Yonglin Liu

University of Chinese Academy of Sciences

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Yang‐Kun Chen

Dongguan People’s Hospital

Jian‐Feng Qu

Dongguan People’s Hospital

Kunli Luo

Institute of Geographic Sciences and Natural Resources Research

Yan Jun-ping

Shanxi Normal University

Weimin Xiao

Huawei Technologies (United States)

Wen‐Cong Liang

Dongguan People’s Hospital

Minyi Cen

Southwest Jiaotong University

Xinglei Tian

Shandong Geological Sciences Institute

Lei Cai

Sun Yat-sen University

Wei‐Min Xiao

Shenzhen Academy of Metrology and Quality Inspection

Cooperative Institutions

Chinese Academy of Sciences

Sun Yat-sen University

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Northwest University

Southern Medical University

Huazhong University of Science and Technology

Dongguan People’s Hospital

Shanghai Jiao Tong University

Capital Medical University

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Biosafety assessment of delivery systems for clinical nucleic acid therapeutics

Biosafety and Health (2022)

Zhimin Li Li Zhang Kai Jiang Yijing Zhang Yonglin Liu

Nucleic acid therapeutics, which involve transferring exogenous genes inside target cells, are a promising clinical treatment option that can regulate gene expression at the transcriptional or post-transcriptional level. Ideally, this kind of treatment modality will not lead to an unwanted immune response. Compared with traditional treatment methods, nucleic acid therapeutics can achieve prolonged and stable curative effects. As an emerging treatment method, nucleic acid therapeutics have played an increasingly important role in clinical settings for the treatment of various conditions, including infectious diseases, cancer, immune-related diseases, and monogenetic diseases. To date, a large number of clinical trials have been conducted, and more than 30 nucleic acid drugs have been approved, highlighting the strong potential of this approach in clinical practice. Diverse carriers are used to protect nucleic acids from being degraded and to help them reach their targets accurately. However, some carriers are known to cause negative effects on the release and expression of nucleic acid drugs as well as adverse effects such as allergic reactions and accumulation in the liver. Therefore, biosafety assessment of delivery systems before their application in clinical settings is critical. In this review, we describe different delivery systems for nucleic acid drugs and discuss their biosafety in both preclinical and clinical studies, with particular focus on the carriers themselves, drug administration method, and overall treatment of the disease.

Biosafety

10.1016/j.bsheal.2022.03.003

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Citations (19)

Prevalence and factors associated with overweight, obesity and central obesity among adults in Shenmu City, Shaanxi Province, China

Preventive Medicine Reports (2024)

Mingxia Liu Chunjiao Jia Yaoda Hu Juan Liu Lizhen Liu

This research aimed to explore the prevalence and determinants of overweight, obesity, and central obesity in Shenmu City, Shaanxi Province, China and to offer guidance for preventative health measures.

10.1016/j.pmedr.2024.102673

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The logical framework of 1:1 digital learning

Yonglin Liu Meng Shimin Rick van der Zwan

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Levels of nasal exhaled hydrogen sulfide in the general population and allergic rhinitis patients

Journal of Clinical Laboratory Analysis (2020)

Lisha Li Yonglin Liu Qiang Wang Zixi Wang Le Cui

Abstract Background Objective measures used for the differential diagnosis and severity assessment of allergic rhinitis (AR) are still lacking. The involvement of hydrogen sulfide (H 2 S) in the development of AR indicates that nasal exhaled H 2 S (NeH 2 S) has potential as a biomarker to be used in AR patients. This study aimed to evaluate the application value of NeH 2 S measurement in the diagnosis and assessment of AR. Methods This study was a multi‐center cross‐sectional survey conducted in Northwestern China. Demographic information collection and rhinitis assessment were completed through questionnaires. The level of NeH 2 S and serum immunoglobulin E were measured. Results The level of NeH 2 S in general population ranged from 0 to 35 ppb, with a median value of 2 ppb. The NeH 2 S levels in seasonal allergic rhinitis (SAR) patients were significantly lower than those in general population (2 [1, 2.75] vs. 2 [2, 3] ppb; p = .023), and the NeH 2 S value of the SAR group tended to be lower than that of the non‐allergic rhinitis (NAR) group (2 [1, 2.75] vs. 2 [2, 3] ppb; p = .094). The subgroup of AR patients with symptoms lasting longer than 2 weeks per month had a lower NeH 2 S level compared with the subgroup of patients with symptoms lasting less than 2 weeks per month (2 [1, 2] vs. 2 [2, 3] ppb; p = .015). Conclusion This study described the distribution range of NeH 2 S levels in the general population. Further study with larger sample size was needed to clarify the relationship between NeH 2 S level and AR.

