Dongdong Ban

University of Science and Technology Beijing

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Lu Liu

University of Science and Technology Beijing

Lidong Li

University of Science and Technology Beijing

Xiaoyu Wang

University of Science and Technology Beijing

Shuxian Zhu

Jiangxi Normal University

Ronghua Liu

Collaborative Innovation Center of Advanced Microstructures

Jinjin Guo

Huazhong University of Science and Technology

Chuang Yao

Yangtze Normal University

Xiaohong Shi

Inner Mongolia Agricultural University

Jiahao Liang

Universidad del Noreste

Shu Wang

Chinese Academy of Sciences

Cooperative Institutions

University of Science and Technology Beijing

Nanjing University

University of California, Berkeley

University of Southern California

Yangtze Normal University

Hebei University of Technology

Xi'an University of Science and Technology

Chinese Academy of Sciences

University of Chinese Academy of Sciences

Collaborative Innovation Center of Advanced Microstructures

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Controllable accumulation of conjugated polymer nanoparticles on the surface of adhesive bacteria

Colloids and Surfaces A Physicochemical and Engineering Aspects (2020)

Lu Liu Xiaoyu Wang Dongdong Ban Shuxian Zhu Lidong Li

Sterilization

10.1016/j.colsurfa.2020.124569

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Citations (9)

Dual-emitting nanocomposites for oxygen-carrying capacity analysis and boosted singlet oxygen generation in stored red blood cells

Dyes and Pigments (2019)

Jinjin Guo Xiaoyu Wang Shuxian Zhu Lu Liu Xiaofeng Jiang

Nile red

10.1016/j.dyepig.2019.107751

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Controllable Targeted Accumulation of Fluorescent Conjugated Polymers on Bacteria Mediated by a Saccharide Bridge

Chemistry of Materials (2019)

Lu Liu Xiaoyu Wang Shuxian Zhu Chuang Yao Dongdong Ban

Current antibacterial systems face challenges associated with limited targeting ability and low antibacterial efficiency. Here, we used a "saccharide bridge" to promote accumulation of fluorescent-conjugated polymer nanoparticles (CNPs) around Pseudomonas aeruginosa (P. aeruginosa). The CNPs contained bifunctional surface groups, including phenylboronic acid (PBA) and quaternary ammonium (QA) salts. Interactions between galactose moieties in lactulose and surface LecA of P. aeruginosa promoted specific binding of lactulose to the surface of P. aeruginosa. Lactulose on the bacterial surface in turn promoted CNP adhesion through CH−π interactions between the PBA group and fructose moieties of lactulose. In addition, the electrostatic interactions between positive QA salts and negative P. aeruginosa was preserved. This dual binding mode promoted the formation of covalent bonds between the CNPs and lactulose. Molecular docking studies have shown that cis-diols in the fructose structures of lactulose provide many binding sites for multivalent covalent bond formation in CNPs. Thus, through the use of lactulose as a saccharide bridge, a large amount of CNPs are actively and tightly bound to the P. aeruginosa surface. This effective accumulation of CNPs on P. aeruginosa was leveraged to efficiently kill the bacteria through reactions with toxic singlet oxygen from photosensitized CNPs. Notably, this killing mode is not subject to drug resistance. Hence, we demonstrate the ability to control the accumulation of antibacterial agents on a bacterial surface at the molecular scale. The saccharide bridge strategy offers a simple approach to improving bacterial disinfection efficiency.

10.1021/acs.chemmater.9b04034

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Research on Key Technology in 5G Mobile Communication Network

Yunfeng Ni Jiahao Liang Xiaohong Shi Dongdong Ban

Based on the information about 5G network issued by various organizations and communication enterprises, this paper introduces what is 5G network and the development direction of 5G network technology. This paper mainly analyzes the potential wireless technology of 5G network, and introduces the basic concepts, advantages and challenges of large-scale antenna technology and ultra-dense networking technology, as well as the application scenarios of full-spectrum access technology.

Wireless WAN

10.1109/icitbs.2019.00054

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Citations (35)