A commercial spacecraft should survive on orbit for more than 10 years under the severe circumstances without any maintenance. To realize this subject, not only performance but also other design factors such as reliability, mass, robustness, cost, etc. should be taken into consideration. From point of the thermal design, it is very important to obtain the robust thermal control subsystem with matrix heat pipe layout while minimizing the mass (weight). A new thermal optimization method without compromising the thermal robustness and the mass of thermal subsystem is highly anticipated. This paper proposes a robust thermal design approach for optimizing the heat pipe shape to minimize the mass of the spacecraft panel. We apply a combination of Design of Experiments (DOE), Response Surface Methodology (RSM) and Monte Carlo Simulation to determine the robust design parameters that minimize the mass of the heat pipe structure. Dimensions of the heat pipe design parameters were determined with rationally in a short time and practical robust optimization method was established.
In a developing nervous system, axon‐dendrite formation is instructed by extrinsic cues, and the mechanism whereby a developing neuron interprets these cues using intracellular signaling is particularly important. Studies using dissociated hippocampal neurons have identified many signaling pathways underlying neuronal polarization. Among the components of these pathways, Rap1B is essential for axon specification in hippocampal cultures. However, spatiotemporal regulation of Rap1B activity in polarizing neurons and how it affects neuronal polarization remain unclear. Herein, we investigated spatiotemporal activity‐change of Rap1B and its target molecules in hippocampal neurons. FRET imaging showed that specific activation of Rap1B was observed at the tip of a future axon. To dissect downstream signaling, we used three effector mutants of Rap1B. Expression of Rap1B‐G12V/E37G and G12V/Y40C mutants resulted in supernumerary axons. The targets of Rap1B‐G12V/E37G were RalA and Nore1A, whereas Rap1B‐G12V/Y40C activated PI 3‐kinase. RalA was activated in the tip of stage 3 axons, and RalA‐S28N expression reduced the fraction of neurons with supernumerary axons induced by Rap1B‐G12V/E37G. Furthermore, Nore1A depletion reduced the number of cells without axons. These results indicate that specific activation of Rap1B contributes to neuronal polarization via interaction with RalA and Nore1A in addition to PI 3‐kinase.
Electrochemical machining (ECM) is a processing method for metals that uses a DC power supply and flowing electrolyte. In some cases, discharge occurs during ECM when the gap between the electrode and workpiece, whose distance is rather small, is filled with hydrogen generated via electrolysis. We attempt to utilize a DC inductor placed between the DC supply and the electrochemical machining load in order to limit di/dt of the short or discharge current, which damages both the electrode and workpiece. When the output current surges, that is, when discharge occurs, the output voltage is suppressed by the DC inductance. In this paper, we propose a method for designing a PWM rectifier to reduce the discharge current, establish a linear approximation model for use in the PWM rectifier, describe a control method of the PWM rectifier, and demonstrate the efficacy of the model via simulations and experiments.
