FU You-yu

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A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels

Nanoscale (2022)

Panli Han Lianxue Zhang Yaqi Fu FU You-yu Jianxiang Huang

The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials. Thus, the development of effective clinical applications of TPZ requires advanced strategies to intensify hypoxia levels in tumors effectively and safely. In this study, we designed and fabricated a paclitaxel (PTX)-loaded dual-response delivery system with a low dose (e.g., 2 Gy) of X-ray and reactive oxygen species on the basis of diselenide block copolymers. Upon the external X-ray stimulus, the system accurately released encapsulated PTX at tumor sites and remarkably improved tumor hypoxia levels by causing severe damage to tumor blood vessels. Subsequently, these enhanced tumor hypoxia levels effectively activated the reduction of TPZ into benzotriazinyl free radicals, which significantly improved the antitumor efficacy of our system against 4T1 breast cancer cells with an initial tumor volume of 500 mm3. Moreover, the dual-stimulus coordinated and controlled release of PTX was found to largely avoid the off-target effects of PTX on normal cells while exhibiting very limited side effects in experimental mice. The current novel strategy for regulating tumor hypoxia levels offers an effective and safe way to activate TPZ for the treatment of large solid tumors.

Tirapazamine

Tumor Hypoxia

Hypoxia

10.1039/d2nr04021b

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Citations (6)

Low noise electronic design method for laser range finding and tracking system

Optics and Precision Engineering (2000)

FU You-yu

There are all kinds of noises in electronic component and device, photo-translating device, e. g. shot noise, 1/f noise, thermal noise and background noise in system etc. Noise reducing is all along the main task of . increasing the active distance of system. In this paper, based on the essential theory of noise, the primary noise source and the design method of low noise for laser range finding and tracking system are demonstrated in engineering field. An example of design procedures for the head amplifier applied in engineering is introduced.

Noise generator

Component (thermodynamics)

Noise temperature

Tracking (education)

Noise-figure meter

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In-situ TiN reinforced composite coatings prepared by plasma spray welding on Ti6Al4V

Materials Letters (2020)

Baoming Shi Shiming Huang Ping Zhu Changen Xu Peng Guo

Titanium alloy

10.1016/j.matlet.2020.128093

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Citations (23)

Research on method of measuring the time of remote explosion point

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2007)

Jianmin Zhou Hongyan Yin Kai Xu FU You-yu

The time when the bomb explodes is one of the most important indexes to appraise the test. According to the principles concerned with explosion radiation, the principle of measuring the time of remote explosion point and composition of measuring system is introduced. Use CCD to record the explosion radiation, DSP to process and record the highcapacity, high-speed video signals, and convert the exploding process examined by floating amplifier into digital signals. Besides, the article analyzes the composing and structural design of the log's optical system, principle of electric control and floating amplifier, dynamic range of the system, power analysis of the incident light, and how to improve the accuracy of measurement in great detail.

10.1117/12.725261

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Analysis of the disturbance of remote aerial detector induced by laser

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE (2005)

Jianmin Zhou Jin Guo FU You-yu

It is important to study the interaction effect between laser and photoelectric detector. In most of the laser detecting systems, laser must irradiate the photoelectric detector. The detector will be saturated or damaged easily if the fluence of the laser is higher than the saturation threshold of the detector. Now, many photoelectric detectors are used in space. To achieve their interaction, "Cat's eye" effect is applied to find and locate the remote aerial detector by laser. The possibility and mechanism of disturbance to remote aerial detector induced by laser are analyzed, and the factors of influence are also analyzed. The fluence of laser on the photoactive area of remote aerial detector is estimated. With two samples of CCD and TV tracking system, the mechanism of soft damage to CCD and TV tracking system induced by laser are introduced. The saturation of CCD and crosstalk of CCD are the main reasons of disturbance. When the tracking system is used in wave-door tracking mode, it will lose its tracking target if the saturation or crosstalk of CCD can enter into wave-door. At last, the influence to disturbance induced by atmosphere effect is also analyzed.

Photoelectric effect

10.1117/12.569231

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Citations (1)

Simulating Turbulence Method of the Atmosphere Scene Simulator

Bandaoti guangdian (2006)

Xinji Gan Jin Guo FU You-yu Tingfeng Wang Cheng Shou-guo

Atmospheric models

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A method of decoding laser pulse-coded signal based on self-correlation

Optical Technique (2006)

FU You-yu

The method of encoding laser pulse is one of the anti-jamming ways and means used by self-active laser homing weapons.In order to meet the requirement of the electro-optics countermeasure for laser homing weapons,a new method of decoding laser pulse-encoded signal was proposed,depending on the relativity of time of those pulse-encoded signals themselves.The signal decoding can be actualized by that confirming the value of the pulse repetition interval(PRI)of the signal and the number of the pulse repetition interval of the signal and the scheduling of the pulse repetition interval of the signal in one signal period.The signal period can be worked out by doing self-correlation disposal for pulse-encoded signal and depending on the characters of self-correlation function.The time of pulse arriving(TOA)of laser signal is used as the only parameter of decoding signal.The principle and the realization of this decoding method were expatiated on in this paper.Having been proved by the principle experiment and the numeral simulation experiment,taking this method to decode these signals which are the bulk of laser pulse-encoded signals used by the self-active laser homing weapons currently,the time used during the course of signal decoding is usually about 4 signal periods.

SIGNAL (programming language)

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Various methods for evaluating laser beam quality

Jiguang zazhi (2004)

FU You-yu

Various criterions for evaluating laser beam quality are introduced in detail.This paper points out that laser beam quality's evaluating criterion is related to real application types.By contrast to the definition and expression of these methods their applied range and limitation are indicated respectively for specific application purpose.The applied popularity of M 2-factor is illustrated emphatically,and the demonstration of M 21 is also presented.The factors of influencing laser beam quality are discussed too.

Popularity

M squared

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Citations (2)