Guillermo Fernández‐Sanz

Instituto de Salud Carlos III

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Marc Veckeneer

ZNA Middelheim Hospital

Khalil Ghasemi Falavarjani

Rasool Akram Hospital

Charles W. Mango

Presbyterian Hospital

Javier Zarranz‐Ventura

Hospital Clínic de Barcelona

J. Marticorena Salinero

Complexo Hospitalario Universitario A Coruña

B. Fernandez Arevalo

Hospital Universitario de Guadalajara

José Carlos Pastor Jimeno

Universidad de Valladolid

Ester Carreño

Hospital Universitario Rey Juan Carlos

Francisco Cabrera López

Hospital Universitario Insular de Gran Canaria

Jorge I. Calzada

CIATEQ

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Hospital Universitario Fundación Jiménez Díaz

University College London

Moorfields Eye Hospital

Moorfields Eye Hospital NHS Foundation Trust

Instituto de Salud Carlos III

Universidad Autónoma de Madrid

Sydney Hospital

Clinica Universidad de Navarra

Ministerio de Ciencia, Innovación y Universidades

Hospital Clínico San Carlos

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Benefits of omega-3 fatty acid dietary supplementation on health-related quality of life in patients with meibomian gland dysfunction

Clinical ophthalmology (2014)

Andrea Oléñik Sol Luxan Silvia Quintana Ignacio Jiménez-Alfaro Blanca C. Garcia

We assessed the impact of a dietary supplement based on the combination of omega-3 essential fatty acids and antioxidants on health-related quality of life in patients with meibomian gland dysfunction (MGD).Patients of either sex (aged 18-85 years) diagnosed with MGD according to criteria identified at a 2011 International Workshop on Meibomian Gland Dysfunction participated in this randomized, double-masked, placebo-controlled study. Group A patients (controls) received an oral placebo supplement and group B patients received the oral study supplement (Brudysec(®) 1.5 g; Brudy Laboratories, Barcelona, Spain). At baseline and at 3-month follow-up, the patients completed the 36-Item Short Form Health Survey questionnaire using a Spanish validated version. The Physical (PCS) and Mental (MCS) Component Summary scores were the main outcome variables.A total of 61 patients completed the study (group A, n=31; group B, n=30). There were no significant differences in PCS and MCS scores at baseline between the two study groups, but after 3 months of treatment, significantly higher mean PCS and MSC scores were observed in patients treated with the active omega-3 dietary supplement as compared with controls (mean [standard deviation] PCS score 53.33±5.57 versus 47.46±7.31, P=0.008; mean MCS score 54.60±5.64 versus 47.80±8.45, P=0.0005). Moreover, mean differences between values at 3 months as compared with baseline were statistically significant for patients in group B (PCS score 7.14±5.81, 95% confidence interval 4.97-9.31, P=0.000; MCS score 5.96±7.64, 95% confidence interval 3.10-8.81, P=0.0002), whereas mean differences in patients assigned to group A were not statistically significant.Dietary supplementation with a combination of omega-3 essential fatty acids and antioxidants had a significant beneficial effect on HRQoL (health-related quality of life) in patients with MGD.

Meibomian gland

10.2147/opth.s62470

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Quantitative assessment of macular and circumpapillary retinal vessel density across all stages of Leber hereditary optic neuropathy using swept source optical coherence tomography angiography

Acta Ophthalmologica (2022)

L. Castillo Clara Berrozpe‐Villabona S. Miserachs García Hanan Haulani Cecilia Gómez‐Gutiérrez

To investigate the macular and circumpapillary retinal microvasculature across all stages of Leber hereditary optic neuropathy (LHON) using swept source optical coherence tomography angiography (OCTA).This prospective, multicentre, cross-sectional, observational study analysed a total of 119 eyes of 60 patients with molecularly confirmed LHON across all stages and 120 eyes of 60 control subjects. Optical coherence tomography angiography maps centred on the fovea and optic disc were obtained to measure vessel densities (VDs) in the macular superficial (SCP) and deep (DCP) capillary plexuses, and the radial peripapillary capillary plexus (RPCP) respectively.In asymptomatic eyes, only the SCP showed significant changes on average (B coefficient = -0.72, 95% CI = -1.34 to -0.10, p = 0.022) or in sectors representing the papillomacular bundle (PMB) (B coefficient = -1.17, 95% CI = -2.23 to -0.11, p = 0.031). However, in chronic eyes, the greatest magnitude of change was found in the temporal sector of the RPCP (B coefficient = -12.36, 95% CI = -14.49 to -10.23, p < 0.001). The RPCP showed the strongest correlations with visual acuity (VA, logarithm of the minimum angle of resolution; R = -0.677, p < 0.001) and structural parameters (R = 0.747, p < 0.001).Retinal VD changes in the circumpapillary region of the PMB appear later than in the macula but end up being more profound and correlate better with VA and structural parameters. Further studies are needed to assess the clinical utility of retinal VDs as potential LHON biomarkers.

