Zeinab Latifi

Semnan University of Medical Sciences

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Amir Fattahi

Tabriz University of Medical Sciences

Mohammad Nouri

Tabriz University of Medical Sciences

Hamid Reza Nejabati

Tabriz University of Medical Sciences

Ainaz Mihanfar

Urmia University of Medical Sciences

Tohid Ghasemnejad

Tabriz University of Medical Sciences

Laya Farzadi

Tabriz University of Medical Sciences

Kobra Hamdi

Tabriz University of Medical Sciences

Zahra Bahrami‐Asl

Tabriz University of Medical Sciences

Hamed Hajipour

Tabriz University of Medical Sciences

Leila Roshangar

Tabriz University of Medical Sciences

Cooperative Institutions

Tabriz University of Medical Sciences

University of Tabriz

Hamedan University of Medical Sciences

Tehran University of Medical Sciences

Sakarya University

Urmia University of Medical Sciences

Urmia University

Biotechnology Research Center

Alzahra Medical and Education Center

University of Tehran

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Placental growth factor (PlGF) as an angiogenic/inflammatory switcher: lesson from early pregnancy losses

Gynecological Endocrinology (2017)

Hamid Reza Nejabati Zeinab Latifi Tohid Ghasemnejad Amir Fattahi Mohammad Nouri

Placental growth factor (PlGF) is an angiogenic factor which belongs to vascular endothelial growth factor (VEGF) family. In addition to the angiogenic function of PlGF, in some conditions such as preeclampsia and early pregnancy losses, it can induce inflammatory reactions which could be accompanied with reduced angiogenesis. Hence, it is crucial to investigate inflammatory and angiogenic switching states and understand underlying mechanisms. PlGF is expressed in endometrium, placenta and trophoblast cells and is involved in maturation of uterine NK cells. Up-regulation of PlGF directs VEGF to VEGFR-2 and reinforces angiogenesis. However, when VEGF/VEGFR-2 signaling pathway is impaired, PlGF may shift to severe inflammation and cause tissue damages which could lead to early pregnancy losses. Downregulation of PlGF has also been reported in pregnancy complications. In this review, we discussed the role of PlGF in embryo implantation failure and early pregnancy loss and also possible mechanisms regarding the role of PlGF in angiogenic/inflammatory switching in early pregnancy losses. Furthermore, we summarized the effects of various compounds on PlGF expression and briefly talked about its therapeutic potential that may be an opportunity for prevention of pregnancy loss.

Trophoblast

10.1080/09513590.2017.1318375

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Citations (54)

Oncostatin M: friend or foe in PCOS pathogenesis

Journal of Endocrinology (2024)

Saba Nikanfar Farnaz Oghbaei Hamid Reza Nejabati Reza Zarezadeh Zeinab Latifi

Polycystic ovary syndrome (PCOS) is a primary endocrinological disorder in women of reproductive age that is characterized by androgen excess and ovulatory irregularities. This syndrome is associated with adipose tissue dysfunction, an elevated risk of insulin resistance, hyperinsulinemia, obesity, and type 2 diabetes. Adipocyte dysfunction affects the secretion of adipokines and pro-inflammatory cytokines. Nevertheless, adipose tissue is not an exclusive source of adipokines as it can also be produced locally by reproductive tissues. Although adipokines have been recognized in the development of PCOS, the role of oncostatin M (OSM), a multifaceted adipokine, remains unclear. Current evidence suggests that this cytokine is associated with key aspects of the syndrome, including obesity, insulin resistance, hyperandrogenism, and inflammation. However, the data are often contradictory, likely due to variations in study designs, methodologies, and species differences. By investigating the link between OSM and PCOS-associated issues, this review identified the potential role of this adipokine in PCOS pathogenesis. This underscores the need for further research to clarify its predominant effects and assess its relevance as a therapeutic target.

Hyperandrogenism

Hyperinsulinemia

Chemerin

Resistin

Oncostatin M

10.1530/joe-24-0140

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Citations (2)

Induction of immune-related gene expression by seminal exosomes in the porcine endometrium

Biochemical and Biophysical Research Communications (2017)

Rulan Bai Zeinab Latifi Kazuya Kusama Keigo Nakamura Masayuki Shimada

Exosome

10.1016/j.bbrc.2017.11.100

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Citations (66)

Economic Design of Epprecht Proactive Mode

Ijoss Iranian Journal of Official Statistics Studies (2010)

Zeinab Latifi M. Bameni Moghadam

Source

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Citations (0)

Exosomal miRNAs in osteoarthritis

Molecular Biology Reports (2020)

