Seyede Nargess Sadati Lamardi

Tehran University of Medical Sciences

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Mahdi Vazirian

Tehran University of Medical Sciences

Mohammad Sharifzadeh

Tehran University of Medical Sciences

Mohammad Reza Shams Ardekani

Tehran University of Medical Sciences

Mahnaz Khanavi

Tehran University of Medical Sciences

Malihe Tabarrai

Tehran University of Medical Sciences

Laila Shirbeigi

Tehran University of Medical Sciences

Paria Sharafi-Badr

Iran University of Medical Sciences

Zahra Majidi

Birjand University of Medical Sciences

Seyed Nasser Ostad

Tehran University of Medical Sciences

H. R. Monsef‐Esfahani

Tehran University of Medical Sciences

Cooperative Institutions

Tehran University of Medical Sciences

University of Tehran

Tabriz University of Medical Sciences

Islamic Azad University Pharmaceutical Sciences Branch

Iranshahr University

Iran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Tarbiat Modares University

Saarland University

Academic Center for Education, Culture and Research

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Effectiveness of Persian Golnar on Excessive Menstrual Bleeding in Women with Abnormal Uterine Bleeding, Compared to Tranexamic Acid: A Triple‐Blind, Randomized Equivalence Trial

Evidence-based Complementary and Alternative Medicine (2023)

Somayeh Es-haghee Ashteany Marzieh Vahid Dastjerdi Malihe Tabarrai Fatemeh Nejatbakhsh Seyede Nargess Sadati Lamardi

Abnormal uterine bleeding (AUB) is a major healthcare problem in females of reproductive age and impacts women's health and quality of life (QoL). This study aimed to test the equivalence of Persian Golnar (PG) and tranexamic acid (TA) for the treatment of excessive menstrual bleeding.A triple-blind randomized equivalence trial with parallel design and block randomization technique was performed. A total of 80 patients with AUB were randomly allocated to receive either PG or TA for three consecutive menstrual cycles. Blood loss was measured by the Pictorial Blood Loss Assessment Chart (PBAC). Hematological evaluations were done before the intervention and after treatment. QoL and premenstrual dysphoric disorder (PMDD) as secondary outcomes were assessed using the menorrhagia questionnaire (MQ) and Premenstrual Symptoms Screening Tool (PSST). Statistical analysis was performed using an independent t-test, paired t-test, χ2 test, Mann-Whitney test, and Wilcoxon signed-rank test.Seventy-six women completed the 12-week follow-up. Both PG and TA groups experienced a significant reduction in blood loss. Furthermore, the serum level of hemoglobin in the PG group enhanced significantly (P < 0.001). QoL and PMDD scores were significantly improved in both groups (P< 0.001).The findings of the current trial supposed that the Golnar product is as effective as tranexamic acid in controlling bleeding and enhancing the quality of life and premenstrual symptoms.

Menstruation

10.1155/2023/5355993

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Citations (1)

Urtica pilulifera L. seed extract promotes folliculogenesis and alleviates the diminished ovarian reserve in the Balb/c mice model: An experimental study

International Journal of Reproductive BioMedicine (IJRM) (2024)

Sharareh Hekmat Mohammad Sharifzadeh Tayebeh Toliyat Roghayeh Savary Kouzehkonan Mozhgan Mehri Ardestani

Background: Urtica pilulifera L. seed (UPS) is a Persian traditional medicine prescription that positively affects female infertility. Objective: This study aimed to evaluate the beneficial effects of UPS on a diminished ovarian reserve (DOR) model induced by cyclophosphamide in Balb/c mice. Materials and Methods: A single intraperitoneal (75 mg/kg) of cyclophosphamide was administered to establish a DOR model. 25 female Balb/c mice (6–8 wk, 25 ± 2 gr) were randomly divided into 5 groups (n = 5/each), including control (normal saline), model (DOR), DOR+50, DOR+100, and DOR+200 (mg/kg UPS, gavage) groups for 14 days. The levels of follicle-stimulating hormone, luteinizing hormone, estradiol, malondialdehyde, superoxide dismutases, apoptosis, and histopathological alterations were analyzed. Gas chromatography-mass spectrometry analysis was performed to identify the phytochemicals of the UPS. Results: It was observed that the UPS extract reduced malondialdehyde concentration and apoptosis in the DOR model as well as enhanced superoxide dismutases activity in the ovaries in a dose-dependent manner. Moreover, it exerted a modulatory effect on steroidal hormones such as follicle-stimulating hormone, luteinizing hormone, and estradiol. The histopathological analysis revealed the therapeutic potential of the UPS extract. The main chemical components of UPS were linoleic acid (59.25%), n-hexadecanoic acid (10.36%), and oleic acid (8.29%). Conclusion: The results indicated that the UPS extract has therapeutic potential in the DOR model. This potential is attributed to the reduction of oxidative stress, modulation of apoptosis, and regulation of steroidal hormones that may be associated with the observed beneficial effects of fatty acids on fertility improvement. Key words: Apoptosis, Fatty acids, Female infertility, Herbal medicine, Persian medicine, Oxidative stress.

