and levels of social isolation. An algorithm was defined to calculate the Homestay Index (HSI), using data from the Google Mobility Report. We analyzed the decree’s timeline, the HSI evolution, the Covid-19 incidence and the number of deaths from March/2020 to January/2021. The population of Fortaleza was exposed to more consistent measures of social distancing than that of Manaus. Longer homestay was observed from March to May 2020 and Fortaleza achieved higher and more lasting levels. As of June 2020, the HSI fell, notably in Manaus, reaching levels below zero in late December. As an aggravating factor, the government decreed broad isolation in Manaus on December 23, 2020, but after protests it was repealed on December 26, 2020. A judicial decision determined the complete closure in Manaus on January 2nd 2021, but it was too late: the SUS collapsed with an exponential increase in deaths. In Fortaleza, the demand for health services was high, but under control. We consider that only the strict application of non-pharmacological measures and mass immunization can prevent further deaths.

Pandemic

Decree

Social distance

Isolation

Time line

10.1590/0103-1104202113114i

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Citations (18)

Laboratory Readiness and genomic surveillance of Covid-19 in the Capital of Brazil

medRxiv (Cold Spring Harbor Laboratory) (2024)

Fabrício Vieira Cavalcante Christina Pacheco Gustavo Saraiva Frio Rodrigo G. Stábeli Leonor Maria Pacheco Santos

Abstract Objective Analyze the diagnostic readiness to Covid-19 and the genomic surveillance of SARS-CoV-2 in Brasília, the capital of Brazil. Method Retrospective, cross-sectional study, with data from: cases/deaths - Ministry of Health; RT-PCR analyzes Brasília Central Public Health Laboratory (LACEN); genomics - Global Initiative on Sharing All Influenza Data (GISAID). Results In March 2021, with the Gamma variant being predominant, RT-PCR dosages by LACEN reached their peak, followed by a reduction, possibly due to the start of vaccination. New peaks were observed in September 2021 and January 2022. The average time for releasing RT-PCR results was reduced from eight days (July 2020), to around eight hours in 2023. The participation of private laboratories was evident in sequencing the SARS-CoV-2 variants of concern in Brasília (n=1,897). LACEN received 571 samples, sequencing 50%. A decrease in the incidence of cases and deaths due to Covid-19 was noted in the years 2022 to 2023, following the national trend. Conclusion LACEN maintained RT-PCR dosages satisfactorily throughout the period. Regarding the genomic surveillance of SARS-CoV-2, the vast majority of samples were sequenced by private laboratories and the sequencing predicted by LACEN was not covered in its entirety.

Capital (architecture)

2019-20 coronavirus outbreak

10.1101/2024.05.10.24307182

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Transição nutricional e a organização do cuidado em alimentação e nutrição na Atenção Básica em saúde

Divulg. saúde debate (2014)

Patrícia Constante Jaime Leonor Maria Pacheco Santos

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Tolerance to administration of massive doses of vitamin A associated to mass immunization of children in Northeast Brazil

Ana Marlúcia Oliveira Assis Leonor Maria Pacheco Santos Matildes Silva Prado Maísa Cruz Martins Maurício L. Barreto

A follow-up study was carried out in two localities in the semi-arid region of the State of Bahia, Northeast Brazil, with the aim of identifying the occurrence and nature of possible acute side effects subsequent to vitamin A megadose supplement given together with mass immunization in children 6-59 months old. The sample consisted of 852 children, 416 from the county of Teofilandia who received vitamin A together with vaccines and 436 from Santa Barbara, who received only vaccine. In the 24 hours before immunization, children from both groups had similar incidences of diarrhea, fever, and vomiting. Anorexia was more prevalent in Teofilandia and remained so throughout the study period. The results suggest that acute side effects like diarrhea, vomiting, fever, or anorexia were not associated with the vitamin A dosage given with mass OPV, DPT, and measles immunization.

