Ana Maria Oliveira‐Brett

Abstract Isotretinoin redox behaviour, by voltammetry, at the cathodic pre‐treated boron doped diamond electrode by cyclic, differential pulse and square wave voltammetry, and by spectrophotometry in a wide pH range, was investigated. The isotretinoin oxidation was an irreversible, diffusion‐controlled process, occurred in a three‐step cascade mechanism, and the isotretinoin diffusion coefficient D 13‐cis‐RA =7.35×10 −6 cm 2 s −1 , was calculated. The UV‐Vis isotretinoin maximum absorption was pH‐dependent. The detection limits LOD=0.53 μM, by differential pulse voltammetry, and LOD=0.38 μM, by UV‐Vis spectroscopy, were obtained. The isotretinoin in the pharmaceutical drug Roacutan ® , using differential pulse voltammetry, was determined.

Differential pulse voltammetry

Isotretinoin

10.1002/elan.201600206

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Electrochemical principles

Oxford University Press eBooks (1998)

Christopher M. A. Brett Ana Maria Oliveira‐Brett

This chapter discusses electrochemical principles. Electrochemistry is the study of phenomena caused by charge separation. In the context of electrode processes, which are heterogeneous in nature, it deals with the study of charge transfer processes at the electrode/solution interface, either in equilibrium at the interface, or under partial or total kinetic control. Most of the charge transfer processes are transfer of electrons, which can be represented in the simplest case of oxidised species and reduced species, both soluble in solution. In a real situation, both reduction and oxidation must occur to an equal extent, so as not to violate the law of conservation of energy. The chapter then looks at electrochemical cells, the kinetics of electrode reactions, the interfacial region and electrolyte double layer, hydrodynamic electrodes, microelectrodes, and electroanalytical titrations.

Charge transfer coefficient

Double layer (biology)

Chemically modified electrode

10.1093/hesc/9780198548164.003.0002

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Contents: Electroanalysis 17/2004

Electroanalysis (2004)

Karolina Caban Paweł J. Kulesza Zbigniew Stojek Mikołaj Donten Krzysztof Miecznikowski

10.1002/elan.200490016

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Mechanism of interaction of in situ produced nitroimidazole reduction derivatives with DNA using electrochemical DNA biosensor

Methods in enzymology on CD-ROM/Methods in enzymology (1999)

Ana Maria Oliveira‐Brett Sílvia Helena Pires Serrano Mauro Aquiles La-Scalea Ivano Gebhardt Rolf Gutz Maria Luíza Cruz

Hydroxylamine

Nitroimidazole

Nitrobenzene

10.1016/s0076-6879(99)00137-8

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Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode

Electroanalysis (2012)

Ana Dora Rodrigues Pontinha Sônia Maria Alves Jörge Victor C. Diculescu Marilene Vivan Ana Maria Oliveira‐Brett

Abstract Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH‐dependent, diffusion‐controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7‐hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH‐dependent, quasi‐reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.

Glassy carbon

Carbon fibers

10.1002/elan.201100558

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Ana Maria Oliveira‐Brett

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