Xiu-fang Yue

Shanghai Institute of Materia Medica

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[Effect of oxalysine on pulmonary metastases of Lewis lung carcinoma in mice].

PubMed (1985)

Xiu-fang Yue Fu-geng Wu Bin Xu

Oxalysine was found to be an antitumor antibiotic with a simple chemical structure very similar to lysine. In this paper, the antimetastatic action of oxalysine was studied and compared with ICRF-159. The Lewis lung carcinoma-bearing mice were killed at intervals during 10-21 d after sc implantation of tumor. The lungs from these mice were transplanted to other mice to examine the presence of tumor cells by bioassay. On d 21 after implantation of lung the tumor growth was found in 78% of the recipient mice. Oxylysine(160 mg/kg/d) was injected ip for 10 d to the Lewis lung carcinoma-bearing mice. The antimetastatic action could be detected when the treatment was started on the next day after implantation of tumor cells(P<0.05).When the drug was started on d 8 after implantation, antimetastatic action was more marked with 17% incidence of lung metastases(P<0.01). Hence oxalysine possesses a definite antimetastatic effect on Lewis lung carcinoma.

Lewis lung carcinoma

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[Antitumor activities of 4 derivatives of artemisic acid and artemisinin B in vitro].

PubMed (1992)

Weichen Sun Jia-Xian Han Weiyi Yang Ding-An Deng Xiu-fang Yue

The cytotoxicities of 2 derivatives of artemisinin B and 2 derivatives of artemisic acid (designated as Compound A, B, C, and D) were investigated, using trypan blue dye exclusion test and colony-forming units assay. At the concentration of 5 micrograms.ml-1, the inhibition rates of these 4 compounds against murine leukemia cell line P388 were > 85%. When tested against human hepatoma cell line SMMC-7721 at 25 micrograms.ml-1, the inhibition rates of Compound A, B, C, and D were found to be 92.3%, 96.9%, 84%, and 82.1%, respectively, and 27%, 8%, 37.8%, 1.7% against normal human embryonic lung cell line WI-38, respectively. These 4 compounds all showed an inhibition rate of 100% against human gastric cancer cell line SGC-7901 at 50 micrograms.ml-1.

Trypan blue

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Cytotoxic activity of trewiasine in 4 human cancer cell lines and 5 murine tumors.

PubMed (1992)

Xiu-fang Yue Jia-Xian Han Zu-Ming Shen Weiyi Yang Lijuan Lu

Trewiasine (TWS) is a mytansinoid compound. It possessed a significant cytotoxic activity against various human cancer cell lines in vitro. U937 cells, which were more sensitive to the TWS, required TWS 1 microgram.ml-1 to inhibit cell growth over 90% (P less than 0.01). TWS also showed activities against murine tumors in vivo, such as the ascitic tumors S180, hepatoma, U14, and solid tumor Lewis lung carcinoma. Depression of leukocytes was not seen when mice were given ip TWS 10 or 50 micrograms.kg-1.d-1 x 7 d. TWS 0.1-1 micrograms.ml-1 caused no sister chromatid exchange induction in Chinese hamster cell line V79.

Lewis lung carcinoma

Sister chromatid exchange

Chinese hamster

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[Influence of oxalysine (I-677) on the incorporation of lysine and its subcellular distribution].

PubMed (1983)

Xiu-fang Yue WU Shu-yun Fu-geng Wu Jin-zhu Gui Bin Xu

Oxalysine (I-677) was found to be an antitumor antibiotic with a simple chemical structure very similar to lysine. In this paper, we investigated the effect of I-677 0n protein biosynthesis, in particu- lar the synthesis of histone. When [14C]lysine or [3H]lysine was used as a precursor, a 17% inhibition of protein synthesis in vitro and a 59% inhibition on biosynthesis of histone in vivo were noted. But such an inhibitory effect of I-677 was not seen in the experiments using [3H]leu_cine as a precursor. The subcellular distribution of I-677 in liver and tumor of mice bearing sarcoma was determined by a microbiological as-say. The drug content was highest in the soluble cytoplasmic fraction.

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[Effect of oxalysine on plasma fibrinogen content in tumor-bearing mice (author's transl)].

PubMed (1982)

Xiu-fang Yue Fu-geng Wu Bin Xu

Oxalysine (I-677) is a new antitumor antibiotic found in our laboratory. In tumor-bearing mice the plasma fibrinogen level was determined by Astrup’s method. The plasma fibrinogen was elevated significantly in mice bearing B-22 and other solid tumors, but not in mice bearing ascites tumors. The uptake of [125I]fibrinogen in tumor tissue of B-22 was significantly higher than that of Ehrlich carcinoma cells (P<0.01). Oxalysine inhibited markedly the solid forms of mouse tumor, but not the ascites forms. Oxalysine 0.20 g/kg reduced markedly the fibrinogen content in mice bearing B-22 to normal level. Lysine antagonized the fibrinogen-lowering effect of oxalysine in mice bearing solid tumor B-22. The results suggest that fibrin lattice-work plays an important role in the growth of solid tumor and the antitumof activity of oxalysine may be associated with its inhibiting action on fibrinogen synthesis.

Solid tumor

Neoplasm

Ehrlich ascites carcinoma

Lewis lung carcinoma

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Citations (2)