Anorexia

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Tipologia da estrutura das Unidade Básicas de Saúde do Distrito Federal

Saúde em Debate (2024)

Denise de Lima Costa Furlanetto Wallace dos Santos Fabrício Vieira Cavalcante Mayra Fernandes Xavier Adriano de Almeida de Lima

RESUMO A tipologia da estrutura é um indicador composto que compreende a estrutura física, a disponibilidade de equipamentos, recursos materiais e humanos, além dos sistemas de informação. Com o objetivo de desenvolver uma tipologia para avaliar as Unidades Básicas de Saúde (UBS) do Distrito Federal (DF), construiu-se um instrumento com 43 variáveis, a partir da proposta de tipologia nacional. Entre agosto/2020 e janeiro/2021, coletaram-se dados nas UBS e nos sistemas de informação do DF. Na análise, ponderando as dimensões, gerou-se a classificação nos tipos A, B, C, D e E (A adequada/E insuficiente). Das 165 UBS existentes, 157 forneceram dados completos para avaliação. Três UBS obtiveram classificação Tipo A, máxima, representando 1,9% do total; 53 UBS do Tipo B (33,8%); 52 do Tipo C (33,1%); 30 do Tipo D (19,1%) e 19 do Tipo E (12,1%). Nove UBS apresentaram pontuação muito baixa em ‘serviços disponíveis’, expondo indisponibilidade de vacinação, teleatendimento, exames, medicamentos e incompletude de equipes. O resultado evidenciou que as UBS do DF necessitam de melhorias estruturais, que, em consonância com as demais ações previstas no Programa Qualis-APS, contribuirá para a melhoria da qualidade da atenção primária no DF e o desenvolvimento do pleno potencial das equipes de saúde.

10.1590/2358-28982024e28903p

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Ethnic differences in maternal near miss

Archives of Gynecology and Obstetrics (2017)

Karayna Gil Fernandes Renato T. Souza Maria C Leal Erly Catarina de Moura Leonor Maria Pacheco Santos

Human genetics

10.1007/s00404-017-4530-6

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Citations (8)

Disponibilidade de dados públicos em tempo oportuno para a gestão: análise das ondas da COVID-19

SciELO (SciELO Preprints) (2021)

Erly Catarina de Moura Everton Nunes da Silva Mauro Niskier Sanchez Fabrício Vieira Cavalcante Luciana Gonzaga de Oliveira

O objetivo deste estudo é apoiar a gestão em saúde, com informações recentes e confiáveis, durante a pandemia de COVID-19. Casos notificados e confirmados e óbitos por COVID-19 foram avaliados a partir de três bancos de dados públicos.1) Dados do Painel Coronavírus do Ministério da Saúde, atualizados diariamente, mostram a existência de duas ondas epidêmicas. 2) O Portal da Transparência do Registro Civil, também com dados recentes, aponta altas taxas de mortalidade do COVID-19, especialmente nas faixas etárias mais velhas. 3) Os casos notificados pelo Sistema de Informação da Vigilância Epidemiológica da Influenza (Sivep-gripe), confirmados principalmente por exame laboratorial, mostram predominância de homens, faixas etárias elevadas, raça/cor branca, residência em áreas urbanas, presença de comorbidades, maior ocorrência de internação e menor uso de unidade de terapia intensiva. Esta última base de dados, além da primeira onda, registra apenas as primeiras oito semanas epidemiológicas da segunda onda. A vertiginosa taxa de aumento de casos e óbitos na segunda onda aponta para a necessidade de medidas mais drásticas de distanciamento social, além da expansão da vacinação contra o COVID-19. A combinação dos três bancos expande as informações, que podem apoiar a tomada de decisões em tempo oportuno.

10.1590/scielopreprints.2316

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A dimensão da insegurança alimentar

Revista de Nutrição (2008)

Rosângela Alves Pereira Leonor Maria Pacheco Santos

The dimension of food insecurity EDITORIALIn a time where the whole world gathers around the problem of feeding six billion people, the food insecurity theme becomes central, exceeding the limits of academic debate and reaching the great media.Of unquestionable relevance, this theme has been receiving contributions from different approaches and occupies, to an ever-growing extent, the scenario of public policies.The growing attention devoted to the theme in Brazil is very positive as it resulted in the inclusion of a module to investigate food security in surveys done by Instituto Brasileiro de Geografia e Estatística (IBGE) 1 and in an increased supply of funds for researches on the theme -consequently -in more scientific production in this area.This special issue was planned with the objective of promoting the debate among different segments that deal with food insecurity and, this way, contributing to the advance and improvement of research in this area.