Ainaz Mihanfar Seyed Kazem Shakouri Mohammad Hassan Khadem Ansari Amir Fattahi Zeinab Latifi

Cell type

10.1007/s11033-020-05443-1

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Citations (27)

Messenger RNA and protein expression of tumor necrosis factor α and its receptors in human follicular granulosa cells

Journal of Cellular Physiology (2019)

Ali Salmassi Amir Fattahi Nora Simon Zeinab Latifi Tohid Ghasemnejad

Abstract To evaluate the concentration of tumor necrosis factor α (TNF‐α) and its soluble receptors (sTNFR I and II) in serum and follicular fluid (FF) at the time of oocyte retrieval and to detect expression of TNF‐α and its receptors by luteinized granulosa cells (GCs). In a cross‐sectional study and through an in vitro fertilization–intracytoplasmic sperm injection (IVF–ICSI) program, 81 women undergoing oocyte retrieval were recruited. Serum and FF were obtained from 81 women. GCs were pooled from 20 patients (from six different days of oocyte retrievals, 5–16 follicles per patient). TNF‐α and its soluble receptors concentration were determined by enzyme‐linked immunosorbent assay and also their expression by immune cytochemistry and reverse‐transcription polymerase chain reaction analysis. The median TNF‐α concentration in serum was 4.06 pg/ml (interquartile range [IQR], 3.71–6.14) and significantly higher than that in FF with 3.50 pg/ml (IQR, 3.05–5.01), p < 0.001. The sTNFR I and II levels in serum were lower and higher than FF, respectively. The TNF‐α levels in serum and FF of good responders were higher than low responders ( p = 0.017 and 0.021, respectively). TNF‐α cut‐off level for low responders versus good responders was 4.174 pg/ml in serum with a pregnancy rate of 25.8% and 40% for below and above of this level, respectively ( p = 0.19). For FF, the cut‐off value was 3.89 pg/ml. TNF‐α and its receptors were expressed by GCs. The presence of TNF‐α and its soluble receptors in serum and FF and their expression by GCs suggest an important role for this cytokine in ovarian function.

Follicular fluid

Interquartile range

10.1002/jcp.28624

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Cytokines in embryonic secretome as potential markers for embryo selection

American Journal of Reproductive Immunology (2020)

Zahra Bahrami‐Asl Hamed Hajipour Yeganeh Rastgar Rezaei Tannaz Novinbahador Zeinab Latifi

Abstract Despite performing certain morphological assessments for selecting the best embryo for transfer, the results have not been satisfactory. Given the global tendency for performing quick and noninvasive tests for embryo selection, great efforts have been made to discover the predictive biomarkers of embryo implantation potential. In recent years, many factors have been detected in embryo culture media as a major source of embryo secretions. Previous studies have evaluated cytokines, miRNAs, extracellular vesicles, and other factors such as leukemia inhibitory factor, colony‐stimulating factor, reactive oxygen species, soluble human leukocyte antigen G, amino acids, and apolipoproteins in these media. Given the key role of cytokines in embryo implantation, these factors can be considered promising molecules for predicting the implantation success of assisted reproductive technology (ART). The present study was conducted to review embryo‐secreted molecules as potential biomarkers for embryo selection in ART.

Single Embryo Transfer

10.1111/aji.13385

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Prostaglandin E Pathway in Uterine Tissue During Window of Preimplantation in Female Mice Mated With Intact and Seminal Vesicle-Excised Male

Reproductive Sciences (2017)

Mahnaz Shahnazi Mohammad Nouri Gisou Mohaddes Zeinab Latifi Amir Fattahi

Prostaglandin E2 receptor

10.1177/1933719117718272

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Citations (15)

Wnt Signaling Pathway in Uterus of Normal and Seminal Vesicle Excised Mated Mice during Pre-implantation Window

Geburtshilfe und Frauenheilkunde (2018)

