Liting Zhou

Research Field

Supplementary Table S2 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Count of CD8+T cell and iNKT cell products in each course

10.1158/2767-9764.23098866

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FIGURE 2 from Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Characteristics of iNKT cells and PD-1+CD8+ T cells in the cell products were assessed by flow cytometry. A, Gating strategy of iNKT cells identified as CD3+TCR Vα24+ cells in PBMCs (left) and in cell products after expansion (right). B, The purity of iNKT cells as a percentage in CD3+ T cells before and after expansion ex vivo (paired t test). C, Gating strategy of PD-1+CD8+ T cells. PD-1 FMO was applied to rigorously define the PD-1+ cells. D, Memory status of PD-1+CD8+ T cells before (orange) and after expansion ex vivo (blue) by staining CD27 and CD45RA on cell membrane. E, Staining of CXCR3 and CXCR4 on PD-1+CD8+ T cells before (orange) and after expansion (blue).

10.1158/2767-9764.23312569.v1

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Supplementary Table S1 from Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Representativeness of Study Participants

Table (database)

10.1158/2767-9764.23312542.v1

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Association between statin usage and mortality outcomes in aging U.S. cancer survivors: a nationwide cohort study

Aging Clinical and Experimental Research (2024)

Shan Ding Feng‐Ling Yang Pan Lai Weiwen Jiang Minze Chen

The population of Aging cancer survivors in the United States has surged to over 16.9 million. Research on the relationship between statin usage and post-cancer survival rates remains limited.

10.1007/s40520-024-02851-2

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FIGURE 3 from Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Clinical records and detections. A, The body temperature of patients recorded each hour for 20 hours after cell infusion. All the records in 59 courses are included here in gray. The mean temperature in each timepoint is shown in black bold. Changes in tumor markers CA19-9 in serum during cellular therapy were shown in B. Impact of cell infusion on the cytokines in serum and key populations of lymphocytes in PBMCs. Quantification of Th1/2/17 cytokines in plasma after cell infusion were analyzed by CBA. All results are displayed in C. Change of IL6 in serum over time are shown in D, on which red dots indicated elevated IL6 levels post infusion. Change of IL6 (left) and IL17A (right) during treatment are shown in E. Changing percentage of CD4+ T, CD8+ T, B, and NK cells during treatment are assessed by flow cytometry, and data relative to baseline are shown in F, G, H, and I, respectively. Changes in number of IFNγ-secreting cells responding to α-Galcer were also recorded using ELISPOT and are shown in J with increased IFNγ-secreting cells responding to α-Galcer in some patients (solid) and not in others (dotted).

ELISPOT

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TABLE 2 from Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Adverse events

10.1158/2767-9764.23312530.v1

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Supplementary Figure S5 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Proliferation curve of iNKT cells of P001 (A) and P002 (B) during expansion ex vivo. Curves representing iNKT cells expanded in later courses is shown in darker color.

10.1158/2767-9764.23098872.v1

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Supplementary Figure S2 from Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Change of tumor markers recorded over time during treatment.

10.1158/2767-9764.23312557.v1

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FIGURE 1 from Safety and Clinical Response to Combined Immunotherapy with Autologous iNKT Cells and PD-1+CD8+ T Cells in Patients Failing First-line Chemotherapy in Stage IV Pancreatic Cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Schematic of study design and patient deposition. A, Treatment regimen. B, Patient deposition per Consolidated Standards of Reporting Trials guidelines.

Schematic

10.1158/2767-9764.23312572

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Supplementary Figure S3 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer

Jing Wang Xiaobo Cheng Yanling Jin Bili Xia Ran Qin

Gating strategy to detect CD4+ T, CD8+ T, B and NK cells by flow cytometry. Only living cells were included in the analysis (A). Changing in percentages of CD4+ T, CD8+ T, B, and NK cells during treatment are shown in panels B, C, D and E respectively.

10.1158/2767-9764.23098884.v1

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