Malondialdehyde

10.18502/ijrm.v22i2.15708

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Evaluation of some medicinal plants effect on Rhodamine 123 accumulation and efflux in Caco-2 cell line by flowcytometry

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Seyede Nargess Sadati Lamardi N. Golbashirzadeh Mohammad Reza Shams Ardekani Gholamreza Amin Seyed Nasser Ostad

Background and objectives: In review of traditional Persian medicine (TPM) literature concerning multi drug therapy, a group of medicinal plants that are called convoy drugs, agents which penetrate fast into whole or specific part of the body and accelerate delivery of drugs into specific target has been mentioned. In this study, the inhibitory effect of the aqueous extracts of some selected medicinal plants on P-glycoprotein (P-gp) was assessed in order to determine the possibility of herb-drug interactions. Methods: P-gp inhibitory effect of aqueous extracts (250 µg/mL) from some medicinal plants and verapamile (5 µg/mL) was measured using flow cytometry by Rhodamine 123 (Rh123) in Caco2 cell line. Inhibition percent of each sample (%) was compared with a control group (Caco-2 cell with Rh 123). Results: According to the results pennyroyal, aniseed (p<0.001), celery seed, melon seed and white agaric extract (p<0.01) exhibited the highest Rh123 percent in Caco-2 cells that could be associated with inhibitory effect on P-gp efflux activity. Conclusion: Considering that pennyroyal and aniseed showed the highest inhibitory effect on P- glycoprotein, pharmacokinetic interactions of these plants and P-gp substrates should be planned in future. Further studies about the effects of these plants on the pharmacokinetics of oral drugs should be considered.

Efflux

Rhodamine 123

Caco-2

Rhodamine

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Comparison between the Efficacy of Nigella sativa-Honey and Clotrimazole on Vulvovaginal Candidiasis: A Randomized Clinical Trial

Evidence-based Complementary and Alternative Medicine (2022)

Masoumeh Norouzi Allahleh Korabi Seyedeh Tahereh Mirmolaei Malihe Tabarrai Seyedeh Mojgan Ghalandarpoor‐Attar Seyede Nargess Sadati Lamardi

Background and Objective. Vulvovaginal candidiasis (VVC) is one of the most troublesome opportunistic infections in women. In recent years, its prevalence has increased significantly because different types of Candida yeast are resistant to common antifungal medications, supplements, and herbs have become common. This research aimed to compare the effects of N. sativa-honey vaginal cream and 1% clotrimazole on VVC. Materials and Methods. This triple-blind, randomized controlled trial was conducted on eighty-four 18 to 49-year-old nonpregnant women from August 2019 to February 2020. The subjects were randomly divided into two groups after confirming the diagnosis of VVC infection through fungal culture. Clinical signs and symptoms and lab tests were recorded at baseline and 6–10 days after treatment. The treatment time for each group was seven nights. Results. There were no significant differences in clinical and laboratory evaluations between the two groups at the beginning of the study (P > 0.05). After treatment, secretion, redness, itching, and fungal culture improved in the two groups (P < 0.001), while pruritus (p = 0.013) and secretion (p = 0.025) in the control group significantly improved. In this trial, no patients showed drug-specific side effects. Conclusion. The results of this study show that the N. sativa-honey significantly improves the symptoms of VVC; thus, the application of N. sativa-honey can be considered as a complementary therapy in the treatment of VVC. This trial is registered with IRCT20190711044176N1.