Zeinab Latifi Amir Fattahi Kobra Hamdi Aliye Ghasemzadeh Pouran Karimi

The importance of seminal vesicle secretion and uterine Wnt signaling for uterus preparation and embryo implantation has been described.In this study, we evaluated the gene expression of Wnt ligands (Wnt4 and Wnt5a) and their corresponding receptors (Fzd2 and Fzd6) using qRT-PCR and active β-catenin protein levels using western blotting in the uterine tissue of female mice mated with intact and seminal vesicle-excised (SVX) males during the pre-implantation window. We evaluated the association between these factors and implantation rates and embryo spacing.mRNA expression of Wnt4 and Wnt5a and active β-catenin protein levels decreased from Day 1 to Day 4, but reached a peak on the fifth day of pregnancy. Fzd2 also reached its highest level on Day 5. Fzd6 expression showed a decreasing trend towards the day of implantation. Lack of seminal vesicle secretion decreased Wnt4 and Wnt5a expression on Days 1 and 5 and β-catenin levels on Day 5. There were almost no significant differences in expression levels of the Fzd2 and Fzd6 receptors between groups. There were positive and negative correlations, respectively, between implantation rates and embryo spacing and Wnt4, Wnt5a and active β-catenin in the control group, but such correlations were not observed in the SVX-mated mice.Significant changes occurred in the expression of several Wnt signaling members and there was a significant association between Wnt signaling and embryo implantation. Seminal vesicle secretion affects Wnt signaling in mice and consequently also affects murine embryo implantation.Einleitung Die Bedeutung von Bläschendrüsensekret und Wnt-Signale für die Vorbereitung der Gebärmutter auf die Implantation von Embryonen wurde bereits anderweitig beschrieben. Material und Methoden Die Studie untersuchte die Genexpression der Wnt-Liganden Wnt 4 und Wnt 5a sowie deren Rezeptoren (Fzd2 und Fzd6) mithilfe von qRT-PCR und den aktiven β-Catenin-Proteinspiegel mithilfe von Westernblot im Gebärmuttergewebe von Mäusen während der Präimplantationszeit. Die Mäuseweibchen wurden mit Männchen verpaart, die entweder über intakte Samendrüsen verfügten oder die zuvor einer Exzision der Samendrüse (SVX) unterzogen worden waren. Die Assoziationen zwischen diesen Faktoren und den Implantationsraten bzw. dem Abstand zwischen den Embryonen wurde untersucht. Ergebnisse Der mRNA-Expression von Wnt4 und Wnt5a und der aktive β-Catenin-Proteinspiegel sanken zwischen dem 1. und dem 4. Tag nach der Verpaarung, sie erreichten aber einen Spitzenweg am 5. Tag der Schwangerschaft. Die Expression von Fzd2 erreichte ebenfalls am 5. Tag ihren Höhepunkt. Hingegen zeigte die Expression von Fzd6 eine rückläufige Tendenz bis zum Tage der Implantation. Das Fehlen von Samenblasensekret führte zu einem Rückgang von Wnt4- und Wnt5a-Expression am 1. und 5. Tag und des β-Catenin-Spiegels am 5. Tag. Es gab keine signifikanten Unterschiede zwischen den beiden Gruppen hinsichtlich der Expression der Fzd2- und Fzd6-Rezeptoren. Es bestand jeweils eine positive bzw. negative Korrelation zwischen den Implantationsraten und den Abständen zwischen den Embryos und dem Wnt4-, Wnt5a- und β-Catenin-Spiegel in der Kontrollgruppe, aber diese Korrelation fand sich nicht bei den SVX-verpaarten Mäuseweibchen. Schlussfolgerungen Die Expression verschiedener Wnt-Liganden hat sich signifikant verändert, und es gab ebenfalls eine signifikante Assoziation zwischen dem Wnt-Signalweg und der Implantation von Mäuseembryonen. Das Vorhandensein bzw. Fehlen von Samendrüsensekret beeinflusst den Wnt-Signalweg in Mäuseweibchen und wirkt sich daher auch auf die Implantation von Mäuseembryonen aus.

WNT4

10.1055/a-0589-1513

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Citations (11)

N1‐methylnicotinamide (MNAM) as a guardian of cardiovascular system

Journal of Cellular Physiology (2018)

Hamid Reza Nejabati Ainaz Mihanfar Masoud Pezeshkian Amir Fattahi Zeinab Latifi

Atherosclerosis is identified as the formation of atherosclerotic plaques, which could initiate the formation of a blood clot in which its growth to coronary artery can lead to a heart attack. N‐methyltransferase (NNMT) is an enzyme that converts the NAM (nicotinamide) to its methylated form, N1‐methylnicotinamide (MNAM). Higher levels of MNAM have been reported in cases with coronary artery disease (CAD). Further, MNAM increases endothelial prostacyclin (PGI2) and nitric oxide (NO) and thereby causes vasorelaxation. The vasoprotective, anti‐inflammatory and anti‐thrombotic roles of MNAM have been well documented; however, the exact underlying mechanisms remain to be clarified. Due to potential role of MNAM in the formation of lipid droplets (LDs), it might exert its function in coordination with lipids, and their targets. In this study, we summarized the roles of MNAM in cardiovascular system and highlighted its possible mode of actions.

Vasoprotective

10.1002/jcp.26636

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Citations (36)