Nair Honda Kawashita

Universidade Federal de Mato Grosso

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Íd

Ísis do Carmo Kettelhut

Universidade de São Paulo

Maria Antonieta Rissato Garófalo

Universidade de São Paulo

Suélem Aparecida de França

Universidade Federal de Mato Grosso

Maísa Pavani dos Santos

Universidade Federal de Mato Grosso

Renato H. Migliorini

Universidade de São Paulo

Mayara Peron Pereira

Universidade Federal de Mato Grosso

Cláudia Marlise Balbinotti Andrade

Universidade Federal de Mato Grosso

Amanda Martins Baviera

Universidade Estadual Paulista (Unesp)

M. A. F. Moura

Universidade de São Paulo

Valéria Ernestânia Chaves

Federal University of São João del-Rei

Cooperative Institutions

Universidade Federal de Mato Grosso

127

Universidade de São Paulo

Universidade de Cuiabá

Universidade de Ribeirão Preto

Universidade Estadual de Campinas (UNICAMP)

Universidade Estadual Paulista (Unesp)

Clinics Hospital of Ribeirão Preto

University of Thessaly

Centre for Research and Technology Hellas

Center for Research and Technology Thessaly

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Low-protein, high-carbohydrate diet increases glucose uptake and fatty acid synthesis in brown adipose tissue of rats

Nutrition (2013)

Suélem Aparecida de França Maísa Pavani dos Santos Roger Vinícius Nunes Queiroz da Costa Mendalli Froelich Samyra Lopes Buzelle

Fatty acid synthesis

Carbohydrate Metabolism

Lipogenesis

10.1016/j.nut.2013.10.004

Cite

Citations (16)

Utilização de glicose e atividade de enzimas glicolíticas e da lipase lipoproteica no tecido adiposo epididimal de ratos adaptados à dieta hiperproteica

Anais (1997)

S M R C Brito Nair Honda Kawashita M.N. Brito Maria Antonieta Rissato Garófalo J. R. Oliveira

Steatosis

Source

Cite

Citations (0)

Acute and subacute oral toxicity assessment of dry encapsulated and non-encapsulated green coffee fruit extracts

Journal of Food and Drug Analysis (2020)

Wanessa Costa Silva Faria Alessandra Almeida da Silva Natalie Veggi Nair Honda Kawashita Suélem Aparecida de França

The coffee fruit is a high source of bioactive compounds such as phenolic acids and methylxanthines, comprising chlorogenic acids and caffeine, respectively. Extract from this matrix may be used as supplement or active ingredient of functional foods, energy drinks, cosmetics or drugs. Safety of caffeine- and chlorogenic acid-rich encapsulated and nonencapsulated hydroethanolic extracts from green coffee fruit (GCFE) was assessed by acute and subacute toxicity tests. In the acute test, oral single dosage until 1000 mg/kg per body weight (bw) did not show any adverse effect on both female and male mice according to the Hippocratic screening and clinical parameters for a period of 14 days. While the oral median lethal dose of non-encapsulated GCFE was 5000 mg/kg bw/day, that of encapsulated GCFE was not detectable likely due to the delayed release of caffeine and other compounds from GCFE. Non-encapsulated GCFE displayed a stimulating effect at a dose of 1000 mg/kg bw/day after 30 min of oral administration, but not after 60 min. Daily consumption of encapsulated GCFE for 30 days showed no adverse effect in male rats even at the highest dose. Extrapolating this value of no-observed-adverse-effect level (1000 mg/kg bw/day) to human consumption, a human equivalent dose of 189 mg/kg bw/day or 11.34 g/day could be estimated for encapsulated GCFE considering a 60 kg adult body weight.