Optic neuritis

10.1111/aos.15169

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PVR Detachment Questionnaire: Part 1

Springer eBooks (2018)

Diego Ruiz-Casas Félix Armadá-Maresca Francisco Cabrera López Jorge I. Calzada J. M. Cubero Parra

10.1007/978-3-319-78446-5_35

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Mutations inSCAPERcause autosomal recessive retinitis pigmentosa with intellectual disability

Journal of Medical Genetics (2017)

Yasmin Tatour Iker Sánchez‐Navarro Elana Chervinsky Hákon Hákonarson Haithum Gawi

Retinitis pigmentosa (RP) is the most common form of inherited retinal dystrophy, with a worldwide prevalence of 1 in 4000 persons. While in most cases of RP, the disease is limited to the eye (non-syndromic), over 40 forms of syndromic RP have been described.To identify the genetic basis for syndromic RP in three unrelated families from Israel and Spain.Whole exome sequencing was conducted in one Israeli and two Spanish families segregating autosomal recessive RP with intellectual disability. Complete ophthalmic examination included best-corrected visual acuity, funduscopy, optical coherence tomography, fluorescein angiography, flash visual evoked potentials, and electroretinography. Reverse transcription (RT)-PCR and immunostaining were used to examine the spatial and temporal expression pattern of SCAPER.In all patients, biallelic SCAPER mutations were observed. Clinically, patients with SCAPER mutations show signs of typical RP. In addition, they have mild to moderate intellectual disability and attention-deficit/hyperactivity disorder. SCAPER was found to be ubiquitously expressed in a wide range of human tissues, including retina and brain. Furthermore, RT-PCR analysis revealed that in both mouse eye and brain, Scaper is expressed as early as embryonic day 14. In the mouse retina, SCAPER is located in multiple layers, including the retinal pigment epithelium, photoreceptor outer and inner segments, the inner plexiform layer and the ganglion cell layer.Deleterious SCAPER mutations were identified in four patients from three unrelated families of different ethnic backgrounds, thereby confirming the involvement of this gene in the aetiology of autosomal recessive syndromic RP.

Electroretinography

10.1136/jmedgenet-2017-104632

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Multicolor Imaging for the Detection of Inner Nuclear Layer Microcysts Secondary to Optic Nerve Atrophy

Journal of Neuro-Ophthalmology (2020)

Belén Jimenez‐Rolando Ester Carreño Miguel A. Alonso-Peralta María Isabel López-Molina Guillermo Fernández‐Sanz

Abstract: Inner nuclear layer (INL) microcysts have been reported in diseases affecting the optic nerve. The new ocular imaging techniques detect minimal structural alterations at the macula and correlate these findings to different etiologies with less invasive procedures. The relationship between ganglion cells distribution at the macula and chiasmal nerve fibers enables the diagnosis and location of neurological lesions by new generation optical coherence tomography (SD-OCT) imaging devices. We report the evaluation of a patient with a history of optic nerve trauma and macular INL microcysts with multicolor SD-OCT technology that shows a pattern that localizes the lesion to the left optic nerve and proximal segment of the chiasm.

Optic chiasm

10.1097/wno.0000000000000976

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Vitreoretinal Surgeons Assess Surgical Cases: A Questionnaire

Springer eBooks (2018)

Diego Ruiz-Casas Ulrich Spandau Félix Armadá-Maresca Francisco Cabrera López Jorge I. Calzada

Vitreoretinal Surgery

10.1007/978-3-319-78446-5_26

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Management of patients with macula-on retinal detachment in the retinal department of a tertiary hospital in Spain

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Raquel Castro-Florez R Isabel Gese-Bordils M. García-Torre Ignacio Jiménez-Alfaro Guillermo Fernández‐Sanz

Tertiary care

10.3980/j.issn.1672-5123.2017.12.04

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Early Micro-incisional Pars Plana Vitrectomy for the treatment of Acute Infective Endophthalmitis: The Sydney Eye Hospital Experience

Investigative Ophthalmology & Visual Science (2016)

Guillermo Fernández‐Sanz Steve D. Levasseur Eugene Ting Gerald Liew Justin Playfair

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Idiopathic full thickness macular hole in a 10-year-old girl

International Journal of Retina and Vitreous (2018)

Li‐Anne Lim Guillermo Fernández‐Sanz Steven Levasseur John Grigg Alex P. Hunyor

Macular holes in children are generally associated with trauma. We report the first case of an idiopathic full thickness macular hole in a 10-year-old girl. 23-gauge transconjunctival pars plana vitrectomy, induction of a posterior vitreous detachment, ILM blue-assisted internal limiting membrane peel, fluid–air exchange and air-26% sulfur hexafluoride (SF6) exchange was performed with subsequent macular hole closure. This is the first reported case of an idiopathic full thickness macular hole in a child. Treatment with pars plana vitrectomy with peeling of the ILM resulted in significant anatomic and functional improvement.

Internal limiting membrane

10.1186/s40942-018-0128-9

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Open-globe-injury: A single center Spanish retrospective 5-year cohort study

European Journal of Ophthalmology (2020)

Elena Guzmán Almagro Guillermo Fernández‐Sanz Diana Herrero-Escudero Inés Contreras J. González Martín-Moro

To review and analyze the epidemiological profile, clinical characteristics and visual outcomes in patients attended for traumatic open globe injury (OGI) at our hospital over a 5-year period.Retrospective chart review study.Retrospective analysis of all patients attended at Fundación Jiménez Díaz University Hospital for OGI between 2011 and 2015. Data from 104 patients including demographics, ocular examination, medical and surgical treatment, visual outcomes, and complications were analyzed.Most patients were male (79.8%) and the median age at the time of injury was 41 years (interquartile range 31.5-58 years). Work-related accidents represent more than half of the cases and their main mechanism was penetrating trauma or foreign body. This type of accident had good prognosis (median final visual acuity in decimal scale 0.8; interquartile range 0.4-1). Falls were the second most common cause of OGI, predominantly affecting senior women (50%), with a high incidence of ocular rupture (50%) and associating a poor visual prognosis (median final visual acuity 0.01; interquartile range 0-0.5). There was a strong correlation (0.75; p < 0.001) between ocular trauma score (OTS) and final best corrected visual acuity.Two different patterns of OGI were identified in our sample. Work-related trauma in young males was the most common form of OGI and was associated with good prognosis. However, falls in senior women were associated with poor prognosis.

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Penetrating Trauma

10.1177/1120672120962039

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Citations (5)