Danyu Lu

The Second Nanning People's Hospital

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Co-Authors

Hongquan Zhang

Peking University

Wanyun Ma

Tsinghua University

Xiaochun Chi

Peking University

Jing-gao Zheng

Changchun Institute of Optics, Fine Mechanics and Physics

Dieyan Chen

Tsinghua University

Tiancheng Huo

Beckman Laser Institute and Medical Clinic

Chengming Wang

Shandong Institute of Business and Technology

Ying Li

Jilin Agricultural University

Ping Xue

Beijing University of Chemical Technology

Yu Yu

Xinjiang Academy of Agricultural and Reclamation Science

Cooperative Institutions

Peking University

Tsinghua University

Ministry of Education of the People's Republic of China

State Key Laboratory of Natural and Biomimetic Drugs

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

State Key Laboratory of Low-Dimensional Quantum Physics

Center for Life Sciences

Sichuan University

Peking University Third Hospital

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Evaluation of CYP2C19 Genetic Variant and Its Lack of Association with Valproic Acid Plasma Concentrations Among Zhuang and Han Schizophrenia Patients in Guangxi

Pharmacogenomics and Personalized Medicine (2024)

Jun Mei Teng Shuiqing Qin Danyu Lu Yefa Gu Shi Tang

To investigate the

Valproic Acid

Kazakh

10.2147/pgpm.s457805

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Citations (0)

Increased Expression of Kindlin 2 in Luteinized Granulosa Cells Correlates With Androgen Receptor Level in Patients With Polycystic Ovary Syndrome Having Hyperandrogenemia

Reproductive Sciences (2013)

Mei Yang Juan Du Danyu Lu Caixia Ren Huan Shen

Pathogenesis

10.1177/1933719113512536

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Citations (13)

Effect of homocysteine on HCY-2 expression of human embryonic ventricular myocytes

Chieh P'ou Hsueh Pao (2003)

Guangming Wang Li Ying Danyu Lu Yang Jing-jing

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FERM domain‐containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5‐mediated cell adhesion and migration

FEBS Letters (2014)

Yuqing Liu Lizhao Guan Jun Zhan Danyu Lu Junhu Wan

Unconventional myosin VIIA (Myo7a) has been known to associate with hereditary deafness. Here we present a novel function of Myo7a by identifying that Myo7a directly interacts with integrin β5 subunit and regulates cell adhesion and motility in an integrin‐dependent manner. We found that Myo7a bound to the cytoplasmic tail of integrin β5. Further, we pinpointed an integrin‐binding domain at F3 of the first FERM domain and F1 of the second FERM domain. Functionally, Myo7a‐induced cell adhesion and migration were mediated by integrin αvβ5. These findings indicated that Myo7a interacts with integrin β5 and selectively promotes integrin αvβ5‐mediated cell migration.

FERM domain

CD49c

10.1016/j.febslet.2014.06.049

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Citations (12)

Expression and distribution of laminin in the mouse embryos during early development

The Journal of Beijing Medical University (2001)

Ying Li Danyu Lu Jingjing Yang

Objective: To study the expression and distribution of laminin(LN) in the mouse early embryos during the various stages of development. And to inquire further the relationship of LN with embryo differentiation and implantation of blastocyst. Methods: Indirect immunofluorescence technique and immunohistochemical ABC method were used to observe LN in mouse early embryos during the various stages of development. Results: Strong immunofluorescence or brown granules for LN staining were found in the blastomere of pronucleus stage, two cell to eight cell stage, but not in the extracellular matrix. In morula, positive LN immunoreactive substance appeared simultaneously in both blastomere and extracellular matrix. LN chiefly distributed in the inner cell mass and between trophoblasts in early blastocyst. When it was later blastocyst, LN expression was enhanced in trophoblast cells, but not in the extracellular matrix. And strong positive LN immunoreactive substance was also found in the inner cell mass and polar trophoblast cells. Conclusion: LN existed in the blastomere during early mouse embryo development; LN appeared in extracellular matrix in morula; LN in the polar trophoblast cells and inner cell mass increased when blastocyst intruded into endometrium; LN in early mouse embryos was related to embryo development, attachment and implantation.

Inner cell mass

Blastomere

Trophoblast

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Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts

Cell stem cell (2008)

Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou

KLF4

Reprogramming

Induced stem cells

10.1016/j.stem.2008.10.014

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Citations (475)

Association of Interleukin-6 Polymorphisms with Schizophrenia and Depression: A Case-Control Study

Laboratory Medicine (2022)

Danyu Lu Minli Wang Tongfei Yang Jianyou Wang Lin Baiquan

Growing evidence suggests a crossover in genetic susceptibility to schizophrenia and depression. We aimed to investigate the association of the rs1800795 and rs1800796 polymorphisms of the IL-6 gene with schizophrenia and depression in the Han Chinese population, combined with IL-6 serum levels.Gene sequencing and enzyme-linked immunosorbent assay were performed on 113 subjects with schizophrenia, 114 subjects with depression, and 110 healthy controls.Our findings showed that IL-6 concentrations in schizophrenia and depression groups were significantly higher than in the control group. The rs1800796 CC genotype and C allele were significantly associated with depression (P = .012 and P < .05, respectively). The rs1800796 CC and CG genotype was significantly associated with chronic schizophrenia (P = .020 and P = .009, respectively). Regarding the rs1800795 polymorphism, only one case of CG genotype was detected. The remainder were of the GG genotype.The IL-6 rs1800796 might serve as a protective factor for depression and schizophrenia in the Han Chinese population.

Depression

SNP

Han Chinese

10.1093/labmed/lmac099

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Citations (3)

A quantification model for apoptosis in mouse embryos in the early stage of fetation

Science in China Series C Life Sciences (2009)

Pengfei Wang Jianhua Fu Wanyun Ma Dieyan Chen Danyu Lu

Blastula

Blastomere

10.1007/s11427-009-0130-4

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Citations (1)

BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells

Cell stem cell (2012)

Zhongwei Li Fei Teng Jianping Zhang Gaoyang Zhu Lu Wang

Dual-specificity phosphatase

10.1016/j.stem.2011.12.016

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Citations (148)

Noninvasive three-dimensional live imaging methodology for the spindles at meiosis and mitosis

Journal of Biomedical Optics (2013)

Jing-gao Zheng Tiancheng Huo Ning Tian Tianyuan Chen Chengming Wang

The spindle plays a crucial role in normal chromosome alignment and segregation during meiosis and mitosis. Studying spindles in living cells noninvasively is of great value in assisted reproduction technology (ART). Here, we present a novel spindle imaging methodology, full-field optical coherence tomography (FF-OCT). Without any dye labeling and fixation, we demonstrate the first successful application of FF-OCT to noninvasive three-dimensional (3-D) live imaging of the meiotic spindles within the mouse living oocytes at metaphase II as well as the mitotic spindles in the living zygotes at metaphase and telophase. By post-processing of the 3-D dataset obtained with FF-OCT, the important morphological and spatial parameters of the spindles, such as short and long axes, spatial localization, and the angle of meiotic spindle deviation from the first polar body in the oocyte were precisely measured with the spatial resolution of 0.7 μm. Our results reveal the potential of FF-OCT as an imaging tool capable of noninvasive 3-D live morphological analysis for spindles, which might be useful to ART related procedures and many other spindle related studies.

Telophase

Polar body

10.1117/1.jbo.18.5.050505

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Citations (11)