Chlorogenic Acid

Ingredient

10.38212/2224-6614.1067

Cite

Citations (17)

Effects of a low-protein, high-carbohydrate diet administered after weaning and the reversal of that diet in adult rats

Anais da Academia Brasileira de Ciências (2023)

Thays Queiroz Santos Edgar Willibaldo Allebrandt Neto MAÍSA P. SANTOS FRANCYELE S. CORREIA DIEGO A. DE MAGALHÃES

To evaluate the effects in adults rats submitted of a low-protein, high-carbohydrate (LPHC; 6% protein, 74% carbohydrate) diet and reversion (R) to a balanced diet introduced after weaning. Research methods & procedures: Male rats weigting approximately 100g (30 to 32 d old) were treated with control (C; 17% protein, 63% carbohydrate) or LPHC diets for 120 days. The reverse group (R) was treated with the LPHC diet for 15 days, and changed to C diet for another 105 days. Results: The LPHC group showed an increase in serum fasting triglycerides (TAG). Serum adiponectin was increased only in the LPHC group. Lipoprotein lipase (LPL) activity was decreased in the extensor digitorum longus (EDL) and cardiac muscles. The adiponectin receptor 1 content is the same among groups in the cardiac muscle, but it is lower in the EDL muscle in the LPHC group. In animals from the R group, these parameters are the same as the LPHC group. Thus, the LPHC diet administered for a long period, it promotes an increase in TAG. It is possible that there is adiponectin resistance in the EDL muscle, due to the lower LPL activity. The reversal of the LPHC diet did not normalize these parameters.

High-protein diet

10.1590/0001-3765202320220436

Cite

Citations (0)

Effects of the acute exposition to glyphosate-based herbicide on oxidative stress parameters and antioxidant responses in a hybrid Amazon fish surubim (Pseudoplatystoma sp)

Ecotoxicology and Environmental Safety (2014)

Valéria Dornelles Gindri Sinhorin Adilson Paulo Sinhorin Jhonnes Marcos dos Santos Teixeira Kelly Márcia Lazarotto MILÉSKI Paula Carine Hansen

TBARS

Thiobarbituric acid

10.1016/j.ecoenv.2014.04.040

Cite

Citations (102)

Antidiabetic activity of Vatairea macrocarpa extract in rats

Journal of Ethnopharmacology (2007)

Helder Oliveira Maísa Pavani dos Santos Rafael Grigulo Layla L. Lima Domingos Tabajara de Oliveira Martins

Phytotherapy

10.1016/j.jep.2007.10.025

Cite

Citations (94)

Hydroethanolic extract of the inner stem bark of Cedrela odorata has low toxicity and reduces hyperglycemia induced by an overload of sucrose and glucose

Journal of Ethnopharmacology (2015)

Morenna Alana Giordani Thiago Carvalho Mamede Collicchio Sérgio Donizeti Ascêncio Domingos Tabajara de Oliveira Martins Sikiru Olaitan Balogun

Cedrela odorata L. (Meliaceae) is a native plant of the Amazon region and its inner stem bark is used in the treatment of diabetes in the form of maceration in Brazilian popular medicine. Until now, there is no scientific study on this activity. The present study was aimed at evaluating the anti-hyperglycemic activity, anti-diabetic, toxicity, antioxidant and potential mechanism of action of hydroethanolic extract of the inner stem bark of Cedrela odorata.The inner stem bark extract of Cedrela odorata was prepared by maceration in 70% ethanol for 7 days to obtain hydroethanolic extract of Cedrela odorata (HeECo). The preliminary phytochemical analysis was performed according to procedures described in the literature. Selected secondary metabolites detected were quantified by high performance liquid chromatography (HPLC). Acute toxicity of HeECo was investigated in male and female mice with oral administration of graded doses of HeECo from 10 to 5000 mg/kg. Subchronic oral toxicity study was done by oral administration of HeECo (500 mg/kg) and vehicle for 30 days to both sexes of Wistar rats. Clinical observations and toxicological related parameters were determined. Blood was collected for biochemical and hematological analyses, while histological examinations were performed on selected organs. Anti-hiperglycemic and antidiabetic effects were evaluated in streptozotocin-induced diabetic rats. In acute evaluation, the animals received pretreatment with 250 and 500 mg/kg of HeECo, before carbohydrate overload. For subchronic effect, the antidiabetic activity of HeECo was evaluated using the same doses for 21 days. At the end of the treatments, the levels of triacylglycerols, malondialdehyde, total antioxidant status, superoxide dismutase and glutathione peroxidase activities were evaluated in the plasma.The extract showed low acute toxicity. HeECo exhibited inhibitory activity against α-glucosidase and caused a lowering in the peak levels of blood glucose in animals that received glucose overload by 36.7% and 24.1% in the area under the glucose curve (AUC). When the overload was sucrose, HeECo reduced the blood glucose level by 44.4% without affecting AUC. Treatment with HeECo of the blood glucose of the diabetic animals for 21 days did not lead to improvement in weight gain and regularization of the blood glucose level, but reduced the triacylglycerol and malondialdehyde levels by 36.6% and 48.1%, respectively. The activity of the antioxidant enzymes, superoxide dismutase and glutathione peroxidase were significantly increased when compared to diabetic control rats. HPLC analysis showed the presence of polyphenols, such as gallic acid, (-)- gallocatechin and (+)- catechin, the latter is present in higher quantity.Collectively, these data showed that HeECo could blunt the postprandial glycemic surge in rats; possibly through inhibition of alpha-glucosidase and positive modulation of antioxidant enzymes. Our findings confirmed the anti-hiperglycemic activity of HeECo in STZ- diabetic rats. Cedrela odorata is effective in diminishing glucose levels in vitro and in vivo and in ameliorating oxidative damage that occurs in diabetes and/or due to hyperglycemia in rats. According to our results, the efficacy of Cedrela odorata preparation could be due to the presence of active principles with different mode of actions at the molecular level, including α-glycosidases and glucose transporter inhibitors and antioxidant property.