10.1590/s1415-52732008000700002

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Diretrizes nacionais para biorrepositório e biobanco de material biológico humano

Revista da Associação Médica Brasileira (2013)

Gabriela Marodin Jennifer Braathen Salgueiro Márcia da Luz Motta Leonor Maria Pacheco Santos

Caracterizar a construção participativa e democrática das Diretrizes Nacionais para Biorrepositório e Biobanco de Material Biológico Humano com Finalidade de Pesquisa, baseada nos princípios éticos da dignidade humana, da autonomia, da beneficência, da justiça e da precaução. Para a elaboração do documento formou-se um grupo de trabalho interdisciplinar considerando os seguintes critérios: experiência na operacionalização de biobancos, representatividade regional, tipo de material biológico acondicionado e especialistas em bioética. Participaram, também, membros da Agência Nacional de Vigilância Sanitária – Anvisa, pela competência regulatória e da Comissão Nacional de Ética em Pesquisa – Conep, enquanto controle social. O documento, baseado nos preceitos éticos, legais e técnicos, apresenta os conceitos, as atividades, finalidades e diferenças entre biorrepositórios e biobancos, as formas de consentimento do sujeito, além de outros aspectos permeados pela preocupação do uso adequado da informação. As Diretrizes Nacionais para Biorrepositório e Biobanco de Material Biológico Humano com Finalidade de Pesquisa contém 39 artigos, dispostos em cinco capítulos. A importância de uma regulamentação surge da reflexão ética, considerando a moral, e tendo como norteador os aspectos legais, os quais se traduzem em um documento que não se esgota em si mesmo. A dinamicidade da ciência sempre nos remete à mudança de paradigmas, que podem ir além das legislações existentes. To characterize the participatory and democratic creation of the Brazilian guidelines for biorepositories and biobanks of human biological material with the purpose of research based on the ethical principles of human dignity, autonomy, beneficence, justice, and precaution. An interdisciplinary work group was constituted to prepare the document, considering the following criteria: experience in biobank operation, regional representation, type of stored biological material, and bioethics specialists. Members of the National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária – Anvisa), also participated due to their regulatory competence. Members from the National Commission on Ethics in Research (Comissão Nacional de Ética em Pesquisa – Conep) participated as the social control organization. The document, based on ethical, legal, and technical guidelines, presents the concepts, activities, purposes, and differences between biorepositories and biobanks; forms of consent on the part of the subject; in addition to other aspects permeated by concerns regarding the appropriate use of information. The Brazilian guidelines for biorepository and biobank of human biological material with the purpose of research contains 39 articles, which are distributed in five chapters. The importance of legislation arises from the ethical concern, considering morals and taking into account the legal aspects, which translate into a document that does not end in itself. The dynamics of science always leads to changes in paradigms, which can go beyond the existing laws.

10.1590/s0104-42302013000100014

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Citations (11)

Case study: coproduction of the Qualis-APS program to increase quality in Primary Health Care in Brasília

Saúde em Debate (2024)

Leonor Maria Pacheco Santos Magda Duarte dos Anjos Scherer Denise de Lima Costa Furlanetto Cláudia Mara Pedrosa Maria Silvia Fruet de Freitas

ABSTRACT To encourage improvements in the quality of Primary Health Care in Brasília, the Federal District Health Department established the Qualis-APS Program in 2019, a co-production between healthcare professionals, managers and researchers from the University of Brasília and the Fundação Oswaldo Cruz. By involving managers and workers in the design, coordination, planning and execution, the aim was to promote engagement and a sense of ownership, prerequisites for evidence-based decision-making. The aim is to describe the conception and implementation of the evaluative process and the stages of the first evaluation cycle, concluded in 2022. I. Diagnosis of the structure of all 165 Basic Health Units; II. Elaboration of quality standards to compose self-assessment instruments, based on subsidies obtained in workshops with 544 health professionals and users; III. Development of the Qualis-APS Platform; IV. Self-assessment of the 603 Family Health Teams/Oral Health Teams, 100 Primary Health Care Management Teams and 59 Teams from the Expanded Family Health and Primary Care Centers on the Platform; V. Planning and elaboration of the Action Plan for Quality, made by the teams; VI. On-site evaluation of the Basic Units, by external researchers; VII. Certification of teams by the Health Department. The experience of the first cycle was successful and the second cycle is ongoing now.

Coproduction

10.1590/2358-28982024e28830i

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