Clotrimazole

Nigella sativa

Vulvovaginal Candidiasis

Itching

10.1155/2022/1739729

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Beneficial Hypoglycemic, Hypolipidemic Effects of Aerial Branches and Roots Extract of Eryngium caeruleum M. Bieb on Streptozotocin-Induced Diabetes Model in Rats

Traditional and Integrative Medicine (2021)

Aryaneh Sardarbandeh Mohammad Reza Delnavazi Mohammad Sharifzadeh Masoumeh Ghajarieh Sepanlou Zahra Tamiji

Eryngium caeruleum (Apiacea) is native to the northern forests of Iran. The anti-diabetic effect of other species of the genus Eryngium has already been reported in previous studies. In this study, the anti-diabetic effect of this extract on animal blood lipid factors was investigated. Hydroalcoholic extract was obtained from different parts of the plant, including roots, leaves, and aerial branches with fruits were prepared by maceration with 70% ethanol. Oral acute toxicity of the extracts was assayed in different doses of 2000, 4000, and 8000 mg/kg in rats. To induce diabetes in the studied animals, 60-70 mg/kg of streptozotocin (STZ) was injected intraperitoneally (IP). For the purpose of this study, 72 male Wistar rats were randomly divided into different groups of normal, diabetic, and positive controls (metformin 500 mg/kg) as well as 9 diabetic groups that orally received 200, 400, and 800 mg/kg of extracts. The effects of the treatment with extracts for a 14-day period were investigated on weight, blood glucose, and lipid profile. By comparing the control groups with the groups of hydroalcoholic extracts of E. caeruleum showed that the most effective sample on weight gain and also on reducing blood glucose was the group receiving 800 mg/kg of the aerial branches extract (P < 0.01 and P < 0.001, respectively) after 14 days. As well, the most effective sample on lowering the blood lipid factors was the hydroalcoholic extract of the root of E. coareleum with a dose of 200 mg/kg, which showed a significant effect on lowering total cholesterol in diabetic rats compared to the diabetic controls (P < 0.05). Hydroalcoholic extract of leaves with 200 mg/kg also showed a better effect on lowering the LDL and VLDL levels compared to the diabetic control group (P < 0.001). The results of pancreatic histology in the samples showed that the extracts of the aerial branch and root (800 mg/kg) had significant effects on the regeneration of the islets of Langerhans compared to the diabetic control group. In conclusion, E. caeruleum could significantly improve glycemic and lipid profiles in diabetic rats.

Lipid Profile

Maceration (sewage)

10.18502/tim.v6i2.6779

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Citations (2)

Essential Oil Composition and Radical Scavenging Activity of Paeonia Daurica Subsp. macrophylla Root

DOAJ (DOAJ: Directory of Open Access Journals) (2018)

Mahdi Vazirian Elham Vosughian Morteza Pirali‐Hamedani Maryam Khodaei Seyede Nargess Sadati Lamardi

Paeonia daurica subsp. macrophylla (Paeoniacea) is a perennial plant growing in Iran. In Persian traditional medicine, Paeonia officinalis [ Ood-e-Saleeb ] have been used for treatment of some diseases especially for epilepsy and brain disorders. Based on initial phytochemical evaluations of Paeonia spp. roots, steroidal and terpenoid compounds were identified. Hydro distilled essential oil of the roots of P. daurica subsp. macrophylla collected from north of Iran, was investigated using gas chromatography-mass spectrometry (GC-MS). Altogether, five constituents, forming 96.02% of the total oil composition were identified. Major constituents of the essential oil were salicylaldehyde (20.32%), beta-pinene-oxide (13.35%) and thymol acetate (61.12%). Antioxidant effect of the ethanolic (80%) extract was measured using DPPH free radicals. According to the results, IC50 of the extract was 25.2 µg/ml, which can be assessed as strong antioxidant effect using standard Antioxidant Activity Index.

Scavenging

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Effect of Achillea vermicularis ointment on wound healing after episiotomy in primiparous women: a randomised clinical trial

Journal of Herbal Medicine (2023)

Azam Rahmani Julia Fedotova Elham Rezaei Shirin Shahbazi Sighaldeh Arezoo Fallahi

Episiotomy

Ecchymosis

10.1016/j.hermed.2023.100779

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Major phytosteroid from Polygonatum orientale Desf. Rhizome

Seyede Nargess Sadati Lamardi Sepideh Ghambariyan Mohammad Reza Shams Ardekani Gholamreza null Amin

Polygonatum orientale Desf. (Asparagaceae) is herbaceous and perennial plant grown in northern parts of Iran. The rhizomes of Polygonatum, known as Iranian Shaghagho, is used in Iranian traditional medicine as tonic, aphrodisiac, wound healing, lightening, kidney stone remedy, gynecological and internal wounds healing, anti-gout and rheumatism, and anti-diabetic. The aim of this study was to evaluate 2,2 Diphenyl -1- Picryl Hydrazyl (DPPH) free radical scavenging activity, isolation, purification and identification of secondary metabolites from Polygonatum orientale Desf. rhizome collected from north of Iran. The 80% methanol extract from the rhizomes of P. orientale was partitioned between 80% methanol and hexan, chloroform, ethyl acetate, and n-butanol respectively. The inhibitory concentrations 50% (IC50) for ethyl acetate fraction and BHT were measured from the concentration-inhibition curve and were 315.02 μg/ml and 42.3 μg/ml, respectively. Chloroform fraction was loaded on silica gel chromatography column and eluted with hexane:ethyla cetate (90:10 to 100% ethyl acetate).Two major compounds, 12-Hydroxystigmast 4-en 3-one, a phytosteroid, and methyl oleate, a fatty acid ester, were isolated using TLC plates and identified by spectroscopic methods; H and 13C NMR. These major compounds have been reported for the first time from Polygonatum species. A further phytochemical study to find more compounds from this medicinal plant is recommended.