10.1016/j.jep.2014.12.059

Cite

Citations (24)

Protein restriction in pregnancy: effects related to the mother metabolism

Arquivos Brasileiros de Endocrinologia & Metabologia (2009)

Marcia Leão Ormond Ballen Vera L. Moretto Maísa Pavani dos Santos Talita S. S. Gonçalves Nair Honda Kawashita

Objetivo: Avaliar alteracoes no metabolismo materno durante a prenhez em ratas Wistar prenhes e nao-prenhes submetidas a restricao proteica. Metodo: Dietas isocaloricas (15,74 kJ/g), controle ou hipoproteica (17% vs. 6%) foram oferecidas aos grupos (n=7): controle nao-prenhe (CNP) e prenhe (CP), hipoproteico nao-prenhe (HNP) e prenhe (HP), do 1o ao 18° dia de prenhez. Parâmetros bioquimicos, hormonais e relacionados a sintese de lipidios foram avaliados. Utilizou-se ANOVA a duas vias seguido de teste Tukey-HSD e teste t-Student, significância de p<0,05. Resultados: A restricao proteica elevou a sintese de lipidios e atividade da enzima malica (EM) no figado (FIG) e reduziu a massa (%) e a razao lipidio/glicogenio nesse tecido; reduziu a ingestao proteica (total e %), o conteudo (%) de lipidios na glândula mamaria (GMA), proteinas e albumina sericas, com consequente reducao nas massas da placenta e fetos. A prenhez reduziu a proteinemia, albuminemia, a sintese de lipidios, atividade da EM, os lipidios e glicogenio no FIG, e elevou: massa corporal final, massa (%) do tecido adiposo gonadal (GON), FIG e GMA, e reduziu: massa (%) da carcaca (CARC), sintese e conteudo de lipidios no GON e, na GMA, o conteudo de lipidios. A insulinemia elevou-se na prenhez, com glicemia reduzida, caracterizando resistencia hormonal. Leptina e prolactina tambem se elevaram na prenhez, sendo o aumento maior no HP. Conclusao: A restricao proteica na prenhez modificou o metabolismo materno, alterando a sintese de lipidios no figado, o perfil hormonal e reduzindo a massa da placenta e dos fetos. Palavras chave: restricao proteica, prenhez, metabolismo materno.

Source

Cite

Citations (0)

Exercise-induced effects on UCP1 expression in classical brown adipose tissue: a systematic review

Hormone Molecular Biology and Clinical Investigation (2017)

Andreas D. Flouris Petros C. Dinas Angelica Valente Cláudia Marlise Balbinotti Andrade Nair Honda Kawashita

Abstract Understanding the impact of regular exercise training on uncoupling protein 1 (UCP1) activity in classical brown adipose tissue (

Expression (computer science)

10.1515/hmbci-2016-0048

Cite

Citations (30)

A low-protein, high-carbohydrate diet increases browning in perirenal adipose tissue but not in inguinal adipose tissue