Marino Zorzon

University of Trieste

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Giuseppe Cazzato

Istituto Nazionale di Fisica Nucleare, Sezione di Firenze

Robert Zivadinov

University at Buffalo, State University of New York

Alessio Bratina

University of Trieste

Davide Nasuelli

Azienda Ospedaliera San Camillo-Forlanini

Laura Locatelli

University of Milano-Bicocca

Antonio Bosco

University of Trieste

Giovanni Masè

Azienda Ospedaliera Santa Maria Degli Angeli

Maja Ukmar

Azienda Sanitaria Universitaria Integrata di Trieste

Maria Antonietta Tommasi

Istituti di Ricovero e Cura a Carattere Scientifico

Nicola Carraro

Purdue University West Lafayette

Cooperative Institutions

University of Trieste

Ospedale di Cattinara

Istituti di Ricovero e Cura a Carattere Scientifico

Sapienza University of Rome

Azienda Sanitaria Universitaria Integrata di Trieste

University of Naples Federico II

Multiple Sclerosis Foundation

University of Milan

University of Bari Aldo Moro

Federico II University Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Osteopontin gene haplotypes correlate with multiple sclerosis development and progression

Journal of Neuroimmunology (2005)

Annalisa Chiocchetti Cristoforo Comi Manuela Indelicato Luca Castelli Riccardo Mesturini

Osteopontin

10.1016/j.jneuroim.2005.02.020

Cite

Citations (75)

HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis

Journal of Neurology (2003)

Robert Zivadinov Laura Uxa T Zacchi Davide Nasuelli Maja Ukmar

Neuroradiology

10.1007/s00415-003-0164-7

Cite

Citations (42)

ACUTE ENCEPHALOPATHY AND POLYNEUROPATHY AFTER DISULFIRAM INTOXICATION

Alcohol and Alcoholism (1995)

Marino Zorzon Giovanni Masè Emanuele Biasutti B Vitrani Giuseppe Cazzato

A chronic alcoholic who had ingested a very high dose of disulfiram (29 g over a 1-week period) without simultaneous alcohol intake developed an acute encephalopathy and a severe flaccid tetraparesis that worsened over the course of several days, even after the intake of the drug had stopped. Recovery was both slow and incomplete. One year after intoxication, the patient still had distal weakness in the arms and legs, and hypesthesia in the hands and feet.

Tetraparesis

Hypesthesia

Disulfiram

Drug withdrawal

Toxic encephalopathy

Drug intoxication

10.1093/oxfordjournals.alcalc.a045773

Cite

Citations (10)

Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients

Journal of Translational Medicine (2011)

Valentina Durastanti Alessandra Lugaresi Placido Bramanti Maria Pia Amato Paolo Bellantonio

Increased synthesis of neopterin and degradation of tryptophan to kynurenine, measured as kynurenine/tryptophan ratio (kyn/trp ratio), are considered in vitro markers of interferon beta-1a (IFNβ-1a) activity. The aim of the study was to investigate the dynamic profile of neopterin and kyn/trp ratio in patients with relapsing remitting multiple sclerosis (RRMS) treated with two different doses of IFNβ-1a over a period of 24 months. RRMS patients (n = 101) received open-label IFNβ-1a 22 mcg (low dose, LD) or 44 mcg (high dose, HD) subcutaneously (sc), three times weekly for 24 months. Serum measurements of neopterin, kyn/trp ratio and neutralizing antibodies (NAbs) were obtained before treatment (i.e., at baseline) and 48 hours post-injection every 3 months thereafter. Clinical assessments were performed at baseline and every 6 months. Changes in biomarkers over time were compared between LD- and HD-group as well as between patients with/without relapses and with/without NAbs using Analysis of Variance and Mann-Whitney tests. Neopterin (p < 0.001) and kyn/trp ratio (p = 0.0013) values increased over time vs baseline in both treatment groups. Neopterin values were higher (p = 0.046) in the HD-compared to the LD-group at every time point with the exclusion of months 21 and 24 of therapy. Conversely, there were no differences between the two doses groups in the kyn/trp ratio with the exclusion of month 6 of therapy (p < 0.05). Neopterin levels were significantly reduced in NAb-positive patients starting from month 9 of therapy (p < 0.05); the same result was observed for kyn/trp ratio but only at month 9 (p = 0.02). Clinical status did not significantly affect neopterin production and tryptophan degradation. Although differences in serum markers concentration were found following IFNβ administration the clinical relevance of these findings needs to be confirmed with more detailed studies.

