We reported a case of Isaacs' syndrome with abnormal F response detected electrophysiologically. A 14-year-old female was admitted to Hirosaki University Hospital with complaints of progressive myokymia and muscle cramp. PHT and CBZ were partially effective, but discontinued for drowsiness. A neurological examination revealed prominent myokymia and muscle cramp in the legs. The myokymia were worsened by exercise, bathing and diet. An electrophysiological examination showed characteristic F-response; high amplitude, long duration and increased number of phases. The epidural nerve block brought about a disappearance of the myokymia and an improvement of the abnormal features of F response. After repeated double filtration plasmapheresis, the myokymia and abnormal features of F response were remarkably reduced. Although Isaacs' syndrome is thought to have a hyperexcitability at the site of distal peripheral nerve, we suggested that the hyperexcitability might exist at the site of proximal region, and that immunological mechanisms underlie the cause of myokymia and unusual F-response in this case.

Myokymia

Fasciculation

Muscle cramp

Channelopathy

Plasmapheresis

Source

Cite

Citations (3)

Clinical Investigation of Serum Adenosine Deaminase Activity In Infants and Children

Pediatrics International (1968)

Minoru Yamagishi Hisao Miura Mitsuoki Yamamoto Yoshiaki Yagi

Adenosine deaminase deficiency

10.1111/j.1442-200x.1968.tb02657.x

Cite

Citations (0)

Rectal Absorption of Clonazepam in Rabbits : A Pharmacokinetic Analysis

Kitasato medicine (1984)

Teruaki Kobayashi Masahide Ishii Masakazu Kuroyama Kenichi Sagawa Fumiya Tomonaga

Clonazepam

Source

Cite

Citations (0)

Anticarbamazepine antibody induced by carbamazepine in a patient with severe serum sickness.

Archives of Disease in Childhood (1991)

Nozomi Hosoda Wataru Sunaoshi Hajime Shirai Yuki Bando Hisao Miura

Anticarbamazepine antibody was detected in a patient who had clinical signs of serum sickness induced by carbamazepine. Skin rash, fever, oedema, and lymphadenopathy are classic signs of severe adverse reaction, but although immunological hypersensitivity is thought to be a contributory factor, the presence of anticarbamazepine antibody has not previously been reported to our knowledge.

Serum sickness

Hypersensitivity reaction

10.1136/adc.66.6.722

Cite

Citations (11)

Long-term prognosis of epileptic children with partial seizures treated with carbamazepine monotherapy.

PubMed (1990)

Wataru Sunaoshi Hisao Miura Hirokazu Shirai Nozomi Hosoda

Complex partial seizures

partial seizures

Partial epilepsy

Source

Cite

Citations (0)

[Aspects of antiepileptic drug therapy in children].

PubMed (1990)

Hisao Miura

During the past 10 years, better results in the treatment of epilepsy have been obtained through the application of pharmacokinetic data to drug therapy of epilepsy. However, pediatric drug therapy is complicated by the continuous change in body weight and body composition with the growth and development, especially during infancy. Younger children require a higher dose per kilogram of body weight than older children in order to achieve comparable plasma concentrations. Plasma levels and seizure control were investigated in a prospective randomized study when phenytoin, carbamazepine (CBZ) or sodium valproate (VPA) was given as a single drug to pediatric patients with several types of epileptic seizures. Studies on newly referred, previously untreated children suggest that both partial and generalized tonic-clonic seizures can be prevented by each of the three drugs. No significant differences in clinical efficacy were found among the three drugs, when optimum plasma concentration ranges were maintained with blood level monitoring. Clonazepam (CZP) may be effective in partial seizures. However, as a wide range of plasma levels was associated with complete freedom from seizures, it was not possible to define a therapeutic range for CZP. Any patient who receives multiple-drug therapy is at risk to develop a drug-drug interaction. Simultaneous administration of VPA was associated with a raised plasma level of carbamazepine-10,11-epoxide (CBZ-E), a major metabolite of CBZ, relative to the CBZ dose, whereas the plasma CBZ level remained unaltered. High plasma concentration of CBZ-E may be responsible for side effects in some patients. Drug-protein binding interactions are another source of side effects.(ABSTRACT TRUNCATED AT 250 WORDS)

Clonazepam

Valproic Acid

Therapeutic index

Source

Cite

Citations (4)

[Osteoporosis and immunity changes of cell-mediated immunity and T-cell subsets responding to 1 alpha (OH) vitamin D3].

PubMed (1983)

Tatsuya Sakamoto Tomoki Watanabe Yasuki Sakamoto H Miyamoto Satoko Yamaoka

Cell mediated immunity

Alpha (finance)

Source

Cite

Citations (0)

Author Index

International Archives of Allergy and Immunology (1993)

Yaron Tomer Dan Buskila Yehuda Shoenfeld Matthias S. Gruschwitz Yehuda Shoenfeld

10.1159/000236443

Cite

Citations (0)

Effectiveness and plasma levels of clonazepam monotherapy in the control of partial seizures in children.

Journal of the Japan Epilepsy Society (1986)

Hisao Miura Kimio Minagawa Satoshi Mizuno Hiroyuki Shirai

小児を対象に, 部分発作に対するclonazepam (CZP) 単剤投与の効果を, 脳波所見におよぼす影響とともに, 血中濃度面と合わせて検討した。CZPの初回維持量は0.1mg/kg/dayを基準とした。対象40例中30例では, 14-43ヵ月 (平均24ヵ月) の観察期間中発作が完全に抑制されており, しかもこのうち22例では, CZP投与後6ヵ月の脳波で発作性異常波が消失していた。一方, 6例では発作が再発し, 2例では発作が増強, また他の2例では過動などの副作用が強く, いずれもCZPの単剤投与あるいは継続投与が困難であった。しかし, 有効例とこれら無効例, 発作増強例ならびに副作用出現例で, CZP血中濃度に差を認めなかつた。

Clonazepam

10.3805/jjes.4.39

Cite

Citations (1)