10.1002/jcla.23678

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Long‐term trends in precipitation and precipitation extremes and underlying mechanisms in the U.S. Great Basin during 1951–2013

Journal of Geophysical Research Atmospheres (2017)

Tingting Xue Guoping Tang Lin Sun Yuzhen Wu Yonglin Liu

Abstract Using daily precipitation records from 151 stations, the Mann‐Kendall nonparametric test, and the rotated empirical orthogonal function, this study examined trends in precipitation and precipitation extremes and underlying mechanisms in the U.S. Great Basin during 1951–2013. The results indicate that annual total precipitation, 1 day and 5 day maximum precipitation, extreme precipitation days over the 95th and 99th percentiles trended upward during 1951–2013. Spatially, stations experienced significant positive trends in six indices are mostly distributed in the eastern basin, while those experienced significant negative trends are a few and situated in the western basin. Four distinct modes characterized by different patterns of annual precipitation variations were identified. They are the northeastern, southern, midwestern, and midnorthern modes. In addition, we found that the effects of El Niño–Southern Oscillation and Pacific Decadal Oscillation on precipitation was low in the basin. The intensifying high‐pressure system over the western North Pacific in winter and the increasing water vapor and air temperature of the atmosphere over the basin in winter and spring were mainly responsible for the upward trends in six indices during 1951–2013. Nevertheless, the topography regulates the effects of synoptic conditions on precipitation, contributing to the “east‐west” contrast in station distribution between those experienced negative and positive trends. Overall, precipitation and precipitation extremes increased significantly in the eastern and northern basin while increases were not significant in the western and southern basin. This information has important implications for not only predicting future precipitation changes but also mitigating precipitation‐change‐associated risks on ecosystems and human society in the Great Basin.

Empirical orthogonal functions

10.1002/2017jd026682

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Citations (32)

International Journal of TROPICAL DISEASE & Health (2022)

Fenglan Wang Juan Liu Yonglin Liu Fuyong Jiao

Kawasaki disease, It is a systemic vasioinflammatory disease in children of Asian descent, Coronary artery injury is its major complication, the disease has now become a major cause of acquired heart disease in children. The etiology of Kawasaki disease is not fully clear, and its pathogenesis is related to infection, immune damage and genetic susceptibility. Genetic research has made new progress in recent years, with the aim of trying to better discover the intrinsic link of pathogenesis and treatment, in order to better understand the pathogenesis and obtain better treatment. The exact etiology of KD is still unknown. However, increasing evidence supports that genetic factors play a key role in their occurrence and development. Studying the changes in related genes in children with Kawasaki disease will help to understand the relationship between the changes in this gene and the onset of Kawasaki disease and its coronary damage and the sensitivity of various treatments, and will contribute to the better treatment of Kawasaki disease.

Pathogenesis

Etiology

Genetic predisposition

10.9734/ijtdh/2022/v43i230576

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The influence of aspect ratios and solar heating on flow and ventilation in 2D street canyons by scaled outdoor experiments

Building and Environment (2020)

Guanwen Chen Xia Yang Hongyu Yang Jian Hang Yuanyuan Lin

Aspect ratio (aeronautics)

Richardson number

10.1016/j.buildenv.2020.107159

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Cognitive Topology Mapping based on HumanComputer Interaction

Journal of Internet Technology and Secured Transaction (2013)

Meng Shimin Cheng Rengui Yonglin Liu

The system point of view, the human-computer interaction (HCI) structure is composed of "brain cognitive body -coupling situation -information manifold" cognitive digital system.HCI process coupled interaction between brain cognition and brain outside the information system, the formation of cognitive coupled states.The Outside brain cognition point of view, the situations of HCI is the point of the link between the brain cognition and brain outside information manifold, the cognitive been induced brain outside the cognitive digital manifold.The Outside brain cognitive information measuring point of view, BSM is a brain cognitive observation, mapping, research platform.The cognitive topology layer is system kernel.We tried to use the coupling cognitive research framework in a word memory.Assuming the brain state of English word to the existence of complex networks, explore the network activity model of word.The coupling method is based on BSM online research of models, acquisition of cognitive symbol sequence data of learning word; The formation of the word topology base on word classification specification, definition of the word linear metric space, form the basis and platform on Complex word network of static structure and dynamic growth.Preliminary results of this study confirmed that Cognitive coupling is feasible way to Brain imaging of cognitive information.

Cognitive map

10.20533/jitst.2046.3723.2013.0017

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The daily fluorine and arsenic intake for residents with different dietaries and fluorosis risk in coal-burning fluorosis area, Yunnan, Southwest China

Environmental Science and Pollution Research (2014)

Ling Li Kunli Luo Yuegang Tang Yonglin Liu

Arsenic poisoning

Skeletal fluorosis

10.1007/s11356-014-3485-4

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Citations (14)