Neopterin

Interferon beta-1b

BETA (programming language)

10.1186/1479-5876-9-42

Cite

Citations (11)

Effect of intravenous methylprednisolone on the number, size and confluence of plaques in relapsing–remitting multiple sclerosis

Journal of the Neurological Sciences (2007)

Robert Zivadinov Marino Zorzon Roberto De Masi Davide Nasuelli Giuseppe Cazzato

Relapsing remitting

10.1016/j.jns.2007.09.025

Cite

Citations (28)

Cysts of the atlantoaxial joint: excellent long-term outcome after posterolateral surgical decompression

Journal of Neurosurgery Spine (2001)

Marino Zorzon Miran Škrap Silvana Diodato Davide Nasuelli B Lucci

✓ Articular cysts of the atlantoaxial joint are infrequently described and probably an underreported cause of upper cervical spinal cord compression. The authors report on two patients with cysts located posteriorly of the dens in whom a C-1 and partial C-2 hemilaminectomy with subtotal resection of the cyst provided adequate and stable decompression 1 year postoperatively. The clinical and magnetic resonance imaging features and the surgical approach are discussed after a review of the literature.

Surgical decompression

Spinal cord compression

Atlanto-axial joint

Atlantoaxial instability

10.3171/spi.2001.95.1.0111

Cite

Citations (41)

Immediate prognosis of primary intracerebral hemorrhage using an easy model for the prediction of survival

Acta Neurologica Scandinavica (1995)

Giovanni Masè Marino Zorzon Emanuele Biasutti Giulia Tasca B Vitrani

We reviewed the medical records and CT scans of 138 patients hospitalized for spontaneous supratentorial hemorrhage and conservatively treated. Seventeen clinico-anamnestic variables and five CT desumed findings were collected. Using univariate analysis we found eight significant predictors of 30-day mortality: intraventricular spread (IVS) of blood, volume of the hemorrhage, Glasgow Coma Scale (GCS) score, midline shift, hyperglycemia, pupillary abnormalities, limb paresis and gaze deviation. With multivariate logistic regression analysis we found three independent predictors of 30-day mortality: IVS of blood, volume of the hemorrhage and GCS score. Using these three independent variables we developed an easy model which allows an immediate estimate of the probability of survival with a high degree of sensitivity and specificity.

Paresis

Univariate analysis

Midline shift

Univariate

10.1111/j.1600-0404.1995.tb07011.x

Cite

Citations (69)

[Familial nature of acute cerebral vasculopathies of the ischemic type].

PubMed (1983)

Giuseppe Cazzato Marino Zorzon

The frequency of cerebrovascular accidents and of risk factors including hypertension and diabetes was examined retrospectively in parents and siblings of 328 patients suffering from transient ischaemic attacks or non-embolic cerebral infarction and in a control group. The frequency of cerebrovascular accidents was significantly higher in the family of the patient compared to the family of the control. The relatives of the patient and the control had essentially the same frequency of diabetes, whereas hypertension was significantly more common in the family of the patient. When the relatives with one or both the risk factors were excluded and those with cerebrovascular accidents alone were compared, a greater frequency, though insignificant, was noted in the family of the patient. Hypertension and diabetes were more common in the relatives of the patient than in the control but this difference was not statistically significant. The significant excess of cerebrovascular accidents in the family of the patients suffering from transient ischaemic attacks and non embolic cerebral infarction cannot exclusively be attributed to the greater frequency of diabetes and hypertension.

Source

Cite

Citations (0)

[Migraine crisis and neurological focal signs of slow or absent resolution (complicated migraine)].

PubMed (1987)

Rodolfo M. Antonello G Cazzato Marino Zorzon Paola Torre B. Decchi

Sixteen cases of vascular headache of the migraine type are referred in whom marked neurological manifestations occurred in a unilateral distribution as part of a migraine attack ("complicated migraine"). The neurologic disorders observed, in order of frequency, include 10 cases of motor hemiparesis, 3 cases of unilateral cerebellar syndrome, 1 case of sensory-motor hemiparesis and 1 case showing signs of the involvement of the motor nuclei of the bulb. The recovery of the motor, sensory, cerebellar and brainstem defects was very slow (average duration: 44.25 days; mode: 14 days) in twelve cases. Two patients showed residual neurological signs respectively after 1 and 7 years from the migraine attack. The patients histories indicate classic or common migraine with a relatively high frequency (80% of the patients experienced one or more crises per month). The most of cases (75%) were female patients. The patients, at time of the attack of complicated migraine, had a mean age years of 32. In ten cases first-grade relatives suffered from classic or common migraine; in no case was there any report of associated or complicated migraine among the relatives. In 4 of the 16 cases the CT scan showed an area of hypodensity consistent to the region of the brain expected to be suffering in view of the clinical type of neurological defect. The Authors take into consideration the controversial relation between complicated migraine with slow or incomplete resolution of neurologic signs and focal brain ischemia due to atherothrombotic infarct, pointing out that the present state of knowledge prevents the reaching of final conclusions.(ABSTRACT TRUNCATED AT 250 WORDS)

Hemiparesis

Stroke

Source

Cite

Citations (0)

MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis

Neuroradiology (2001)

Robert Zivadinov Roberto De Masi Davide Nasuelli L. Monti Bragadin Maja Ukmar

Neuroradiology

Relapsing remitting

Clinically isolated syndrome

10.1007/s002340000500

Cite

Citations (116)