Phytochemical

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Effect of Saffron (Crocus sativus L.), as a Bioenhancer, on Pharmacokinetic of Acetaminophen: An Animal Study

Traditional and Integrative Medicine (2023)

Seyede Nargess Sadati Lamardi Mohammad Reza Shams Ardekani Katayoon Mireskandari Mohammad Sharifzadeh Maryam Yachchali

In Traditional Persian Medicine (TPM) saffron is used as an accompaniment agent “Mobadreq” in polyherbal formulations. According to TPM texts, “Mobadreq” is a substance (or drug) which facilitates access of drugs or food to the whole body or specific organs. This study investigated the effect of oral co-administration of Crocus sativus L. (saffron) on the absorption and some pharmacokinetic parameters of acetaminophen in rats. Two groups of rats (n=6) were treated by 1: acetaminophen 10 mg/kg along with Crocus sativus 4 mg/kg (test group) and 2: 10 mg/kg acetaminophen (control). The plasma concentrations of acetaminophen after oral administration (at 0, 5, 10, 15, 20, 40, 60, 90, and 120 min) were monitored by an HPLC-UV method. Results indicated that the plasma concentration of acetaminophen in the test group was reached to the maximum concentration (Cmax) faster than control group. As a result, at 5 to 40 minutes after drug gavage, the concentration of acetaminophen in both groups was significantly different. It was also found that co-administration of acetaminophen and saffron significantly increased acetaminophen’s area under concentration curve (AUC0-60) in comparison to the acetaminophen alone (p<0.025). These results suggest that saffron could increase the absorption rate of acetaminophen. Consequently, saffron can be considered and introduced as an enhancer of absorption rate and efficacy of acetaminophen and other drugs at least by oral route although the drug interactions with this herb should be considered.

Acetaminophen

10.18502/tim.v8i4.14482

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Medicinal Importance of Ajuga Species in Iran: Ethnobotanical and Traditional Applications, Phytochemical, and Pharmacological Studies

Jundishapur Journal of Natural Pharmaceutical Products (2022)

Aysan Rahiminiya Hamideh Herizchi Ghadim Seyede Nargess Sadati Lamardi Mohsen Haghir Ebrahimabadi Seyyed Mohammadbagher Fazljou

Context: Five species of the genus Ajuga (Lamiaceae) having the common name of "bugle" are found in Iran. In Persian medicine (PM), the genus Ajuga (Kamaphytus) is used for treating jaundice, joint pain, gout, amenorrhea, sciatica, and wound healing. This study aimed to review the ethnobotanical, phytochemical, and biological activities of Ajuga species that grow in Iran to determine their therapeutic potentials and suggest further studies on the healing properties of this genus in Iran. Evidence Acquisition: Electronic databases such as PubMed, Scopus, and Google Scholar were comprehensively searched for studies on Ajuga species in Iran, including "Ajuga austro-iranica," "Ajuga chamaecistus," "Ajuga comata" (Syn.: "Ajuga chia," "Ajuga chamaepitys subsp. Chia"), "Ajuga orientalis," and "Ajuga reptans." The search period was from 1966 to February 2021. The related articles were selected according to the inclusion and exclusion criteria of the current study. Results: Several ethnobotanical and pharmacologic reports have verified the traditional uses of the genus Ajuga for anti-inflammatory, hypoglycemic, hypolipidemic, analgesic, anabolic, anti-arthritis, antipyretic, and hepatoprotective activities. Numerous phytochemicals have been identified from Ajuga species involving phytoecdysteroids, neo-clerodane-diterpenes, iridoids, flavonoids, withanolides, phenylethyl glycoside, and essential oils. Conclusions: Due to the beneficial therapeutic effects of Ajuga genus, it can be considered in future clinical studies as a source of natural antioxidants, dietary supplements in the pharmaceutical industry, and stabilizing food against oxidative deterioration.

Phytochemical

Ethnobotany

10.5812/jjnpp.109209

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Citations (7)